Best Madison County Grants for Nonprofits in Illinois

Nestlé Purina Animal Welfare Grants focus on enhancing the well-being of pets and their owners through monetary donations to 501(c)(3) tax-exempt pet welfare organizations in the U.S. These grants support capacity building, capital improvements, and spay/neuter funding. The program aims to strengthen relationships between pets and people, particularly in communities near Nestlé Purina facilities, ensuring that both pets and their owners thrive together.

Nestlé Purina

Unspecified amount

Tilles Fund Grant

The Tilles Fund Grant focuses on innovative charitable investments in the Greater St. Louis Area, aiming to support children with developmental, intellectual, and physical disabilities. The foundation seeks to partner with effective non-profit organizations that demonstrate measurable outcomes in education and community impact. Since 1926, the Tilles Foundation has been committed to providing essential services and educational opportunities, ensuring disadvantaged children have the tools they need for a brighter future.

Rosalie Tilles Nonsectarian Charity Fund 313743

Up to US $100,000

Gateway Regional Environment Fund Grant Program

Letter of inquiry due Mar 9, 2027

The Gateway Regional Environment Fund Grant Program, managed by the St. Louis Community Foundation, aims to support initiatives in the St. Louis metro area that reduce the carbon footprint. By funding projects that address greenhouse gas emissions, GREF plays a crucial role in combating climate change locally. This program encourages community engagement and innovation to create a sustainable future for the region.

St Louis Community Foundation

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Up to US $25,000

Episcopal Presbyterian Health Trust Grant

Applications due Jul 7, 2027

The Episcopal Presbyterian Health Trust Grant, managed by the St. Louis Community Foundation, focuses on enhancing health care access and addressing chronic diseases. Grants are awarded biannually, prioritizing maternal and infant health in the second cycle. Organizations are encouraged to submit one Letter of Intent (LOI) annually, ensuring their proposals align with the funding priorities to foster sustainable health solutions in the community.

St Louis Community Foundation

Unspecified amount

Highland Area Community Foundation Grants

Applications due Jun 30, 2027

The Highland Area Community Foundation aims to build permanent charitable assets for the Highland community, acting as responsible stewards and responsive leaders in philanthropy. They focus on addressing the community's evolving needs and initiating important charitable endeavors. For more information, view the grant application form available on their website.

Highland Area Community Foundation

Unspecified amount

Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant

Applications due Feb 20, 2027

The Section 5310 – Enhanced Mobility of Seniors and Individuals with Disabilities Grant, administered by the East-West Gateway Council of Governments, aims to enhance transportation access for seniors and individuals with disabilities in the St. Louis region. This federal funding supports projects that improve mobility, including vehicle acquisition, travel training, and barrier removal at bus stops. Eligible applicants include non-profits and government entities focused on serving these communities.

East-West Gateway Council of Governments

Unspecified amount

Lutheran Foundation of St. Louis Grants

Applications due Dec 1, 2026

The Lutheran Foundation of St. Louis provides grants aimed at improving the lives of individuals in the greater St. Louis area. With a focus on strategic priorities such as community engagement and support for vulnerable populations, the foundation encourages organizations to apply for funding that aligns with its mission. Grants are available to 501(c)(3) organizations serving specific counties, and applicants are encouraged to demonstrate measurable impact through their proposed programs.

Lutheran Foundation of St. Louis

Unspecified amount

PNC Foundation: Foundation Grant

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

PNC Foundation

Up to US $100,000

United Way of Greater St. Louis: Targeted Fund

Applications due Oct 12, 2027

The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.

United Way Of Greater St Louis Inc

Up to US $10,000

Congregation Mini Grants

Lutheran Foundation of St. Louis

Lutheran School Mini Grants

The Foundation continues to encourage congregations to reach out to their surrounding communities through organized, effective social service outreach ministry efforts. We also recognize congregations are looking for innovative ways, outside the traditional social service outreach model, to build relationships and engage their communities.

We look to accomplish this in two ways:

Supporting congregations as they work to engage and serve their neighbors and community through planning and program implementation grants.
Strengthening the ability of congregations to engage in community engagement efforts through coaching assistance, mentoring, and training (through Send Me St. Louis).Examples of Possible Ministry Projects

Congregation Community Engagement is defined for this Funding Focus Area as activities, services, or efforts designed to reach out to others on a local level (St. Louis metropolitan region). Examples include both serving the immediate needs of people and efforts to engage and build relationships with the community. The focus is on bringing the care of Jesus Christ into the lives of hurting people in the community, rather than serving the congregation’s own members. This funding focus area is not meant to support “Word and Sacrament” activities.

Health care/mental health services
Fitness/healthy living programs
English as a second language
After-school mentoring/tutoring
Social activities for seniors
Community revitalization
Recreation activities
Home repair/beautification
Partnerships with local schools/other institutions
Social enterprise/business that benefits the community and/or creates space for relationships
One-time events (run by the congregation) to meet a need in the community

Idea Exploration

Congregations should know what they want to do and have an idea of how to get started. If you are not at this point, coaching services to assist your congregation are offered through Lutheran Foundation’s relationship with Send Me St. Louis. Services include coaching and guidance on:

mapping the congregation’s and community’s assets,
researching opportunities for social service outreach ministry, and/or
planning for a social service outreach ministry.

There are no grant deadlines for the Congregation Mini Grants. Application can be made at any time of the year.

US $2,500 - US $10,000

Preserve Route 66 Grant Fund

Applications due Nov 12, 2026

The Preserve Route 66 Grant Fund offers financial support to public agencies, tribal governments, and nonprofit organizations aiming to preserve historic places along Route 66. This initiative prioritizes projects that enhance underrepresented narratives, including those related to diverse communities. Grants typically range from $2,500 to $10,000, with a focus on activities that restore, rehabilitate, or educate about significant historical sites, ensuring that this iconic American highway's legacy is maintained for future generations.

National Trust for Historic Preservation

Unspecified amount

Georgia-Pacific Foundation Grant

Applications due Oct 31, 2026

The Georgia-Pacific Foundation Grant supports organizations in the Metro Atlanta area, focusing on education, entrepreneurship, community enrichment, and environmental sustainability. Established in 1958, the foundation prioritizes investments that align with its mission and values, promoting long-term well-being within communities where Georgia-Pacific operates. Eligible applicants include 501(c)(3) nonprofits, public schools, and local government entities located within 30 miles of GP manufacturing sites.

Georgia-Pacific Foundation

US $5,000

PLTW Launch - Program Expansion (Burns and McDonnell)

The PLTW Launch program, in collaboration with Burns and McDonnell, aims to enhance STEM education by expanding access to innovative educational modules in eligible schools. This initiative supports public and charter schools in targeted counties, focusing on increasing student engagement in STEM fields. Through grant funding, participating schools can introduce new PLTW Launch modules and provide essential training for teachers, fostering a richer learning environment to prepare students for future careers in science, technology, engineering, and mathematics.

Applications due Jun 30, 2027

Unspecified amount

ECF of The Boeing Company: St. Louis Missouri Chapter Grant Program

The Employees Community Fund (ECF) of The Boeing Company supports charitable organizations in the St. Louis area through grants focused on Health and Human Services, Education, Arts & Culture, and Civic Engagement. Applications for 2024 will be accepted from April 1 to June 30, with odd-numbered years prioritizing health initiatives. ECF has invested over $165 million in the community, empowering employees to make a significant impact through collaborative giving.

Employees Community Fund Of The Boeing Company

US $100,000 - US $18,000,000

Driving a Cleaner Illinois - Volkswagen (NOFO) (IL)

The Driving a Cleaner Illinois program, managed by the Illinois EPA, offers funding for mobile source electrification projects. This initiative utilizes resources from the Climate and Equitable Jobs Act, the Volkswagen Environmental Mitigation Trust, and the EPA's Diesel Emission Reduction Act (DERA) Program. As funding is limited, applicants are encouraged to apply promptly to support cleaner transportation solutions in Illinois.

Illinois Environmental Protection Agency

Up to US $20,000

PLTW Launch - New Program (Burns and McDonnell)

The PLTW Launch program, supported by Burns and McDonnell, aims to enhance student engagement in STEM education within eligible communities. This initiative will provide grants to schools that implement at least one PLTW Launch module in the 2025-2026 academic year, followed by another module in subsequent years. The program is designed to empower students with hands-on learning experiences that connect real-world challenges to essential skills, fostering a stronger future in STEM fields.

Up to US $10,000

PLTW Gateway - Program Expansion (Phillips 66)

The PLTW Gateway Program Expansion, funded by Phillips 66, aims to enhance educational equity by supporting middle schools in STEM. With a total award of $10,000, the initiative focuses on expanding existing PLTW Gateway programs, particularly for schools serving high-need student populations. This partnership encourages a diverse workforce by providing opportunities for girls and people of color, ensuring they explore various STEM pathways during critical developmental years.

Pre proposal due Nov 15, 2026

US $1,000 - US $10,000

Enbridge - Safe Community First Responder Program

The Enbridge Safe Community First Responder Program is designed to support emergency response organizations across Canada and the U.S. by providing grants for safety equipment, training, and educational programs. Launched in 2002, it has invested over $22 million in enhancing community safety. Eligible organizations include fire departments and medical services located near Enbridge operations. Grants typically range from $1,000 to $10,000, helping improve the capabilities of first responders in rural and underserved areas.

Enbridge

Unspecified amount

Penn National Gaming Foundation Grants

Applications due Jan 1, 2027

The Penn National Gaming Foundation Grants support various community initiatives across North America, emphasizing education, health services, and cultural affairs. Launched post-Hurricane Katrina, the foundation aids local nonprofits, enhancing community development, public safety, and veteran support. The grants cater to organizations that address the needs of children, senior citizens, and disadvantaged populations, ensuring a broad impact in areas where Penn National Gaming operates. This commitment reflects the foundation's dedication to uplifting communities and fostering resilience.

Penn National Gaming

US $10,000

PLTW Gateway - Program Expansion (Burns and McDonnell)

The PLTW Gateway program, in collaboration with Burns & McDonnell, aims to enhance STEM education by expanding access to Project Lead The Way initiatives in eligible communities. By providing grants for program expansion, the initiative encourages schools to implement new PLTW units and train teachers, empowering students with essential skills for future careers. This partnership seeks to inspire a new generation of learners through hands-on, real-world challenges, thereby fostering greater participation in STEM fields across various regions.

Applications due Jul 8, 2027

Up to US $200,000

Nonprofit Security Grant Program (NSGP - MO)

The FY 2025 Nonprofit Security Grant Program (NSGP) aims to enhance the physical and cybersecurity of nonprofit organizations at risk of extremist attacks. This initiative focuses on improving security postures, addressing capability gaps, and fostering collaboration among organizations and local agencies. By providing essential funding for planning, equipment, and training, the NSGP seeks to protect vulnerable facilities and ensure a coordinated community response to security challenges.

Missouri Department of Public Safety (DPS)

Unspecified amount

PNC Foundation: Grow Up Great Grant

The PNC Foundation's Grow Up Great Grant is a significant initiative aimed at enhancing educational opportunities for children from birth to age 5. With a commitment of $500 million, this program focuses on improving school readiness through support in vocabulary development, social-emotional learning, and the arts. By partnering with community-based nonprofits, PNC aims to foster stronger, smarter, and healthier communities, ensuring a brighter future for the next generation.

PNC Foundation

Approximately US $100,809

Regional Site Readiness Program- Site Readiness Planning in Edwardsville

Applications due Nov 16, 2026

The Illinois Department of Commerce and Economic Opportunity (DCEO) is launching the Regional Site Readiness Program to enhance infrastructure for 150 acres of industrial property in Gallatin County. This initiative aims to attract private investments and create new job opportunities in industrial sectors. Eligible entities include special units of government focused on maintaining ports and terminals. Grants will be awarded on a reimbursement basis to ensure effective use of funds and promote economic growth in the region.

Illinois Department of Commerce and Economic Opportunity

Unspecified amount

IL Conservation Stewardship Program (CSP)

Applications due Dec 18, 2026

The Illinois Conservation Stewardship Program (CSP) encourages landowners with five or more acres of unimproved land to manage their properties for environmental conservation. By implementing habitat management plans, participants can potentially lower their property tax valuations. Key goals include restoring native species, controlling invasive species, and enhancing critical habitats. This program is essential for preserving Illinois’ biodiversity in a predominantly private landscape, making it a valuable initiative for local landowners.

USDA: Natural Resources Conservation Service of Illinois

US $50,000 - US $1,500,000

Safety Net Funding

Applications due Apr 17, 2027

United Way of Greater St. Louis

Our Mission: The United Way of Greater St. Louis mission is to mobilize the community with one goal in mind – helping people live their best possible lives. We unite people, resources and funding to help build strong and equitable communities where everyone can thrive.

Safety Net

United Way’s Safety Net is a collaborative network of agencies that deliver an array of essential direct services to address the region’s most pressing needs, helping families and individuals remain and work toward stability. Safety Net agencies provide direct services that address basic, urgent needs – such as access to food and housing— as well as supports that help move individuals and families toward stability, including education, health and well-being, workforce access, and financial mobility.

Safety Net Funding

United Way of Greater St. Louis is now accepting applications for its Safety Net Funding cycle and invites all eligible agencies across its 16-county region in Missouri and Illinois, including those not currently receiving United Way funding, to apply. United Way equips 160 local nonprofits with vital funding and training resources to support measurable impact across its five impact areas. Organizations selected will receive a three-year contract and become part of the UWGSL member agency network.

United Way’s Impact Areas

Basic Needs 
Community Stability and Crisis Response 
Early Childhood and Youth Success 
Health and Wellbeing 
Jobs and Financial Mobility

While needs are great across the five impact areas, United Way will use data derived from its landscape analysis of community needs to inform how service areas will be prioritized to ensure the region has access to a strong and resilient network as needs arise.

United Way Of Greater St Louis Inc

US $10,000

PLTW Engineering - Program Expansion (Burns and McDonnell)

The PLTW Engineering Program Expansion by Burns and McDonnell aims to enhance STEM education in eligible communities. This initiative supports schools in expanding their existing PLTW Engineering programs, providing students with hands-on experiences and essential skills. The program focuses on empowering students through new courses and teacher training, ensuring access for underrepresented populations. By fostering excitement around STEM, Burns and McDonnell is committed to shaping the future workforce and enhancing educational opportunities in critical areas.