Best Large Grants for Nonprofit Organizations in Florida

The Project Cure CRC Early-Career Investigator Award, offered by the Colorectal Cancer Alliance, seeks to attract innovative early-career faculty to colorectal cancer research. This award supports groundbreaking research aimed at enhancing our understanding and treatment of colorectal cancer. With no application deadlines, submissions are reviewed on a rolling basis, allowing awardees to receive funding for their original preclinical, translational, or early clinical research projects, fostering the next generation of CRC research leaders.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites proposals for Specialized Alcohol Research Centers (P50) to enhance interdisciplinary research on alcohol misuse and Alcohol Use Disorder (AUD). These centers aim to foster collaboration among researchers, focusing on innovative topics related to alcohol's effects on health across the lifespan. The program supports the development of research methodologies and mentorship for young investigators, addressing the complex challenges posed by alcohol misuse in society.

The Colon Cancer Coalition offers the Get Your Rear in Gear Grants to support local programs aimed at improving colon cancer screening and awareness. Open year-round, applications are reviewed biannually in February and August. Grants fund initiatives that educate the public about colon cancer and alleviate the financial burden on patients. By applying, organizations commit to promoting local events that raise funds for these important community programs.

Community Foundation of the Fox River Valley

The Community Foundation of the Fox River Valley is a collection of individual funds and resources given by local citizens to enhance and support the quality of life in the Fox River Valley of Illinois.

We are a tax-exempt public charity that allows individuals, businesses, and non-profit organizations to establish permanent endowments and temporary funds within the confines of one large foundation.

Foundation funds are used to provide grants to non-profit organizations and scholarships to area students. The Foundation also hosts a Youth Engagement in Philanthropy (YEP) program, which helps high school students learn more about philanthropy and empowers them to make a difference in the community.

The Community Foundation of the Fox River Valley serves the City of Aurora, Kane County, and Kendall County within the State of Illinois.

Irene & Marie Oberweis Nursing Scholarship Endowment Fund

This scholarship was created by Marie Oberweis as a loving tribute to her sister Irene.

Marie Oberweis (1921-2007) graduated from Madonna High School in 1939.

That year, she started her career with Oberweis Dairy where she later became a partner with her father Peter Oberweis and her brother Joseph Oberweis.

Irene Oberweis (1924-1996) attended Annunciation School in Aurora. She spent many years of her life in hospitals due to fragile health.

In gratitude for the exemplary care her sister received throughout her lifetime from those in the nursing profession, Marie Oberweis created a permanent scholarship fund to support area students entering the nursing field.

The Tribal Transportation Safety Strategy Pilot Program, funded by the Office of the Assistant Secretary for Research and Technology, aims to address high traffic fatality rates among American Indian and Alaska Native populations. With a $2 million budget over three years, the program will create a university-led consortium to develop a strategic safety plan using artificial intelligence for risk analysis, culminating in a pilot project that showcases effective safety infrastructure in a Tribal community.

The Helen M. Heitmann Young Scholar Award, presented by SHAPE America, honors young professionals who have made significant contributions to research in curriculum and instruction within health and physical education. Eligible candidates must be current SHAPE America members and have 3 to 6 years of experience post-doctorate. This award emphasizes active involvement and scholarship in the field, encouraging innovative research that enhances educational practices for preK-12 students.

The Presenter Consortium for Jazz Grant, offered by Chamber Music America, supports U.S.-based presenters collaborating to engage professional jazz ensembles. This grant provides up to $39,000 for expenses like ensemble fees, concert production, and marketing. Each consortium can include up to three presenters and aims to enhance the jazz experience through live performances and streamed concerts. Eligible projects must involve CMA’s New Jazz Works grantees, fostering creativity and community engagement in jazz.

The Estelle Massey Osborne Scholarship supports exceptional African American nurses pursuing master's degrees. Applicants must have at least two semesters remaining in their program, maintain a minimum GPA of 3.6, and hold a current RN license. This scholarship, provided by Nurses Educational Funds Inc., honors Estelle Massey Osborne, the first African American nurse to earn a master's degree in the U.S. It aims to promote nursing leadership through financial assistance for advanced education.

The ORACLE 3C initiative focuses on advancing research into chronic conditions, coinfections, and comorbidities related to HIV. It aims to support early-career investigators through innovative approaches that diverge from existing methodologies. Emphasizing pediatric and maternal health, this funding opportunity encourages interdisciplinary research to better understand HIV-specific pathways and develop effective preventive and therapeutic strategies, addressing a significant public health concern.

The Pediatric Visiting Professorship, funded by the Rheumatology Research Foundation, aims to recognize exceptional scientific abstracts from pediatric rheumatology fellows at ACR Convergence. This award facilitates knowledge sharing and promotes advancements in rheumatic disease care. The professorship spans two to three days and includes diverse teaching formats. Selected fellows receive a $1,000 honorarium for virtual visits or $1,500 for in-person engagements, along with reimbursement for travel expenses, enhancing the future of pediatric rheumatology education.

Request for Proposals

Community Care Corps encourages organizations across the country to apply for 18-month grants ($30,000–$200,000) to develop and scale innovative volunteer programs that provide nonmedical assistance to older adults, adults age 18 and older with disabilities and family caregivers.

Projects funded through this initiative will increase the number of community-based volunteer programs available to provide nonmedical assistance while decreasing the number of older adults, adults with disabilities, and family caregivers who need assistance in maintaining independence in the community but are unable to obtain help. In doing so, the initiative will strengthen community-based supports that help people maintain independence, reduce unmet needs, and improve overall well-being.

The Mastercard Strive USA 2025 Innovation Fund aims to enhance the financial health of small businesses across the U.S. by providing up to $250,000 in grants to organizations developing innovative solutions. This initiative focuses on addressing challenges such as limited access to financial resources and vulnerability to economic shocks, ultimately fostering resilience and growth within the small business sector.

The National Institute of Allergy and Infectious Diseases (NIAID) is launching a funding opportunity for Clinical Trials Units (CTUs) as part of its effort to combat HIV/AIDS. This initiative aims to support innovative clinical trials and implementation research to improve prevention and treatment strategies. With a focus on both domestic and international research sites, CTUs will play a crucial role in addressing the HIV epidemic and enhancing participant recruitment and retention. This funding opportunity is authorized under the Public Health Service Act.

Jack Kent Cooke Foundation

The Jack Kent Cooke Foundation is dedicated to advancing the education of exceptionally promising students who have financial need. Since 2000, the Foundation has awarded $304 million in scholarships to more than 3,400 students from 8th grade through graduate school, along with comprehensive academic advising, career pathway counseling and other support services. The Foundation has also provided $136 million in grants to organizations that serve such students.

The Jack Kent Cooke Foundation’s scholarship programs are designed to encourage and support outstanding students who work hard and have financial need. Our scholarships provide financial assistance and academic support to high school, undergraduate, and graduate students. In addition to the monetary award, students join a thriving network of more than 3,400 Cooke Scholars.

Young Scholars Program

The Cooke Young Scholars Program is a selective five-year, pre-college scholarship for exceptionally promising 7th grade students with financial need. It provides comprehensive academic and college advising, as well as financial support for school, Cooke-sponsored summer programs, internships, and other learning enrichment opportunities.

Program Experience

Educational Advisers support Young Scholars to maximize high school experiences and to go on to thrive at the nation’s top-performing colleges. Our programming and support may include:

• Identifying an appropriately rigorous high school.
• Engaging in four-year planning and goal-setting.
• Funding for academic and extracurricular opportunities, such as music and art lessons, supplemental academic classes and technology.
• Annual summer programs, including two required Young Scholar programs.
• Year-round Young Scholars community programming.
• Networking opportunities with a high-achieving peer community.

The Kids in Motion Grant Program by The Mardy Fish Children’s Foundation aims to empower underserved children in Indian River County, Florida, through health, fitness, nutrition, and enrichment initiatives. This initiative encourages schools and community organizations to enhance their programs by promoting lifelong healthy habits and offering safe environments for children to thrive. The Foundation supports over 2,400 children, fostering positive youth development through active participation in various activities including tennis, dance, and sports.

The RFP for the Rural Rental Housing Preservation Academy offers no-cost training sessions aimed at empowering rural housing providers to acquire and preserve affordable housing financed by USDA, HUD, and LIHTC. Participants will engage in peer learning, receive targeted technical assistance, and access expert guidance tailored to their needs. This initiative seeks to enhance the preservation of affordable housing opportunities, particularly those with rental assistance, in rural communities across the region.

The F26AS00051 FY 2026 Competitive State Wildlife Grant (C-SWG) Program offers federal cost-sharing awards aimed at enhancing conservation efforts for wildlife and their habitats. By prioritizing projects that align with State and Territory Wildlife Action Plans, this program encourages proactive approaches to conservation, helping agencies avoid stringent federal regulations related to endangered species. This announcement details application procedures, award tiers, partnership requirements, and funding limits, promoting collaborative conservation initiatives across jurisdictions.

Our Story

Established over 50 years ago, our founders redefined local philanthropy, fostering connections around a shared sense of place and purpose. As Virginia's largest community foundation, we bring people together to pool resources, co-create solutions and align actions for impactful change in the Richmond region.

Scholarships are offered to students living in the Richmond region and other Virginia locations. Each scholarship was established by a generous individual, family, or organization with a desire to assist high school students, recent high school graduates, and adult learners to continue their education. 

John E. Thomasson Scholarship

The John E. Thomasson Scholarship Fund was established in 2001 to support postsecondary educational opportunities for youth of African American or other minority heritage in the Louisa County (Virginia) Public Schools or Fluvanna County (Virginia) Public Schools. Scholarships will be awarded on a competitive basis to students who have been admitted to an accredited two-year technical school, four-year Historically Black College or University or the school of their choice. Preference will be given to applicants planning to attend Virginia State University, Hampton University, Virginia Union University, or Norfolk State University.

Estimated Award Amount

• (2) $1,000 

The NHLBI SBIR Phase IIB Bridge Awards aim to accelerate the commercialization of innovative technologies targeting heart, lung, blood, and sleep disorders. This funding supports small businesses in later-stage research and development, bridging the gap between SBIR Phase II awards and commercialization. Projects must align with NHLBI's mission and demonstrate potential for clinical relevance, emphasizing partnerships with investors to secure necessary funding for regulatory approval.

The NHLBI SBIR Phase IIB Small Market Awards aim to bridge the funding gap for small businesses developing technologies for heart, lung, blood, and sleep disorders. This initiative supports later-stage research and development for projects addressing rare diseases or pediatric populations. By promoting partnerships with investors and advocacy organizations, the program seeks to facilitate regulatory approval and commercialization of innovative biomedical solutions, ultimately enhancing public health outcomes.

The American Heart Association is inviting proposals for research on the effects of GLP-1 and GIP agonists in individuals with cardiovascular, kidney, and metabolic diseases. This initiative aims to explore how these medications can alleviate the CKM burden. Researchers with expertise in causal inference, machine learning, and cardiovascular research are encouraged to apply, particularly those working in multidisciplinary teams and leveraging various data sources.

The Milton & Phyllis Berg Family Respite Care Grants, offered by the Alzheimer’s Foundation of America, support member organizations in providing respite care scholarships to families affected by Alzheimer's. This initiative enhances the quality of life for both individuals and caregivers by promoting social engagement and offering essential breaks for caregivers. Grants are awarded biannually in memory of Barry E. Berg's parents, who faced Alzheimer's and caregiving challenges.

The HIV Care Grant Program, funded by the US HHS: Health Resources & Services Administration (HRSA), aims to enhance access to high-quality HIV care and treatment for low-income individuals. This initiative supports states and territories in developing comprehensive systems to address the needs of those living with HIV. By providing essential resources, the program seeks to improve health outcomes and ensure that vulnerable populations receive the necessary support and services.

The Special Wildlife Funds - Duck Stamp Grants program in Canada focuses on the development of waterfowl propagation areas specifically for the Mississippi Flyway. It supports projects in Manitoba and Saskatchewan aimed at enhancing breeding populations of migratory waterfowl. This initiative is funded through the sale of State Migratory Waterfowl Stamps and is targeted at not-for-profit organizations dedicated to the conservation and promotion of wild waterfowl, ensuring sustainable habitats and effective management practices.

The Jane Bruckel Early Career Investigator Award in Axial Spondyloarthritis, offered by the Spondylitis Association of America, aims to support MDs and PhDs at the Instructor or Assistant Professor level in the US and Canada. This annual $30,000 research grant promotes innovative research in ankylosing spondylitis and enhances patient care by encouraging emerging researchers to contribute to this important field.

The Elevance Health Foundation's Food as Medicine Grant aims to enhance access to nutritious foods and improve health outcomes for individuals facing diet-related conditions. This initiative invites qualified nonprofits to submit proposals focused on scalable solutions that address food insecurity and promote health equity. The foundation prioritizes programs that demonstrate measurable outcomes and support whole-person health, particularly for populations at high social risk. Grants will be awarded for a term of 1-3 years, with funding based on program needs.

The Miller Indigenous Economic Development Fellowship, established by the Native Forward Scholars Fund, provides financial assistance to American Indian and Alaska Native doctoral candidates engaged in economic research impacting Native communities. This fellowship supports costs associated with data collection, analysis, and travel. It aims to enhance the representation of Native scholars in economics, addressing the current underrepresentation in the field. Eligible candidates are encouraged to apply to further their research and contribute to their communities.