Best Unrestricted Grants for Nonprofits

The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.

The PERF: Career Development Grants - CNS Shields Research Grant supports early-stage investigators in pediatric neurology research. Offered by the Pediatric Epilepsy Research Foundation and the Child Neurology Society, this grant provides $150,000 over two years. Eligible applicants must be within 10 years of completing their terminal degree and have not received independent funding. The grant emphasizes clinical research, fostering advancements in the treatment of pediatric neurological conditions.

Keokuk County Community Endowment Foundation

The KCCEF was formed in 2005 as an affiliate of the Community Foundation of Greater Des Moines. The founding members of the organization had a vision to ensure that our county’s charitable programs were supported now, and in the future. We work together with many individuals, families, businesses and organizations to establish endowment funds that will provide grant awards for years to come.

What We Offer

The Keokuk County Community Endowment Foundation is here to assist our county’s organizations contribute to the local quality of life, and one of the ways that is done is through grant funding. KCCEF accepts grant applications to enable projects and programs impacting a wide range of needs in the community. In the past, grants have been awarded for projects involving arts and culture, health & human services, community betterment, historic preservation, and more. Proof of non-profit status, or sponsorship by a government entity is required. 

Major Grant

What We Support

The Keokuk County Community Endowment Foundation will provide grants to improve life in Keokuk County, Iowa by supporting projects relating to: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

The Community Foundation of Greater Birmingham offers competitive grants in various priority areas, focusing on equity, economic opportunity, and regional cooperation. Grants are available for strategic purposes, general operating support for emerging organizations, and established organizations. Eligible applicants include 501(c)(3) non-profits and government entities serving specific Alabama counties. The foundation aims to foster inclusive, thriving communities through collaborative efforts, addressing persistent poverty and promoting holistic growth and well-being.

The Community Development Block Grant (CDBG) program, administered by the Georgia Department of Community Affairs, supports diverse community projects aimed at improving housing, public facilities, and economic development. This initiative is designed to benefit low and moderate-income individuals, ensuring that essential services and opportunities are available to those in need. By fostering local development, CDBG plays a critical role in enhancing community growth and prosperity across Georgia.

Lawson Family Foundation

The Lawson Family Foundation was established by Phil Lawson in 2020 to serve as a catalyst for the development of a more healthy, prosperous, and inclusive Knoxville community. As a private grantmaking foundation, the Lawson Family Foundation focuses support on organizations involved in the areas of Justice & Economic Mobility, Education & Youth Development, Prevention of Exploitation & Violence, and Community Health & Food Security. 

Driven by the belief that every life has equal value, the Lawson Family Foundation exists to support efforts that promote justice and opportunity in all aspects of society, primarily in Knoxville, Tennessee. In doing so, it seeks to achieve a positive impact in marginalized communities that will last for generations.

Lawson Family Foundation Education & Youth Development Grant

Education is foundational to long-term success and thriving communities. Yet many children in the Knoxville area face disparities in access to quality education, supportive environments, and essential resources—including children with physical, mental, intellectual, and learning disabilities, as well as those from historically underserved communities.

The Foundation invests in efforts that strengthen early childhood development, improve literacy, and expand pathways to college and career. We support programs such as after-school enrichment, mentorship, and family-centered initiatives, with an emphasis on inclusive approaches that ensure all children—regardless of ability or background—have access to the tools, support, and opportunities needed to reach their full potential.

The Performance Excellence Grants by the Asfari Foundation aim to empower organizations in the Levant by strengthening specific functions such as governance, human resources, and financial management. With a grant of £7,000 and expert technical support, eligible organizations can enhance their capacity for sustainable development and community impact. The grants are open year-round, emphasizing transparency and collaboration, and prioritize small to medium-sized organizations committed to social missions.

Lawson Family Foundation

The Lawson Family Foundation was established by Phil Lawson in 2020 to serve as a catalyst for the development of a more healthy, prosperous, and inclusive Knoxville community. As a private grantmaking foundation, the Lawson Family Foundation focuses support on organizations involved in the areas of Justice & Economic Mobility, Education & Youth Development, Prevention of Exploitation & Violence, and Community Health & Food Security. 

Driven by the belief that every life has equal value, the Lawson Family Foundation exists to support efforts that promote justice and opportunity in all aspects of society, primarily in Knoxville, Tennessee. In doing so, it seeks to achieve a positive impact in marginalized communities that will last for generations.

Lawson Family Foundation Community Health & Food Security Grant

Access to basic healthcare and nutritious food is essential for individual well-being and community resilience. However, many families in the Knoxville area lack access to healthy food, preventative care, and wellness resources—contributing to persistent physical and mental health disparities, particularly in historically underserved communities.

The Foundation supports programs that expand access to nutritious food, promote healthy lifestyles, and strengthen community-based health resources. 

The Rhode Island Foundation's Specialized Health Funds program, starting in 2025, will consolidate several funds to support nonprofit organizations addressing health needs in Rhode Island. Key focus areas include care for individuals with renal disease, cancer, and disabilities, as well as support for children with low-vision and blindness. Applications for summer camps are due by April 25, 2025, while other projects must be submitted by August 18, 2025.

The Sidney R. Baer, Jr. Foundation offers Social Support Grants aimed at improving the lives of individuals living with schizophrenia and bipolar disorder. These grants focus on reducing stigma through education and advocacy, fostering a compassionate environment. The foundation prioritizes organizations that provide tangible support and resources, ensuring a meaningful impact on mental health. By addressing the challenges faced by those with mental illness, the foundation strives to create a more inclusive society that recognizes and supports their needs.

Boone County Community Foundation

The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.

Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.

Grants

Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant

Simple Grant

$3,000 and under

Boone County Community Foundation

The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.

Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.

Grants

Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant

Standard Grant

$3,001 - $15,000

Boone County Community Foundation

The Boone County Community Foundation was formed in 2005 to coordinate and provide philanthropic support for community betterment projects in Boone County. The foundation is made up of community minded individuals who have the ability to assess community needs, implement asset development, evaluate area grant applications, encourage partnerships and initiate activities to enhance Boone County.

Mission: The Boone County Community Foundation is a charitable foundation created by and for local citizens to improve the quality of life right here in our communities. We are here to help donors make a positive, local impact by offering a variety of giving tools to help people achieve their charitable giving goals and do good work in our communities that lasts forever.

Grants

Each year the foundation makes grant awards to worthwhile projects located in the county that are identified through a community grants application process. Our foundation’s areas of emphasis include: arts & culture, community affairs & development, education, environmental protection, health, historic preservation and human services.

Three types of grants based on grant amount: Simple Grant; Standard Grant and Impact Grant

Impact Grant

$15,001 and up

The Judy Ziels Memorial Scholarship, offered by the Chuckanut Health Foundation, honors a remarkable leader in public health. This scholarship supports master's-prepared nurse leaders who understand the importance of addressing interconnected health systems. By investing in education and mentorship, the program fosters future leaders who will drive meaningful change in their communities. This initiative reflects Judy's legacy of compassion and commitment to empowering others, ensuring that her influence continues to inspire new generations.

The Reproductive Scientist Development Program (RSDP) aims to enhance maternal and infant health by supporting early-career researchers in obstetrics and gynecology. This program encourages applicants committed to advancing their careers in academic research. With a focus on health equity and the training of scholars, RSDP seeks to foster impactful research proposals that address critical issues such as prematurity and maternal morbidity. Funded by the March of Dimes and other organizations, it empowers diverse talent in the field.

The Pediatric Scientist Development Program (PSDP) supports early-career pediatricians committed to research. It emphasizes flexible research proposals, fostering scientific inquiry in pediatrics, particularly in areas like prematurity and health equity. Funded by March of Dimes and other organizations, the program aids scholars in gaining vital training and mentorship while contributing to advancing pediatric health outcomes. Applicants must have completed pediatric residency in the USA or Canada and demonstrate a strong commitment to medical research.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Eosinophilic esophagitis

Help with healthcare costs for eosinophilic esophagitis

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Eosinophilic Esophagitis (EoE) is a disorder of the esophagus and is increasingly recognized as a major cause of swallowing difficulties in children and adults. It is a chronic disease of the immune system and can be triggered by a food allergy, acid reflux, or an airborne allergy. An allergic trigger causes the immune system to overact which causes many white blood cells, or eosinophils, to collect in the esophagus. This causes the esophagus to become inflamed and not contract properly. The esophagus can also narrow and develop rings or abscesses. This condition can become worse over time.

The Donald C. and Laura M. Harrison Family Foundation, established in 2006, aims to enhance educational opportunities for underprivileged students in the Greater Cincinnati area. With a focus on innovative programs and scholarships, the foundation supports initiatives in primary, secondary, and adult education. Grants range from $5,000 to $15,000 annually, promoting sustainability and collaboration with other donors. Eligible applicants must be IRS-designated 501(c)(3) organizations, prioritizing local community impact.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

Multiple sclerosis (MS)

Help with healthcare costs for Multiple sclerosis (MS)

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system in which the insulating covers of the nerve cells in the brain and spinal cord are damaged. MS is a chronic disease that affects the nervous system.

The Richard S. Shineman Foundation Community Enrichment Grants support organizations in Oswego County that enhance community well-being. Focused on arts, education, civic improvement, and health services, these grants empower projects that address local needs. With a funding limit of $2,499 and quarterly review cycles, the foundation aims to foster sustainable development and improve the quality of life in the region. Eligible applicants must be tax-exempt organizations or have a fiscal sponsor.

The Bernice Ash Memorial Award honors the legacy of a retail music visionary by providing a $5,000 grant to mid-career professionals employed by NAMM member companies. This award aims to support emerging leaders in the music industry through professional development opportunities and a one-year mentorship with NAMM Young Professionals. Eligible applicants must have at least five years of experience and agree to use the funds for professional training, enhancing their leadership skills and career growth.

The Nick Van Pernis Scholarship Fund, established in memory of Nick Van Pernis, supports students from Hawaii's west side pursuing degrees in Marine Science, Biotechnology, Health Sciences, or Early Childhood Education. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.0, and engage in community service. Preference is given to prior recipients who continue to meet requirements. This fund aims to empower students to positively impact the lives of Hawaii residents through their chosen careers.

The Kei Lin Foundation Grant, established in 2012 by Margaret Tsai, honors her mother, Kei Lin. This grant supports charitable organizations that provide essential services such as housing, food, and medical assistance to senior citizens and veterans. Priority is given to tax-exempt organizations under 501(c)(3) status. Applicants must adhere to specific guidelines and provide regular reports on fund usage to ensure transparency and accountability in their operations.

The Rotary Charities of Traverse City Learning Fund Grant supports professional development for staff in 501(c)(3) organizations, Native nations, and local governments in Antrim, Benzie, Grand Traverse, Kalkaska, or Leelanau Counties. Funds can be used for training, workshops, and conferences that enhance skills and community impact. Eligible applicants can receive up to $2,000, fostering collaboration and systems change while aligning with Rotary Charities' mission. Proposals must be submitted two weeks prior to the activity start date.

The Chronic Lymphocytic Leukemia Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients battling chronic lymphocytic leukemia (CLL). This fund provides essential support for prescription copays and premiums, ensuring that patients can access necessary treatments without the stress of financial constraints. Since its inception, the foundation has awarded over $1.2 billion in grants, helping more than 1.1 million patients. The initiative emphasizes the importance of accessible healthcare and aims to improve the quality of life for those affected by this condition.

The Congenital Sucrase-Isomaltase Deficiency Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from this genetic disorder. By providing assistance with prescription drugs and treatment costs, the fund ensures that vital medications are accessible, allowing patients to manage their condition effectively. In 2024, the Foundation is expected to award over $1.2 billion in grants, showcasing its commitment to enhancing healthcare access for those in need.

The Tobacco-Related Disease Research Program (TRDRP) supports California State Universities and Community Colleges to foster mentorship and training for students in tobacco-related research. This initiative, funded by tobacco tax revenues, aims to engage undergraduates and master's students, particularly from priority populations, in meaningful research and local tobacco control activities. With a maximum award of $1,150,000 over four years, this program seeks to eliminate commercial tobacco use and improve public health across California.