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Best Large Grants for Nonprofit Organizations in California

Find the perfect Large Grants for Nonprofit Organizations in California on Instrumentl. 11,000+ Large Grants for Nonprofit Organizations in California in the United States.

11,000+

Available grants

$3.61B

Total funding

$5K

Median grant

11,000+ grants
$3.61B total
$5K median

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10,797 Results based on applied filters

AO Spine NA: Young Investigator Research Grant Award

Ao North America Inc
Private
North America
US $20,000
The AO Spine NA Young Investigator Research Grant Award supports early-career surgeons and researchers focusing on clinically relevant spinal or spinal cord research. With funding of $20,000, this initiative encourages new investigators by providing essential start-up capital. Successful applicants are required to present their findings at the Annual AO Spine North America Fellows Forum and submit progress and final reports detailing their research outcomes. This grant aims to foster innovation and excellence in spinal care.
Spinal Cord Injuries Medical Education & Professional Training Orthopedics

JLSF: Enabling Funds Grant

Junior League Of San Francisco Inc
Private
Alameda County, California, Contra Costa County, California +7 more
Up to US $5,000
The Junior League of San Francisco (JLSF) offers Enabling Funds Grants to support nonprofit organizations in the Bay Area that address essential needs such as housing, food, and personal necessities. With grants up to $5,000, priority is given to those facing urgent financial challenges. Eligible organizations must align their programs with JLSF's mission and provide verification of their 501(c)(3) status. This initiative helps sustain vital community services and empower women’s leadership.
Basic Human Needs Food Access & Hunger Real Estate & Housing

Beth N. Rom-Rymer Travel Scholarship for Native Psychology Students

American Psychological Foundation Inc
Private
United States
US $1,000
The Beth N. Rom-Rymer Travel Scholarship provides $1,000 for Native psychology graduate students to attend the American Psychological Association's annual convention. This opportunity is specifically for members of the Society of Indian Psychologists (SIP). The scholarship aims to support diverse applicants and encourages first-time attendees who demonstrate financial need. APF, the funding organization, is dedicated to enhancing the field of psychology by supporting early career professionals and their contributions to societal improvement.
Native American Services Psychology

Community Support - Fundraising Events and Giveaway Donations

Bass Pro Shops & Cabelas Outdoor Fund
Private
Canada, United States
Up to US $2,500 in in-kind support
Bass Pro Shops & Cabela's Outdoor Fund supports conservation-focused nonprofits through fundraising events and donation of merchandise or gift cards. Organizations eligible for funding must be registered 501(c)(3) entities in the U.S. or provincially registered nonprofits in Canada. This initiative aims to connect communities to outdoor activities while promoting wildlife conservation and support for military veterans. Grants of up to $1,000 are available to enhance local fundraising efforts.
Environmental Conservation Outdoor Recreation Outdoor Equity +1 more

TTP Bridge Program

US Department of Transportation: Federal Highway Administration (FHWA)
Federal Government
United States
Unspecified amount
The TTP Bridge Program aims to enhance the safety and accessibility of bridges in Tribal communities, addressing the urgent need for infrastructure improvements. With aging bridges affecting economic development and children's transportation, this program allows federally recognized Indian Tribes to apply for funding for planning, construction, and rehabilitation of bridges. By focusing on TTP bridges in poor condition, the initiative seeks to strengthen economic foundations and ensure better connectivity with markets, benefiting both families and communities.
Public Infrastructure Native American Services

T.E.A.L. Research Grant

Tell Every Amazing Lady About Ovarian Cancer Foundation
Private
United States
Up to US $20,000
The T.E.A.L. Research Grant supports innovative ovarian cancer research initiatives aligned with the mission of the Tell Every Amazing Lady About Ovarian Cancer Foundation. Designed for researchers affiliated with 501(c)3 not-for-profit institutions in the U.S., the grant aims to enhance women's health awareness and education regarding ovarian cancer. While the application period for 2025 is currently closed, interested parties should anticipate further updates in spring 2026.
Gynecological Cancers

WAEF Scholarships - Danna Gebbers Guzman Memorial

Washington Apple Education Foundation
Private
United States
Unspecified amount
The WAEF Scholarships, supported by the Washington Apple Education Foundation, offer over $1 million in educational awards to more than 300 students this year. These scholarships are primarily for individuals with ties to the tree fruit industry in Washington, with a special focus on the Danna Gebbers Guzman Memorial Scholarship, aimed at nursing students. Eligible recipients can use the funds at accredited institutions with nursing programs.
Agricultural Crops Nursing

Medical Student Mentored Summer Research Program

North American Society For Pediatric Gastroenterology, Hepatology & Nutrition
Association/Society
Canada, United States
Up to US $4,000
The Medical Student Mentored Summer Research Program offers medical students in the U.S. and Canada a unique opportunity to engage in a 10-week research experience under expert mentorship in pediatric gastroenterology, hepatology, or nutrition. With a stipend of $4000 paid in installments, this program is designed for students who have completed at least their first year of medical training. Preference is given to those seeking research experience between their first and second years.
Digestive System Health & Diseases Nutrition & Healthy Eating

Brothers Helping Brothers: Backing Safety Initiative Grants

Brothers Helping Brothers
Private
United States
Unspecified amount in in-kind support
The Brothers Helping Brothers initiative aims to provide essential equipment to small fire departments and EMS organizations in the U.S. Established in 2014, the program offers grants to eligible agencies serving communities with populations under 10,000. With a focus on tools like wireless backup cameras, the organization strives to enhance safety and operational efficiency for first responders. Through community support, they have raised significant funds to assist in this critical mission.
Firefighting & Fire Prevention Emergency Medical Care & Services

Harry and Myrtle Nabstedt Scholarship

Quad Cities Community Foundation
Private
United States
Up to US $50,000
The Harry and Myrtle Nabstedt Scholarship, offered by the Quad Cities Community Foundation, supports students from Scott County, Iowa, pursuing post-secondary education at accredited institutions. With a maximum award of $8,000 per year, this need-based scholarship is renewable for up to five years, contingent on maintaining eligibility. Applicants must demonstrate financial need and a minimum GPA of 2.00, showcasing merit through community involvement and other activities.
Vocational & Trade Education Academic Scholarship Programs College Success / Persistence

NASPGHAN Foundation/APGNN Susan Moyer Research Grant

North American Society For Pediatric Gastroenterology, Hepatology & Nutrition
Association/Society
Mexico, United States
US $500 - US $10,000
The NASPGHAN Foundation/APGNN Susan Moyer Research Grant supports impactful research and quality improvement initiatives aimed at enhancing nursing care for children with gastrointestinal and nutritional disorders. Grants ranging from $500 to $5000 are available for eligible Registered Nurses who are APGNN members. Awardees must present their findings at the NASPGHAN Annual Meeting and adhere to specific funding guidelines, including IRB approval and acknowledgment of support in publications.
Digestive System Health & Diseases Nutrition & Healthy Eating

National Fish Passage Program

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
United States
US $500 - US $2,000,000
The National Fish Passage Program (NFPP) offers technical and financial support to restore aquatic connectivity for fish and other organisms. By improving infrastructure like culverts and bridges, the program enhances fish populations and ecosystem resilience, providing quality fishing experiences. Managed by the US Fish and Wildlife Service, NFPP collaborates with partners to implement strategic projects that align with conservation goals, ensuring biological diversity and effective use of scientific principles in project planning.
Fisheries Fish Conservation

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed) (356718)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The National Cancer Institute (NCI) invites applications for the validation of molecular, cellular, and imaging markers for cancer detection and treatment. This funding opportunity supports both analytical and clinical validation phases, emphasizing multi-disciplinary collaboration. The UH2 phase focuses on analytical validation, while the UH3 phase extends to clinical validation using well-annotated biospecimens. Proposals should justify the relevance of assays for clinical use and may include harmonization efforts across laboratories.
Cancer / Oncology Biomedical Imaging

Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional) (352883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,352,688
The Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42) program invites small business concerns to develop innovative technologies aimed at enhancing minority health and addressing health disparities. This initiative emphasizes the creation of effective, affordable, and culturally acceptable solutions for NIH-defined populations. Key deadlines for applications span from June 2024 to December 2026, with optional Letters of Intent encouraged 30 days prior to submission.
Minority Services Health Disparities & Social Determinants of Health Medical Technology, Devices, and Equipment

MultiState Conservation Grant Program

Association of Fish & Wildlife Agencies
Association/Society
United States
Up to US $1,000,000
The MultiState Conservation Grant Program provides vital funding for wildlife and sport fish restoration projects, as well as initiatives aimed at recruitment, retention, and reactivation (R3) of outdoor enthusiasts. These grants address priority needs identified by the Association of Fish and Wildlife Agencies, supporting collaborative efforts among states to enhance conservation efforts. Eligible projects may include research, education, and public outreach, promoting sustainable use of natural resources and fostering community engagement in conservation.
Sport Fishing Sport Shooting

Brothers Helping Brothers: Equipment Grants

Brothers Helping Brothers
Private
United States
Unspecified amount in in-kind support
Brothers Helping Brothers is a 501c3 non-profit organization dedicated to providing essential tools and equipment to small and rural fire departments. Founded in 2014 after a tragic loss, the organization has raised over $20,000 to support fire services. They grant financial assistance to eligible fire and EMS organizations across the U.S. with a focus on enhancing safety and operational capability. Their mission continues to grow as they research and address the pressing needs of emergency services.
Firefighting & Fire Prevention Emergency Medical Care & Services

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed) (356717)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The National Cancer Institute (NCI) seeks to enhance the validation of biomarkers and assays for cancer detection and treatment through its UH3 funding mechanism. This initiative supports multi-disciplinary collaborations to validate existing assays over three years using clinical trial specimens. Emphasis is placed on harmonizing laboratory tests and validating pharmacodynamic markers. Projects should not focus on early-stage technology development but aim for integration into clinical studies as investigational assays.
Cancer / Oncology Biomedical Imaging

Richard I. Stessel Waste Management Award

Air & Waste Management Association (A&WMA)
Association/Society
United States
Unspecified amount
The Richard I. Stessel Waste Management Award, presented annually by the Air & Waste Management Association, honors outstanding achievements in waste management. This prestigious award acknowledges individuals and organizations for their significant contributions to the science and practice of waste management, including technological advancements, waste regulation, and educational excellence. Named after Professor Richard I. Stessel, the award promotes innovative solutions for environmental sustainability, encouraging professionals to serve as role models in the field.
Waste Management

Apple Crop Protection Request for Proposals

Washington Tree Fruit Research Commission
State/Local Government
United States
Unspecified amount
The Washington Tree Fruit Research Commission is inviting research proposals aimed at apple crop protection, emphasizing organic practices and pollinator protection. Key areas of focus include the management of pests like Codling Moth and Fire Blight, testing new crop protection products, enhancing soil health, and developing efficient monitoring techniques. Collaboration among institutions is encouraged, and projects should aim for practical industry applications to ensure sustainable and profitable tree fruit production.
Agricultural Crops Agricultural Pest Management Pollinator Conservation

Next For Autism: Grants Program

Next For Autism Inc
Private
United States
Up to US $25,000
NEXT for AUTISM's grants program empowers autistic adults by funding innovative initiatives across work, home, social engagement, and health & well-being. With over 380 funded projects nationwide, the program supports 501(c)(3) organizations in the U.S. First-time grantees can apply for up to $10,000, while returning grantees may request up to $25,000. The program emphasizes community-based solutions and aims to enhance the quality of life for autistic individuals.
Autism

Jean Theodore Lacordaire Prize

Coleopterists Society
Association/Society
United States
US $1,000
The Jean Theodore Lacordaire Prize, awarded by the Coleopterists Society, recognizes exceptional doctoral research in beetle biology and systematics. This annual prize is open to nominations for the best published paper derived from Ph.D. dissertations, focusing on Coleoptera. Eligible works must be published in widely available journals or books in any language using the Latin alphabet. Nominations are submitted by the scientific community, ensuring a prestigious selection process.
Entomology

Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional) (352882)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,352,688
The Innovations for Healthy Living program invites eligible U.S. small businesses to apply for SBIR grants aimed at improving minority health and eliminating health disparities. The initiative encourages innovative proposals for effective, affordable, and culturally acceptable solutions. Key deadlines for applications span from June 2024 to December 2026, with optional Letters of Intent recommended 30 days prior to submission. This funding opportunity supports projects that address health challenges faced by underserved populations.
Minority Services Health Disparities & Social Determinants of Health Medical Technology, Devices, and Equipment

Eastern Iowa Angus Association Oliver Hansen Memorial Scholarship

Quad Cities Community Foundation
Private
United States
Up to US $2,000
The Eastern Iowa Angus Association Oliver Hansen Memorial Scholarship, administered by the Quad Cities Community Foundation, supports students from specified Iowa counties pursuing education in agriculture. Applicants must be involved with the Angus breed, maintain a minimum 2.0 GPA, and enroll full-time at accredited institutions. Scholarships provide up to $1,000 annually and are renewable for two years, aiding students in achieving their academic and career goals.
Vocational & Trade Education Career / College Preparation Academic Scholarship Programs

Emily Hall Tremaine Exhibition Award

The Emily Hall Tremaine Foundation Inc
Private
United States
US $50,000 - US $150,000
The Emily Hall Tremaine Exhibition Award, established in 1998, supports innovative, thematic exhibitions that present contemporary art within unconventional frameworks. It fosters creativity by offering funding up to $200,000 for curators partnering with non-profit spaces. The award encourages exploration of critical ideas, emphasizing intellectual quality and public impact. Eligible applicants include established curators and institutions, aiming to promote artistic expression while enhancing community engagement and discourse through diverse projects.
Visual Arts Performing Arts Architecture

Whole Foods Market Store Giving Program

Whole Foods Market
Corporate
Canada, United Kingdom +1 more
Unspecified amount
The Whole Foods Market Store Giving Program supports local communities by providing financial assistance to 501(c)(3) nonprofit organizations that focus on food access and environmental stewardship. This biannual program allows eligible organizations to apply via the Community Engagement Portal, although not all requests can be fulfilled due to high demand. Priority is given to those without recent funding, promoting sustainable community engagement.
Food Access & Hunger Environmental Stewardship

Emily Hall Tremaine Exhibition Research Grant

The Emily Hall Tremaine Foundation Inc
Private
United States
US $10,000
The Emily Hall Tremaine Exhibition Research Grant supports innovative projects that explore contemporary art in new frameworks. With a focus on education in the United States, the foundation emphasizes the importance of research that challenges conventional thought. Grants of $10,000 are awarded to curators collaborating with established non-profits, promoting impactful exhibitions. The foundation aims to foster family unity and respect while addressing enduring societal issues through art, environment, and learning differences.
Visual Arts Performing Arts Architecture

Large Grants for Nonprofit Organizations in California Highlights

Looking for large grants for nonprofit organizations in California?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in California recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in California

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

400+ Large Grants for Nonprofit Organizations in California grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

200+ Large Grants for Nonprofit Organizations in California over $25K in average grant size

200+ Large Grants for Nonprofit Organizations in California over $50K in average grant size

38 Large Grants for Nonprofit Organizations in California supporting general operating expenses

300+ Large Grants for Nonprofit Organizations in California supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in California?

Most grants are due in the first quarter.

Q1
28.5%
Q2
25.8%
Q3
23.3%
Q4
22.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in California?

Grants are most commonly $100,000.

$0 $0 Min.
$100,000 $100 K Median
$2,149,932 $2.1 M Average
$150,000,000 $150 M Max.

Average Grant Size

What's the typical amount funded for California?

Grants are most commonly $145,539.

$145,539

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in California year over year?

In 2024, funders in California awarded a total of 256,564 grants.

2022 237,186

2023 236,635

2024 256,564

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in California given out in California, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in California changing over time?

Funding has increased by -1.38%.

2022 $34,364,756,699

2023 $37,770,770,141
9.91%

2024 $37,247,795,891
-1.38%

California Counties That Receive the Most Funding

How does grant funding vary by county?

Los Angeles County, San Francisco County, and San Mateo County receive the most funding.

County Total Grant Funding in 2024
Los Angeles County $10,841,756,858
San Francisco County $5,409,542,294
San Mateo County $5,358,878,304
Santa Clara County $3,811,026,208
Alameda County $3,749,322,182

Related Grants in California

Browse Other Nonprofit Operations & Capacity Grants in California

Browse Grants For Nearby Locations

Browse Grants by Major US Cities within California