Best Large Grants for Nonprofit Organizations in California

The NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) support small businesses in conducting clinical trials for NIH-funded projects. This initiative encourages partnerships with investors to assist in the commercialization of innovations in neurological disorders. Applicants must submit a comprehensive Commercialization Plan detailing anticipated funding. The program aims to promote effective transitions from research to market, enhancing the development of drugs, devices, and therapies for neurological conditions.

The McConnell Fund, established in 2001 by the Community Foundation of the North State, aims to enhance communities in Shasta, Siskiyou, Tehama, Trinity, and Modoc counties through grants up to $50,000. It focuses on funding projects in areas such as arts, recreation, and social services, while prioritizing nonprofits and public entities. Eligible applicants can seek financial support for equipment and building-related initiatives, reinforcing the foundation's commitment to community development and philanthropy.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

Native Forward awards are allocated based on the financial aid information provided by the institution’s Financial Aid Office. Awards can vary, ranging from $100 to $30,000 per academic year.

Native Forward Scholars Fund members of federally and state-recognized Tribes as well as first and second-generation descendants. However, Native Forward Scholars Fund scholarship opportunities have different Tribal eligibility requirements and can be determined by submitting a Tribal Eligibility Certificate.

Hillman Barnett Adkins Endowed Fund Scholarship

The Hillman Barnett Adkins Endowed Fund is provided in honor of members of the Hillman, Barnett, and Adkins families. The purpose of the Hillman Barnett Adkins Endowed Fund is to provide financial assistance to eligible American Indian and Alaska Native vocational, undergraduate, and graduate students enrolled at an accredited not-for-profit college/university, vocational school, or Tribally controlled college or university (TCU) and pursuing degrees with a focus in Fine Arts (studio arts), Performing Arts (music, drama, musical theater, dance), Creative Writing, Art History, Visual Communication, Photography, Culinary Arts, Film (Cinematography, Screenwriting), or Fashion Design & Jewelry Design.

This opportunity is a merit-based award.

The Kimball Foundation Grant Program supports college access, workplace training, cultural enrichment, and environmental education for low-income residents in the San Francisco Bay Area. By providing pathways to higher education, vocational training, and arts education, the foundation empowers youth to overcome barriers and achieve their goals. The foundation emphasizes culturally competent leadership and structured support, ensuring effective mentorship and long-term success for participants. Organizations are encouraged to apply for funding that aligns with these impactful missions.

The Rheum for Kids: Pediatric Skin and Joint Grant, offered by the Arthritis National Research Foundation, is aimed at early-career researchers focused on pediatric joint and skin diseases. This grant provides funding of up to $50,000 for one year to support innovative research projects. It encourages applications from diverse fields to advance the understanding and treatment of rheumatic diseases in children, fostering new insights and potential breakthroughs in pediatric healthcare.

The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) aims to support clinical trials that evaluate interventions for communication disorders. This funding opportunity encourages collaboration between NIDCD Project Scientists and investigators, focusing on trials that require FDA oversight, establish efficacy, or pose risks of harm. By fostering well-designed studies, the NIDCD seeks to advance treatment and prevention strategies in the field of communication disorders.

The Crail-Johnson Foundation focuses on enhancing the well-being of children and families in Los Angeles through grants aimed at Health, Human Services, and Education. It supports non-profit organizations that provide essential services, prioritizing communities such as San Pedro and Watts. The Foundation emphasizes mental health, access to care, and innovative programs for disadvantaged youth. Grants are typically one-year, with a focus on systemic change and proven approaches to community health and education.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) supports innovative, hypothesis-driven clinical studies with a focus on diseases relevant to NIDDK. This initiative facilitates early peer review and assessment of study designs while providing essential support for operational documents. Applicants are encouraged to consult with NIDDK staff before submission to enhance the chances of success.

The Elizabeth M. Pfriem Foundation, established in 2015 in Rye Brook, New York, is committed to enhancing the human condition through grants to 501(c)(3) public charities. Focusing primarily on the greater Bridgeport, Connecticut area, it supports initiatives in education, healthcare, food security, and housing. The foundation prioritizes organizations demonstrating fiscal responsibility and innovative programs with significant impact potential, ensuring sustainable support for vulnerable populations, especially children and families in need.

The National Institutes of Health (NIH) is inviting applications for the Multidisciplinary Research to Accelerate Hepatitis B Cure in Persons Living with HIV and HBV (MRA-HBV) program. This initiative aims to enhance understanding of hepatitis B persistence and pathogenesis, identify biomarkers, validate drug targets, and create non-invasive diagnostics. It supports observational cohorts paired with multidisciplinary teams utilizing existing clinical data, contributing to innovative research in hepatitis B cure strategies.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Required) invites applications for high-risk clinical trials that involve multiple centers and aim to change clinical practice or public health. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline, with various deadlines set from February 2025 to October 2026. Planning activities must be completed before submission, and consultation with NIDDK staff is advised.

The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.

The Kars4Kids Small Grant Program aims to support educational initiatives globally, impacting the lives of children. This program welcomes applications from IRS-recognized nonprofit organizations focused on youth development, mentorship, and education. Grants typically range from $500 to $2,000, depending on mission alignment and available funds. Kars4Kids, a national Jewish nonprofit, is dedicated to nurturing productive community members through educational and mentoring opportunities.

The Robert and Doreen Marshall Fund for Dramatic Arts and Classical Music, managed by the Orange County Community Foundation, supports dramatic arts and classical music programs in Orange County. This competitive grant program prioritizes funding for opera, choral, and symphonic performances, as well as dramatic arts performance groups and arts education for youth. It reflects the Marshall's enduring commitment to enhancing the cultural landscape through the performing arts.

The Quality of Life Grants Program, established by the Dana Reeve Foundation, aims to enhance the lives of individuals with disabilities and their families by funding nonprofit organizations. Priority Impact Grants - Tier 2 provide support for critical issues affecting those with paralysis, with grants ranging from $25,000 to $30,000. These grants focus on improving access, independence, and community engagement through innovative programs, including assistive technology, disaster preparedness, and respite services.

The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.

Just One More Grant aims to transform lives by providing financial support to individuals and nonprofit organizations in the U.S. who are overcoming challenges like mental health issues, drug misuse, and educational barriers. The foundation encourages applications from those committed to personal growth and community support. Though current grants are paused for nonprofits, interested individuals with actionable plans are invited to apply. More information and past winners can be found on their website.

The Samuel H. French and Katherine Weaver French Fund provides grants focused on the welfare and education of the elderly, sight-impaired, and young in the San Diego region. Established by a couple committed to community support, the fund prioritizes programs that directly benefit these populations. Eligible organizations must be 501(c)(3) exempt and demonstrate project-specific requests rather than general operating support. The fund aims to enhance educational and health services, contributing to the well-being of vulnerable community members.

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Solar Moonshot Program Grant

The Solar Moonshot Program is helping nonprofit organizations across the United States afford the switch to clean energy.

Grants up to $25,000 are typically awarded, with grant amounts dependent on various factors, including the organization’s need for funding. 

In addition to grants given through the program, we also offer short-term, low-interest recoverable grants to help cover the project costs offset by the Investment Tax Credit.

Grants for 2026 are made possible by the BQuest Foundation and two anonymous donors, and the program is managed by Hammond Climate Solutions Foundation. Learn more about the program's status and participants below! 

The Pasadena Community Foundation's Arts & Culture Grants support local nonprofits that enrich the community through arts and culture. Established in 2023, this program focuses on ongoing needs and responses to the Eaton Fire, emphasizing innovation, technology, audience engagement, and collaboration. Eligible organizations must be located within the Pasadena Unified School District and have a record of effective service. Applications are prioritized based on their potential to foster community impact and inclusivity.

The Community Fund for Carmel Valley (CFCV) provides grants to nonprofit organizations that support the communities of Carmel Valley, Cachagua, and Jamesburg. It aims to enhance community resources, focusing on community development, youth and senior programming, and educational initiatives. Eligible applicants include 501(c)(3) organizations, public programs, and those with fiscal sponsors. Special consideration is given to local organizations addressing basic needs and emergency responses, ensuring sustainable community benefits.

The Thomas C. Ackerman Foundation Grant supports K-12 educational programs in San Diego, focusing on mathematics, sciences, arts, and music. Established in 1991, it aims to assist local non-profits in becoming self-sustaining. Organizations eligible for funding must have operated for over a year without prior funding from the Foundation in the last 24 months. The Foundation seeks to address funding challenges faced by local groups while fostering economic development in the community.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

The 2026 Vilcek Prizes for Creative Promise in Biomedical Science will award three $50,000 prizes to exceptional young immigrant scientists in the U.S. This prestigious prize recognizes innovative research contributions in biomedical science. Eligible candidates must be under 38 years old, hold a doctoral degree, and have made significant achievements in their field. The Vilcek Foundation aims to highlight the impact of immigrant scientists on the advancement of biomedical research, fostering diversity and excellence.

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The San Marcos Community Foundation offers Regular Grants ranging from $1,500 to $10,000 to nonprofit organizations benefiting the residents of San Marcos. Established in 1987, the Foundation aims to enhance community quality of life through diverse programs in arts, health, education, and more. Eligible organizations must meet specific requirements, including tax-exempt status. The Foundation prioritizes applications with matching funds at its discretion, fostering a collaborative approach to community enrichment.