Best Unrestricted Grants for Nonprofits in South Carolina

The EMF Family Building Grants, offered by the Expect Miracles Foundation, support young adult cancer survivors in their fertility treatment and family-building efforts. These grants are designed for applicants with a clear family-building plan and financial strategy, helping bridge the gap in costs associated with fertility preservation, assisted reproductive technologies, and related services. By prioritizing those actively engaged in their journey, the foundation aims to empower survivors to pursue their dreams of family.

The Reel Change Film Fund is a five-year initiative aimed at supporting underrepresented film composers in the industry. It provides grants averaging $20,000 to assist US-based projects in production or post-production. Created by Christophe Beck and SESAC, this fund addresses the lack of diversity in film scoring, promoting inclusivity for diverse composers. Through mentorship and financial support, it seeks to elevate the careers of talented individuals from various backgrounds, enhancing the overall landscape of film music.

The Undergraduate Development Program Student Travel Award offers undergraduate science majors a unique opportunity to attend the Society of Toxicology Annual Meeting from March 21–23, 2026. The program aims to inspire students pursuing research careers in toxicology and related biomedical sciences. Participants will engage with professionals, attend sessions, and explore various educational and career paths. SOT emphasizes inclusiveness, encouraging diverse perspectives to enhance innovation in the field.

The Joan M. Wismer Foundation, established in 2001, honors the legacy of Joan Marilynn Wismer, who was dedicated to charitable work and community service. The foundation focuses on improving lives through education, youth development, safety, humanitarian services, and medical research. It primarily supports IRS-recognized 501(c)(3) organizations, schools, and churches, while emphasizing the importance of sustainable funding and effective financial management in its grant-making process.

The Birth Center Membership Support Grants, offered by the American Association of Birth Centers Foundation, aim to assist birth centers facing financial hardships in paying membership fees. Eligible centers can receive support covering up to 50% of the fees, whether they are applying for membership for the first time or renewing their membership. This initiative emphasizes the importance of maintaining high standards in maternity care and supports centers committed to serving low-income women.

The Changemaker Accreditation Grants support birth centers in achieving and maintaining accreditation by covering up to 100% of the initial or annual fees required by the Commission for the Accreditation of Birth Centers. This initiative honors the pioneers of the birth center movement and aims to assist centers that demonstrate financial hardship and a commitment to serving low-income communities. Special consideration is given to those fostering public education and located in rural areas.

The NIH is inviting applications for interventions aimed at enhancing cancer screening and preventive services in underserved populations. This initiative focuses on addressing barriers to healthcare access and promoting timely follow-up on abnormal findings. Collaborations with community partners are encouraged to foster effective outreach. The program particularly seeks to engage patients, clinicians, and healthcare settings in improving health equity and outcomes in cancer prevention.

The NIDCD Early Career Research (ECR) Award (R21) supports new scientists establishing independent research careers in areas related to hearing, balance, smell, taste, voice, speech, or language. This grant encourages innovative projects such as secondary data analysis, small research initiatives, and technology development, aiming to generate preliminary data for future R01 applications. All applications must be submitted by 5:00 PM local time of the applicant organization.

The NHLBI is launching a Limited Competition Small Grant Program aimed at NHLBI career development award recipients. This program supports researchers transitioning to independence by providing small grants for expanding research objectives or initiating new studies based on their prior work. It encourages applicants to form collaborations and develop impactful projects, although applications are not currently being solicited. This initiative aims to facilitate the generation of essential preliminary data and publications, aiding recipients in their K-to-R transition.

The Puffin Foundation's Annual Artist Grant Program focuses on supporting artists and organizations that are often marginalized. In even years, proposals are accepted in fine arts, music, and photography. With a maximum grant size of $3,500, it aims to empower individuals and groups with limited resources to flourish creatively. This initiative reflects the Foundation's commitment to ensuring diverse artistic expressions thrive in society. Applicants must be U.S. citizens or residents, and only one proposal is permitted per year.

The BUILD Grant Program, managed by the USDOT, focuses on enhancing surface transportation infrastructure with substantial local impact. It supports a variety of project sponsors, including state and local governments, in pursuing complex multi-modal initiatives that are often challenging to fund through traditional grants. Established under the American Recovery and Reinvestment Act of 2009, this program reflects a commitment to sustainable and equitable infrastructure development.

The AHA Collaborative Sciences Award aims to promote innovative research by pairing investigators from diverse disciplines to tackle cardiovascular issues. Funded by the American Heart Association, this award supports collaboration between established and early-career researchers. Projects must involve at least two co-principal investigators from different fields, and funding is set at $250,000 per year for three years, totaling $750,000. This initiative encourages novel ideas and interdisciplinary partnerships to enhance research outcomes.

The David E. Rogers Student Fellowship Award, offered by the New York Academy of Medicine, aims to enhance the educational journey of medical and dental students through impactful community health projects. This initiative supports research endeavors during the summer, providing stipends of $4,000 for up to five selected projects. Eligible candidates must be U.S. citizens or authorized residents, pursuing research that addresses health disparities and the needs of underserved populations.

The National Fish and Wildlife Foundation (NFWF) invites proposals for the Bats for the Future Fund RFP to combat white-nose syndrome (WNS) affecting bat populations in North America. This initiative seeks to advance treatments, implement management strategies, and support research that enhances bat survival and recovery. A match of 50% of the grant amount is preferred, aimed at fostering innovative conservation efforts and collaboration among stakeholders to ensure the future of affected bat species.

The National Institute on Deafness and Other Communication Disorders (NIDCD) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) are seeking innovative research applications for non-invasive imaging technologies to study the human olfactory system. This initiative emphasizes the need for advanced multimodal imaging techniques to enhance diagnostic capabilities for olfactory disorders, addressing challenges posed by the system's unique anatomical features. Collaboration among experts is encouraged to foster impactful research developments.

The AABE National & Regional Scholarship, awarded by the American Association of Blacks in Energy, supports students pursuing careers in the energy sector. Annually, over $350,000 is distributed through multiple scholarships, including six regional awards of $3,000 and one national award of $5,000, renewable for up to four years. Applicants must maintain a GPA of 3.0 and demonstrate commitment to energy-related fields, promoting diversity and equity in education.

The Boomer Esiason Foundation Academic Scholarship provides crucial financial support to students with cystic fibrosis. This scholarship not only alleviates educational expenses but also recognizes students who exhibit resilience and academic excellence. Annually, the foundation awards scholarships to deserving candidates, ensuring they can pursue their educational goals without overwhelming financial stress. Eligible applicants must demonstrate strong character and leadership while maintaining academic achievement. With awards up to $30K for undergraduates and $45K for graduates, this scholarship is pivotal for affected students.

This funding opportunity aims to address the urgent mental health crisis in the U.S. by promoting research that enhances access to evidence-based practices for youth. It encourages applications focusing on interventions for underserved populations, including those facing housing and food insecurities. Researchers are invited to explore strategies for improving service delivery, overcoming workforce challenges, and integrating care into accessible settings, ultimately striving for equitable mental health services for all youth.

The Cystic Fibrosis Foundation's Screening Improvement Program (SIP) Award aims to enhance early diagnosis of cystic fibrosis (CF) through improved newborn screening processes. This initiative emphasizes equitable screening practices for diverse populations and seeks innovative approaches to strengthen communication with primary care providers. Grants of up to $75,000 per year for two years are available to support projects that focus on algorithm transformation and best practices in screening, without funding clinical trials.

The SHAPE America Hall of Fame Award recognizes individuals who have made significant contributions to health and physical education, ensuring these fields remain central to educational programs. This prestigious award honors dedicated professionals, including educators and leaders, who have demonstrated exemplary commitment and leadership in promoting physical activity, health education, and related disciplines. Through their efforts, they enhance the quality of education and the well-being of students across the nation.

The Woman's National Farm and Garden Association (WNF&GA) Scholarship supports graduate students pursuing careers in conservation and natural resource management. This annual scholarship aims to continue the legacy of conservationists dedicated to protecting our planet's resources. Eligible candidates must demonstrate a strong commitment to environmental stewardship through their academic and community involvement. However, WNF&GA members and their immediate families are excluded from eligibility. The scholarship is a vital resource for future leaders in conservation.

The NIH Countermeasures Against Chemical Threats (CounterACT) initiative invites applications for basic research on chemical agents affecting the nervous system. This program aims to explore the toxicity mechanisms of chemical warfare agents, industrial chemicals, and pesticides. Researchers are encouraged to generate data that could reveal new therapeutic targets and manifestations of toxic exposures, contributing to public health safety against potential chemical threats.

The Broadcasters Foundation of America Emergency Grant provides vital financial assistance to broadcasters facing acute financial hardship due to natural disasters or emergencies. These one-time grants support those who have dedicated years to the broadcasting profession and are in need of help to recover. Applications can be submitted by individual broadcasters or their employers within 30 days of the event, ensuring timely support for those affected.

The Animal and Veterinary Innovation Centers (U18) funding opportunity, led by the FDA, aims to foster collaborations with academic institutions to tackle critical veterinary health challenges. This includes addressing Highly Pathogenic Avian Influenza, promoting genomic advancements in agriculture, and developing veterinary solutions for minor species. Applications are invited to enhance animal health and public safety, with Letters of Intent due prior to the July 2024 deadline.

The Rural Climate Partnership Grant supports innovative, community-led climate solutions in rural America. With funding ranging from $20,000 to $150,000, it empowers organizations focused on rural leadership and equitable climate actions. The grant aims to strengthen rural economies and enhance climate resilience by providing critical resources and support to rural-serving entities. It prioritizes projects that benefit under-resourced communities and actively engage in addressing pressing rural issues, making a meaningful impact on local climate narratives.

The VCRC-VF Fellowship Program, a collaboration between the Vasculitis Clinical Research Consortium and the Vasculitis Foundation, offers a two-year mentored training opportunity for physician-investigators dedicated to vasculitis research. This tailored fellowship allows candidates to gain clinical and translational research experience at VCRC-affiliated sites in North America, focusing on patient-oriented investigation. Applicants must hold an MD, demonstrate a commitment to vasculitis care, and ideally possess relevant subspecialty training.

The Racial Equity & Women’s Intercultural Ministries Grants and Scholarships, supported by the Presbyterian Mission Agency, aim to empower leaders, congregations, and organizations that promote racial equity and women's rights. This initiative reflects the Presbyterian Church's commitment to justice and inclusivity, fostering an environment where diverse voices can thrive and contribute to the community. By providing these resources, the program seeks to uplift marginalized groups and promote social equity within faith-based settings.