Best Unrestricted Grants for Nonprofits in South Carolina

The National Science Foundation (NSF) is offering funding through the Engineering (ENG) program, focusing on foundational research in civil, mechanical, and manufacturing innovation. Key areas include advanced manufacturing systems, civil infrastructure, and intelligent dynamic systems. The NSF ENG encourages innovative and transformative proposals that may not require immediate commercial outcomes. Award sizes and durations will vary based on budget availability, aiming to support long-term research advancements.

The NIH Support for Conferences and Scientific Meetings (R13) grant aims to facilitate high-quality conferences that contribute to public health and the scientific missions of NIH Institutes and Centers. Key application deadlines range from April 2024 to January 2027, providing vital opportunities for researchers to gather and share knowledge. This grant is particularly focused on enhancing the impact of scientific dialogue in critical health areas.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

The Japanese-Language Education Project Grant supports initiatives that enhance Japanese language education across various regions. Offered by the Japan Foundation, Los Angeles, this grant targets workshops, seminars, and original projects that connect language learning with Japan Studies. Eligible applicants include non-profit educational organizations in the U.S. Projects should benefit multiple programs, ensuring a broad impact on Japanese language education. The deadline for applications is two months before the project start date, which must be between April 1, 2025, and March 31, 2026.

Marion Community Foundation

Since 1998, area residents have been turning to Marion Community Foundation to make their philanthropic giving as effective as possible. We are a public charity serving thousands of people who share a common concern … improving the quality of life in Marion County. We use distributions from the more than 500 charitable funds — created by generous, local donors — to award more than $2.5 million in grants and scholarships each year to many of the humanitarian, educational and cultural organizations in this remarkable community we call home.

Marion Community Foundation is the area’s leading philanthropic organization, providing charitable donors the opportunity to easily create endowment funds to benefit and support our community through grants and scholarships. We serve communities throughout Marion County through philanthropy, leadership, and civic engagement.

Calvin H. & Elizabeth L. Topliff Scholarship

Georgia Mathews, mother to Marion Community Foundation board member, Spencer Mathews, created this endowed scholarship in 2023 in honor of her parents. The scholarship will be awarded to Marion County students who are pursuing a career in either education or engineering, with special consideration for students who will be attending Ohio Northern University, which is where Georgia’s parents met.

Betty Beatty Topliff was born in Pittsburgh but ended up in Marion after meeting Calvin at Ohio Northern and moving to his hometown of Marion. Betty (1928-2022) was a dedicated teacher for 30 years, most recently at Ridgedale High School. Calvin (1924-2009) was an Army veteran who served in Europe during WWII and was awarded the Bronze Star. Calvin retired from the marketing department of Ohio Edison Marion Division after 36 years of service.

Following retirement, Calvin and Betty were Florida snowbirds, but Betty returned to Marion after Calvin’s death to be with her beloved children, grandchildren, and great grandchildren.

The NIH Director's New Innovator Award supports creative early-stage investigators pursuing innovative research with transformative potential for science relevant to the NIH mission. Applications are encouraged across all NIH-related fields, enhancing support for emerging talent. This award is part of the NIH Common Fund's High-Risk, High-Reward Research Program, which aims to cultivate groundbreaking research and foster the next generation of scientists.

The NIH Independent Scientist Award (K02) aims to support the development of independent scientists and enhance their research capabilities. This award offers salary support and protected time for three to five years, specifically for those leading independent clinical trials or feasibility studies. Applicants must demonstrate a need for focused research to advance their careers. Key deadlines for applications span from June 2024 to February 2027, catering to various submission types including standard and AIDS-related grants.

The NIH Independent Scientist Award (K02) supports the development of outstanding scientists by providing three to five years of salary support and protected time for newly independent researchers. This funding opportunity is specifically for applicants proposing research that does not involve leading an independent clinical trial, allowing them to gain experience in trials led by others. Key deadlines for applications span from June 2024 to February 2027.

The Hanna H. Gray Fellows Program, funded by the Howard Hughes Medical Institute, aims to enhance diversity in the scientific community by supporting early-career researchers. The program provides funding for postdoctoral training and early faculty years, promoting an inclusive academic culture. Fellows receive an initial salary of $80,000 and a $20,000 annual expense allowance. This initiative helps develop future leaders in biological and biomedical sciences, ensuring equitable opportunities for all backgrounds.

The FY 2027 Department of War Multidisciplinary Research Program of the University Research Initiative (MURI) aims to fund U.S. academic teams conducting innovative research to tackle complex challenges for the Department of War. Established in 1985, MURI promotes collaboration among diverse scientific disciplines, enhancing the defense workforce and addressing critical areas of interest through multidisciplinary research efforts at U.S. universities.

The Hanna H. Gray Fellows Program, supported by the Howard Hughes Medical Institute, aims to enhance diversity in the academic research community. It provides funding of $250,000 and a $20,000 annual expense allowance for early-career researchers committed to fostering an inclusive scientific culture. Eligible applicants must hold a PhD or MD, commit to at least 75% research effort, and have no more than 24 months of postdoctoral experience. This initiative empowers fellows to become leaders in science.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.

The Foundations of Trusted Systems initiative seeks innovative research to develop secure, resilient, and affordable technologies for Command, Control, Communications, Computers, and Intelligence (C4I) and Cyber systems. This Broad Agency Announcement (BAA) aims to establish trusted foundations for hardware and software, building on previous work to enhance information processing systems. Researchers are encouraged to submit white papers for evaluation and potential funding.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

Women Create Foundation Grants

Empowering women creators.

About

Women Create, LLC is the publisher of two industry leading magazines, Where Women Create and What women Create. Every issue of WHAT & WHERE includes in-depth features about women from diverse geographies and backgrounds, the mediums they use and the projects and studios that support their passion.

Through our search for women artist/creators, we’ve seen the significant barriers and disparities in accessing funding they face to nurture their visions. The Women Create Foundation was created with the mission to empower women creators through grants that help bring projects to life and foster innovation.

The grant amounts vary depending on the artist’s needs. Financial awards typically range from $500-$2,000.

The SLEEP Travel Grant for Medical Students and Residents, offered by the American Academy of Sleep Medicine Foundation, provides $2,000 to support medical students and residents attending the SLEEP meeting. This grant fosters career development in the sleep field and is available to those currently enrolled in accredited medical or residency programs. The funding is aimed at enhancing sleep health through research and community engagement, aligning with AASM's mission.

The SLEEP Travel Grant for AASM Patient Advocacy Roundtable, funded by the American Academy of Sleep Medicine Foundation, aims to enhance sleep health by supporting organizations with limited financial resources. This grant offers $2,000 for travel and registration to the SLEEP 2026 meeting, fostering connections among members of the AASM Patient Advocacy Roundtable. This initiative emphasizes the importance of advocacy in sleep medicine and encourages participation in vital discussions surrounding sleep health.

The Beveridge Family Prize in American History, awarded annually by the American Historical Association since 1945, recognizes exceptional historical writing. Eligible works include biographies, monographs, and interpretations published in 2024. This prestigious award honors Senator Albert J. Beveridge and aims to promote outstanding scholarship on American, Latin American, and Canadian history. Recipients will be announced in October 2025 and celebrated at the 2026 AHA annual meeting in Chicago.

The SLEEP Travel Grant for Sleep Technologists and Advanced Practice Providers, funded by the American Academy of Sleep Medicine Foundation, offers a $2,000 grant to support first-time attendance at the SLEEP 2026 meeting. This initiative aims to enhance engagement among non-physician members of the sleep team, such as sleep technologists and advanced practice providers, while promoting networking opportunities within the sleep community.

The NIH Mentored Patient-Oriented Research Career Development Award (K23) aims to support healthcare professionals with a clinical doctoral degree in their pursuit of patient-oriented research. This award is essential for those committed to advancing their research careers, ensuring they focus on enhancing patient care. Key application deadlines for standard and renewal submissions span from June 2024 to February 2027, providing ample opportunity for interested candidates to apply.

The National Library of Medicine (NLM) is seeking applications for a Training Center under the Network of the National Library of Medicine (NNLM). This initiative aims to enhance professional development for librarians, community engagement, and access to health information. By fostering partnerships and disseminating NIH resources, the NNLM will broaden its impact and improve public understanding of health data and information. The NTC will develop innovative training curricula and materials to meet diverse audience needs.

The National Library of Medicine (NLM) is inviting applications for its Coordinating Center within the Network of the National Library of Medicine (NNLM). Established in 1965, the NNLM enhances public access to health information through collaboration with libraries and community organizations. The NCC will oversee network administration and evaluation, fostering partnerships and supporting local clinical research. This initiative aims to expand NIH engagement and improve public understanding of health resources and information available through the NNLM.

The Barbara Stone Foundation

Barbara Stone served as a champion for individuals with disabilities and the Foundation strives to continue her legacy. The Barbara Stone Foundation is a 501 (C) 3 non-profit organization based in Greenville County, South Carolina.

Our primary focus is to influence community systems policies and culture to result in equitable opportunities for individuals with disabilities. We do this by identifying gaps in the system, investing in or creating our own innovative programs, leveraging partnerships in the community and through our signature initiative Greenville CAN. Greenville CAN is a multi-stakeholder collective impact coalition focused on creating systemic community change through specific community projects focused on people with disabilities. Through our multi-faceted approach we believe we can achieve our vision of a community where all people with disabilities flourish.

Barbara Stone Foundation: Community Innovations Grant

The Barbara Stone Foundation is committed to empowering individuals with disabilities. One of the ways we do this is by investing in innovative programs and initiatives that address unmet needs and provide creative solutions for the disability community in the Upstate of South Carolina. Our Community Innovations Grant program prioritizes applications that propose groundbreaking approaches to bridging service gaps and fostering inclusion. Our hope is that creative individuals and organizations in our community’s amazing network of providers will develop new ways to ensure our community is place where individuals with disabilities flourish.

The American Bible Society (ABS) Research Grant invites Christian higher education scholars to explore ways to enhance Bible engagement among young adults aged 18-35. With $50,000 in funding, this grant encourages innovative proposals that promote meaningful interactions with Scripture, evaluate engagement strategies, and cater to diverse Christian traditions. Research teams or individual faculty members with expertise in spiritual formation and discipleship are encouraged to apply, aiming for scalable solutions that positively impact spiritual well-being.

The National Home Library Foundation Grant supports nonprofits in distributing books and reading materials to libraries and community groups with limited resources. This initiative aims to promote literacy and combat illiteracy among all ages through various programs. Grants are available only to tax-exempt organizations that adhere to non-discrimination policies. Preference is given to requests from the Washington DC, Maryland, and Virginia areas, with applications considered on a rolling basis.

Who We Are

Buiding a stronger, More Vibrant Community

For over 70 years, the Scranton Area Community Foundation has served Northeastern Pennsylvania as a steward of charitable resources, a grantmaker, and a catalyst for positive change. Guided by our core values of collaboration, trust, integrity, innovation, and inclusivity, we work to ensure that our communities thrive with opportunities for all.

This scholarship is awarded to a graduating senior from a high school in Lackawanna County who is matriculating to a college or university to study in the field of education.