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Best Large Grants for Nonprofit Organizations in California

Find the perfect Large Grants for Nonprofit Organizations in California on Instrumentl. 11,000+ Large Grants for Nonprofit Organizations in California in the United States.

11,000+

Available grants

$3.61B

Total funding

$5K

Median grant

11,000+ grants
$3.61B total
$5K median

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10,797 Results based on applied filters

REACHing Communities (REACH) Consortium (U01) Clinical Trials Optional

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
US $3,000,000
The REACHing Communities (REACH) Consortium (U01) Clinical Trials Optional grant aims to advance health equity among racial and ethnic minorities through cooperative agreements. It focuses on research, outreach, and mentoring diverse students and researchers. Although the grant information has not been updated in over six months, it remains under observation for potential updates. The initiative is part of the FDA Office of Minority Health and Health Equity's commitment to improving minority health.
Minority Services Diversity, Equity & Inclusion Health Disparities & Social Determinants of Health

Health Equity Innovation Award: Enhance Equity Funding Opportunity (U01) Clinical Trials Not Allowed

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
US $1,000,000
The Health Equity Innovation Award (U01) aims to support innovative research that enhances minority health and health equity. Key areas include promoting diversity in clinical trials, improving data visibility for underrepresented groups, and amplifying diverse patient perspectives. This initiative, funded by the US Department of Health and Human Services' FDA, seeks to ensure equitable health outcomes and address unmet needs within varied populations.
Biology Health & Medicine Health Disparities & Social Determinants of Health +1 more

The William Simes Research Fund

University of California, Berkeley
Private
Monterey County, California
US $2,000
The William Simes Research Fund, managed by UC Berkeley, supports graduate and postdoctoral research at the Hastings Natural History Reservation. Established in 2017, the fund honors Frances Simes Hastings and her husband, who donated the land in 1937. The fund provides multiple annual awards of $2000 to offset costs related to extended field research, including housing and supplies, fostering scientific inquiry in diverse habitats of California.
Humanities & Social Science Science Biology +3 more

1Fur1 Foundation Grant

1Fur1 Foundation
Private
United States
US $500 - US $7,500
The 1Fur1 Foundation Grant supports U.S.-based 501(c)(3) charities that engage in animal-assisted programs. Eligible organizations can apply for grants ranging from $500 to $7,500 to support Animal Assisted Therapy, Activity, and Service Dog programs. The foundation focuses on charities that align with its mission and does not fund individual requests, for-profit businesses, or initiatives that promote animal cruelty. Applications are reviewed within 90 days.
Service Animals Human-Animal Interactions & Therapy

Biocodex Microbiota Foundation- Call for Projects USA

Biocodex Microbiota Foundation
Private
United States
US $50,000
The Biocodex Microbiota Foundation invites early career researchers in the microbiome field from U.S. institutions to apply for the 2024 grant. This initiative focuses on groundbreaking research into gut microbiota's role in human health and disease, particularly in areas like circadian rhythms and metabolic disorders. The grant supports operational costs, allowing for innovative projects aimed at fostering independent research careers in microbiota studies.
Microbiomes Digestive System Health & Diseases

Post-Doctorate Research Grants: W. Storrs Cole Memorial Research Award

Geological Society of America (GSA)
Association/Society
United States
US $7,000 - US $10,000
The W. Storrs Cole Memorial Research Award, offered by the Geological Society of America (GSA), supports innovative research in invertebrate micropaleontology. This prestigious award honors the legacy of Dr. W. Storrs Cole, a pivotal figure in the society's history. Recipients may be previous awardees and must have published significant works in the field. The GSA aims to advance geoscience through such initiatives, fostering scientific discovery and professional growth among earth scientists globally.
Palynology Paleontology Geology

Willis C. Helm Charitable Trust Grant

Willis C. Helm Charitable Trust
Private
United States
US $5,000 - US $15,000
The Willis C. Helm Charitable Trust, established in 1954, focuses on supporting organizations that work on juvenile delinquency and the development of boys from broken homes. It provides annual grants averaging between $5,000 and $15,000, with a total giving of around $60,000 for five grants each year. Eligible organizations must be 501(c)(3) exempt and preferably located in Minnesota. Applications are accepted year-round, with a deadline of March 31 for annual review.
Juvenile Justice Youth Development & Leadership

Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed) (357002)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
This funding opportunity invites applications for R01 grants focused on molecular imaging methods to explore cancer inflammation in vivo. It aims to enhance understanding of dynamic interactions between inflammation and cancer through innovative imaging techniques. The initiative encourages collaborations between cancer researchers and imaging scientists to leverage molecular imaging for identifying cellular physiology changes in response to treatment. Deadline dates for applications range from February 2025 to October 2027, emphasizing timely submission for prospective researchers.
Cancer / Oncology Biomedical Imaging

Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) (357003)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) aims to enhance cancer treatment by integrating imaging and liquid biopsy assays. This initiative, led by the National Cancer Institute (NCI), encourages grant applications focused on assessing therapy responses and resistance emergence in patients. Key deadlines for submissions span from February 2025 to January 2028, providing ample opportunities for researchers to contribute to this vital area of cancer research.
Cancer / Oncology Biomedical Imaging

Hannah T. Croasdale Fellowship

Phycological Society of America
Association/Society
Canada, Cheboygan County, Michigan +16 more
Up to US $2,250
The Hannah T. Croasdale Fellowship, offered by the Phycological Society of America, supports graduate students in expanding their phycological training. This fellowship provides up to $2,250 to help cover costs associated with attending phycology courses at biological field stations. Eligibility requires applicants to be currently enrolled in or admitted to a graduate program. Proposals for courses at non-affiliated field stations are highly encouraged, fostering broader educational experiences in phycology.
Phycology

AHA Quest for Quality Prize

American Hospital Association
Private
United States
Unspecified amount
The AHA Quest for Quality Prize recognizes hospitals and health systems that demonstrate exceptional leadership in improving care quality and advancing health. Applicants should showcase innovative models of care and effective partnerships with community organizations. One winner and two finalists will be honored at the 2026 AHA Leadership Summit in Denver. This award aims to inspire hospitals to commit to patient-centered care and address healthcare disparities, ultimately enhancing community health outcomes.
Patient Care & Services Health Disparities & Social Determinants of Health

Leukemia Exploration and Prevention Grant Program (LEAP) - Research Scholar Grant

American Cancer Society
Association/Society
United States
Up to US $860,000
The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention strategies for patients with RUNX1 familial platelet disorder. This initiative, supported by the American Cancer Society, focuses on understanding the mechanisms behind leukemia development and fostering innovative research leading to effective treatment options. Grants of up to $215,000 per year for four years are available, emphasizing the urgent need for targeted therapies in high-risk populations.
Leukemia

Leukemia Exploration and Prevention Grant Program (LEAP) - Team Award

American Cancer Society
Association/Society
United States
Up to US $1,720,000
The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention for patients with RUNX1 familial platelet disorder (RUNX1-FPD). This program supports interdisciplinary research teams investigating the mechanisms of leukemogenesis and innovative treatment strategies. With funding of up to $430,000 per year, LEAP encourages projects focused on both understanding clonal evolution and developing novel therapeutic approaches. The initiative seeks to bridge critical knowledge gaps and provide urgent interventions for high-risk populations.
Leukemia

AES Infrastructure Grants

American Epilepsy Society
Private
United States
Up to US $50,000
The AES Infrastructure Grant, offered by the American Epilepsy Society, provides up to $50,000 to support the development of national or international multicenter research programs. This funding is intended for organizational planning sessions, infrastructure development, and pilot projects, facilitating future investments from other organizations. These grants are available annually in the spring, enabling researchers to enhance their collaborative efforts.
Epilepsy

Pilot Research Grant

The Society of Interventional Radiology Foundation
Association/Society
Canada, United States
Up to US $35,000
The Pilot Research Grant, offered by the Society of Interventional Radiology Foundation, supports innovative research in interventional radiology to improve patient care. Grants of up to $35,000 are available for full-time faculty and post-doctorates with relevant degrees in the U.S. and Canada. Applicants must be current SIR members and can submit proposals for preliminary data generation, enhancing their chances for future funding opportunities.
Patient Care & Services Biomedical Imaging

Hilda M. Hill Memorial Scholarship

Four County Community Foundation
Private
United States
US $1,000 - US $2,500
The Hilda M. Hill Memorial Scholarship is offered by the Four County Community Foundation to support high school seniors and recent graduates from Capac, Almont, and Imlay City. Eligible students planning to pursue vocational or technical programs may apply, with financial need considered. Recipients will be recognized at the Foundation Scholarship Celebration in May, as well as during high school awards ceremonies. Students can receive up to two awards, promoting continued educational advancement in skilled trades.
Vocational & Trade Education Academic Scholarship Programs Educational Access & Equity

Radiology Resident Research Grant

The Society of Interventional Radiology Foundation
Association/Society
Canada, United States
Up to US $20,000
The Radiology Resident Research Grant, funded by The Society of Interventional Radiology Foundation, aims to promote research among residents in accredited clinical radiology training programs in the U.S. and Canada. With a budget of up to $20,000 for 12 months, this grant encourages innovative research projects that advance interventional radiology and improve patient care. Eligible applicants must designate a project advisor and secure a three-month commitment from their residency program, fostering a supportive research environment.
Patient Care & Services Biomedical Imaging

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) (356888)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.
Biomedical informatics Epidemiology & Public Health Health Information Technology

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) (356883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.
Medical Technology, Devices, and Equipment Health & Medicine Biotechnology +1 more

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (356879)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.
Human Genome & Genetics Rare Diseases

Civic Engagement Microgrant Grant Program

Research!America
Private
United States
Up to US $4,000
The Civic Engagement Microgrant Grant Program, funded by Research!America, aims to enhance public engagement skills among early-career scientists. By providing financial support for innovative projects, this initiative encourages collaborations across various STEM disciplines. Grantees will develop essential skills in communication and policy-making to strengthen community ties and promote science as a national priority. This program addresses the critical need for scientists to connect with local communities and policymakers to ensure the relevance and impact of scientific research.
Science Communications STEM / STEAM Education Public Policy

Psoriatic Arthritis/Ankylosing Spondylitis Research Grant

Arthritis National Research Foundation
Private
United States
Up to US $250,000
The Arthritis National Research Foundation (ANRF) offers grants for research focused on Psoriatic Arthritis (PsA). With funding of up to $125,000 over two years, the ANRF encourages innovative projects that reveal the underlying mechanisms of PsA. Eligibility includes M.D. or Ph.D. qualifications and affiliation with a U.S. nonprofit research institution. Preference is given to senior post-doctoral researchers transitioning to independent status and new assistant professors. Applications without a Co-PI or those who have previously received ANRF funding will not be accepted.
Arthritis

American Journalism Project

American Journalism Project Inc
Private
United States
Unspecified amount
The American Journalism Project is dedicated to enhancing local news organizations by investing in their business capacities and providing personalized coaching. They prioritize diversity, equity, and inclusion, encouraging inquiries from organizations serving underrepresented communities. Their approach offers tailored support based on grantees' strategic challenges, fostering sustainable growth in revenue and programming. They seek grantees with strong public-service missions, independent 501(c)(3) status, and a commitment to transparency and accountability in their operations.
Journalism Internet / Media Freedom News Media & Communications

Community Collaboration Challenge

National Partnership for Student Success
Association/Society
United States
US $5,000 - US $10,000

Community Collaboration Challenge

Applications for the 2026 Community Collaboration Challenge are now open! With support from the Leon Lowenstein Foundation, the Challenge provides $5,000 – $10,000 awards to communities and is designed to support collaboration that expands and pilots evidence-based K-12 student supports in the form of high-impact tutoring, mentoring, student success coaching, postsecondary transition coaching, and/or wraparound/integrated student supports.

Tutoring & Mentoring College Success / Persistence

Journalism & Media Grant

John D and Catherine T MacArthur Foundation
Private
United States
Unspecified amount
The Journalism & Media Grant aims to promote inclusive narratives and accurate media that engage communities in democratic processes. It supports U.S.-based nonprofit organizations focused on professional reporting, multimedia storytelling, and civic media. The grant addresses barriers to media participation and fosters innovation in journalism, providing essential infrastructure for a diverse media landscape. While unsolicited proposals are not accepted, organizations can share ideas through a Letter of Inquiry (LOI).
Internet / Media Freedom Journalism News Media & Communications +1 more

Igor Gorin Memorial Award

Community Foundation for Southern Arizona
Private
United States
Up to US $12,000
The Igor Gorin Memorial Award, established in 1993 by the Community Foundation for Southern Arizona, honors the legacy of Igor Gorin by supporting aspiring vocalists. With $382,000 awarded to 49 young talents, this fund provides unrestricted financial assistance for coaching, travel, and auditions. The 2026 award offers up to $12,000, aimed at those overcoming financial barriers to pursue operatic careers, ensuring that exceptional vocalists can thrive in their artistic journeys.
Opera

NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3) is designed to support clinical trial planning and implementation for dental, oral, and craniofacial conditions. This funding opportunity encourages applications that propose innovative research strategies within the NIDCR mission. Key deadlines span from February 2025 to January 2028, with emphasis on milestone-driven planning phases leading into possible clinical trial phases.
Dental Health Pharmacology Drug Safety +1 more

Large Grants for Nonprofit Organizations in California Highlights

Looking for large grants for nonprofit organizations in California?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in California recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in California

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

400+ Large Grants for Nonprofit Organizations in California grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

200+ Large Grants for Nonprofit Organizations in California over $25K in average grant size

200+ Large Grants for Nonprofit Organizations in California over $50K in average grant size

38 Large Grants for Nonprofit Organizations in California supporting general operating expenses

300+ Large Grants for Nonprofit Organizations in California supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in California?

Most grants are due in the first quarter.

Q1
28.5%
Q2
25.8%
Q3
23.3%
Q4
22.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in California?

Grants are most commonly $100,000.

$0 $0 Min.
$100,000 $100 K Median
$2,149,932 $2.1 M Average
$150,000,000 $150 M Max.

Average Grant Size

What's the typical amount funded for California?

Grants are most commonly $145,539.

$145,539

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in California year over year?

In 2024, funders in California awarded a total of 256,564 grants.

2022 237,186

2023 236,635

2024 256,564

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in California given out in California, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in California changing over time?

Funding has increased by -1.38%.

2022 $34,364,756,699

2023 $37,770,770,141
9.91%

2024 $37,247,795,891
-1.38%

California Counties That Receive the Most Funding

How does grant funding vary by county?

Los Angeles County, San Francisco County, and San Mateo County receive the most funding.

County Total Grant Funding in 2024
Los Angeles County $10,841,756,858
San Francisco County $5,409,542,294
San Mateo County $5,358,878,304
Santa Clara County $3,811,026,208
Alameda County $3,749,322,182

Related Grants in California

Browse Other Nonprofit Operations & Capacity Grants in California

Browse Grants For Nearby Locations

Browse Grants by Major US Cities within California