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Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

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$2.62B

Total funding

$5K

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9,000+ grants
$2.62B total
$5K median

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Fall 2026 Early Childhood Education Grant

Stranahan Foundation
Private
United States
Up to US $150,000

Fall 2026 Early Childhood Education Funding Cycle

Overall Early Childhood Education Program Blueprint

The Stranahan Foundation’s Early Childhood Education grant program supports efforts to improve access to high-quality early care and education for young children (birth to five), especially those from low-income families. We do this by investing in strategies that strengthen, support, and retain a high-quality, thriving early educator workforce.

The Foundation has a history of supporting professional development (PD) and learning systems through its Provider strategy (). We believe strong professional development systems are essential for building a skilled early childhood workforce and creating positive learning environments for young children.

The Fall 2026 funding cycle is available for organizations that align with this Provider strategy.

Funding Opportunity

This funding opportunity will provide up to $750,000 to support early childhood education providers in strengthening existing professional development (PD) systems. Funding is intended to improve a specific area of an established PD system—not to build a brand-new system from scratch or put the foundational elements in place.

What kind of improvements can funding support?

Organizations should focus their projects on strengthening their professional development systems. The Stranahan Foundation defines a strong professional development system as one that includes:

  • Connect learning opportunities that build on one another over time.
  • Use adult learning best practices.
  • Align staff learning to educator competencies, credentials, career growth, or compensation.
  • Provide learning experiences that are individualized, scaffolded, and responsive to educators’ needs, experience, and goals.
  • Have dedicated leadership and organizational capacity to support ongoing implementation.

  • Gather regular feedback from staff and families.
  • Use standardized assessment and evaluation tools to understand what is working and where improvements are needed.
  • Make ongoing improvements based on what is learned.
  • Support reflective practice, peer learning, and collaborative inquiry among educators.

  • Offer both individual and group learning opportunities, such as training, professional learning communities, coaching, and mentoring.
  • Provide learning opportunities on an ongoing basis rather than in a one-and-done situation.
  • Connect internal and external learning opportunities to make the best use of available resources.
  • Support classroom implementation through observation, modeling, feedback, and continuous improvement cycles.

  • Provide learning experiences that are practical, relevant, and easy to apply in daily work.
  • Include fundamental topics such as family engagement, effective instruction, developmentally appropriate practice, and classroom management.
  • Align with established standards, research, and effective practices in the early childhood field.
  • Equip educators to support all learners, including multilingual learners, children with disabilities, and children impacted by trauma or adverse experiences.
Education - Preschool / Early Learning Workforce Preparation & Job Readiness Early Childhood Development +1 more

Robert L. Johnson Memorial Research Grant

Midwest Aquatic Plant Management Society
Association/Society
Canada, Mexico +1 more
Up to US $10,000
The Robert L. Johnson Memorial Research Grant, offered by the Midwest Aquatic Plant Management Society, supports graduate students in aquatic plant management with grants of up to $10,000. This initiative promotes research that advances the management of aquatic ecosystems and fosters educational opportunities. Recipients are required to present their findings at the annual conference, contributing to the society's mission of sustainable aquatic resource management and ecological preservation.
Plant Science Environmental Conservation Marine / Ocean Conservation +1 more

Dashanna K. McNeil Memorial Scholarship

Dashanna K. McNeil Foundation
Association/Society
United States
Unspecified amount
The Dashanna K. McNeil Memorial Scholarship honors the legacy of a dedicated nursing professional who inspired many through her passion for healthcare. This scholarship encourages aspiring nurses at various educational levels to pursue their dreams in nursing. It supports individuals planning to attend accredited nursing institutions, fostering a new generation of compassionate caregivers, just as Dashanna did throughout her impactful career.
Academic Scholarship Programs Education - Higher Education Nursing +2 more

Clifford and Rubye Angleton Scholarship Fund

Central Kansas Community Foundation
Private
United States
Unspecified amount
The Clifford and Rubye Angleton Scholarship Fund, managed by the Central Kansas Community Foundation, supports graduating high school seniors and college students from Butler County, Kansas, pursuing higher education. Scholarships are based on available funds and applicants' merit. Recipients may renew their scholarships for up to three years with satisfactory academic progress. This initiative emphasizes the importance of rural philanthropy and aims to empower local students to achieve their educational goals.
Education - Higher Education Agriculture Vocational & Trade Education +3 more

Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative

Appalachian Regional Commission
State/Local Government
Adair County, Kentucky, Adams County, Ohio +428 more
Up to US $2,500,000
The Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative aims to revitalize communities impacted by coal industry transitions. This initiative provides funding for projects that diversify local economies, enhance job training, and create new employment opportunities. By fostering collaboration among various stakeholders, the POWER Initiative supports strategic investments that align with regional economic development plans, ensuring a more resilient future for coal-affected areas.
Economic Services & Development Workforce Preparation & Job Readiness Job Creation +1 more

A. Wlock and E. Woodruff Scholarship

Saginaw Community Foundation
Private
United States
Unspecified amount

A. Wlock and E. Woodruff Scholarship

The A. Wlock and E. Woodruff Scholarship was created by Emilee Woodruff and Autumn Wlock’s family and the W2 Foundation in loving memory of Emilee and Autumn. Emilee and Autumn passed away in February 2020 when a fire destroyed their home. Emilee was diagnosed with epilepsy as a preteen. Autumn was Emilee’s first child and love of her life. Emilee was a great mother and Autumn was a happy baby. This scholarship is aimed to help students attend college that have been affected by a fire or who have been diagnosed with epilepsy.  

Education - Higher Education Epilepsy Career / College Preparation

Colin and Sally Rowell Memorial Scholarship Fund

Central Kansas Community Foundation
Private
United States
Unspecified amount
The Colin and Sally Rowell Memorial Scholarship Fund, managed by the Central Kansas Community Foundation, offers financial assistance to graduating seniors from Butler County, KS high schools pursuing higher education or vocational training. This scholarship aims to support students with a demonstrated interest in education or agriculture, emphasizing financial need and potential for success in college. It reflects the foundation's mission to strengthen communities through charitable giving, promoting rural philanthropy in the central Kansas region.
Education - Higher Education Vocational & Trade Education Education - High School +3 more

Black Men Building Resources Scholarship

Grand Rapids Community Foundation
Private
United States
US $2,000 - US $5,000
The Black Men Building Resources Scholarship, offered by the Grand Rapids Community Foundation, supports African-American undergraduates from Kent County. This scholarship aims to empower students pursuing college or career training by removing barriers to academic success. With awards ranging from $2,000 to $5,000, the program prioritizes applicants with high financial need, ensuring that opportunities are accessible to those who strive for educational advancement in West Michigan.
Education - Higher Education College Success / Persistence Educational Access & Equity +1 more

Elisa B. Hughey Scholarship for the Arts

Cattaraugus Region Community Foundation
Private
United States
US $500 - US $1,000

Elisa B. Hughey Scholarship for the Arts

Scholarships will be awarded annually from this fund for college-bound students from any Cattaraugus County High School committed to advancing their skills in any aspect of the arts. Preference will be for graduating seniors of Ellicottville, Cattaraugus-Little Valley, West Valley, Salamanca or Franklinville/Ten-Broeck Academy high schools. First preference will be for students pursuing the fine arts, with second preference for students pursuing performing arts fields. This award is not limited to students majoring in art.

Education - Higher Education Performing Arts Fine Art +2 more

Empower To Grow (E2G) Manufacturing in America Grant

U.S. Small Business Administration
Federal Government
United States
Up to US $1,148,658

U.S. Small Business Administration

SBA works to ignite change and spark action so small businesses can confidently start, grow, expand, or recover. Created in 1953, the U.S. Small Business Administration (SBA) continues to help small business owners and entrepreneurs pursue the American dream. SBA is the only cabinet-level federal agency fully dedicated to small business and provides counseling, capital, and contracting expertise as the nation’s only go-to resource and voice for small businesses.

Manufacturing grants

SBA provides grants to help empower small manufacturers.

Empower To Grow (E2G) Manufacturing in America Grant

The goal of this grant is to provide workforce development in key manufacturing industries, such as timber, energy, aluminum, steel, digital, and automotive.

SBA is looking for organizations that will provide technical proficiency and essential skills, including operating machinery, quality control, welding, utilizing industrial software, and workplace safety. 

Workforce Preparation & Job Readiness Manufacturing Engineering Business Development

Martha Rodriguez Scholarship Fund

Nurses Educational Funds Inc.
Private
United States
Unspecified amount

Nurses Educational Funds

Nurses Educational Funds, Inc. depends solely on donations to advance our only mission, to promote nursing leadership through annual scholarship support for professional nurses seeking masters and doctoral degrees in nursing education, practice, research, and administration.

NEF’s only purpose is to provide nursing scholarship assistance to make graduate level nursing education possible. NEF is one of the largest, national, private, professionally endorsed source of funds for advanced nursing study with over one hundred years of service to and for professional nursing. NEF is a non-profit organization with 501(c) status.

Martha Rodriguez Scholarship Fund

Martha Rodriguez Memorial Scholarship was initiated in 2025 by Lisa Ackerman, close friend and then Director of the Columbus Citizens Foundation. Raised in Gary, Indiana and a true New Yorker, Martha died as the result of traumatic head injuries from a tragic accident just outside her NYC apartment. Martha Rodriguez gave in life, working as a nurse helping patients navigate the trauma of breast cancer at Memorial Sloan Kettering Cancer Center. In her death, she was lauded by the President of LiveOnNY, an organization that coordinates and oversees organ donations, for her last selfless act of giving. Martha donated organs that gave life and hope and helped three people lead better lives. Her zest for life was contagious, and her dedication, compassion, and expertise left an indelible mark on the lives of countless MSKCC patients and caregivers. She was a friend and mentor to many. She loved being a nurse at MSKCC and worked for more than 28 years as a nurse practitioner and for the last 15 years of her life dealing with breast cancer patients. This scholarship is awarded to nurses studying in master's or doctoral programs who are dedicated to oncology care, or women’s health, or are Latinx nurses.

Education - Higher Education Nursing Cancer / Oncology +1 more

Edward C. Snyder Memorial Scholarship

Scranton Area Foundation Inc
Private
United States
Unspecified amount

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a student who is matriculating in a performing arts program, has demonstrated commitment to their art, and has demonstrated evidence of community involvement and service to others.

Education - Higher Education Performing Arts Youth Development & Leadership +2 more

Rod's Tire and Service Scholarship Fund

Central Kansas Community Foundation
Private
United States
US $2,500
The Rod's Tire and Service Scholarship Fund, managed by the Central Kansas Community Foundation, offers $2,500 to assist graduating Marion County high school seniors pursuing higher education or vocational training. The foundation, established in 1994, focuses on enhancing community welfare through charitable giving and emphasizes support for students majoring in agricultural fields. This scholarship aims to empower local youth and strengthen the community by investing in their educational futures.
Education - Higher Education Vocational & Trade Education Education - High School +3 more

The Jenna’s Rainbow Moving Forward Grant

Childrens Brain Tumor Foundation Inc.
Private
United States
Unspecified amount
The Jenna’s Rainbow Moving Forward Grant, offered by the Children’s Brain Tumor Foundation, provides crucial financial assistance to adult survivors of brain or spinal cord tumors. Aimed at fostering independence, this grant supports costs associated with job transitions, new living situations, and resources to enhance self-sufficiency. Eligible applicants must be at least 18 years old, diagnosed before 21, and not have received recent funding from CBTF or JRF. This initiative empowers survivors to overcome challenges and move forward in their lives.
Education - Higher Education Vocational & Trade Education Education - High School +2 more

Judith Heavenrich Memorial Scholarship

Saginaw Community Foundation
Private
United States
US $500 - US $4,000
The Judith Heavenrich Memorial Scholarship, established in memory of Judith Heavenrich, aims to support single, low-income mothers in Saginaw County as they pursue higher education or vocational training. Judith, a lifelong advocate for education and environmental issues, faced numerous challenges in her life but remained dedicated to her community. This scholarship reflects her spirit and commitment to empowering women to achieve their educational goals, with awards typically ranging from $500 to $4,000.
Education - Higher Education Education - High School Academic Scholarship Programs +3 more

Llewellyn L. Cayvan String Instrument Scholarship

Grand Rapids Community Foundation
Private
United States
Unspecified amount

Generally the Community Foundation's scholarships are awarded to applicants who have high financial need. Applicants with household income exceeding $100,000 are less likely to be awarded, but applying will allow you to be considered for targeted scholarships.

Llewellyn L. Cayvan String Instrument Scholarship

Open to students studying music with concentration in viola, violin, violincello, or bass viol.

Performing Arts Classical Music Music Education

David Bruce Belcher Fund Scholarship

Benton Community Foundation
Private
United States
Unspecified amount

About

Mission, Vision & Values

To enhance our community through philanthropy.

We aspire to co-create diverse, meaningful and innovative charitable giving that yields an exponential positive impact within local communities and beyond.

David Bruce Belcher Fund

About the fund

The David Bruce Belcher Scholarship Fund was established for the training of professionals in nursing, special education, and therapy (physical, speech and occupational) as a legacy of David Bruce Belcher and the caregivers who comforted him. This fund reflects David’s rare spirit and bright love in its support of those who seek to advance their nurturing skills in nursing, therapy, and special education.

Education - Higher Education Nursing Physical Therapy +2 more

Brady Education Foundation Grants

Brady Education Foundation
Private
United States
Unspecified amount
The Brady Education Foundation offers grants aimed at enhancing educational outcomes for children, particularly in low-income areas. Through collaborations among researchers and educators, the foundation funds Research Projects and Program Evaluations that adhere to strength-based approaches. Eligible organizations include non-profits and academic institutions, with a focus on projects that evaluate effective educational strategies. The foundation emphasizes the importance of measurable outcomes and the potential to inform future educational practices and policies.
Education - K through 12 Education System Policy & Reform Academic Success & Enrichment +2 more

Herbek Humanitarian Award

College Of American Pathologists Foundation
Private
United States
Up to US $1,500
The Herbek Humanitarian Award honors a CAP member pathologist for significant contributions to the See, Test & Treat® program, which offers free cancer screenings to underserved women. Established in 2011, it commemorates Gene N. Herbek, MD, FCAP, who pioneered this initiative for Native Americans. Nominees must have led or significantly contributed to the program, with submissions due by May 3, 2024. Self-nominations or incomplete entries will not be accepted, ensuring high standards in recognition.
Reproductive Health Breast Cancer Women's Health

Limited Competition: Tribal Institutional Review Board Establishment and Enhancement (TIRBEE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The TIRBEE funding opportunity supports federally-recognized Tribes and Tribal Entities in establishing or enhancing Institutional Review Boards. This initiative aims to strengthen the capacity for biomedical research involving human participants within these communities by improving review and oversight capabilities. Eligible organizations are invited to apply, with applications subject to NIH's standard peer-review process to ensure only the most meritorious proposals are considered.
Epidemiology & Public Health Native American Services Health Disparities & Social Determinants of Health +1 more

Stanford Childern's Health Center for IBD and Celiac Disease - Intramural Seed Grants Research Program

Stanford Health Care
Private
United States
Up to US $200,000
The Stanford Children's Health Center for IBD and Celiac Disease offers Intramural Seed Grants to promote innovative research in pediatric diseases. This program supports high-risk, high-reward projects, encouraging multi-PI collaborations across disciplines. Awards of up to $100,000 per year for two years are available, aimed at generating preliminary data for future funding applications. Eligible applicants include Stanford faculty holding specific university positions. Proposals should focus on advancing understanding of pediatric IBD and celiac disease through various research approaches.
Digestive System Health & Diseases Maternal And Perinatal Health Children’s Health & Pediatrics

Teresa and David R. Schmidt, M.D. Scholarship Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Teresa and David R. Schmidt, M.D. Scholarship Fund, managed by the San Antonio Area Foundation, supports high school seniors pursuing careers in the medical field. Eligible applicants must demonstrate financial need and maintain full-time enrollment at accredited institutions. This renewable scholarship assists with tuition, fees, and books for students from specific Texas counties, fostering community growth and educational opportunities in healthcare since 1964.
Nursing Physical Therapy Medical Education & Professional Training +2 more

Robert B. Taylor Fund

San Antonio Area Foundation
Private
United States
Unspecified amount
The Robert B. Taylor Fund, managed by the San Antonio Area Foundation, supports students pursuing higher education in vocational fields or those seeking associate degrees. Available to high school seniors, college students, and adult learners, it emphasizes financial need and academic performance, specifically a minimum GPA of 2.5. Preference is given to Black or African American students and those enrolled in Alamo Community Colleges. This fund aims to enhance educational opportunities and community growth.
Adult Education Nursing Vocational & Trade Education +3 more

Stanford Medicine Children’s Health Center for IBD and Celiac Disease Postdoctoral and Early Career Support Award

Stanford Health Care
Private
United States
Up to US $200,000
The Stanford Medicine Children’s Health Center for IBD and Celiac Disease offers funding for postdoctoral fellows and instructors to conduct innovative research focused on pediatric IBD and celiac disease. This initiative aims to nurture future researchers and prepare them for independent funding opportunities. Eligible research includes basic, clinical, epidemiological, and health policy studies related to maternal and child health. Funding supports substantial salary and benefits, ensuring commitment to impactful research in this critical area.
Digestive System Health & Diseases Children’s Health & Pediatrics Maternal And Perinatal Health

Surayria T. Hasan Scholarship

Beckley Area Foundation
Private
United States
Unspecified amount

Mission Statement

Beckley Area Foundation exists to inspire and facilitate generous charitable giving that advances our community.

The Beckley Area Foundation is committed to enriching lives and strengthening communities across Southern West Virginia.

Scholarship

Supporting Student Success

The Beckley Area Foundation proudly manages scholarship funds established by individuals, businesses, and organizations dedicated to helping students pursue higher education. Many of these scholarships are tailored for specific schools, fields of study, or graduates from local high schools, while others offer broader opportunities. No matter the path, our scholarships aim to support students from our region as they work toward achieving their educational goals.

Surayria T. Hasan Scholarship

Eligibility

Both need and merit will be considered in selecting applicants; Must be a minority student from Raleigh County, West Virginia; Pursuing either a masters in nursing degree, a nurse practitioner degree, or physician’s assistant degree at a West Virginia school, preferably in Raleigh County.

Educational Access & Equity Minority Services Nursing +2 more

Debra Slater Memorial Scholarship

Ashland County Community Foundation
Private
United States
Unspecified amount
The Debra Slater Memorial Scholarship, offered by the Ashland County Community Foundation, assists graduating seniors from Hillsdale High School and continuing college students pursuing accredited two or four-year degrees. Eligible applicants must major in Agriculture or Animal Sciences and maintain a GPA of 2.5 or higher, with preference given to current or former members of FFA or 4-H. This scholarship aims to support future leaders in agriculture and contribute to the community's growth.
Education - Higher Education Academic Scholarship Programs College Success / Persistence +2 more

Daland Fellowships in Clinical Investigation

American Philosophical Society
Association/Society
United States
Up to US $80,000
The Daland Fellowships in Clinical Investigation, awarded by the American Philosophical Society, support research in clinical medicine across various fields, including internal medicine and psychiatry. Each fellowship provides $40,000 annually for up to two years, contingent on satisfactory progress. Eligible candidates include those with recent M.D. or Ph.D. degrees, and applicants must conduct research under a scientific advisor in the U.S. Preference is given to those with limited postdoctoral training.
Diseases & Conditions Surgery Children’s Health & Pediatrics +2 more

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

53 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

40 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
25.2%
Q3
24.8%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$535,356 $535.4 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081