Best Large Grants for Nonprofit Organizations in South Carolina

The Louis N. Cassett Foundation provides grants to support a variety of charitable endeavors, particularly focusing on organizations in the Philadelphia and South Florida areas. As a private foundation operating under Section 501(c)(3) of the Internal Revenue Code, it empowers tax-exempt organizations to apply for funding. The Foundation does not impose religious affiliation requirements on recipients, ensuring that support is inclusive and aimed at a broad range of charitable, cultural, and educational projects.

The Prof. Rahamimoff Travel Grants for Young Scientists support PhD students in research requiring expertise unavailable in their home countries. Named after renowned scientist Prof. Rami Rahamimoff, the grants fund trips to higher education or research facilities in the U.S. or Israel, lasting up to two months. Eligible applicants must be U.S. or Israeli citizens conducting supervised research at accredited institutions. This program honors Prof. Rahamimoff's legacy in science and medicine.

The Health Careers Scholarship of Sonoma County, administered by 10,000 Degrees, supports students pursuing careers in medicine, nursing, or allied health fields. Established in 2001, it is open to undergraduate and graduate students who are residents of Sonoma County or graduated from its high schools. Applicants must demonstrate academic excellence with a minimum 3.0 GPA and provide two letters of recommendation, excluding relatives. This scholarship is a vital resource for aspiring healthcare professionals in the community.

The Park Foundation Grants for the Environment focus on ensuring clean and accessible drinking water while opposing shale gas extraction and infrastructure expansion. They fund diverse initiatives aimed at promoting sustainable practices and policies, particularly within New York State. The Foundation supports advocacy, organizing, and corporate responsibility efforts that align with their mission to foster a just and sustainable environment, empowering communities to protect their natural resources.

The Ruby Bridges Walk to School Day Mini-Grant supports events that honor civil rights activist Ruby Bridges by encouraging students to walk to school and engage in discussions about activism, anti-racism, and anti-bullying. Grants of $500 or $1000 are available based on the number of students reached. This initiative aims to inspire positive changes within communities and promote meaningful dialogue among young people about social justice issues.

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a student matriculating at a college, university, or business in the year of the scholarship.

The Northrop Grumman Corporation Graduate Education Scholarship, part of the Graduate Education Fund, supports Australian students pursuing graduate-level studies in the USA. Offering up to $40,000 for one year, it is aimed at fields such as Artificial Intelligence, Quantum Physics, and Aerospace Engineering. Eligible candidates must be Australian citizens or permanent residents and have a formal offer from an accredited American institution. This scholarship promotes academic exchange and fosters international collaboration in specialized disciplines.

The Yawkey Foundation's Strategic Investment Grant supports nonprofit organizations aiming for strategic growth through board-approved plans. Grants, ranging from $250,000 to $1 million, may fund regional expansions, collaborative efforts among nonprofits, and organizational mergers. Initial Proposals are highly competitive and must demonstrate strong leadership, proven impact, and alignment with the Foundation's Areas of Giving. Review periods for proposals can take 6-12 months, during which feedback is not provided.

The Sidney R. Baer, Jr. Foundation focuses on improving the lives of individuals with schizophrenia and bipolar disorder through education grants. By funding programs that enhance educational opportunities, the foundation aims to reduce isolation and promote understanding. Grants are awarded to qualified organizations that prioritize mental health initiatives, ensuring that those affected have access to the resources and support necessary for a better quality of life. The foundation's mission is rooted in the belief that education can be transformative for those facing mental health challenges.

The Audrey L. Wright Scholarship, offered by the Grand Rapids Community Foundation, supports undergraduate students who are long-term residents of Kent County. This scholarship is aimed at those pursuing education or language studies and requires a minimum GPA of 3.0. By removing barriers to academic success, it empowers local students to achieve their educational ambitions and contributes to a thriving and inclusive community in West Michigan.

About Us

We are a philanthropic organization committed to catalyzing the impact of social entrepreneurs who are expanding access and opportunity in America. 

At New Profit, we partner with social innovators, philanthropists, and other impact leaders who are creating a more inclusive and prosperous America. We invest in and support leaders and organizations that are transforming our education, economic, and democratic systems. And we are guided by the belief that those who are most proximate to the communities we serve are the best positioned to develop effective and sustainable solutions.

We seek and support leaders and organizations with scalable solutions that match the size of the problems we face and expansive visions that match the scale of our ambitions for America.

Connected Futures Cohort Grant

New Profit is launching Connected Futures, a Catalyze cohort for organizations that bridge divides and bring people together to solve problems collectively. Submit a Discovery Form to signal your interest and to be considered to submit an application for this funding cycle. 

New Profit’s Catalyze cohorts support innovative social impact organizations expanding access and opportunity in America. This model brings together cohorts of organizations with similar focus areas and stages, providing each with a one-year $100,000 unrestricted grant, a $10,000 grant for leadership development, and strategic advisory support.

Social Entrepreneurs* participate in a year-long cohort experience designed to build community, facilitate peer learning, and provide capacity-building support, including workshops on topics such as board development, fundraising, scenario planning, and storytelling. 

About Connected Futures

Connected Futures is a new Catalyze cohort for organizations that help people move across active divides to take action toward common goals. We are looking for organizations that build trust, strengthen collaboration, and create ways for people to act together when mistrust, polarization, exclusion, or disconnection would otherwise keep them apart and prevent them from solving problems together.

These organizations may work in the health, economic mobility, democracy, and/or education sectors. What connects them is not a single issue area, but a common approach to bridgebuilding: creating the relationships, skills, and structures people need to work together toward positive change.

Catalyze cohorts are at their best when cohort members are fully engaged. The Social Entrepreneurs that lead selected organizations are expected to participate in the Catalyze support model and peer learning community in the following ways:

• Social Entrepreneurs attend three in-person convenings, each of which are held over 3-4 days in cities across the United States. Convening dates for this cohort will be shared with organizations invited to complete a full application.
• Social Entrepreneurs attend three virtual learning sessions, each lasting 2-3 hours. Webinar dates for this cohort will be shared with organizations invited to complete a full application.
• Social Entrepreneurs engage with the New Profit team via 1:1 strategic advising, including a minimum of six virtual sessions over the yearlong cohort.
• Entrepreneurs receive a $10,000 stipend specifically to support their own leadership development goals.
• Programming requires a commitment of 6-8 hours per month on average. New Profit covers the cost of travel, accommodation, and meal expenses for each in-person convening.

The EPSCoR Research Infrastructure Improvement (RII): EPSCoR Research Fellows program, funded by the National Science Foundation (NSF), aims to enhance research capacity and workforce development in STEM. This initiative fosters collaborations between underrepresented researchers and leading institutions, providing essential resources and support. With two tracks available—one focusing on NSF and the other on NASA—this program uniquely positions Fellows to leverage transformative research experiences and contribute to sustainable advancements in their respective fields.

This funding opportunity from the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to advance mechanistic research on metal exposure and its effects on human health. Studies should focus on biological processes altered by metals, including their absorption, transport, and immune interactions. Innovative methodologies and human biospecimens are encouraged to explore how metals might impact immune homeostasis and cross biological barriers, providing insights into health risks associated with metal exposure.

The Oklahoma City Community Foundation administers the Kirschner Trusts, established to honor Phil and Roberta Kirschner's philanthropic legacy. These trusts focus on supporting young individuals with disabilities, Muskogee nonprofits, and Jewish causes. Since their transfer to the foundation in 2013, the trusts have continued to provide vital grants to organizations that align with the Kirschners’ values, ensuring their charitable impact persists in the community.

The Environmental Grantmaking Program at the Educational Foundation of America (EFA) aims to support projects that facilitate a transition to a net-zero electricity system. Focused on reducing greenhouse gas emissions, the program emphasizes initiatives that enhance access to affordable clean energy, accelerate regional transitions, and strengthen financial investment in electric utilities. Eligible applicants include 501(c)3 public charities, academic institutions, and government entities committed to sustainable energy solutions.

The AAO-HNSF Percy Memorial Research Award offers $25,000 for one year to support innovative research projects in otolaryngology-head and neck surgery. This grant aims to fund projects with clinical significance, encouraging the development of new long-term research initiatives. Applicants must submit a detailed budget and secure letters of support from their Department Chair and key personnel involved in the project. Funds cannot cover salaries or purchase equipment exceeding $500.

The IMA Foundation Grant focuses on empowering communities by supporting nonprofit organizations dedicated to workforce development, financial security for families, and enhancing emergency preparedness. With a mission to provide philanthropic assistance, the foundation seeks partners that align with its vision and operational reach. Organizations must be 501c3 nonprofits and serve areas where IMA has offices, ensuring that their initiatives directly impact youth under 26 years of age.

Bucks County Foundation

Since our founding in 1979, the staff at BCF have been working closely with donors, local leaders, and nonprofit organizations to improve the quality of life in Bucks County. Our work with local charitable organizations helps to improve the health and wellbeing of children and families across the county.

Scholarships

The Bucks County Foundation is proud to support students throughout Bucks County in their pursuit of higher education and attainment of academic, trade and life skills that translate into economic self-sufficiency. Through the generosity of donors in our region, we manage over 100 scholarship distributions for a wide variety of students with diverse educational journeys.

Millennium Medical Women in Science and Medicine Scholarship

Provides scholarships to students attending high school in Bucks County who are planning to pursue a professional career in a scientific or medical related field such as Pre-Med, Nursing, Biology, Pharmacy, Chemistry, etc.

The Fisheries Innovation Fund's Electronic Monitoring and Reporting Grant Program aims to enhance fisheries management through electronic technologies. Administered by the National Fish and Wildlife Foundation (NFWF), this initiative will support U.S. fisheries in implementing electronic monitoring tools to improve data collection, accessibility, and management. The program is open to various fisheries, including commercial and recreational sectors, promoting sustainable practices and fostering stakeholder involvement for better fishery information systems.

The Gertrude L. Hirsch Charitable Trust, founded in New Jersey, aims to support 501(c)(3) organizations for charitable and educational purposes. It focuses on various program areas including arts, education, environment, health, and human services. Although there are no geographic restrictions, preference is often given to organizations based in New Jersey. Additionally, funds awarded cannot be used outside the United States, ensuring that contributions remain within the country to benefit local communities.

The National Bycatch Reduction Engineering Program (BREP) for FY2026/27 offers competitive grants aimed at supporting non-Federal researchers. This initiative, governed by the Magnuson-Stevens Fishery Conservation and Management Act, focuses on developing innovative fishing practices and gear technologies to minimize bycatch and reduce post-release mortality of non-target species. By addressing bycatch reduction, the program seeks to enhance the sustainability of U.S. fisheries and aquaculture, aligning with the National Marine Fisheries Service's conservation goals.

The F. W. Symmes Foundation Grant aims to enhance the quality of life for residents of Greenville County, South Carolina, by supporting charitable, educational, and cultural initiatives. Established by Fred W. Symmes, the foundation prioritizes organizations that align with its mission and are recognized as 501(c)(3) exempt entities. With a minimum grant request of $20,000, the foundation focuses on impactful projects, particularly capital improvements, while ensuring financial sustainability for ongoing programs.

Michael L. Hamaker Memorial Scholarship

A scholarship awarded to a graduating senior or previous graduate from Marshall, Olivet or the surrounding area seeking a career in engineering, manufacturing or industrial technologies with programs such as, but not limited to, architecture, construction, drafting, electronics, welding and/or other related technologies. Applicants must demonstrate financial need. GPA is not a qualifying factor; however, transcripts and test scores are requested. Students who receive this scholarship are encouraged to apply for further support in subsequent years.

The Jeffers, Danielson, Sonn & Aylward Law Scholarship supports Chelan and Douglas County high school graduates pursuing a degree in Law or Paralegal studies. Applicants must maintain a minimum 3.0 GPA and demonstrate financial need through the FAFSA. This scholarship encourages local students to advance their legal education, fostering a new generation of legal professionals committed to serving their communities.

The Sustainable Development Grant Program, funded by The Rockefeller Brothers Fund, aims to combat climate change by promoting ecological stewardship, economic viability, and social equity. It supports initiatives that enhance public understanding, implement clean energy solutions, and foster international cooperation. The program prioritizes projects that address the urgent threats posed by climate change while ensuring that development efforts are sustainable and inclusive for future generations.

The National Institute of Allergy and Infectious Diseases (NIAID) aims to enhance the development of diagnostic tests for infectious diseases through strategic partnerships between academia and industry. By fostering collaborations, NIAID seeks to overcome barriers to commercialization, ensuring promising diagnostics reach the market effectively. This initiative aligns with NIH's mission to advance innovative technologies that improve treatment and prevention strategies for infectious diseases, ultimately contributing to public health advancements.

The BIE Science Post Graduate Scholarship Fund offers financial assistance to American Indian and Alaska Native students pursuing full-time degrees in STEM fields at accredited institutions. This need-based award ranges from $100 to $30,000 per academic year, based on financial aid information provided by the institution's Financial Aid Office. Eligible students must demonstrate Tribal affiliation through a Tribal Eligibility Certificate.