Best Grants for Nonprofit Healthcare Programs in Massachusetts

The James M. Cox Foundation Grant offers support to nonprofit organizations focused on conservation, early childhood education, family empowerment, and health. Organizations must be 501(c)(3) tax-exempt and located in areas where Cox Enterprises operates. Grant applications are accepted year-round, with deadlines before Trustee meetings. Preference is given to organizations with a history of local engagement. This foundation embodies the philanthropic spirit of its founder, James M. Cox, by giving back to the community.

The Katharine C. Pierce Trust Grant aims to enhance the lives of women in Massachusetts facing challenging circumstances. Focusing on health and human services, it supports nonprofit organizations providing essential services, including homecare and emergency assistance. The grant prioritizes program or capital requests, with a typical award of $10,000 for one year. Applications for direct service grants are due by May 1. Special consideration is given to initiatives benefiting elderly women.

The Davis Family Foundation, established in Maine, focuses on granting support to educational, medical, and cultural/arts organizations. With over $63.5 million awarded since 1986, the foundation emphasizes innovative projects that make a significant impact on Maine communities. Eligible organizations must be tax-exempt and align with the foundation's priorities, ensuring projects enhance educational outcomes or address medical issues effectively. The foundation seeks unique projects that engage the community and preserve Maine's cultural heritage.

The Charles F. Bacon Trust Grant supports educational, human services, and health care programs for underserved populations, with a focus on elderly women. Established in 1928, the trust encourages grant requests for operating and program support, including small capital expenses. Most grants are awarded for one year, but multi-year support may occasionally be granted. This initiative aims to enhance the quality of life for vulnerable communities through targeted assistance and resources.

The ACT on Health Equity Community Solutions Challenge Grant, backed by the Astrazeneca Foundation, aims to enhance health equity by funding community-based nonprofit programs. Since its inception in 2021, it has allocated over $2.6 million to initiatives addressing nutrition, healthcare access, and lung health for historically marginalized populations. Eligible US-based 501(c) organizations can apply, with a focus on projects serving underserved communities and improving health outcomes through targeted support.

The Mabel A. Horne Fund Grant, established in 1957, aims to enhance educational, human services, and healthcare for underserved populations. This private fund supports general operating and program-related requests, encouraging small capital expenses. Most grants are for one year, with occasional multi-year support available. The initiative seeks to empower communities by providing essential resources for impactful programs.

The Hamilton Company Charitable Foundation

 The Hamilton Company Charitable Foundation was formed in 2011 by Harold Brown. Its goal is to provide support for local 501c3 organizations which serve the community. Annual funding ranges between $250,000 and over $1,000,000. The chairman is Ronald Brown. Other board members: Jameson Brown, Maura Nolan Brown, Harley Brown, Fred Lebow & Andrea Kozinetz.

Grants

The Hamilton Company Charitable Foundation funds a wide variety of charities, including those that engage in medical and scientific research and deliver medical services and those that provide educational, artistic/musical, and recreational activities for underserved youths. The Foundation also finances scholarships for qualified applicants, aid to those experiencing homelessness, capital renovations or new construction, and animal hospitals and shelters.

Past and current charities supported include but are not limited to the West End House, Franciscan Children’s Hospital, the Coolidge Corner Theatre Foundation, and the Benjamin Franklin Cummings Institute of Technology.

Efficient use of administrative costs relative to benefits received by individuals is considered, and we fund specific projects, not operational costs. 

As of January 1, 2026, the Hamilton Company Charitable Foundation’s annual funding is in excess of $4 million per year. There is one application for requests over $1000. A very brief summary application is required for requests up to $1,000.

These grants may provide educational, recreational, and other services to urban and suburban youth. Funds are also available for arts and culture by way of museums, other learning opportunities. Funds may be directed as assistance to people in need such as supplying care for families, food.

The Alfred E. Chase Charity Foundation Grant supports quality educational, human services, and healthcare initiatives for underserved populations, particularly in Lynn and the North Shore of Massachusetts. Established in 1956, it encourages requests for both general operating and program support, with small capital expenses considered. Grants typically last one year, with occasional multi-year funding available. This foundation prioritizes charitable organizations that directly benefit local communities.

The Ludcke Foundation

Guidelines

To identify and support charitable endeavors that provide needed resources and services to children and families, with an emphasis on emotional and physical health, education, and social development.

The Foundation devotes its grants to the fields of education, health, and human services. The trustees have a special interest in programs that focus across two or three of the foundation’s areas of interest and in partnering with other donors with similar objectives to enable more ambitious projects.

Current Grantmaking Preferences

Job training for systems involved young people, job training for adults facing significant barriers, and limited support for innovative approaches to helping children in underserved New England communities overcome significant and often overlapping barriers to educational success.

Access to health programs for all ages, and behavioral health services for children and teens in underserved communities or otherwise facing significant barriers.

Homelessness prevention, housing assistance, food security, legal assistance, holistic family support, support for young people at risk, and support for victims of domestic violence.

The MMS&A Charitable Foundation provides organizational grants aimed at promoting equitable health outcomes for marginalized communities. They focus on funding non-profit organizations that deliver quality healthcare services to the un- and underinsured, as well as enhancing behavioral health services. Eligible organizations must be tax-exempt and have limited government funding. Capital campaigns, for-profit entities, and discriminatory practices are not supported. The foundation prefers innovative proposals over repeat requests, emphasizing new programs to address health inequities.

The L.B. Research and Education Foundation Grant Program supports U.S.-based nonprofits focusing on innovative education and health solutions for underserved populations. Eligible organizations can apply by submitting a 400-word concept paper, and selected applicants may receive funding ranging from $10,000 to $75,000. The Foundation prioritizes projects that foster critical thinking and creativity, address health disparities, and encourage collaboration. There are no application deadlines, promoting year-round engagement.

The Highland Street Foundation Grant supports critical needs for children and families in Massachusetts and California. Focused on education, housing, health care, and the arts, it awards grants based on established relationships with nonprofit partners. The foundation does not accept unsolicited proposals and limits submissions to one letter of inquiry per organization each year. Organizations outside the U.S. are not eligible for funding, ensuring support remains local.

The Immediate-Need Investments grant focuses on supporting historically underfunded organizations in Massachusetts. With an emphasis on respect-based grantmaking, it provides one-time investments averaging $2,500 for urgent needs. Eligible applicants include 501(c)(3) nonprofit organizations and local branches of national organizations. The grant prioritizes those that empower communities and enhance transparency, ensuring that funding reaches those who are actively shaping shared narratives within their communities.

Creating Health Access for Next Generation Equity (CHANGE) Grant Program

Launched in 2023, the AstraZeneca Foundation’s signature Creating Health Access for Next Generation Equity (CHANGE) program works to improve access to quality healthcare.

Beginning April 1, 2026, the AstraZeneca Foundation will accept grant requests of $200,000 - $220,000 for review and consideration for its next cohort of CHANGE grant awardees. Organizations receiving funding in 2026 may be considered for renewed funding on an annual basis for two additional years, contingent upon meeting objectives, funding availability and approval by the Foundation’s Board of Trustees.

The intent of the grants is to provide general operating support for organizations working in innovative, collaborative ways at the community level to help improve access to quality healthcare in their community during the grant year and beyond. Our aim is for funded organizations to maximize the benefit to community members and community-based organizations and to work toward continuing their services beyond potential AstraZeneca Foundation funding.

Please see FAQs for additional guidelines.

The Albert W. Rice Charitable Foundation Grant supports educational, health, and human services programs for underserved populations in Worcester, MA. Established in 1959, the foundation encourages grant requests for general operating or program support, with special consideration for local organizations. Most grants are for one year, though multi-year support may be awarded on occasion. This commitment aims to enhance the quality of life for those in need within the community.