Best Unrestricted Grants for Nonprofits

The Broadrick Family Foundation Grant, established in 2010, focuses on supporting local charities dedicated to aiding children and those in need. With a commitment to enhancing community welfare, the foundation raises funds for programs that match at-risk youth with mentors, support research for childhood cancer, and provide educational opportunities. The foundation seeks to collaborate with organizations that demonstrate fiscal responsibility and grassroots impact, ensuring that help reaches those who need it most in the community.

The Competitive Graduate Research Fellowship, offered by Maryland Sea Grant, supports graduate students conducting research on critical issues affecting the Chesapeake Bay and coastal waters. This fellowship emphasizes social relevance and community engagement, particularly focusing on underserved populations. Awarded fellows receive a stipend of $34,000, tuition remission, and travel allowance. A professional mentor is required to ensure research aligns with the needs of resource managers and policy makers. Applications are encouraged from a diverse pool of candidates.

The Harold J. Miossi Charitable Trust Grant Program aims to enhance the quality of life for residents of San Luis Obispo, California, focusing on key areas such as animal welfare, education, environmental protection, support for the Catholic Church, fine arts, and youth development. Grants are available to California-based organizations for specific projects that align with these priorities, promoting community engagement and sustainable development.

Major Grant Fund

Apply for $50,000 to $200,000 per year, renewable up to two times for a total of three years of funding. Funds may support health-related direct service delivery or advocacy efforts. New for 2026, Major Grant funds can also support evaluation projects.

Funding Principles

Projects funded by the Health Equity Fund should align with the following funding principles:

Improving health outcomes and access

for communities and populations experiencing the deepest and most persistent health and economic disparities in King County.

Actively addressing the issues of systemic, structural, and institutional barriers

including racism, sexism, homophobia, transphobia, income inequality, and other forms of oppression or discrimination that negatively impact healthcare delivery and health outcomes.

Partnering or collaborating with other organizations

to enhance the impact of addressing health disparities.

Building capacity and empowerment

for communities addressing health disparities.

Funding for service delivery is limited to King County. There are no geographic restrictions on the residence of clients served or advocacy efforts, as long as the program can demonstrate the use of funds addressing disparities in health among residents of the Puget Sound region (King, Snohomish, Pierce, and Kitsap counties).

Organizations may not receive two PHPDA grants in the same year for the same project. Applicants can request grant funds for a different project as long as the time period covered by funding ends by the new contract period.

Organizations may only submit one application.

Focus Areas

Specific populations are facing heightened threats to their safety, security, and access to care, and the organizations that support them are experiencing drastic funding cuts. Our Major Grant program aims to support these organizations who are facing disproportionate burdens to their wellbeing. This year, Major Grants will be limited to organizations with projects in one or more of these three focus areas:

• Gender Affirming Care and/or HIV Prevention and Care for LGBTQIA2S+ Communities
• Barrier-Reducing Healthcare Delivery for Immigrant and Refugee Populations that is Responsive to Community Concerns 
• Access to Birth Control and Abortion Care

The Denver Children's Foundation (DCF) has been pivotal in transforming the lives of at-risk children in Colorado for over 30 years. Focused on education, health, advocacy, and personal growth, DCF provides strategic grants to organizations that effectively address the challenges faced by disadvantaged youth. By fostering partnerships, DCF helps create opportunities for children to thrive, ensuring they have access to essential resources and support that promote their overall development and well-being.

The SBM Charitable Foundation Grant aims to enhance the quality of life for residents in Hartford, Tolland, and Windham Counties through funding programs in health, education, human services, housing, and the arts. Eligible organizations must be tax-exempt or municipalities, focusing on community benefit. The Foundation prioritizes educational scholarships and health programs, emphasizing direct services and broad-based community projects. Applications are accepted annually, promoting accessibility and support for local initiatives.

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The EBSCO Community Impact Grant Program supports initiatives in education, environment, human services, and arts and culture. This grant is available to 501(c)(3) organizations serving specific counties in Alabama. Applicants may submit a Letter of Inquiry, but full proposals are by invitation only. EBSCO is dedicated to enhancing community well-being through innovative programs that promote equitable education, environmental protection, and access to basic human services.

The Mellon Foundation's Economic Development Grant Program aims to address economic disparities in Pittsburgh and southwestern Pennsylvania by enhancing workforce skills and creating job opportunities. The program focuses on talent development, workforce systems, and community building, advocating for innovative education and training that aligns with future job markets. It seeks proposals that promote 21st-century skills, foster entrepreneurship, and support underrepresented groups, ultimately driving economic independence and community vitality.

The PGE Foundation's Career Pathways Grant Program aims to enhance economic mobility for Oregonians by providing support for programs that facilitate access to family-wage jobs and entrepreneurship. This initiative prioritizes nonprofit organizations focused on skill development, mentorship, and wrap-around services. The foundation is particularly interested in proposals that address barriers faced by underrepresented communities, including BIPOC and women-owned businesses, and encourages collaborative efforts among nonprofits to achieve measurable outcomes.

The UWGNB Community Impact Grants aim to enhance local communities by funding projects focused on Healthy Community and Child and Youth Opportunity. This initiative prioritizes access to basic needs, mental health, and youth development programs. Eligible applicants include non-profits and public entities, with one application allowed per organization. The funding supports programs that foster health and learning, ultimately helping individuals and families thrive in the Greater New Bedford area.

About Us

The Department of Environmental Protection (DEP) is responsible for protecting and restoring Maine's natural resources and enforcing the state's environmental laws. The agency can trace its roots back to the Sanitary Water Board that was created in 1941. The purpose of that Board was to study, investigate, recommend means of eliminating and preventing pollution in waters used for recreational purposes. The Board was renamed the Water Improvement Commission in 1951. In 1969, the Commission's title was abbreviated to the Environmental Improvement Commission.

Solid Waste Diversion Grant Program

The Maine Legislature established the Maine Solid Waste Diversion Grant Program to provide grants to public and private entities to assist in the development, implementation or improvement of programs, projects, initiatives or activities designed to increase the diversion of solid waste from disposal in the State.

Funding will be considered for proposals which include, programs, projects or ideas that address, but are not limited to:

• Establishing municipal or regional composting, organics recovery or recycling programs,
• urchasing infrastructure, equipment or other items necessary to implement such programs or improve existing programs,
• Programs or projects designed to provide equipment for or otherwise support residential composting and recycling,
• Programs or business models designed to collect, transport for processing or process organic or recyclable materials,
• Pilot programs designed to evaluate the feasibility of targeted composting, organics recovery, recycling or other waste management programs or initiatives, or
• Initiatives or programs designed to educate certain categories of individuals or the general public about composting, organics recovery or recycling or to otherwise improve individual or community waste management practices.

Applications should include information demonstrating how programs will:

• Take advantage of regional economies of scale,
• Increase organics management and recycling infrastructure in underserved areas of the state,
• Promote waste reduction through reuse, repair, and sharing economy initiatives,
• Reduce wasted food through donation or other sharing initiatives,
• Enhance the delivery of educational initiatives to promote organics management or recycling efforts,
• Address a statewide need,
• Reduce “carbon footprint” of existing or proposed waste management programs, and/or
• Expand the types of materials managed through composting and recycling.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Santa Clara County Fish and Game Commission invites applications for Fish and Wildlife Preservation Grants. These funds support projects aimed at enhancing local fish and wildlife resources, including education events and habitat improvements. Established in 1960, the Commission emphasizes ecosystem health and sustainable practices. Eligible organizations can apply for funding to conduct activities that protect and restore wildlife, with applications due 17 days prior to Commission meetings.

The Climate Change Investment Initiative Grant Program, funded by the Exelon Foundation, aims to support innovative start-ups focused on climate change solutions within Exelon's service territories. With a commitment of $20 million over ten years, the program promotes not only environmental sustainability but also social equality and economic prosperity. Eligible businesses can benefit from substantial equity investments and valuable in-kind services. The initiative seeks to empower diverse leadership teams, particularly those representing women and minorities, to drive impactful change.

The Kirkpatrick Foundation Small Grants program supports diverse initiatives in arts, culture, education, animal wellbeing, environmental conservation, and historic preservation, primarily in Central Oklahoma. With no specific deadlines and monthly reviews, the foundation aims to enhance the quality of life through strategic funding. Organizations that qualify as 501(c)(3) nonprofits and serve the local community are encouraged to apply. This program reflects the foundation's commitment to fostering a vibrant and sustainable environment for all citizens.

The Joseph B. Whitehead Foundation supports various initiatives in metro Atlanta, focusing on early childhood education, K-12 education, human services, health, and youth development. The foundation seeks to enhance educational opportunities and improve quality of life for vulnerable populations. Through collaborations with established organizations, it aims to address community needs and invest in proven solutions that empower children and families, ultimately fostering economic opportunities and health improvements in the region.

The Santander Charitable Sponsorship Program focuses on supporting low- to moderate-income communities primarily in the Northeast and Florida. With a commitment of $100 million in charitable giving, the program addresses key community development needs, including affordable housing, job creation, financial education, and disaster relief. Eligible organizations must have IRS 501(c)(3) status or be public agencies, demonstrating capacity to meet community needs. Unsolicited applications are not accepted.

The Medica Foundation Grant for MN Early Childhood Health supports early intervention programs aimed at the growth and development of children from birth to age 12. With a focus on health equity, the grant prioritizes proposals that serve marginalized communities, including BIPOC, immigrants, and individuals experiencing homelessness. Grants can be up to $100,000 and are awarded to eligible 501(c)(3) organizations in Minnesota. This initiative aims to improve healthcare access and quality through measurable outcomes.

The Robinson-Broadhurst Foundation, established in 1984, is dedicated to enhancing the quality of life for residents in Stamford and Worcester, New York, and Winchendon, Massachusetts. By funding charitable 501(c)(3) organizations, the foundation supports various initiatives, including community health services, historical preservation, education, and public safety. Organizations aligned with these goals are encouraged to apply for grants to foster community spirit and cooperation.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Fund for the Arts: Event Artist program invites artists and organizations from the Greater Louisville area to participate in community events. This initiative aims to create a diverse roster of artistic talent, compensating participants for their contributions. Artists can engage in various events, from large public festivals to intimate performances. Applicants must align with the Fund's commitment to equity and inclusion, ensuring a vibrant arts scene that reflects the community's diversity.

The Sacramento District California In-Lieu Fee Program, established by the National Fish and Wildlife Foundation, offers a mitigation option for permittees to compensate for authorized impacts to aquatic resources in California. Approved by multiple agencies, this program facilitates the purchase of mitigation credits to meet compensatory mitigation requirements. It employs a watershed approach to evaluate wetland threats, prioritize restoration, and implement mitigation projects, ensuring effective management of aquatic resources across designated service areas.

The England Family Foundation Grant aims to amplify local solutions for inclusive prosperity in Washington, DC. It welcomes 501(c)(3) organizations to apply for general operating grants that align with its strategic priorities, including economic justice and community safety. The foundation prioritizes funding for organizations addressing systemic inequalities and fostering leadership among youth. Grants are awarded twice a year, with a commitment to reducing gun violence and supporting vulnerable communities. Interested applicants can submit inquiries via an online portal.

California Department of Health Care Access and Information

Mission: HCAI expands access to quality, equitable, affordable health care for all Californians by supporting high value delivery systems, resilient health facilities and workforces, and actionable health information and strategies.

HCAI is committed to expanding access to quality, equitable, affordable health care for all Californians by supporting high value delivery systems, resilient health facilities and workforces, and actionable health information and strategies.

California Rural Health Transformation (CalRHT) Program – California’s Implementation

The California Rural Health Transformation (CalRHT) program is California’s approach to the federal Rural Health Transformation Program (RHTP), led by the Department of Health Care Access and Information, with Centers for Medicare & Medicaid Services (CMS) oversight. CalRHT is designed to strengthen health care delivery in rural communities where access challenges, workforce shortages, and infrastructure gaps create unique barriers to care.

California Rural Healthcare Transformation (CalRHT) Initiative 1: Transformative Care Model Expand and Support Rural Workforce Capacity

The Family Medicine Obstetrics (FM-OB) Fellowship Subaward Program under Expand and Support Rural Workforce Capacity is intended to fund the programmatic and infrastructure costs of expanding FM-OB fellowship capacity. Primary applicants for the FM-OB Fellowship Subaward Program must be aspiring or existing graduate medical education (GME) sponsoring institutions. The Program expands access to high-quality maternity and perinatal care in California’s rural communities by increasing the number of family physicians with advanced obstetrics training. Through support for family medicine obstetrics fellowship programs and regional collaborative care models, the program builds sustainable obstetric workforce capacity where rural patients receive care, preparing physicians to practice in underserved communities and improving maternal and infant health outcomes.

The Weston Family Boreal Research Fellowship, supported by the Wildlife Conservation Society Canada, offers financial assistance to graduate students conducting field-based research in the Ontario Northern Boreal and Northern Boreal Mountains. This fellowship encourages projects that align with WCS Canada's conservation objectives and that collaborate with Indigenous communities. Successful applicants will benefit from mentorship and networking opportunities, while contributing to significant conservation efforts in North America's boreal regions.

The Louisville Water Foundation is dedicated to enhancing global health and well-being through water education and assistance. Their mission focuses on ensuring safe water access for all communities. They support innovative projects that demonstrate clear objectives, community engagement, and sustainability. Eligible applicants include non-profits addressing water-related needs within specified service areas. The foundation emphasizes measurable impacts and reasonable budgeting, fostering a collaborative approach to water stewardship.