Upcoming Webinar
How Funders Feel About AI, and What Keeps Them Saying Yes.
Wed, Oct 14 @ 2PM ET

Skip to main content
Main content

Best Operating Grants for Nonprofits in California

Find the perfect Operating grants for nonprofits in California on Instrumentl. 11,000+ Operating grants for nonprofits in California in the United States.

11,000+

Available grants

$3.61B

Total funding

$5K

Median grant

11,000+ grants
$3.61B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

10,803 Results based on applied filters

PEO, Chapter BE Scholarship

Erie County Community Foundation
Private
United States
Unspecified amount
The PEO, Chapter BE Scholarship, offered by the Erie County Community Foundation, supports female graduates of Erie County high schools pursuing undergraduate or graduate degrees. Since 1995, the foundation has focused on enhancing community needs and leadership, aiming for a lasting impact in Erie County, Ohio. This renewable scholarship is awarded at the discretion of the Scholarship Advisory Committee, ensuring continued support for students dedicated to their academic pursuits.
Education - Higher Education Education - High School Academic Scholarship Programs

Applied regulatory science research to evaluate and treat cardiotoxicity of oncology therapeutics

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
Unspecified amount
This grant aims to enhance applied regulatory science research for the evaluation and treatment of cardiotoxicity associated with oncology therapeutics. The initiative will facilitate collaboration with the FDA to develop effective methodologies and solutions, ensuring that research outcomes are directly relevant to regulatory decision-making. Key activities include regular communication with funded investigators and a focus on improving detection and management of cardiotoxicity, ultimately leading to impactful publications and presentations.
Cancer / Oncology Drug Safety

JPF Principal Grant Program RFP

Jacques Pepin Foundation
Private
United States
Up to US $10,000
The Jacques Pepin Foundation (JPF) is dedicated to advancing culinary arts education by supporting community kitchens that provide culinary training to individuals facing employment barriers. Grants of up to $10,000 are available for nonprofits to enhance their culinary programs, including operating costs and facility improvements. Eligibility extends to organizations funded in prior cycles, those that applied but were not funded, and newcomers to JPF funding. This initiative aims to empower underserved communities through culinary skills.
Workforce Preparation & Job Readiness Culinary Arts

Roesler, Max and Elizabeth Memorial Scholarship Fund

Noble County Community Foundation
Private
United States
US $1,500
The Roesler, Max and Elizabeth Memorial Scholarship Fund supports non-traditional students aged 25 and older in Noble County, Indiana, pursuing higher education or retraining. This fund awards $1,500 to applicants enrolled in any accredited college, university, or trade school. Applicants may be full-time or part-time students and may reapply. The scholarship reflects the commitment of generous donors to invest in local students' educational goals.
Vocational & Trade Education Career / College Preparation Academic Scholarship Programs

SER Northwest Chapter: Student Research Grants

Society for Ecological Restoration
Association/Society
Alameda County, California, Alaska +51 more
Up to US $3,000
The Society for Ecological Restoration Northwest Chapter offers Student Research Grants up to $3,000 to support research that enhances ecosystem restoration in the Cascadia bioregion. Eligible applicants include social or natural science graduate students and upper-level undergraduates. The grant can cover various project expenses, fostering innovative approaches to restore natural systems while promoting the diversity of life in the region.
Habitat & Ecosystem Restoration

Igor Gorin Memorial Award

Community Foundation for Southern Arizona
Private
United States
Up to US $12,000
The Igor Gorin Memorial Award, established in 1993 by the Community Foundation for Southern Arizona, honors the legacy of Igor Gorin by supporting aspiring vocalists. With $382,000 awarded to 49 young talents, this fund provides unrestricted financial assistance for coaching, travel, and auditions. The 2026 award offers up to $12,000, aimed at those overcoming financial barriers to pursue operatic careers, ensuring that exceptional vocalists can thrive in their artistic journeys.
Opera

The Walt Secord “Always Sunny and 75” Memorial Trade Scholarship

Midlands Community Foundation
Private
United States
US $1,000

About Us

Midlands Community Foundation (MCF) is here to serve and add value to donors’ philanthropic needs by providing them an opportunity to “invest in the power of community.” It is our goal to identify current and emerging issues, channel resources to address community needs, and help prepare for the future.

MCF Mission

The mission of Midlands Community Foundation is to be a catalyst for lasting impact in Sarpy and Cass counties and to give opportunities to organizations and individuals to pursue their charitable goals.

Scholarships Through MCF

Midlands Community Foundation is committed to the futures of communities in Sarpy and Cass Counties, and across the country. Supporting higher education of students is a direct investment in the futures of these communities.

The Walt Secord “Always Sunny and 75” Memorial Trade Scholarship Application

The Fund shall annually distribute two (2) scholarships in the amount of $1,000 each.

Vocational & Trade Education Apprenticeship & Internship Programs Educational Access & Equity

Community Collaboration Challenge

National Partnership for Student Success
Association/Society
United States
US $5,000 - US $10,000

Community Collaboration Challenge

Applications for the 2026 Community Collaboration Challenge are now open! With support from the Leon Lowenstein Foundation, the Challenge provides $5,000 – $10,000 awards to communities and is designed to support collaboration that expands and pilots evidence-based K-12 student supports in the form of high-impact tutoring, mentoring, student success coaching, postsecondary transition coaching, and/or wraparound/integrated student supports.

Tutoring & Mentoring College Success / Persistence

Two Joes Scholarship

Cattaraugus Region Community Foundation
Private
United States
Unspecified amount

Two Joes Scholarship

This fund, named for two local community-minded businessmen, Joe DeRose and Joe Sgro, will support a scholarship for students in Cattaraugus County interested in pursuing technology-, marketing and communications- or business-related degrees.

Education - Higher Education Career / College Preparation Business Education

Collaborative Centers in Children’s Environmental Health Research and Translation (P2C Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $750,000
The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.
Epidemiology & Public Health Environmental Health Children’s Health & Pediatrics

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed) (360946)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Cancer Institute (NCI) invites applications for the validation of biomarkers and assays for cancer detection and treatment. This funding opportunity allows for biphasic or monophasic applications to support both analytical and clinical validation phases. Successful projects will leverage human specimens to develop assays that enhance cancer treatment and prevention, ensuring multidisciplinary collaboration among scientists and clinicians. This initiative aims to improve cancer management through reliable and clinically validated tools.
Cancer / Oncology Biomedical Imaging

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (356879)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.
Human Genome & Genetics Rare Diseases

Arthritis Foundation: Clinical Fellowship RFP

Arthritis Foundation
Private
United States
Up to US $300,000
The Arthritis Foundation's Clinical Fellowship RFP aims to address the rheumatology workforce shortage by inviting applications from institutions with clinical training programs. It encourages innovative training approaches to prepare future rheumatologists for the evolving needs of the arthritis community. Funding includes $150,000 for a two-year adult fellowship, $225,000 for a three-year pediatric fellowship, and $300,000 for a four-year Med-Peds fellowship, all designed to enhance access to specialized care.
Arthritis

William L. & Mary Ann Brown STEM Endowment Scholarship Program

United Negro College Fund Inc
Private
United States
Unspecified amount

William L. & Mary Ann Brown STEM Endowment Scholarship Program

The William L. & Mary Ann Brown STEM Endowed Scholarship Program was established by William L. and Mary Ann Brown to provide need-based scholarship support to seniors graduating from a high school in Mecklenburg County, North Carolina, enrolled at a UNCF member institution, four-year HBCUs, and four-year institutions.

Successful applicants must be graduating high school seniors entering their first year of college, pursuing a STEM degree, including, but not limited to, fields in physical sciences, mathematics, the biological sciences, the chemical sciences, computer sciences, and engineering. Applicants must be enrolled or planning to enroll as a full-time student.

Education - Higher Education Career / College Preparation STEM / STEAM Education

Trans Justice Funding Project Grants

Trans Justice Funding Project
Association/Society
American Samoa, Guam +4 more
Unspecified amount
The Trans Justice Funding Project (TJFP) provides grants to grassroots trans-led organizations in the U.S. and territories, focusing on those with budgets under $250,000. TJFP supports initiatives that address varying needs within trans communities, including health, legal aid, and mutual aid projects. The organization prioritizes groups led by trans people of color and emphasizes the importance of centering marginalized voices in the fight for trans justice.
Intersex & Transgender Rights

Ginger D. Schroder Cattaraugus County Legislative District 2 Scholarship

Cattaraugus Region Community Foundation
Private
United States
Approximately US $500

Ginger D. Schroder Cattaraugus County Legislative District 2 Scholarship

The Ginger D. Schroder Legislative District 2 Scholarship is given to a graduating high school student residing in Cattaraugus County Legislative District 2 who will pursue a trade degree or 2-or 4-year college degree.

Education - Higher Education Vocational & Trade Education Career / College Preparation

REI Cooperative Action Fund Grant

Rei Cooperative Action Fund
Private
United States
Unspecified amount
The REI Cooperative Action Fund Grant supports U.S.-based organizations that align with its mission to serve communities, particularly those connecting historically excluded individuals to the outdoors. The fund prioritizes initiatives that promote equitable access to outdoor spaces, enhance community health through nature, and create inclusive outdoor experiences. Eligible applicants must have a 501(c)(3) status and demonstrate a commitment to these values. However, individuals and certain organizations are not eligible for funding.
Outdoor Equity Outdoor Recreation Healthy Habits & Behaviors +1 more

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) (356883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.
Medical Technology, Devices, and Equipment Health & Medicine Biotechnology +1 more

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) (356888)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.
Biomedical informatics Epidemiology & Public Health Health Information Technology

AMD Resident Research Grant

Association of Migraine Disorders (AMD)
Association/Society
United States
Up to US $12,000
The AMD Resident Research Grant aims to foster innovative research projects related to migraine, encouraging residents to explore diverse topics that are scientifically sound. Applicants, who must be enrolled in accredited training programs, can collaborate with preceptor investigators and receive support from their institutions. The grant is open to all residents without country restrictions, promoting advancements in migraine understanding and treatment.
Neurological Diseases & Disorders Neuroscience

Ashby C. and John T. Pinkard Scholarship Fund

Community Foundation Serving Western Virginia
Private
United States
Approximately US $2,500

Who We Are

Community foundations began nationally in 1914 and are publicly-supported, 501(c)(3) philanthropic organizations that hold, administer, invest and make grants from both endowed and non-endowed funds established by individuals, families and others. They were designed to be simple, flexible, convenient, tax-wise, cost-effective and perpetual charitable vehicles.  

Our Community Foundation was established in Roanoke in 1988. With our growth, we expanded into the Martinsville/Henry County area in 2005. Today, we administer many hundreds of named endowment funds ranging in size from a minimum of $10,000 to millions of dollars. To date, donors have also committed very significant resources to the Foundation through future estate gifts.

Information for Scholarship Seekers

Community Foundation Serving Western Virginia, the region’s community foundation, administers a variety of scholarships to reward and assist capable and deserving students based on the criteria established by the fund donors.

Specifics of the Foundation’s scholarship program may be subject to change from time to time. If you have any questions or need additional information, please contact the Foundation at (276) 656-6223.

Ashby C. and John T. Pinkard Scholarship Fund

 Fund provides higher education scholarships to deserving young men and women.

Education - Higher Education Adult Education Academic Scholarship Programs +1 more

Avel Louise Gordly Scholarship for Oregon Black Women

Oregon Community Foundation
Private
United States
Unspecified amount
The Avel Louise Gordly Scholarship supports Black women graduates of Oregon high schools who wish to pursue post-secondary education in Oregon or at Historically Black Colleges and Universities. Award amounts vary, with the possibility of renewal for up to four years. Eligible applicants must be Oregon residents, identify as Black and female, and enroll at least half-time in a public or nonprofit private college or university in the United States.
Career / College Preparation Black American Services

St. Baldrick’s Foundation Fellowship Award

St Baldricks Foundation Inc
Private
United States
Up to US $195,000
The St. Baldrick’s Foundation Fellowship Award supports pediatric oncology training through a two-year fellowship, with a potential third year based on need and achievements. This initiative, powered by community fundraising events, aims to advance research for childhood cancer cures. The award provides a salary capped at $97,500 per year, covering salary and benefits for fellows. This fellowship not only fosters professional growth but also contributes significantly to the fight against childhood cancers.
Pediatric Cancers

St. Baldrick’s Foundation Research Grant Award

St Baldricks Foundation Inc
Private
United States
Up to US $200,000
The St. Baldrick’s Foundation Research Grant Award supports innovative research aimed at curing childhood cancers. With funding of $100,000 per year for two years, this grant is designed for hypothesis-driven projects that can be laboratory, clinical, or epidemiological in nature. Established through community-driven fundraising events, the foundation empowers volunteers and donors to make a significant impact in the fight against cancer, ensuring a brighter future for young survivors.
Pediatric Cancers

Bret A. Rosenthal Patient Assistance Fund

Mesothelioma Applied Research Foundation Inc
Private
United States
Up to US $2,000

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

  • funding research to improve treatment options;
  • providing treatment support and education for patients and their families;
  • and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Bret A. Rosenthal Patient Assistance Fund

Patients diagnosed with cancer at a younger age often face greater financial burdens. This is a time in a patient’s life when they are raising a family, starting a career, or have not accumulated savings. For patients 49 and under, the Foundation administers the Bret A. Rosenthal Patient Assistance Fund grant program. This program is made possible by the generosity of the Rosenthal family.

Cancer / Oncology Patient Care & Services

Brothers Helping Brothers: Backing Safety Initiative Grants

Brothers Helping Brothers
Private
United States
Unspecified amount in in-kind support
The Brothers Helping Brothers initiative aims to provide essential equipment to small fire departments and EMS organizations in the U.S. Established in 2014, the program offers grants to eligible agencies serving communities with populations under 10,000. With a focus on tools like wireless backup cameras, the organization strives to enhance safety and operational efficiency for first responders. Through community support, they have raised significant funds to assist in this critical mission.
Firefighting & Fire Prevention Emergency Medical Care & Services

Orthopedic Physical Therapy Research Grant

Foundation for Physical Therapy Research
Private
United States
US $40,000
The Orthopaedic Physical Therapy Research Grant, funded by the Foundation for Physical Therapy Research, aims to support innovative research that optimizes movement and enhances societal health. With a commitment to addressing health disparities, the foundation will award $40,000 for one or two years to promising researchers. This initiative not only strengthens the physical therapy profession but also contributes to the growing evidence base that underscores the value of physical therapy in various healthcare settings.
Physical Therapy Musculoskeletal Diseases

Operating Grants for Nonprofits in California Highlights

Looking for operating grants for nonprofits in California?


Read more about each grant below or start your 14-day free trial to see all operating grants for nonprofits in California recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Operating Grants for Nonprofits in California

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

400+ Operating grants for nonprofits in California grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

200+ Operating grants for nonprofits in California over $25K in average grant size

200+ Operating grants for nonprofits in California over $50K in average grant size

38 Operating grants for nonprofits in California supporting general operating expenses

300+ Operating grants for nonprofits in California supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Health & Medicine

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits in California?

Most grants are due in the first quarter.

Q1
28.5%
Q2
25.8%
Q3
23.3%
Q4
22.4%

Typical Funding Amounts

What's the typical grant amount funded for Operating Grants for Nonprofits in California?

Grants are most commonly $100,000.

$0 $0 Min.
$100,000 $100 K Median
$2,149,932 $2.1 M Average
$150,000,000 $150 M Max.

Average Grant Size

What's the typical amount funded for California?

Grants are most commonly $145,539.

$145,539

Total Number of Grants

What's the total number of grants in Operating Grants for Nonprofits in California year over year?

In 2024, funders in California awarded a total of 256,564 grants.

2022 237,186

2023 236,635

2024 256,564

Top Grant Focus Areas

Among all the Operating Grants for Nonprofits in California given out in California, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Operating Grants for Nonprofits in California changing over time?

Funding has increased by -1.38%.

2022 $34,364,756,699

2023 $37,770,770,141
9.91%

2024 $37,247,795,891
-1.38%

California Counties That Receive the Most Funding

How does grant funding vary by county?

Los Angeles County, San Francisco County, and San Mateo County receive the most funding.

County Total Grant Funding in 2024
Los Angeles County $10,841,756,858
San Francisco County $5,409,542,294
San Mateo County $5,358,878,304
Santa Clara County $3,811,026,208
Alameda County $3,749,322,182

Related Grants in California

Browse Other Nonprofit Operations & Capacity Grants in California

Browse Grants For Nearby Locations

Browse Grants by Major US Cities within California