Best Large Grants for Nonprofit Organizations in South Carolina

The A.D. and Peggy Hewlett and Colonel David R. Inman Medical Scholarship, established by Steve Hewlett, Pam Inman, and Faye Houston, honors their parents' commitment to education and healthcare. This scholarship supports students pursuing nursing, pharmacy, or physical therapy, prioritizing applicants from Hancock, Ohio, or Daviess County, Kentucky. Applicants must demonstrate academic potential and compassion through relevant experiences. The Community Foundation of Middle Tennessee administers this fund to foster a more inclusive and thriving community.

Mary Joan Keeney Scholarship

The Mary Joan Keeney Scholarship was established in 2017 to honor the memory of Joan Keeney and her dedication to continuing education. In 1992, at the age of fifty-nine, she attended Denver Seminary in Denver, Colorado and completed a life-long dream of earning a Master’s in Counseling. Upon graduation, she volunteered as a grief and bereavement counselor at The First Presbyterian Church in Boulder, Colorado. Her life passion was helping others heal and return to love.

The purpose of this scholarship is to provide non-traditional, female students interested in nursing and mental health careers access to funds to help further their education and/or certification. In 2026, two one-time scholarship awards of $5,000 each will be offered.

The Limited Competition: Clinical and Translational Science Award (CTSA) Program's Collaborative and Innovative Acceleration Award aims to enhance translational research by fostering collaboration in developing and implementing innovative solutions. This funding opportunity invites applications focused on new approaches and technologies that will improve research impact across various diseases and expedite treatment availability. Eligible applicants include organizations with active CTSA hub prime or partnering awards.

The R. Don Cowan Music & Performing Arts Scholarship, administered by the East Texas Communities Foundation, supports students pursuing studies in music and performing arts, including musical theater and dance. Applicants must be graduating seniors or current college students from Smith County, with no specific financial need requirement. This scholarship is available for one year and allows recipients to major in any subject while continuing their performing arts education.

Mission

To empower worthy nonprofits by providing critically needed, unrestricted funding that helps them fulfill their missions with confidence and sustainability.

How We Serve Nonprofits

AmFund partners with nearly 800 organizations annually—supporting causes related to health, education, the arts, human services, animal welfare, and more. We’re known for our:

• Signature silent and live auctions featuring once-in-a-lifetime travel experiences.
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• Ongoing educational resources, grants, and consulting support for nonprofit development.

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Our model is built on relationship, trust, and results. Every trip sold, every service provided, and every donor interaction is designed to maximize your fundraising impact—without adding burden to your team.

The Luther Halsey Gulick Award, presented by SHAPE America, recognizes individuals with over ten years of membership who have made outstanding contributions to health and physical education. This prestigious honor is awarded annually to a candidate selected for their exemplary leadership and service in the field. Nominations are carefully evaluated based on the candidate's impact on the profession and their ability to inspire future generations to lead healthy, active lives.

The Native Forward Community Impact Research Funding supports doctoral candidates conducting research that addresses issues affecting Indian Country. This initiative provides essential financial assistance for data collection, analysis, and research travel, ensuring that Native perspectives are included in academic discourse. By fostering the next generation of Native leaders, this funding aims to empower scholars and enhance community impact through education and advocacy, ultimately preserving and enriching Native cultures.

The Measurement and Evaluation Honor Award recognizes exceptional contributions by a SHAPE America professional towards the Measurement and Evaluation SIG's mission. This prestigious accolade celebrates those who advance health and physical education practices, inspiring educators to enhance student well-being. Eligibility requires current membership in SHAPE America and the Measurement and Evaluation SIG, ensuring that only dedicated professionals are honored. This award embodies the commitment to fostering excellence in educational environments, ultimately aiming to prepare all children to lead active, healthy lives.

The Robert B. Taylor Fund, managed by the San Antonio Area Foundation, supports students pursuing higher education in vocational fields or those seeking associate degrees. Available to high school seniors, college students, and adult learners, it emphasizes financial need and academic performance, specifically a minimum GPA of 2.5. Preference is given to Black or African American students and those enrolled in Alamo Community Colleges. This fund aims to enhance educational opportunities and community growth.

The MyGOAL Autism Grant Program provides essential financial support for families caring for individuals with Autism Spectrum Disorders. This need-based grant assists with non-reimbursable medical expenses, nutritional needs, personal care, and educational enrichment activities. With a funding amount of $1000, the program prioritizes first-time applicants and aims to enhance the well-being and development of children with ASD, addressing gaps left by other funding sources.

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a student who is matriculating in a performing arts program, has demonstrated commitment to their art, and has demonstrated evidence of community involvement and service to others.

The Allison Adams Wieczorek Scholarship supports graduate nurses pursuing degrees in maternal-infant and pediatric nursing. Established through the Nurses Educational Funds, Inc., this scholarship honors the contributions of Allison Adams Wieczorek, a dedicated board member with extensive experience in financial services. Applicants must have at least two semesters of study remaining and meet specific eligibility criteria, including holding a current RN license and maintaining a minimum GPA of 3.6. This initiative fosters nursing leadership and education.

The Leonard Litz LGBTQ+ Foundation, via its TransPLUS Resource Center, supports transgender, gender-nonconforming, non-binary, and intersex individuals. By providing grants and resources, the Foundation aims to address urgent needs in healthcare, housing, and legal services while fostering community connections. They build peer-support networks, publish updates, and support initiatives to empower TGNCNBI individuals and their allies, ensuring that marginalized voices are heard and uplifted.

The Jonathan Sherman Spradling Memorial Scholarship Fund, established in 2023, honors the legacy of Jonathan Sherman Spradling, a dedicated New Mexico resident committed to education and community service. This scholarship provides financial assistance to high school seniors who demonstrate a strong commitment to volunteerism. With a focus on applicants from Valencia County, NM, the fund aims to support students pursuing higher education at accredited institutions while encouraging continued involvement in community service.

The Partnerships for Opportunity and Workforce and Economic Revitalization (POWER) Initiative aims to revitalize communities impacted by coal industry transitions. This initiative provides funding for projects that diversify local economies, enhance job training, and create new employment opportunities. By fostering collaboration among various stakeholders, the POWER Initiative supports strategic investments that align with regional economic development plans, ensuring a more resilient future for coal-affected areas.

Napa Valley Community Foundation

There are more than 800 Community Foundations in the US, each devoted to a specific region. We operate independently, with a common goal in mind: to be a platform for local people who want to pay it forward. To deliver resources to effective charitable programs. And to make our communities stronger and more successful by doing these two things.

Among our peers, Napa Valley Community Foundation ranks first on several key measures of donor satisfaction and impact, according to a recent donor survey conducted by the Center for Effective Philanthropy. Our donors say that we deeply understand their interests, and deeply understand the needs of Napa Valley. That, in a nutshell, is our job.

Ted Kohler Music Scholarship

The Ted Kohler Music Scholarship benefits Calistoga students who are committed to music and wish to advance their musical development. The scholarship can be used to pay for activities such as music lessons or summer camp, or for college tuition (where the student demonstrates their desire to continue their musical education). The Ted Kohler Scholarship was established in 1997 to promote musical participation and aspirations in honor of Ted, who upon retirement from San Francisco State University, became a full-time musician and leader of the Napa Valley Jazz Band. He encouraged people of all ages to express themselves musically.

The David R. Woodling Memorial Scholarship, established by The Stocker Foundation in 2007, supports students pursuing certificates or degrees in metals technology, focusing on machine tool technology and welding. Open to legal residents of New Mexico, eligible applicants include high school seniors and nontraditional students. The scholarship aims to provide financial assistance for tuition, fees, books, and required materials, ensuring that recipients can achieve their educational and career goals in this vital field.

The Public Health Nursing initiative aims to enhance the health and wellness of American Indian and Alaska Native men by implementing a culturally sensitive case management model. Through this program, Public Health Nurses will provide preventive health services, facilitate access to care, and encourage healthy lifestyle choices. By promoting early identification and management of health issues, the initiative strives to improve overall community health outcomes through targeted, collaborative interventions.

The Graham Foundation for Advanced Studies in the Fine Arts, established in 1956, supports innovative projects that explore architecture's role in society and culture. It offers grants to individuals for production and presentation, as well as research and development, focusing on diverse ideas that provoke critical dialogue. The foundation prioritizes first-time applicants and seeks to amplify underrepresented perspectives while fostering collaboration across various disciplines in the arts and education.

The Graham Foundation for Advanced Studies in the Fine Arts offers grants to organizations focused on architecture and its role in society. Established in 1956, the Foundation promotes innovative projects that encourage public dialogue, raise awareness, and foster experimentation in the field. Grants, not exceeding $30,000, support diverse practitioners and initiatives, enhancing discourse in architecture, design, visual arts, and related fields. The Foundation encourages projects that demonstrate originality, feasibility, and potential for meaningful impact.

The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.

The OVW Fiscal Year 2026 Consolidated Grant Program aims to support community-based initiatives that assist children and youth impacted by domestic violence, dating violence, sexual assault, and stalking. It also focuses on engaging men and youth in prevention efforts. Eligible applicants can develop or expand strategies for prevention, intervention, and treatment, addressing the needs of affected individuals aged 0-24. Applications are due by September 10, 2026.

The Zonta Club of Greater Sandusky High School STEM Scholarship Fund provides financial support to female high school seniors from Erie, Huron, or Ottawa County, Ohio, who plan to pursue a degree in STEM or medical fields at accredited institutions. Established by the Zonta Club, this scholarship aims to empower young women to contribute positively to their communities by facilitating access to higher education opportunities. Since its inception, it has fostered academic growth and leadership among recipients.

The Native Forward Direct Scholarship supports American Indian and Alaska Native students by providing mid-year funding opportunities to alleviate educational costs. With over 50 years of experience, Native Forward has empowered more than 22,000 students from diverse backgrounds. This scholarship recognizes the limited access these students face in higher education and aims to enhance their academic journeys while fostering community engagement and mentorship through a strong alumni network.

The Louis Stokes Alliances for Minority Participation (LSAMP) Bridge to Doctorate Scholars Program, funded by the National Science Foundation, aims to recruit and retain minority graduate students in STEM fields. This program offers significant benefits, including a $32,000 annual stipend and $12,000 educational allowance for two years, fostering a supportive community through monthly dinners for Indigenous graduate students. Eligible applicants must be U.S. citizens, identify as American Indian or Alaska Native, and have participated in an LSAMP program.

The NC Hunter and Jumper Association’s Norah Morris Memorial Scholarship Endowment supports individuals pursuing higher education who have engaged in equestrian activities. Open to undergraduates, graduates, and adult re-entry students, the scholarship aims to assist those attending various educational institutions in the United States. Applications for NCCF scholarships will be accepted from December 16, 2025, to March 3, 2026. Be sure to check specific eligibility requirements for each scholarship.

The Joyce Price Johnson’s Samaritan Fund provides scholarships for young people in North Carolina who are exiting foster care or facing poverty. Eligible candidates include undergraduates, graduates, and adult re-entry students attending various accredited institutions. Applications for NCCF scholarships open on December 16, 2025, and close on March 3, 2026. Preference is given to applicants from Wayne County and adjacent areas, ensuring support for those with exceptional financial need.