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Best Large Grants for Nonprofit Organizations in California

Find the perfect Large Grants for Nonprofit Organizations in California on Instrumentl. 11,000+ Large Grants for Nonprofit Organizations in California in the United States.

11,000+

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$3.61B

Total funding

$5K

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11,000+ grants
$3.61B total
$5K median

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Disability Inclusion Fund Grant

Borealis Philanthropy
Private
American Samoa, Guam +4 more
US $75,000 - US $150,000
The Disability Inclusion Fund Grant, managed by Borealis Philanthropy, aims to support organizations advocating for disability inclusion, rights, and justice. As a partner in philanthropy, Borealis facilitates donor collaboratives to maximize impact across various communities and movements. Organizations interested in applying for this grant are encouraged to review the detailed FAQ for further information. This initiative is a vital step towards fostering inclusivity and promoting the rights of individuals with disabilities.
Disability Care & Services Disability Rights & Justice Diversity, Equity & Inclusion

MOORE Equity in Mental Health Community Grants Program

American Psychiatric Association Foundation
Private
United States
US $10,000
The MOORE Equity in Mental Health Community Grants Program, initiated by the American Psychiatric Association Foundation, aims to enhance mental health services for young people of color. With grants up to $10,000 over two years, it supports community organizations addressing mental health and substance use inequities. Eligible applicants include non-profits with a focus on culturally relevant care and sustainable solutions. The program fosters collaboration and awareness through innovative initiatives aimed at improving access to essential mental health services.
Mental Health & Psychiatric Diseases Addiction & Substance Use Disorders Health Care Access & Delivery

Weiss Writing Prize

American College Health Foundation
Corporate
United States
US $1,500
The Weiss Writing Prize, established by the American College Health Foundation in 2010, aims to enhance mental health care quality for college students. It honors the lead author of a significant publication addressing student retention programs for those with mental health challenges. By fostering innovative and effective solutions, this prize encourages the dissemination of impactful research among American College Health Association members, ultimately contributing to the well-being and success of students across campuses.
Wellness & Healthy Living Education - Higher Education Mental Health & Psychiatric Diseases

Pilot and Feasibility Grants

Myasthenia Gravis Rare Disease Network (MGNet)
Association/Society
United States
Up to US $75,000

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

  • Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
  • Late-onset AChR Ab positive MG with a disease bias towards men
  • Paraneoplastic thymoma-associated MG
  • Muscle specific kinase (MuSK) Ab positive
  • AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

  • Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
  • Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
  • Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
  • Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Pilot and Feasibility Grants

Objectives

MGNet, a NIH-funded Rare Diseases Clinical Research Consortium (RDCRC) in partnership with the Myasthenia Gravis Foundation of America and Conquer MG, is seeking proposals for highly innovative investigations in early stages of development.

The priorities of the Pilot Grant Program are:

  • Identification treatment responsive biomarkers
  • Assess clinical measures and improve that enhance clinical trial readiness
  • Evaluation of therapeutic interventions for one or more of the five distinct sub-types of MG

Pilot studies must be designed to access the resources of MGNet and focused on clinical and translational research, including fulfilling the definition of clinical and translational research and exclusion of animal studies.

Funding

The MGNet expects to fund up to two grants, each at a level of $75,000 (IDCs will be limited to 10% and included in the $75,000). Projects will be funded for 12 months. Selection among the applications received will be based on the recommendations of a review committee. A grant may be renewed for an additional one year with approval of interim report by the same review process and availability of funds. Demonstration of fulfillment of initial aims and justification for additional funding will be required. The request will be required a minimum of three months prior to the initial funding period completion.

Rare Diseases Immune System Diseases

NFWF: The Guy Bradley Award

National Fish and Wildlife Foundation (NFWF)
Private
United States
Unspecified amount
The Guy Bradley Award, established in 1988 by the National Fish and Wildlife Foundation (NFWF), honors individuals who have made significant contributions to wildlife law enforcement. Named after the first wildlife officer killed in the line of duty, this award recognizes the vital role of law enforcement agents in wildlife conservation. Eligible candidates include current and retired personnel from state and federal agencies who have demonstrated exemplary dedication to protecting wildlife and advancing enforcement goals.
Wildlife Management Fish Conservation

NCB - Botany Research Scholarship Program

Northern California Botanists
Association/Society
United States
US $1,500
The NCB - Botany Research Scholarship Program, offered by Northern California Botanists, targets undergraduate and graduate students pursuing research in botany and plant ecology. Scholarships of $1,500 support independent study, thesis, or dissertation projects within a specific geographic area of Northern California. Eligible applicants may reapply for funding for up to four years. This initiative aims to foster academic careers in botany and promote valuable ecological research.
Plant Science Ecology Botanical Conservation

Tri-M Foundation: Performing Arts Grant Program

Tri M Foundation
Private
United States
US $3,000 - US $10,000
The Tri-M Foundation's Performing Arts Grant Program aims to support innovative and high-quality performing arts projects by regional non-profit organizations. The program prioritizes projects that align with the organization's mission, engage audiences, and provoke important discussions. Grants range from $3,000 to $10,000, intended for diverse artistic expressions, including theatre and dance. Applications are encouraged from eligible organizations that demonstrate detailed project planning, inclusivity, and a commitment to addressing sensitive topics.
Theater Dance

Shasta Chapter CNPS scholarship award

Sacramento-Shasta Chapter of The Wildlife Society
Association/Society
Lassen County, California, Modoc County, California +2 more
Unspecified amount
The Shasta Chapter CNPS scholarship is awarded to undergraduate and graduate students conducting research relevant to the flora of Shasta, Lassen, Modoc, and Siskiyou counties. Eligible candidates must be full-time students engaged in botany or plant ecology studies. The scholarship prioritizes projects on rare or endemic species and invasive plants impacting native species. Applicants should indicate their eligibility in their cover letter and application. For more details, visit the Shasta Chapter's website.
Plant Science Ecology Botanical Conservation

MGNet Scholar Awards

Myasthenia Gravis Rare Disease Network (MGNet)
Association/Society
United States
Up to US $100,000

Myasthenia Gravis Rare Disease Network (MGNet)

The Myasthenia Gravis Rare Disease Network (MGNet) is a consortium of academic medical centers partnering with the Myasthenia Gravis Foundation of America and Conquer MG as well as collaborators in other research groups and industry. We are working together to enhance therapeutic development for this rare disease.

Diseases Studied

Myasthenia Gravis (MG) and its subtypes:

  • Early-onset acetylcholine receptor (AChR) antibody (Ab) positive MG, which primarily affects women
  • Late-onset AChR Ab positive MG with a disease bias towards men
  • Paraneoplastic thymoma-associated MG
  • Muscle specific kinase (MuSK) Ab positive
  • AChR/MuSK antibody negative MG

Goals, Mission, & Vision

The goal of MGNet is to advance therapeutic development. To do so we have four specific aims:

  • Improve the tools scientists and doctors have for performing clinical trials through rigorous monitoring of patients over time and evaluate better measures of how patients are doing.
  • Identify objective measures (biomarkers) to show how the disease is responding to treatment and better predict treatment response or side effects, to improve the design of clinical trials and care of patients in clinical practice.
  • Enhance the education of young investigators focusing their careers on rare diseases and specifically MG.
  • Improve the awareness of scientists, physicians, and the public regarding the unique needs of patients with MG through training of clinician scientists and engagement of the patient and scientific communities in clinical research and therapeutic development.

Scholar Awards

Objectives

There is a critical need for investigators prepared to conduct clinical and translational research in myasthenia gravis (MG). The MGNet Scholar Program provides individualized training and mentorship in one of two tracks, Clinical Research or Biomarker Development Research.

Award Description

The MGNet Scholar Program provides mentored research training to prepare Scholars for an independent research career in the field of MG. The MGNet Scholar Program is 1 year in duration and selected Scholars receive up to $100,000 to support salary, research costs and didactics with potential for renewal. The program will provide an additional $3,000 to travel to MGNet sites to learn specific skills and/or to scientific meeting(s) to present the results of their research. If available for renewal, the program requires approval after interim report and is contingent on demonstration of adequate progress on the research and career development plan. Indirect costs are not allowed. Scholars are encouraged to transition to NIH (e.g., K award), departmental, or private foundation support for their research and further career development.Research must constitute at least 50% of each Scholar’s professional effort. Each Scholar must form a 2-3-member advisory committee to include a primary mentor, an additional clinician investigator or collaborator, and a MGNet faculty sponsor. The advisory committee will meet with the Scholar at least quarterly to review progress and each Scholar will develop an individual academic career development plan and renew it with the committee at least every 6 months.
Immune System Diseases Rare Diseases

NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $300,000
The NIH Research Software Engineer (RSE) Award aims to provide salary support for outstanding Research Software Engineers who play a vital role in creating and sharing biomedical, behavioral, or health-related software and tools. This opportunity encourages RSEs to enhance the development of algorithms and support training for prospective users. Applications are due by 5:00 PM local time, with optional Letters of Intent recommended 30 days prior to the proposal deadline.
Health Information Technology Computer Science & Engineering Health & Medicine +1 more

EmpowHer Grants

Boundless Futures Foundation
Private
United States
Up to US $50,000
EmpowHer Grants, offered by the Boundless Futures Foundation, provide essential financial support and resources to female entrepreneurs in the U.S. who are committed to creating social impact through their businesses. Grants, which can go up to $25,000, are available to those with businesses that are less than three years old and demonstrate revenue generation. This initiative aims to empower women by reducing barriers and fostering a supportive entrepreneurial community.
Entrepreneurship Business Development

Parkinson's Foundation: Community Grants

Parkinson's Foundation Inc.
Private
United States
US $10,000 - US $25,000
The Parkinson's Foundation offers Community Grants to support impactful programs for people with Parkinson's disease across the U.S. With over $5 million awarded in the last three years, the Foundation aims to enhance health, wellness, and education. Eligible applicants include local non-profits and healthcare facilities focusing on mental health, care partner support, and exercise programs tailored for PD. This initiative promotes diversity, equity, and inclusion in service delivery.
Parkinson’s Disease

Spotlight Fund Grants - Racial Equity in Schools

Adopt-A-Classroom Inc
Private
United States
US $500 - US $5,000
The Spotlight Fund Grants aim to enhance racial equity in K-12 education by providing flexible funding to BIPOC educators. With grants ranging from $500 to $1,000 per educator, these funds are essential for sourcing tools and materials that support diverse student needs. As schools face budget cuts exacerbated by COVID-19, this initiative focuses on proven strategies that foster an inclusive learning environment for students of color, ensuring they have equal opportunities to thrive.
Education - K through 12 Educational Access & Equity Minority Services

Field-of-Interest Grant Program - Disaster Relief, Recovery, and Resilience

Community Foundation of Mendocino County Inc.
Private
Mendocino County, California
US $1,000 - US $6,500
The Field-of-Interest Grant Program supports Mendocino County nonprofits with projects focused on disaster relief, recovery, and resilience. Established in 2016, it aims to provide immediate assistance for natural and human-caused disasters, emphasizing community preparedness and service continuity. Funding priorities include disaster preparedness workshops, community resiliency initiatives, and service continuity projects. Grants range from $1,000 to $5,500, with proposals over $5,000 undergoing a two-stage review process.
Disaster Preparedness Disaster Relief / Humanitarian Aid Firefighting & Fire Prevention

National Scleroderma Foundation: New Investigator Grant

National Scleroderma Foundation
Private
United States
Up to US $200,000
The National Scleroderma Foundation's New Investigator Grant aims to support emerging researchers dedicated to scleroderma studies. This three-year grant, totaling $200,000, encourages applicants with doctoral degrees and postdoctoral experience. Eligible candidates are invited to submit proposals that may lead to further research funding. The grant emphasizes innovative research approaches while providing essential financial support for early-career investigators. Note that the grant does not cover certain costs, ensuring focused investment in research advancement.
Immune System Diseases Rare Diseases

Solidaire Network: Janisha R. Gabriel Movement Protection Fund

Solidaire Network
Private
United States
Unspecified amount
The Solidaire Network's Janisha R. Gabriel Movement Protection Fund supports frontline organizers facing security threats while fostering long-term safety. With $7.9 million allocated, the fund aids groups working towards racial, climate, gender, and reproductive justice. Despite a pause on new applications due to high demand, the fund remains committed to resourcing movement partners and addressing the disproportionate targeting of marginalized leaders amidst rising aggression from right-wing forces.
Black American Services Racial / Ethnic Justice & Rights

H20 For Life: Mini-Grant

H20 For Life
Private
United States
Up to US $500

Kickstart Your Project with a Mini-Grant

At H2O for Life, we never want finances to be a barrier to participating in a service project. The H2O for Life Mini-Grants are meant to be a supportive resource for teachers and students who want to kick-start their projects with us. Mini-grants of up to $500 will be awarded to support teachers and students with the necessary funds for their service-learning programs.

Our Mission

H2O for Life offers a service-learning opportunity designed to engage, educate and inspire youth to take action to solve the global water crisis by raising awareness and funds to support implementation of water, sanitation and hygiene education projects for global partner schools.

Since 2007, nearly 1 million students from H2O for Life schools have supported water, sanitation, and hygiene education projects for partner schools in the developing world.

What is H2O for Life doing to address the global water crisis?

H2O for Life’s service-learning opportunities are designed to engage, educate, and inspire youth to become global citizens. Our innovative school-to-school approach helps young people develop a concern for others by taking a major global crisis and scaling it down to a manageable size — one water project in the developing world.

Through the service-learning opportunity we provide, students learn that they can make a tangible difference for the students in their partner school.

Sanitation & Clean Drinking Water Education - Middle School

The Andrew Lloyd Webber Initiative: Classroom Resources Grants

American Theatre Wing Inc
Private
United States
Up to US $50,000
The Andrew Lloyd Webber Initiative offers Classroom Resources Grants aimed at enhancing theatre education in under-resourced public schools. Funded by a $1.3 million grant from the Andrew Lloyd Webber Foundation, the initiative provides essential resources, scholarships, and grants to foster artistic growth. By supporting diverse students and schools, this program opens pathways to careers in theatre, ensuring all young people have access to quality arts education, thereby enriching the cultural landscape of America.
Theater Youth Involvement in the Arts

Towsley Foundation Grants

Harry A. & Margaret D. Towsley Foundation
Private
United States
More than US $250,000
The Towsley Foundation Grants support initiatives that enhance community welfare and sustainability, focusing on diverse fields such as education, health, and the arts within Michigan. With a commitment to effective philanthropy, the foundation prioritizes projects that demonstrate creativity and strategic impact. Eligible organizations must operate in Michigan and adhere to specific funding guidelines, fostering financial sustainability. Grants are allocated based on project merit and organizational capacity, reinforcing the foundation's mission to improve lives through thoughtful partnerships.
Art & Culture Civic Affairs Community Development & Revitalization +4 more

Student Enrichment Grants: Level II Awards

Music & Entertainment Industry Educators Association (MEIEA)
Private
United States
Up to US $500
The Student Enrichment Grants: Level II Awards, offered by the Music & Entertainment Industry Educators Association (MEIEA), provide up to $500 for non-institutional members to support student activities in music and entertainment. Eligible applicants include faculty in good standing, promoting diverse initiatives. Grants can fund workshops, guest speakers, and community projects, with a focus on enhancing student education and engagement in the industry. Special consideration is given to first-time applicants and impactful projects.
Music Music Education

AMA Foundation Physicians of Tomorrow Scholarship: Alliance Grassroots

American Medical Association Foundation
Private
United States
US $10,000
The AMA Foundation Physicians of Tomorrow Scholarship: Alliance Grassroots provides $10,000 in tuition assistance to medical students entering their final year. With a commitment to supporting diversity in medicine, this scholarship focuses on candidates interested in women's and children's health issues. Open to all medical students, it recognizes volunteerism and research in health-related fields. Since 1950, the AMA Foundation has awarded over $61 million in scholarships, fostering a diverse cohort of future healthcare professionals.
Medical Education & Professional Training Children’s Health & Pediatrics Women's Health

Craft Archive Fellowship

The Center For Craft Creativity & Design Inc
Private
United States
US $5,000
The Craft Archive Fellowship supports archival research on underrepresented craft histories in the U.S., including feminist, queer, Black, Indigenous, and other marginalized communities. It offers a $5,000 stipend for scholars and artists to conduct research in chosen archives, encouraging innovative approaches. Participants will present their findings in a virtual program, and their work will be published in Hyperallergic, broadening accessibility and awareness of vital craft research.
Visual Arts Community Culture & Heritage Art History +1 more

John Lennon Endowed Scholarship

United Negro College Fund Inc
Private
United States
Up to US $5,000
The John Lennon Endowed Scholarship, established by Yoko Ono to honor John Lennon, supports students attending UNCF member institutions. This initiative addresses financial need and promotes education among African American youth. With over $65 million awarded annually, UNCF empowers thousands of students, advocating for minority education and community engagement. Eligible applicants must have a minimum GPA of 3.0, complete a FAFSA, and demonstrate unmet financial need. This scholarship plays a crucial role in fostering future leaders.
Education - Higher Education Performing Arts Media Arts +1 more

Jonathan Larson Grants

American Theatre Wing Inc
Private
United States
US $10,000
The Jonathan Larson Grants provide essential support to emerging musical theatre artists, helping composers, lyricists, and librettists further their creative endeavors. Established in memory of Jonathan Larson, creator of the iconic musical "Rent," these grants empower artists to create impactful work that resonates with contemporary culture. The program, sustained by the American Theatre Wing and the Larson Family, encourages professional growth and artistic exploration without the limitations of specific projects.
Theater Performing Arts Writing & Literature

Antoinette Lierman Medlin Scholarship (Energy Geology Division)

Geological Society of America (GSA)
Association/Society
United States
US $1,500 - US $2,000
The Antoinette Lierman Medlin Scholarship, administered by the Geological Society of America, supports graduate students in coal science. It offers two awards: $2000 for laboratory research and $1500 for fieldwork. This scholarship aims to recognize and assist students in completing their research projects successfully. Contributions from personal and corporate sponsors help sustain this valuable fund, encouraging commitment to advancing knowledge in energy geology.
Petrology Geochemistry & Biogeochemistry Mining Engineering

Gender Justice Organizing Fund Grant

Bread & Roses Community Fund
Private
United States
US $10,000
The Gender Justice Organizing Fund Grant supports initiatives led by women, girls, trans, gender nonconforming, and LGBTQI+ individuals to achieve gender justice. Organizations must prioritize community organizing and demonstrate an understanding of systemic oppression. Grants from the Bread & Roses Community Fund are crucial for groups that lack traditional funding due to their commitment to amplifying marginalized voices. The fund emphasizes long-term strategies that foster sustainable social change in the Philadelphia area.
Women's Rights & Equality Sexuality & LGBTQIA+ Rights

NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Independent Clinical Trial Not Allowed) (355088)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Up to US $225,000
The NINDS Faculty Development Award aims to enhance diversity in neuroscience research by supporting junior faculty from underrepresented backgrounds. This award provides essential research cost support, protected research time, and mentorship for individuals holding doctoral degrees within their first three years on a faculty tenure track. It specifically encourages research proposals that do not involve independent clinical trials, while allowing participation in trials led by mentors. Key application deadlines span from October 2024 to June 2027.
Neuroscience Diversity, Equity & Inclusion Medical Education & Professional Training

Large Grants for Nonprofit Organizations in California Highlights

Looking for large grants for nonprofit organizations in California?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in California recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in California

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

400+ Large Grants for Nonprofit Organizations in California grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

200+ Large Grants for Nonprofit Organizations in California over $25K in average grant size

200+ Large Grants for Nonprofit Organizations in California over $50K in average grant size

38 Large Grants for Nonprofit Organizations in California supporting general operating expenses

300+ Large Grants for Nonprofit Organizations in California supporting programs / projects

400+ Grants on Instrumentl focused on Disaster Relief / Humanitarian Aid

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in California?

Most grants are due in the first quarter.

Q1
28.5%
Q2
25.8%
Q3
23.3%
Q4
22.4%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in California?

Grants are most commonly $100,000.

$0 $0 Min.
$100,000 $100 K Median
$2,149,932 $2.1 M Average
$150,000,000 $150 M Max.

Average Grant Size

What's the typical amount funded for California?

Grants are most commonly $145,539.

$145,539

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in California year over year?

In 2024, funders in California awarded a total of 256,564 grants.

2022 237,186

2023 236,635

2024 256,564

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in California given out in California, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in California changing over time?

Funding has increased by -1.38%.

2022 $34,364,756,699

2023 $37,770,770,141
9.91%

2024 $37,247,795,891
-1.38%

California Counties That Receive the Most Funding

How does grant funding vary by county?

Los Angeles County, San Francisco County, and San Mateo County receive the most funding.

County Total Grant Funding in 2024
Los Angeles County $10,841,756,858
San Francisco County $5,409,542,294
San Mateo County $5,358,878,304
Santa Clara County $3,811,026,208
Alameda County $3,749,322,182

Related Grants in California

Browse Other Nonprofit Operations & Capacity Grants in California

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