Best Large Grants for Nonprofit Organizations in South Carolina

The Frankenthaler Climate Initiative's Catalyst Grant supports organizations in the visual arts sector to take quick, impactful actions toward sustainability. Since 2021, the initiative has awarded over $10 million, fostering a shift to carbon-neutral operations. Eligible applicants include nonprofit entities that prioritize visual arts, aiming to reduce environmental impact through clean energy, efficiency improvements, and innovative practices. This grant promotes a greener future while enhancing the importance of arts education and ecological stewardship.

The Start-Up Research Grant aims to support early-career researchers establishing independent research careers. Grants are awarded for two years, enabling applicants to submit future proposals. The program emphasizes scientific excellence and collaboration between Israeli and American scientists. Eligible junior principal investigators (PIs) must be within ten years of their PhD or MD completion. Notably, the grant does not cover PI salaries and requires adherence to BSF's application standards.

About The NRA Foundation

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

The NRA Foundation Supports Freedom, Family, and the Future of the Shooting Sports

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans.

The heart of The NRA Foundation’s mission is preserving the core of our American values and traditions in our steadfast effort to Teach Freedom.

Established in 1990, The NRA Foundation, Inc. (“NRA Foundation”) is a 501(c)(3) tax-exempt organization that raises tax-deductible contributions in support of a wide range of firearm-related public interest activities of the National Rifle Association of America and other organizations that defend and foster the Second Amendment rights of all law-abiding Americans. These activities are designed to promote firearms and hunting safety, to enhance marksmanship skills of those participating in the shooting sports, and to educate the general public about firearms in their historic, technological and artistic context. Funds granted by The NRA Foundation benefit a variety of constituencies throughout the United States including children, youth, women, individuals with physical disabilities, gun collectors, law enforcement officers, hunters and competitive shooters.

The NRA Foundation Frontline Heroes Scholarship

The NRA Foundation Board of Trustees has established the Frontline Heroes Scholarship to institute a memorial to this distinguished group of First Responders, Law Enforcement Officers, and Military personnel*, who have served continuously and unselfishly in the highest tradition of our great nation.

The Frontline Heroes Scholarship will give a one-time annual award of up to $10,000** for one eligible candidate.

The Marv VandenBosch Scholarship, established by Sandra VandenBosch and her children in memory of Marv VandenBosch, supports Tri-Cities students pursuing careers in criminal justice or law enforcement. This scholarship considers financial need and requires applicants to have a minimum GPA of 2.5. The Grand Haven Area Community Foundation administers the scholarship through a competitive process, ensuring that each applicant is thoroughly reviewed to promote academic achievement and community involvement.

The James E. Bugley Scholarship, managed by the Berkshire Taconic Community Foundation, honors the memory of Jamie Bugley, a talented musician and dedicated community member. Established to support high school seniors from Berkshire County, MA, this scholarship encourages students pursuing careers in music or vocational arts. With a mission to promote economic mobility and quality of life, it reflects the foundation's commitment to philanthropy and leadership in the community.

The Level 1 Fair Housing Grant, offered by the National Association of REALTORS®, supports initiatives aimed at educating REALTORS® on fair housing issues. Grants can fund classes, forums, or workshops, with a maximum award of $3,000. Starting in 2025, the grant will also support expenses related to the At Home With Diversity class to align with new training requirements. This initiative ensures REALTORS® have the resources to promote diversity and inclusion in their communities.

Nurses Educational Funds

Nurses Educational Funds, Inc. depends solely on donations to advance our only mission, to promote nursing leadership through annual scholarship support for professional nurses seeking masters and doctoral degrees in nursing education, practice, research, and administration.

NEF’s only purpose is to provide nursing scholarship assistance to make graduate level nursing education possible. NEF is one of the largest, national, private, professionally endorsed source of funds for advanced nursing study with over one hundred years of service to and for professional nursing. NEF is a non-profit organization with 501(c) status.

Terry Fulmer Scholarship

This 2022 scholarship honors Dr. Terry Fulmer, PhD, RN, FAAN, and focuses on long term care of the elderly in nursing homes. Dr. Fulmer’s life's work has been devoted to geriatric nursing education, mentoring, research, and policy development. Among her many accomplishments, she is nationally and internationally recognized as a leading expert in geriatrics and is also known for the conceptualization and development of the national NICHE program and research on the topic of elder abuse and neglect, work that has been funded by the National Institute on Aging and the National Institute of Nursing Research. In 2021, Dr. Fulmer was named a Living Legend by the American Academy of Nursing. This scholarship was initiated in December of 2021 by Dr. Mathy Mezey, EdD, RN, FAAN, an NEF Board member, and a noted international geriatric expert.

The National Fish and Wildlife Foundation (NFWF) invites proposals for the Bats for the Future Fund RFP to combat white-nose syndrome (WNS) affecting bat populations in North America. This initiative seeks to advance treatments, implement management strategies, and support research that enhances bat survival and recovery. A match of 50% of the grant amount is preferred, aimed at fostering innovative conservation efforts and collaboration among stakeholders to ensure the future of affected bat species.

National Collegiate Cancer Foundation

The National Collegiate Cancer Foundation (NCCF) is a national 501(c)(3) nonprofit organization dedicated to supporting young adults diagnosed with or impacted by cancer. Its mission is to provide services, resources, and need-based financial assistance that empower survivors and their families to adopt a resilient “Will Win” mindset throughout treatment and beyond. NCCF is one of the few national organizations that provides direct financial support to young adult cancer survivors, primarily through its Survivor and Legacy Scholarships, which assist students pursuing higher education during or after treatment. The Foundation also promotes cancer awareness and prevention within the young adult community. Recognizing that adolescents and young adults (ages 15–39) face unique challenges—including delayed diagnoses, limited access to insurance and clinical trials, fertility concerns, employment disruption, and social isolation—NCCF prioritizes addressing the significant service gaps affecting this underserved population. Operated entirely by volunteers, NCCF remains committed to advancing educational access, financial relief, and hope for young adult cancer survivors nationwide.

NCCF: Survivor Scholarship Program

The National Collegiate Cancer Foundation (NCCF) Survivor Scholarship Program provides a competitive scholarships to young adults who are cancer survivors or current patients and are pursuing higher education during or after treatment. The program supports students who have demonstrated resilience and continued their educational journey despite the challenges of cancer. Applications are evaluated based on six criteria: demonstration of a strong “Will Win” attitude, quality of essays, financial need, overall cancer survivorship story, commitment to education, and the quality of recommendations. The scholarship recognizes perseverance, hope, and dedication to academic and personal growth.

The Mary Lou Lukhard Nursing Scholarship, established by the Community Foundation for a Greater Richmond in 2004, honors Mrs. Lukhard's dedication to nursing. It supports aspiring nurses from Central Virginia, including high school seniors and adult learners. Eligible applicants must demonstrate academic excellence, financial need, and a commitment to community service. This scholarship aims to empower individuals pursuing nursing careers, ensuring a brighter future for healthcare in the region.

The NIA Expanding Research in AD/ADRD Postbaccalaureate Research Education Program aims to enhance the research workforce by providing intensive research experiences for recent graduates. This initiative supports early-stage investigators in Alzheimer's Disease and related dementias, addressing a critical shortage of researchers in the field. Participants engage in independent research, mentorship, and professional development, equipping them with skills necessary for advanced degrees and research careers in aging and dementia. The program fosters innovation and interdisciplinary collaboration essential for advancing AD/ADRD research.

The NHLBI is launching a Limited Competition Small Grant Program aimed at NHLBI career development award recipients. This program supports researchers transitioning to independence by providing small grants for expanding research objectives or initiating new studies based on their prior work. It encourages applicants to form collaborations and develop impactful projects, although applications are not currently being solicited. This initiative aims to facilitate the generation of essential preliminary data and publications, aiding recipients in their K-to-R transition.

The Bernice M. Brightbill Fund Scholarship offers a one-time award to a senior female student from the Central Dauphin School District pursuing a college degree in business studies. This scholarship aims to support students demonstrating financial need, regardless of citizenship or documentation status. Eligible applicants can apply for multiple scholarships and may be selected for any or all they qualify for, promoting accessibility in education.

The AVID: Priscilla and Ranney Draper Scholars Fund offers scholarships to high school seniors enrolled in the AVID elective, supporting their transition to a four-year college or university. Administered by Scholarship America, this program recognizes students from Orange County, CA, who have demonstrated commitment and financial need. Each applicant completes a single application for multiple scholarships, with awards of up to $5,000 available for undergraduate studies.

The Richmond African American Scholarship, established by The Community Foundation for a Greater Richmond, aims to support African American students from public high schools in Richmond. This scholarship provides financial assistance for college expenses and is awarded to students based on academic achievement, leadership, and community involvement. Eligible candidates must maintain a GPA of 3.0 or higher and plan to enroll in a full-time Baccalaureate program at an accredited institution after graduation.

The Pediatric Oncology Student Training (POST) Program Grant, offered by Alex’s Lemonade Stand Foundation, aims to foster the next generation of pediatric oncology researchers. This summer internship provides undergraduate, graduate, and medical students with hands-on research experience in a supportive environment, focusing on diversity and inclusion. Grants will specifically support students from underrepresented communities in the scientific workforce, enabling impactful research and mentorship opportunities to advance pediatric cancer care.

National Collegiate Cancer Foundation

The National Collegiate Cancer Foundation (NCCF) is a national 501(c)(3) nonprofit organization dedicated to supporting young adults diagnosed with or impacted by cancer. Its mission is to provide services, resources, and need-based financial assistance that empower survivors and their families to adopt a resilient “Will Win” mindset throughout treatment and beyond. NCCF is one of the few national organizations that provides direct financial support to young adult cancer survivors, primarily through its Survivor and Legacy Scholarships, which assist students pursuing higher education during or after treatment. The Foundation also promotes cancer awareness and prevention within the young adult community. Recognizing that adolescents and young adults (ages 15–39) face unique challenges—including delayed diagnoses, limited access to insurance and clinical trials, fertility concerns, employment disruption, and social isolation—NCCF prioritizes addressing the significant service gaps affecting this underserved population. Operated entirely by volunteers, NCCF remains committed to advancing educational access, financial relief, and hope for young adult cancer survivors nationwide.

NCCF: Legacy Scholarship Program

The National Collegiate Cancer Foundation (NCCF) offers $1,000 competitive scholarships to young adults pursuing higher education who have lost a parent or guardian to cancer. The award is designed to provide financial assistance and encouragement to students continuing their education despite personal loss. Applications are evaluated based on the applicant’s personal journey, sources of encouragement, demonstrated financial need, notable accomplishments, and the quality of recommendations. The scholarship recognizes resilience, perseverance, and academic commitment in the face of cancer-related loss.

The Emergency Assistance Funds, provided by the Entertainment Community Fund, offer vital support to performing arts and entertainment professionals facing unforeseen financial hardships. This program aids with essential living expenses, including healthcare and housing, to prevent eviction or service shut-offs. Eligible applicants must document their earnings and demonstrate a genuine need for assistance. Established in 1882, the Fund understands the unique challenges faced by those in the arts industry, ensuring they receive the help necessary to maintain stability.

The Columbus Foundation

In 1943, during the darkness of World War II, a group of passionate citizens, led by Columbus businessman Harrison M. Sayre, envisioned a way to improve the well-being of the community and the quality of life in central Ohio. With little more than this sound idea and faith, The Columbus Foundation was established.

Our Mission

To assist donors and others in strengthening and improving our community for the benefit of all its residents.

Craig Memorial Scholarship Fund

This scholarship fund was established by the family of John E. Craig, Jr. and Larry William Craig. Both John and Larry were extremely gifted musicians. John was a noted musician in the central Ohio community, studying at the Berklee College of Music in Boston at the time of his death. A well-known musician and businessman, Larry excelled at playing the piano and worked with his father in Craig & Sons Wrecking Company. This scholarship fund will provide support to students who are pursuing careers in musical arts, theatre or drama.

The Ruth E. Reed Nursing Scholarship, established by the Community Foundation of the Northern Alleghenies, honors the legacy of Ruth Reed, a dedicated nurse. This scholarship supports students from Elk, Warren, and Clearfield Counties pursuing nursing degrees, with a GPA requirement of 2.5 or higher. With an annual award of approximately $500, it encourages future generations to pursue careers in nursing while recognizing the importance of continued education in healthcare.

The Marlene and Spencer Hays Foundation Grants support tax-exempt organizations working to enhance lives through arts, healthcare, education, and youth programs. The foundation requires a Letter of Intent (LOI) from all applicants, emphasizing its mission to select grant recipients who align with its values. Grants are not available for political purposes, endowment campaigns, or organizations that discriminate based on race, gender, or religion. This framework ensures a focused impact on community betterment.

The James W. Junior and Jane T. Brown Scholarship, established by Jane and James Brown in 2006, offers financial support to adult students over 21 in the Tri-Cities. This scholarship aims to ease the financial burdens faced by those returning to education. Applicants must demonstrate financial need and provide necessary documentation, including transcripts and a Student Aid Report. The program encourages recipients to assist others in their educational journeys, fostering a cycle of support in the community.

The Steven C. Leuthold Family Foundation Grants support 501(c)(3) non-profits in areas such as land conservation, environmental protection, human services, and animal welfare. Founded in 1991 by philanthropist Steven C. Leuthold, the foundation prioritizes organizations that align with its giving preferences. Applications are due by June 30, 2025, with grants distributed by December 2025. Note that incomplete applications will not be accepted.

The Blue Bird Auxiliary Scholarship Fund, established by the San Antonio Area Foundation, offers financial support for graduate and current college students pursuing degrees in healthcare-related fields. Eligible candidates must maintain a GPA of 3.1 and be active volunteers with the Blue J/Blue Bird organization. This scholarship, renewable for up to three years, covers tuition, fees, books, and living expenses, helping students achieve their educational goals while serving the community.

The James V. Gray Memorial Scholarship, established by the Erie Community Foundation, honors a dedicated educator and coach. This need-based scholarship supports Erie School District graduating seniors who have been accepted into accredited colleges with a minimum GPA of 3.0. In 2023, the Foundation awarded over $800,000 in scholarships to assist more than 500 deserving students in their pursuit of higher education.

The H. Wayne VanAgtmael Cosmetology Scholarship, established in 2005 by Wayne Van Agtmael's family, honors his legacy in the cosmetology field. This scholarship supports high school graduates from the Tri-Cities pursuing a cosmetology degree, focusing on financial need and academic achievement. Applicants must provide transcripts and additional required documents. The scholarship aims to empower students, particularly those who are the first in their families to succeed beyond high school, in their educational journeys.

Fund the Dream Scholarship

The Fund the Dream Scholarship Fund was established in 2022 by the Hispanic Alliance, GA. The purpose of this scholarship is to ‘Build the Dream, One Graduate at a Time.’ Minority students from first-generation/low-income backgrounds face systemic roadblocks while navigating the college admissions process. Graduating seniors coming from low-income families are seven times more likely to drop out than those from families with higher income. In addition, 74% of Latino students enrolled in colleges and universities in the U.S. cut their education short due to the financial pressures of supporting their families. To help mitigate the educational opportunity gap and student debt crisis, the Hispanic Alliance Georgia Fund the Dream Scholarship will support one student who has huge aspirations for their life and is willing to work through anything to achieve them. This scholarship is funded by proceeds from the annual Latino Fest in Gainesville, Georgia and is part of our commitment to making academic and scholarship support more accessible for all students.

When choosing a recipient, the selection committee will take into consideration factors such as the applicant’s academic achievement, financial need, immigration status, volunteering efforts, future educational goals, and responses to essay question. Special consideration will be given to students participating in the Latino Youth Leadership Academy. The 2026 scholarship will be a one-time award of $1,500.