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Best Large Grants for Nonprofit Organizations in South Carolina

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 9,000+ Large Grants for Nonprofit Organizations in South Carolina in the United States.

9,000+

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$2.62B

Total funding

$5K

Median grant

9,000+ grants
$2.62B total
$5K median

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Lakken’s Legacy Survivor Scholarship

Childrens Brain Tumor Foundation Inc.
Private
United States
US $1,000
The Lakken’s Legacy Survivor Scholarship, offered by the Children’s Brain Tumor Foundation, awards $1,000 to brain tumor survivors pursuing education beyond high school. This initiative honors Lakken, who faced challenges during her cancer journey yet remained passionate about education. The scholarship aims to support individuals diagnosed with brain or spinal cord tumors before age 21, ensuring they have the opportunity to continue their studies in various educational institutions. It's a commitment to empower survivors and foster their dreams.
Education - Higher Education Vocational & Trade Education Education - High School +2 more

Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.
Children’s Health & Pediatrics Genetic Conditions & Birth Defects Pediatric Cancers

The Women in Rhetoric and Logic Scholarship

Albuquerque Community Foundation
Private
United States
Up to US $3,000
The Women in Rhetoric and Logic Scholarship, established by the Sandia Foundation, supports female students from Albuquerque Academy pursuing higher education in the U.S. This one-time, non-renewable award of up to $3,000 aims to empower young women by alleviating financial burdens associated with college. Applicants must present a high school transcript, a résumé, a personal essay detailing their college aspirations, and a letter of reference. Preference is given to those with debate team experience.
Vocational & Trade Education Career / College Preparation Academic Scholarship Programs +2 more

Scotiabank Corporate Giving Program: ScotiaRISE

Scotiabank
Corporate
Antigua and Barbuda, Aruba +29 more
Unspecified amount
The ScotiaRISE initiative by Scotiabank aims to foster economic resilience among disadvantaged groups over ten years, with a budget of $500 million. By focusing on enhancing educational opportunities, facilitating employment for newcomers, and removing barriers to career advancement, ScotiaRISE seeks to create a more inclusive society. This program highlights the importance of collective efforts in supporting individuals and communities to thrive, ensuring everyone has the chance to rise above challenges and contribute positively to their environments.
Economic Services & Development Education - High School Educational Access & Equity +1 more

Ralph W. Shrader Graduate Scholarship in Communications and Electronics

AFCEA
Association/Society
United States
US $3,000
The Ralph W. Shrader Graduate Scholarship offers $3,000 to full-time graduate students in STEM-related fields at accredited U.S. institutions. Applicants must be U.S. citizens, enrolled in their second semester, and maintain a GPA of 3.5 or higher. The scholarship supports tuition and course-related expenses, encouraging students with financial needs to further their education. Notably, the expected graduation date cannot coincide with the award year, ensuring students are committed to their studies.
Geoinformatics & Geospatial Sciences Mathematics Physics +8 more

Woodcock Family Education Scholarship Program

Albuquerque Community Foundation
Private
United States
US $10,000
The Woodcock Family Education Scholarship Program, established in 1993 by C.E. (Woody) Woodcock and Dixie, offers merit-based scholarships of up to $10,000 for Albuquerque metro area high school seniors excelling in science and math. With a strong belief in the importance of education, the program aims to support students with a minimum GPA of 3.8 who demonstrate exceptional promise and commitment to these fields. Scholarships are renewable for up to four years.
Education - Higher Education Vocational & Trade Education Career / College Preparation +2 more

Edward and Sandra Meyer Family Scholarship

United Negro College Fund Inc
Private
United States
Unspecified amount

Who We Are

Our Mission

UNCF envisions a nation where all Americans have equal access to a college education that prepares them for rich intellectual lives, competitive and fulfilling careers, engaged citizenship and service to our nation.

UNCF’s mission is to build a robust and nationally-recognized pipeline of under-represented students who, because of UNCF support, become highly-qualified college graduates and to ensure that our network of member institutions is a respected model of best practice in moving students to and through college.

UNCF’s North Star is to increase the total annual number of African American college graduates by focusing on activities that ensure more students are college-ready, enroll in college and persist to graduation. This is done through a three-pillar strategy. Positioning member institutions as a viable college option for students and investing in institutional capacity to improve student outcomes; creating transformational support programs to ensure students are enrolling and persisting through college completion; building awareness of educational attainment and cultivating college-going behaviors within the African American community.

For Students

UNCF is more than just scholarships. We’re the nation’s leading minority education organization and our goal is to help you get to and through college.

Our support takes many different forms. From merit scholarships to financial assistance, on-campus assistance to professional development, emergency financial aid to community support, UNCF is committed to getting more students like you to and through college.

2026-2027 The Edward and Sandra Meyer Family Scholarship

The Edward and Sandra Meyer Family Scholarship is directed towards current talented high school seniors within the Class of 2026 from the state of New York, who will be enrolling at any accredited UNCF member institution or other accredited Historically Black College/University.

The Edward and Sandra Meyer Family Scholarship is directed towards academically achieving high school seniors, who are seeking enrollment at any accredited UNCF member institution or other Historically Black College/University. 

The Edward and Sandra Meyer Foundation, Inc. is a social impactful philanthropic organization based in New York. The foundation actively focuses on funding critical initiatives in the arts and culture, education, health and religion.

The Edward and Sandra Meyer Foundation, Inc. has partnered with UNCF to establish the Edward and Sandra Meyer Family Scholarship. This scholarship is focused on providing vital financial assistance to ensure that high school seniors within the state of New York have access to a quality college education.

The candidates will have the opportunity to enroll in any accredited field of study at their selected institution. The candidates must be enrolled as first-time freshman within the 2026-27 Academic year. The eligible candidates must have maintained a cumulative grade point average of 2.50 throughout the entire application process. 

The selected recipients will be eligible for renewal awards upon their continual adherence to the program guidelines and have established financial need by their institution each year.

Education - Higher Education College Success / Persistence Black American Services +1 more

Lakken’s Legacy Sibling Scholarship

Childrens Brain Tumor Foundation Inc.
Private
United States
US $1,000
The Lakken’s Legacy Sibling Scholarship, established by the Children’s Brain Tumor Foundation, honors Lakken Burzynski's courage and resilience in her battle with cancer. This $1,000 scholarship is designed for siblings of children diagnosed with brain tumors, emphasizing support for families impacted by such challenges. Eligible applicants must be 21 or younger at diagnosis and reside in the U.S. This initiative promotes positivity and hope, continuing Lakken's legacy of strength and family support.
Education - Higher Education Vocational & Trade Education Education - High School +2 more

Alkermes Pathways Research Awards

Alkermes
Corporate
United States
Up to US $100,000
The Alkermes Pathways Research Awards program aims to foster research in neuroscience, specifically targeting schizophrenia and bipolar disorder. With grants up to $100,000, it supports early-career investigators exploring critical areas, including sleep and circadian disturbances related to these conditions. This initiative addresses the urgent need for innovative solutions in mental health research, empowering the next generation of scientists to make impactful contributions in understanding and treating these complex disorders.
Schizophrenia Mental Health & Psychiatric Diseases Sleep

ABPN Dorthea Juul, PhD, Education Research Award

American Board Of Psychiatry and Neurology, Inc.
Private
United States
Up to US $100,000
The ABPN Dorthea Juul, PhD, Education Research Award offers up to $100,000 for research projects aligned with the ABPN's mission of enhancing lifelong learning and certification standards for psychiatrists and neurologists. Two awards each in psychiatry and neurology are available annually, with projects lasting up to two years. Eligible applicants must hold faculty appointments or have confirmed offers, comply with conflict of interest policies, and, if MDs or DOs, maintain ABPN certification and licensure.
Neuroscience Neurological Diseases & Disorders Mental Health & Psychiatric Diseases +1 more

Carson Bailey Memorial Scholarship for Siblings

Childrens Brain Tumor Foundation Inc.
Private
United States
US $1,000
The Carson Bailey Memorial Scholarship for Siblings, established by the Children’s Brain Tumor Foundation, honors the memory of Carson Bailey. This scholarship aims to support brain tumor survivors pursuing their educational goals. Eligible applicants must have been diagnosed with a brain or spinal cord tumor before age 21, reside in the U.S., maintain a GPA of 2.0 or higher, and be at least a senior in high school. A $1000 scholarship is available for those attending various educational institutions.
Education - Higher Education Vocational & Trade Education Education - High School +2 more

NC Hunter and Jumper Association’s Norah Morris Memorial Scholarship Endowment

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The NC Hunter and Jumper Association’s Norah Morris Memorial Scholarship Endowment supports individuals pursuing higher education who have engaged in equestrian activities. Open to undergraduates, graduates, and adult re-entry students, the scholarship aims to assist those attending various educational institutions in the United States. Applications for NCCF scholarships will be accepted from December 16, 2025, to March 3, 2026. Be sure to check specific eligibility requirements for each scholarship.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

Fash Foundation Grants

Fash Foundation
Private
United States
US $1,000 - US $25,000
The Fash Foundation Grants aim to support and enhance children's education and the arts in Tarrant County, Texas. The Foundation prioritizes contributions to higher education institutions that align with its mission statement. Grants are awarded to initiatives that promote health and educational advancements in various disciplines including sciences and the arts. The Foundation seeks to foster a nurturing environment for children's educational growth.
Education - Preschool / Early Learning STEM / STEAM Education Education - K through 12 +3 more

Dr. Gary King Sharp Memorial Scholarship

Central Kentucky Community Foundation
Private
United States
Unspecified amount
The Dr. Gary King Sharp Memorial Scholarship, offered by the Central Kentucky Community Foundation, aims to support students with a cumulative GPA of 2.5 or higher. Priority is given to those connected with Hospice services or in the foster care system, and to first-generation college students. This scholarship serves as a vital resource to empower students in their educational pursuits and enhance community life.
Education - Higher Education Hospice / End of Life Care Child Foster Care & Adoption Services +1 more

Children and Youth with Special Health Care Needs Research Network

US HHS: Health Resources & Services Administration (HRSA)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Children and Youth with Special Health Care Needs Research Network aims to enhance the lives of children and youth with special health care needs (CYSHCN) and their families. By establishing a robust research infrastructure, the program will generate evidence-based solutions to foster well-being and community engagement. It focuses on identifying effective interventions and measures that can be integrated into essential services and supports, ultimately helping CYSHCN thrive throughout their lives.
Disability Care & Services Health Policy & Advocacy Intellectual / Developmental Disabilities +2 more

Hyperoxaluria Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Hyperoxaluria Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from hyperoxaluria, a condition characterized by excessive oxalate in urine. This fund assists with prescription drug copays and insurance premiums, providing vital support for treatments. In 2024 alone, HealthWell allocated over $1.2 billion in grants, ensuring access to essential medications for those in need. The organization is committed to improving healthcare access and reducing disparities for affected individuals.
Health Care Access & Delivery Kidney Diseases Genetic Conditions & Birth Defects

Mantle Cell Lymphoma Fund

Healthwell Foundation
Private
United States
Up to US $8,500
The Mantle Cell Lymphoma Fund, managed by the HealthWell Foundation, provides financial assistance to underinsured patients diagnosed with Mantle Cell Lymphoma. The fund covers prescription drug copays and Medicare Part B premiums, with a maximum award of $8,500. Eligible patients must have insurance that covers their medication and meet specific income guidelines. The foundation aims to reduce financial barriers to essential treatments, ensuring that patients receive necessary care without undue financial strain.
Health Care Access & Delivery Lymphoma Cancer / Oncology

Metabolic Dysfunction-Associated Steatohepatitis Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Metabolic Dysfunction-Associated Steatohepatitis Fund, established by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients facing chronic illnesses. It provides critical support for expenses related to prescription copays, insurance premiums, and transportation for treatment. With a maximum award of $8,000, the fund ensures that individuals can access necessary healthcare services without financial strain. This initiative emphasizes the commitment to improving health outcomes for those affected by metabolic dysfunction-associated steatohepatitis.
Health Care Access & Delivery Liver Disease Cystic Fibrosis +1 more

Princess Grace Awards

Princess Grace Foundation
Private
United States
US $15,000
The Princess Grace Awards support early career artists in theater, dance, and film with unrestricted cash grants of $15,000. Open to U.S.-based artists, the awards recognize both creative generators and performance-based creatives. Nominations are required from non-profit organizations or previous award winners, ensuring a robust evaluation of artistic merit. With a focus on nurturing talent, the Princess Grace Foundation honors the legacy of Princess Grace of Monaco by fostering the next generation of artists.
Theater Dance Film +1 more

RADM (ret.) Jeffrey A. & Linda J. Cook Scholarship

United Negro College Fund Inc
Private
United States
Up to US $4,250

Our Impact

UNCF was founded in 1944 to help more African American students attend and graduate from college.

Since then, we've helped to more than double the number of minorities attending college.

For Students

UNCF is more than just scholarships. We’re the nation’s leading minority education organization and our goal is to help you get to and through college.

Our support takes many different forms. From merit scholarships to financial assistance, on-campus assistance to professional development, emergency financial aid to community support, UNCF is committed to getting more students like you to and through college.

2026-2027 The RADM (ret.) Jeffrey A. & Linda J. Cook Scholarship

The RADM (ret.) Jeffrey A. & Linda J. Cook Scholarship is a need-based, recurring scholarship for active-duty, retired U.S. military veterans, or their dependents who are enrolled full time and pursuing undergraduate STEM degrees at an accredited HBCU. Recipients will receive a renewable award of up to $4,250 to support them in obtaining their undergraduate degree.

This scholarship is in honor of CPO Arthur A. Cook and Capt. Delbert E. Colwell, the fathers of the Grantors who served honorably during WWII.

Education - Higher Education Military & Veterans Services Educational Access & Equity +2 more

Barbara Miller Meeker Art Scholarship

Legacy Foundation: Lake County's Community Foundation
Private
United States
Up to US $500

About Legacy Foundation

Legacy Foundation is the community foundation for Lake County, Indiana. We connect people, knowledge, and funding to build an equitable, accessible, and inclusive Lake County, now and for generations to come.

Legacy Foundation is supported by a broad base of individuals, families, and businesses connected by the desire to improve Lake County, Indiana. With a growing portfolio of over 300 funds and approximately $80 million in assets, Legacy Foundation is a trusted source for philanthropic giving in the region.

For over 30 years, Legacy Foundation has been empowering people, providing strategic leadership, and impactful philanthropic support to create an equitable Lake County where all people thrive.

Mission Statement

Transforming Lake County by providing strategic leadership and impactful philanthropic support to ensure equitable opportunity for all communities that we serve.

Vision Statement

Create an equitable Lake County where all people thrive.

Barbara Miller Meeker Art Scholarship

Use the chart below to see which scholarships are the best fit for you! You must complete the Legacy Universal Application to apply.

Scholarship eligibility requires students to attend an accredited 2 or 4 year public or private institution of higher learning. All scholarships are for full-time students, unless otherwise noted. Renewable awards are for 4 years of undergraduate study and cannot be used for post graduate coursework; all awards are paid directly to the school or may be used for book reimbursement.

Education - High School Education - Higher Education Academic Scholarship Programs +2 more

Luther Halsey Gulick Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Luther Halsey Gulick Award, presented by SHAPE America, recognizes individuals with over ten years of membership who have made outstanding contributions to health and physical education. This prestigious honor is awarded annually to a candidate selected for their exemplary leadership and service in the field. Nominations are carefully evaluated based on the candidate's impact on the profession and their ability to inspire future generations to lead healthy, active lives.
Kinesiology & Sports Medicine Education - K through 12 Dance +2 more

GLLCF Nursing Scholarship

Greater Lake City Community Foundation
Corporate
United States
Unspecified amount

About

Created by the community for the good of the community, the GLCCF is here to turn problems into opportunities through strategic grant making and initiatives created to address our region’s most pressing needs. We work with you to identify your charitable goals, and we ensure that they are carried out efficiently.

Work with us to make the kind of impact you want to see in your community. Let us take on the financial complexities and paperwork, while you focus on the important things like fostering good works throughout our community.

When you give to the Greater Lake City Community Foundation, you are making an investment that will benefit the community, now and in the future.

GLLCF Nursing Scholarship

To award annually a scholarship to a qualified applicant who intends to further his/her education toward a degree in nursing.

Education - Higher Education Education - High School Academic Scholarship Programs +2 more

Measurement and Evaluation Honor Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Measurement and Evaluation Honor Award recognizes exceptional contributions by a SHAPE America professional towards the Measurement and Evaluation SIG's mission. This prestigious accolade celebrates those who advance health and physical education practices, inspiring educators to enhance student well-being. Eligibility requires current membership in SHAPE America and the Measurement and Evaluation SIG, ensuring that only dedicated professionals are honored. This award embodies the commitment to fostering excellence in educational environments, ultimately aiming to prepare all children to lead active, healthy lives.
Community Health Education Education - K through 12 Dance +2 more

Measurement and Evaluation Lifetime Achievement Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Measurement and Evaluation Lifetime Achievement Award recognizes a distinguished SHAPE America professional who has significantly impacted measurement and evaluation in health and physical education. This prestigious award highlights the importance of scholarly achievement and the influence of national standards in enhancing educational practices. It aims to honor those who have dedicated their careers to improving the quality of health and physical education, ultimately promoting healthier lifestyles for students across the nation.
Kinesiology & Sports Medicine Education - K through 12 Dance +2 more

LinkScholars Program Scholarship

Central Carolina Community Foundation
Private
United States
Unspecified amount

About

Central Carolina Community Foundation is a nonprofit organization that helps generous people give back to the Midlands of South Carolina in ways that matter. Since 1984, we’ve been a trusted partner, helping individuals, families, and businesses make smart, meaningful contributions that support local nonprofits, scholarships, and community projects.

LinkScholars Program Scholarship ($2,000) 

This renewable scholarship supports graduating high school seniors from Fairfield, Kershaw, Lexington, Richland, or Sumter counties in South Carolina.

Education - Higher Education Vocational & Trade Education Education - High School +2 more

ASSP Foundation Career Development Grant

American Society of Safety Professionals (ASSP) Foundation
Association/Society
United States
US $500 - US $1,000
The ASSP Foundation Career Development Grant supports individuals in the environmental health and safety field by providing financial assistance for certification and professional development activities. Since its inception in 1990, the foundation has awarded over $6 million in grants and scholarships, aiming to enhance the skills and careers of safety professionals. Preference is given to applicants who have not previously received a grant, promoting a sustainable talent pipeline within the industry.
Environmental Health Workforce Preparation & Job Readiness Occupational Health & Safety

Large Grants for Nonprofit Organizations in South Carolina Highlights

Looking for large grants for nonprofit organizations in South Carolina?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in South Carolina recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

53 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

40 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

32 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

Q1
28.9%
Q2
25.2%
Q3
24.8%
Q4
21.1%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $15,000.

$500 $500 Min.
$15,000 $15 K Median
$535,356 $535.4 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081