Best Unrestricted Grants for Nonprofits in South Carolina

The DHQP Global NOFO aims to enhance the CDC's mission against antimicrobial resistance (AR) by integrating non-research implementation with focused research. This initiative addresses urgent global threats posed by various pathogens and healthcare-associated infections (HAIs). By leveraging existing CDC networks, the NOFO seeks to improve detection, surveillance, and infection control measures, ultimately reducing illness and mortality while protecting healthcare workers and patients, especially in low and middle-income countries.

The Mercer Vu Farms/Ron and Judy Hissong Scholarship for Agriculture Fund honors Ron Hissong, a dedicated dairy farmer. Established by his family, this scholarship supports students from the Tuscarora School District pursuing education in agriculture or related fields, ensuring they can continue Ron's legacy of community contribution. Applicants must demonstrate financial need and a commitment to agriculture, making this opportunity vital for aspiring agricultural professionals.

The JA Community Foundation focuses on funding solutions that address the needs of the Japanese American and broader Asian American communities. They prioritize programs that enhance senior health, promote history, arts, culture, and support youth. Eligible applicants must be registered 501c3 organizations and can apply from all 50 states. However, organizations with open grants cannot submit new applications until their current grants are closed.

The Graham Foundation for Advanced Studies in the Fine Arts, established in 1956, supports innovative projects that explore architecture's role in society and culture. It offers grants to individuals for production and presentation, as well as research and development, focusing on diverse ideas that provoke critical dialogue. The foundation prioritizes first-time applicants and seeks to amplify underrepresented perspectives while fostering collaboration across various disciplines in the arts and education.

The Graham Foundation for Advanced Studies in the Fine Arts offers grants to organizations focused on architecture and its role in society. Established in 1956, the Foundation promotes innovative projects that encourage public dialogue, raise awareness, and foster experimentation in the field. Grants, not exceeding $30,000, support diverse practitioners and initiatives, enhancing discourse in architecture, design, visual arts, and related fields. The Foundation encourages projects that demonstrate originality, feasibility, and potential for meaningful impact.

The Zonta Club of Greater Sandusky High School STEM Scholarship Fund provides financial support to female high school seniors from Erie, Huron, or Ottawa County, Ohio, who plan to pursue a degree in STEM or medical fields at accredited institutions. Established by the Zonta Club, this scholarship aims to empower young women to contribute positively to their communities by facilitating access to higher education opportunities. Since its inception, it has fostered academic growth and leadership among recipients.

The Ruth Goldstein Memorial Music Scholarship supports graduating seniors from Capital Region high schools who plan to pursue music education or performance. Offered by The Community Foundation for the Greater Capital Region, this scholarship prioritizes students specializing in woodwind instruments, piano accompaniment, or those demonstrating financial need. Since 1968, the foundation has empowered the community through generous giving opportunities, enhancing the quality of life for all residents.

The Indigo Hope Foundation offers grants to organizations in the Upstate of South Carolina, focusing on addiction, homelessness, at-risk youth, veterans, and first responders. They award between $250 and $100,000, prioritizing projects that demonstrate measurable results and address critical community needs. Eligible applicants must be 501(c)(3) tax-exempt or government units, with only one application allowed per grant period. The foundation emphasizes collaboration and favors faith-based organizations.

The Virtual Living Room Grant Program aims to create welcoming spaces for veterans in rural communities, providing access to advanced medical technologies via telehealth. By establishing these rooms in accessible locations, veterans can connect with VA resources without the burden of travel, ensuring they receive essential care in a comfortable environment. This initiative not only supports health access but also fosters community engagement and enhances the quality of life for our nation's heroes.

The Joette P. Delia Curiano Scholarship is designed for graduating high school seniors from specific schools in the Greater Capital Region who plan to pursue a degree in health care or nursing. Applicants must demonstrate both academic excellence and financial need. This scholarship is part of a universal application process, allowing students to apply for multiple scholarships with one form, thereby increasing accessibility to educational funding.

The Municipal Workforce Learning Lab, initiated by the National League of Cities in partnership with the American Institutes for Research, aims to tackle workforce challenges faced by city governments. The program seeks three cities to engage in an 8-month action planning process focused on recruiting, training, and retaining skilled workers. Participants will receive free coaching and technical assistance, helping them enhance their workforce policies and potentially serve as national models for effective local government employment strategies.

The Periodic Paralysis Grant, offered by the Patient Advocate Foundation, assists individuals diagnosed with periodic paralysis in managing out-of-pocket healthcare costs. Eligible applicants must be in treatment or planning to begin treatment for this rare muscle disease. The fund covers various expenses, including medication copays and insurance premiums, ensuring that patients can afford essential care. With a mission to empower and support patients, this grant plays a crucial role in navigating healthcare challenges.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Help with healthcare costs for Paroxysmal Nocturnal Hemoglobinuria (PNH)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Paroxysmal Nocturnal Hemoglobinuria (PNH), also known as Marchiafava– Micheli syndrome, is a rare disease that is characterized by impaired bone marrow function and destruction of red blood cells. PNH is a rare disease that affects the circulatory system.

The BioMarin Medical Education Grant offers funding for educational activities aimed at enhancing the knowledge and skills of healthcare professionals. Eligible applicants include accredited providers, medical associations, and patient advocacy groups. The grant focuses on supporting initiatives related to rare diseases, ensuring timely access to treatments and education. Applications are accepted year-round, but a minimum of 60 days is required for review prior to events. This commitment underscores BioMarin's dedication to improving patient care and advancing medical knowledge.

The Hyperkalemia Grant, provided by the Patient Advocate Foundation, offers crucial financial assistance to patients struggling with hyperkalemia. This grant covers out-of-pocket healthcare costs, including medication copays and health insurance premiums. Eligible applicants must have a confirmed diagnosis and meet specific income and residency requirements. Since its inception, the foundation has supported millions of patients, ensuring they can access the necessary treatment and resources for their health needs.

The Hypercholesterolemia Grant by the Patient Advocate Foundation offers financial assistance to individuals diagnosed with hypercholesterolemia, helping cover out-of-pocket healthcare costs such as medication copays and insurance premiums. This nonprofit aims to improve patient access to necessary care while supporting over 3.8 million patients since its inception. Eligible applicants must have health insurance and meet specific income requirements to receive assistance in managing their healthcare expenses effectively.

The Greenpoint Foundation Grant aims to enhance community life by supporting organizations that focus on agriculture, food security, education, and community enhancement. Established in 2022, the Foundation accepts grant applications year-round for both general operating budgets and specific projects. Priority is given to 501(c)(3) organizations and local government entities, while faith-based programs are considered on a case-by-case basis. Grant recipients must submit impact reports to ensure continued support.

The Les Paul Foundation Grant supports innovative music education and medical research related to hearing loss. Eligible organizations must be U.S.-based public charities under 501(c)(3) and avoid religious, political, labor, or business affiliations. The foundation prioritizes projects that enhance music production, performance, and STEM/STEAM initiatives, particularly those benefiting individuals in challenging situations. Proposals must detail how they will share Les Paul's legacy in their work.

Mission

The Fish Family Foundation of Maine is a faith based charitable organization located in Bangor, Maine. Founded in 2007, our mission is to provide resources for many initiatives including, but not limited to, missions, education scholarships, ministries, medical research, and employment creation. The Fish Family Foundation of Maine is primarily funded by the family. However, contributions from like minded individuals and organizations is appreciated. The Fish Family Foundation of Maine has a balanced strategy of making funds available for immediate needs, while also investing to build a perpetual earning endowment ensuring the Foundation's successful future.

Missions:

We support needs of missionary organizations including sponsorships for young people who wish to attend youth group sponsored mission trips. We ordinarily make one time contributions but on occasion have made up to a three year commitment. 

Education/Scholarships:

The Foundation makes scholarships available to Colleges, Universities, and other Schools for student enrollment and expenses. We also consider new construction, existing renovation, equipment, and support material contributions.

Independent Churches and Ministries:

We accept a wide variety of requests, including, but not limited to: materials, equipment, new construction, renovations, programs, and services. 

Medical Research:

We support medical research opportunities close to our hearts and organizations that our family and friends have experienced. 

Job Creation:

We Support organizations that fund entrepreneurs in impoverished areas to start small businesses providing services and employment to the community.

Requests are considered by the trustees the first week of each month. Foundation payments are made by paper check in US dollars and are reported to the appropriate tax agencies. While we certainly wish that we could contribute to all the applications that meet our funding criteria, there are times when when available funding is limited and we are not able to contribute to some very worthy causes. If we are not in a position to help in the timeline requested, we will keep the information on file for possible consideration in the future. 

National Community Care Corps Grant

Community Care Corps encourages organizations across the country to apply for 18-month grants ($30,000–$200,000) to develop and scale innovative volunteer programs that provide nonmedical assistance to older adults, adults age 18 and older with disabilities and family caregivers.

Projects funded through this initiative will increase the number of community-based volunteer programs available to provide nonmedical assistance while decreasing the number of older adults, adults with disabilities, and family caregivers who need assistance in maintaining independence in the community but are unable to obtain help. In doing so, the initiative will strengthen community-based supports that help people maintain independence, reduce unmet needs, and improve overall well-being.

Focus Areas

Proposals must include one or more of the following focus areas:

• Integrate principles of the National Strategy to Support Family Caregivers
• Support grandparent/kinship-led households
• Use off-the-shelf materials. Off-the-shelf materials are products, components, or resources that are readily available for purchase and immediate use, without the need for custom development, modification, or special ordering
• Engage college students/interns for intergenerational connections
• Expand virtual or low-tech access
• Provide volunteer chaperone programs for non-emergency medical appointments
• Increase access to respite programs
• Build opportunities for volunteer skill-building

 Cherokee Nation Nursing and Allied Health Scholarship

The Cherokee Nation Nursing and Allied Health Scholarship is to provide financial assistance to Cherokee Nation citizens pursuing college degrees in nursing and health care fields to support their readiness to contribute to and grow within the Cherokee Nation reservation labor market. 

The LEGO Foundation Fellowship

Advancing the science and practice of supporting children to thrive

The LEGO Foundation Fellowship is a global initiative supporting researchers working to deepen our understanding of how children thrive. Spanning disciplines from education and psychology to public health, data science, and humanitarian studies, the fellowship brings together early- and mid-career scholars whose work has the potential to generate evidence that matters for children’s lives.

Fellows receive three years of flexible support to pursue rigorous, practically relevant research, and join a cohort of peers working across the fellowship’s themes. In addition to funding research, the program fosters a community of scholars engaged in meaningful exchange with one another and with research, policy, and practice audiences.

The LEGO Foundation Fellowship is developed in partnership with the LEGO Foundation, and administered by SSRC as part of its commitment to supporting scholars whose work bridges research and real-world impact.

Research themes

The LEGO Foundation Fellowship welcomes research proposals that advance understanding of children’s thriving through one of the following three themes: the youngest children in crisis and conflict settings; inclusion and wellbeing of neurodivergent children; and children’s learning and development in an AI-enabled world. Applicants may explore the role of play where it is relevant to the research question. The consideration of play is optional and not a condition of eligibility.

The Isabelle Rowe Nursing Scholarship supports non-traditional students aged 21 and older from the Fox Valley and Waupaca areas pursuing nursing degrees. Established in 2007 by Julian Rowe in honor of his wife, Isabelle, this fund provides non-renewable scholarships of $2,000 for 4-year colleges and $1,000 for 2-year institutions. Applicants must maintain a minimum GPA of 2.5, have work experience in healthcare, and demonstrate financial need, with opportunities to reapply annually.

Patagonia supports environmental organisations with bold, direct-action agendas and a commitment to long-term change.

We support innovative work that addresses the root causes of the environmental crisis and seeks to protect both the environment and affected communities. We focus on places where we’ve built connections through outdoor recreation and through our network of retail stores, nationally and internationally.

We believe local battles to protect a specific stand of forest, a stretch of river, an indigenous wild species or a community from a polluting refinery build public support and confront larger, more complex issues like climate change, biodiversity loss and environmental justice.

We encourage work that brings underrepresented communities to the forefront of the environmental movement and defends communities whose health and livelihoods are threatened by environmental exploitation.

We support multipronged campaigns that push for greater environmental protections and force the government to abide by its own laws.

We fund work that:

• builds an equitable, inclusive and diverse environmental movement
• confronts systemic bias, discrimination and injustice in environmental policy or outdoor spaces
• is action-oriented
• focuses on root causes
• has a clear strategy
• identifies specific goals and objectives that can be effectively measured to evaluate success
• builds public involvement and civic engagement

Patagonia believes that the most direct path to real change is through building grassroots momentum.

Our funding focuses on organisations that have or can create a strong base of support. Because we’re a privately held company, we have the freedom to fund risk-taking, off-the-beaten-track groups, and that’s where we believe our small grants are most effective.

Danny Did Foundation

The Danny Did Foundation is a not-for-profit corporation organized in the state of Illinois and recognized by the Internal Revenue Service as a 501©(3) tax-exempt organization. 

Founded by Chicagoans Mike and Mariann Stanton in January 2010 after the death of their four-year-old son Danny, the Danny Did Foundation works toward its mission to prevent deaths caused by seizures with these main goals in mind: advancing public awareness of Sudden Unexpected Death in Epilepsy (SUDEP), enhancing SUDEP education and disclosure between medical professionals and families afflicted by seizures, and the mainstreaming of seizure detection and prediction devices that may assist in preventing seizure-related deaths.

Danny Did Foundation Reimbursement Grant

The Danny Did Foundation (“Foundation”) strives to assist individuals and families living with seizures. With an approved Request for Funding, the Foundation will provide monetary funding to the Grantee so they may gain access to a particular device or technology (“Device”) that the Grantee, in collaboration with the Grantee’s medical providers and professionals, independently deem appropriate. This money shall be defined as “Funds” and the spending of any Funds shall be at the sole discretion of the Grantee. The Foundation does not direct, limit, participate, or manage the decision-making or purchase of any specific Device.

While no Device has been proven to prevent epilepsy-related mortality (including SUDEP), the Danny Did Foundation is devoted to seeking out resources that may assist families living with epilepsy.

Reimbursement Grant: Danny Did will consider partial reimbursement for device purchases made in the last 30 days. I have already purchased the epilepsy device. I am seeking reimbursement and will provide receipt of purchase to the Danny Did Foundation to be considered for funding.

Danny Did Foundation

The Danny Did Foundation is a not-for-profit corporation organized in the state of Illinois and recognized by the Internal Revenue Service as a 501©(3) tax-exempt organization. 

Founded by Chicagoans Mike and Mariann Stanton in January 2010 after the death of their four-year-old son Danny, the Danny Did Foundation works toward its mission to prevent deaths caused by seizures with these main goals in mind: advancing public awareness of Sudden Unexpected Death in Epilepsy (SUDEP), enhancing SUDEP education and disclosure between medical professionals and families afflicted by seizures, and the mainstreaming of seizure detection and prediction devices that may assist in preventing seizure-related deaths.

Danny Did Foundation Hardship Grant

The Danny Did Foundation (“Foundation”) strives to assist individuals and families living with seizures. With an approved Request for Funding, the Foundation will provide monetary funding to the Grantee so they may gain access to a particular device or technology (“Device”) that the Grantee, in collaboration with the Grantee’s medical providers and professionals, independently deem appropriate. This money shall be defined as “Funds” and the spending of any Funds shall be at the sole discretion of the Grantee. The Foundation does not direct, limit, participate, or manage the decision-making or purchase of any specific Device.

While no Device has been proven to prevent epilepsy-related mortality (including SUDEP), the Danny Did Foundation is devoted to seeking out resources that may assist families living with epilepsy.

Hardship Grant: I am unable to make a purchase for the epilepsy related resource I seek therefore I am requesting a hardship grant. If I am approved for funding, I agree to provide a receipt for the resource I purchase to the Danny Did Foundation within 14 days of receiving the grant check, or I will return the funds to the Danny Did Foundation. 

The US Acute Care Solutions Scholarship Fund, established by Stark Community Foundation, supports the dependent children of non-physician employees of US Acute Care Solutions and its affiliates. Eligible applicants must be accepted into or attending a college, university, nursing school, or vocational program, with a minimum GPA of 3.0. This initiative highlights the Foundation's commitment to empowering future generations through education and community service involvement.