Best Large Grants for Nonprofit Organizations in Kentucky

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Therapeutic Giving program from Johnson & Johnson Innovative Medicine aims to support local and regional organizations focused on improving patient access to treatment and advancing health equity. Eligible applicants include 501(c)(3) nonprofit organizations, with funding preferences for programs that address significant healthcare disparities, mental health initiatives, and innovative solutions with measurable outcomes. The application period for local organizations runs from March 1 to May 31, while national organizations can apply in September.

The Kentucky Conference Mission Grants provide financial support for mission work within the Kentucky Annual Conference and internationally. Grants of up to $2,000 are awarded to churches, institutions, and projects that align with the mission of the United Methodist Church, focusing on outreach in areas such as addiction, food insecurity, and support for refugees. This initiative aims to foster community transformation through various mission efforts across Kentucky.

The Therapeutic Giving: Oncology program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatments and services, promote health equity, and strengthen healthcare workforces. It supports programs that raise disease awareness, empower patients, and improve health systems with measurable outcomes. Eligible applicants include nonprofit organizations with 501(c)(3) status, emphasizing innovative programs addressing healthcare disparities and unmet needs.

The Doyle Undergraduate Fellowship, offered by New Hampshire Sea Grant, provides a unique opportunity for undergraduates to engage in marine resource projects while receiving mentorship and training. This paid fellowship supports students interested in marine-related research and education, with potential earnings of up to $5,000 over a 10-week summer period. By participating, fellows gain valuable insights into coastal and marine management, enhancing their skills and expanding their professional networks.

The Therapeutic Giving initiative by Johnson & Johnson focuses on funding programs in neuroscience aimed at enhancing patient access to treatments and promoting health equity. Nonprofit organizations classified as 501(c)(3) can apply for support from March 1 to May 31. The initiative emphasizes innovative, measurable programs in areas like Alzheimer’s disease and mental health, prioritizing those that address healthcare disparities and improve quality of life for affected individuals.

The U.S. Healthcare Donations program by Amgen aims to support not-for-profit organizations in the healthcare sector. As a leading biotechnology company, Amgen provides funding for initiatives that improve science, technology, education, and public awareness on medical conditions. Organizations eligible for funding must be tax-exempt entities, focusing on genuine philanthropic efforts that align with Amgen's mission to enhance health outcomes and reduce the burden of diseases.

The Entergy Charitable Foundation Grant focuses on supporting initiatives that foster thriving communities through education, poverty solutions, and environmental programs. The foundation prioritizes funding for 501(c)(3) organizations and similar entities. Key areas include education development, innovative poverty solutions, and environmental restoration efforts, such as coastal wetland preservation. Organizations are encouraged to apply at least three months before funding is needed, ensuring timely support for impactful community projects.

The Sundt Foundation, established in 1999, supports local communities by offering grants and volunteer opportunities for 501(c)(3) nonprofit organizations. Focused on youth development, hunger and nutrition, and veteran services, the Foundation prioritizes projects in regions such as the Southwest and Southeast United States. However, they do not fund requests exceeding $25,000 or support multi-year pledges, fundraising events, or political causes. Their mission continues to foster community connections and belonging.

About Us

The Foundation for a Healthy Kentucky (FHKY) is a nonprofit organization funded by an endowment that aims to transform our state so that every Kentuckian has what they need to live a healthy life. Since it opened its doors in 2001, the Foundation has invested millions in health policy advocacy, research, and demonstration projects across the Commonwealth.

Partnerships for Success Grants

Partnerships for Success (PFS) provides funding to enhance and support Kentucky community-based organizations that serve communities with limited opportunities. Applicants should focus on reducing alcohol, nicotine (including vaping), and cannabis use/misuse and related consequences by implementing evidence-based prevention programs, practices, and policies that are trauma and resilience informed, and responsive to local and community context. The Foundation for a Healthy Kentucky (FHKY) is facilitating this funding opportunity as one of its pass-through grant programs. The project is supported by the Kentucky PFS 2023 Grant via the Substance Abuse and Mental Health Services Administration (SAMHSA) Grant H79SP083680.

Grants will provide up to $50,000 in funding for 12 months. 

Goal

To provide funding that enhances and supports evidence-based strategies to prevent alcohol, nicotine (including vaping), and cannabis use/misuse in communities that are at higher risk in Kentucky.

Overview

This funding opportunity allows potential grantees to creatively address localized behavioral health-related issues. Funding is intended to support solutions that address the issues, identified by those who live and work locally, as most relevant to communities that are at higher risk in Kentucky.

Proposed projects should:

• Focus on communities with limited opportunities as the primary focus of a proposed or existing project or program, including leadership and decision-making power.
• Make communities that are at higher risk the primary beneficiaries of the project or program's outcomes.
• Address a substance use challenge identified by the community.
• Plan, develop, implement, and/or sustain a prevention initiative.

The Maine Cancer Foundation is seeking proposals for cancer screening initiatives aimed at early detection and prevention. This RFP focuses on screenings for breast, cervical, colorectal, lung, prostate, and skin cancers. Proposals should align with evidence-based practices endorsed by the CDC and U.S. Preventive Services Task Force. Interested applicants are encouraged to consult with MCF prior to submission to discuss project concepts and receive feedback on draft applications.

TC Energy’s Build Strong program supports vital organizations in communities near its operations. By providing grants, scholarships, and in-kind support, the program aims to enhance safety, education, environmental protection, and community well-being. Eligible applicants include non-profits and community groups addressing local needs. Ineligible activities include operational expenses and for-profit endeavors. The program prioritizes projects demonstrating measurable community impact, fostering a collaborative relationship between TC Energy and local stakeholders.

The Arts in Rural Places Grant, offered by South Arts, aims to enhance access to the arts in rural and isolated communities across nine southern states. Grants of up to $3,000 support public activities featuring Southern artists, requiring a dollar-for-dollar cash match. Eligible organizations must host at least two public events and engage a professional artist, promoting cultural engagement and artistic expression within these communities.

The Ron Goellner Conservation Fund Award, administered by the Cryptobranchid Interest Group, offers grants up to $2,000 for projects focused on the conservation of giant salamanders. This initiative supports innovative research, field conservation, and educational initiatives that aim to protect these species and their habitats. Open to all applicants, the fund prioritizes projects that demonstrate broad conservation impact and partnerships. Applications are automatically considered for two separate grants of up to $1,000 each.

The Kentucky Agricultural Development Fund (KADF) offers the County Agricultural Investment Program (CAIP) to support agricultural producers in enhancing their farm operations. This program provides cost-share assistance up to $5,000 for various agricultural enterprises, including livestock, horticulture, and energy efficiency initiatives. CAIP aims to improve the diversity and sustainability of farming practices across Kentucky, benefiting producers through financial support for innovative agricultural practices.

The Thornton S. Glide, Jr. and Katrina D. Glide Foundation provides grants to qualified 501(c)(3) organizations in California that focus on animal protection, land conservancy, agriculture, and civic endeavors. Established in 1995, the foundation prioritizes grants for specific capital acquisitions and does not support operational costs or direct aid to individuals. Emphasizing local impact, California-based organizations are favored over out-of-state counterparts.

Kentucky Cabinet for Health and Family Services

Our mission is to be a diverse and inclusive organization providing programs, services and supports that protect and promote the health and well-being of all Kentuckians and their communities.

Rural Health Transformation Program Funding Opportunity For Public Health Dental Hygiene Teams in Local Health Departments 

About the Program

This project is 100% funded by the Centers for Medicare and Medicaid Services of the U.S. Department of Health and Human Services (HHS) for a total of $212.9 million in budget year 1 with 100% by CMS/HHS. The RHTF grant spans five budget periods aligned with federal fiscal years (FY2026–FY2030). Funding is disbursed annually by CMS based on achievement of performance metrics.

The Commonwealth of Kentucky has been awarded funding through the Centers for Medicare & Medicaid Services (CMS) Rural Health Transformation Fund (RHTF). This investment will empower Kentucky to launch and implement its Rural Health Transformation Plan (RHTP) — a community-driven strategy to expand access and improve health outcomes for rural residents across the Commonwealth.

Rooted in Health: Rural Dental Access

A key component of Kentucky’s Rooted in Health: Rural Dental Access initiative involves expansion of the PHDH teams that have been serving multiple counties in Kentucky since 2013. Through this grant opportunity, the Kentucky Department for Public Health (DPH) is soliciting applications from qualified organizations to establish new or expand current PHDH teams to expand access to rural dental care. The newly created programs must demonstrate commitment to providing services including:

• Preventive dental hygiene services for children and adults
• Dental hygiene-focused oral health services for residents of long-term care settings as defined in Kentucky’s Dental Practice Act KRS 216B
• Teledentistry-enabled preventive care, education, triage, and care coordination

Program Objectives

Funded PHDH programs must demonstrate their willingness and ability to:

• Increase access to school-based preventive dental hygiene services for all students, regardless of ability to pay.
• Deliver dental hygiene services in long term care facilities through teledentistry consultation with university dentists.
• Utilize teledentistry to expand access to care, improve quality and continuity of care, and enable more rural residents to stay in region for dental care and specialty consultations.
• Integrate Community Health Workers (CHWs) and/or social determinants of health (SDOH) screenings to support patient navigation and continuity of care.
• Achieve measurable improvements in oral health outcomes and service utilization.
• Operate in a cost-effective, sustainable, and compliant manner. Compliance is defined as adherence to the provision of hygiene services to the aboveidentified populations within KRS 313. 

The Nonpoint Source Pollution Control Grant, established under the Clean Water Act, aims to reduce nonpoint source pollution through funding innovative best management practices (BMPs), educational programs, and the development and implementation of Watershed Based Plans. The Kentucky Energy and Environment Cabinet administers this grant, providing up to 60% of project costs, with a required 40% nonfederal match, fostering sustainable environmental practices across the state.

The LG&E and KU Foundation is dedicated to enhancing community welfare by supporting nonprofit organizations that address essential needs. Every year, the foundation awards grants to initiatives focused on student success, essential services, child protection, community building, and cultural promotion. Additionally, through the Power of One campaign, employees and retirees contribute to charitable efforts, raising nearly $9 million to support local nonprofits, alongside volunteering over 20,000 hours annually.

Investing in Our Communities

Regions Bank and Regions Foundation are committed to helping individuals, families, and businesses achieve financial success.

We work alongside nonprofit organizations, local businesses, government and service agencies to address social and economic issues, assist in building inclusive economic prosperity and help more members of our communities benefit from the rewards of a growing economy.

We make strategic and disciplined community investments in programs that seek to achieve three target outcomes:

Economic and Community Development

• Affordable housing
• Job creation
• Small business development
• Homebuyer education and retention
• Neighborhood revitalization and stabilization

Education and Workforce Readiness

• Student competency and skill building
• College and career readiness
• Educational access and success
• Credential building and employment
• Educator training and resources

Financial Wellness

• Financial education to youth, adults, and vulnerable populations
• Financial planning tools and resources, including Regions Next Step®
• Integrated asset-building

The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.

The NACD Technical Assistance Grants program, in partnership with NRCS, has been enhancing conservation district support since 2018. By funding staff hires, it aims to improve service for agricultural producers and address conservation workload challenges. The initiative focuses on outreach, education, and civic engagement to empower local communities, promote sustainability, and support historically underserved producers in implementing conservation practices, thereby fostering both individual and community resilience.

The Old National Bank Foundation offers grants to nonprofit organizations for community impact initiatives across Indiana, Illinois, Kentucky, Tennessee, Michigan, Minnesota, Iowa, and Wisconsin. Focused on four key areas—Affordable Housing, Workforce Development, Economic Development, and Financial Empowerment—the foundation prioritizes programs that support underrepresented communities. Organizations must have 501(c)(3) status and align with the foundation’s funding priorities to qualify for grants, which can be applied for every two years.

The Looking Out Foundation Grant supports social justice and humanitarian initiatives, having donated nearly $6 million to various causes globally. With an average donation of $25 per campaign, it aids organizations focused on disaster relief, racial justice, and support for marginalized communities. Eligible applicants must be tax-exempt public charities under Section 501(c)(3). The foundation prioritizes diverse funding sources and encourages organizations to adapt to changing needs, with grant allocations ranging from $5,000 to $25,000.

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

Lilly Foundation

To extend Lilly’s charitable reach and impact, the Eli Lilly and Company Foundation (Lilly Foundation) was established in 1968 and is supported by donations from Eli Lilly and Company.

The Foundation is a tax-exempt, private foundation supporting programs that align with its philanthropic priorities.

Grantmaking Approach

The Lilly Foundation’s work is guided by a charitable vision of a world where every person has an opportunity to live their healthiest life. Through grantmaking focused on Lilly Foundation’s charitable vision, grants can serve as a catalyst for closing gaps and empowering individuals and communities to thrive.

All proposals should demonstrate clear alignment with at least one focus area and include charitable outcomes that are measurable and consistent with the Foundation’s long-term charitable goals.

Global Health, K-12 STEM Education and Economic Mobility Grant

Focus Areas

Global Health

Lilly Foundation, through its charitable grants, aims to support permissible charitable efforts to improve access to quality healthcare for resource-limited communities in low- and lower-middleincome countries (L/LMICs) and in the United States. Strengthening access to care is essential for enhancing community well-being and supporting economic stability in resource-limited settings.

The Global Health focus area aims to close gaps in quality healthcare by supporting charitable solutions that improve access, bring care closer to where people live, and address the high burden of non-communicable diseases (NCDs) in resource-limited settings. To the extent permissible, the Foundation prioritizes charitable efforts related to cardiometabolic health in resource-limited settings.

K-12 STEM Education

The K-12 STEM Education focus area aims to close the gaps for students from low-income communities by supporting programs that foster new pathways and pipelines to STEM education through focused K-12 efforts, concentrating on the critical middle school years. The Foundation’s K-12 STEM Education grants are focused on initiatives that benefit Marion County, Indiana.

Economic Mobility

The Economic Mobility focus area supports charitable and educational programs that strengthen workforce readiness, postsecondary and skills-based educational pathways, and housing stability to promote long-term prosperity. This support is focused on Marion County, Indiana, with the goal of improving economic opportunity for low-income communities and advancing community well-being.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.