Best Grants for 501(c)(3) in Missouri

The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.

The Park Foundation Grants: Media support public interest media that raises awareness of critical environmental and social issues. They prioritize funding for investigative journalism, media policy, public broadcasting, and documentary films to promote a better-informed citizenry. Eligible organizations must be 501(c)(3) certified, and funding is aimed at projects that ensure diverse perspectives and community engagement. The foundation is committed to fostering a robust democracy and independent media, reflecting its mission to advance a just and sustainable society.

The Systemic Sclerosis with Interstitial Lung Disease Fund, managed by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from systemic sclerosis. This rare autoimmune disease leads to excessive collagen production, causing serious health issues. The fund assists with prescription copays and insurance premiums to ensure patients receive necessary treatments. In 2024, HealthWell awarded over $1.2 billion in grants, supporting more than 1.1 million patients in accessing vital healthcare services.

The Jim Flynn Outstanding Corporation Award, presented annually by NALMS, honors the corporation that has made significant contributions to advancing lake management goals. This award emphasizes the importance of facilitating information exchange, promoting public awareness of lake ecosystems, and supporting management programs at all levels. Eligible nominations can come from any individual or entity, focusing on achievements in lake and reservoir management. Notably, current NALMS board members and awards committee members are excluded from eligibility.

The Core State Injury Prevention Program (Core SIPP) aims to enhance public health infrastructure and partnerships to prevent unintentional injuries through data-driven strategies. Focusing on key areas such as traumatic brain injury, falls among older adults, and drowning, it seeks to improve community safety by strengthening data use and fostering collaborations. This initiative supports states in identifying local injury concerns, thus promoting evidence-based prevention approaches and increasing the capacity for sustained public health actions.

Joseph G Markoly Foundation Inc

When Joseph Markoly originally established the foundation more than thirty years ago, its focus was on Alzheimer’s and heart disease support, funded through a number of the larger national disease-related organizations. Over time the focus has shifted to helping small to mid-size organizations in our local communities which support children and seniors in a variety of effective ways. 

Markoly Foundation was established in honor of Joseph G. Markoly, an entrepreneur and philanthropist who wanted to make a positive impact in people’s lives. Joseph’s family was affected directly by both Alzheimer’s and heart disease having lost a family member to each condition. For that reason, the foundation dedicates a majority of their resources to providing grants to organizations that focus on the treatment of each of these diseases. In addition, Markoly Foundation supports a variety of programs dedicated to helping children and seniors by providing services, supplies, programs and research in areas impacting these demographics.

Joseph G. Markoly Foundation Grant Support for Elder Organizations

The Markoly Foundation takes pride in supporting local organizations that provide services for elders in our community. Seniors face a number of challenges that come with aging, especially when they don’t have loved ones who are able to assist them with their needs. We provide grants for a variety of senior-related programs from Caregiver Education and Support to Emergency Meal Delivery and Transportation Services.

We are dedicated to providing funding for local nonprofit programs that improve the quality of life for all, but particularly for the children and elders in our community.

The David Moses Bridges Scholarship honors the legacy of a renowned Passamaquoddy artist and activist, providing essential support for individuals dedicated to the preservation of Wabanaki culture, traditional arts, and environmental stewardship. This scholarship aims to foster connections between master artists and apprentices, promote research on David's impactful life and work, and protect culturally significant natural spaces. It empowers artists and scholars to continue the vital work of preserving indigenous knowledge and practices for future generations.

The Nicholas B. Ottaway Foundation offers grants through its Education Committee to support programs enhancing educational opportunities for economically disadvantaged students. These grants focus on initiatives like tutoring, college preparation, and internship programs. To qualify, organizations must be tax-exempt under 501(c)(3). Preference is given to projects that provide ongoing support to students post-graduation, particularly in specific geographic areas such as San Diego County and the New York Metropolitan Area.

This funding opportunity invites Small Business Technology Transfer (STTR) grant applications aimed at developing FDA-regulated medical products for patients with opioid and stimulant use disorders. Projects may focus on pharmacotherapeutics or diagnostic devices, including software. The initiative seeks to address the ongoing opioid crisis by supporting innovations that enhance treatment options for individuals and communities affected by these disorders.

The AWWA Arcadis Scholarship offers a $5,000 award to graduate-level students from underrepresented racial and ethnic minority groups pursuing STEM fields. This initiative by the American Water Works Association aims to promote diversity and inclusion in the water service industry, recognizing the critical role of future leaders in ensuring sustainable water supply. Eligible candidates include Black, Latinx, and American Indian or Alaska Native students with the potential for impactful contributions in the sector.

Quest Diagnostics Foundation

Our purpose

Working together to create a healthier world, one life at a time.

About the Foundation

The Quest Diagnostics Foundation® (the Foundation), established in 1991, is a nonprofit corporation exempt from tax under Section 501(c)(3) of the Internal Revenue Code, for charitable, educational, scientific, and literary purposes including:

• Promoting the benefits of healthcare and wellness
• Promoting the prevention, early detection, monitoring, and treatment of disease
• Educating the general public and healthcare professionals regarding healthcare issues

About Quest for Healthy Communities Champions

Through the Quest for Healthy Communities Champion program, the Foundation will recognize and give monetary awards to up to 15 individuals or organizations across the US that have committed to improving health in their own communities. In the case of recognition to individuals, the monetary award will be given to the tax-exempt charity of their choosing.

The program reflects the importance of recognizing individuals and organizations that are committed to the purpose of Quest, “working together to create a healthier world, one life at a time” and the Foundation’s belief that increased awareness of individuals and organizations doing this work can lead to healthier communities.

Successful applicants will demonstrate their commitment to improving health in their communities through actions such as:

• Impact on community systems via policy, programming, and education in areas such as workforce development, health, environment, housing, and safety
• Ongoing community engagement in the development of innovative solutions to drive improved health outcomes
• Commitment to increasing individual health autonomy and empowerment through the advancement of diagnostic screening and testing

The HDR One Water Institute Scholarship, offered by the American Water Works Association, provides $10,000 in funding to support graduate students pursuing degrees that will lead to careers as consultants in the water industry. This initiative highlights the importance of investing in future water professionals and fostering innovative research to address pressing water challenges.

The Gamma Mu Foundation, established in 1988, aims to support the LGBT community in rural and underserved areas through various grants. Initially focused on HIV/AIDS projects, it now funds scholarships and services for diverse LGBT subpopulations. With over $2 million awarded, the Foundation prioritizes initiatives that enhance community support, public education, and health programs. It emphasizes projects that build organizational capacity and provide essential services where resources are limited, ensuring ongoing support for vital health and social services.

The AWWA Scholarship Program, specifically the Mueller HBCU Scholarship, supports undergraduate students from historically black colleges and universities pursuing careers in the water sector. Offered by the American Water Works Association (AWWA), this scholarship recognizes the vital role of future professionals in addressing water industry challenges. AWWA aims to invest in students who will contribute to sustainable water management and innovation within their communities.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34) aims to support high-risk, multi-center clinical studies by facilitating early peer review and assessment of study designs. This program helps in the development of necessary operational documents and essential elements for conducting hypothesis-driven studies focused on diseases relevant to NIDDK. Applications are due by 5:00 PM local time, and consulting with NIDDK staff is strongly encouraged.

The Generosity Collective Grantmaking Program, led by the Community Foundation of the Ozarks, aims to address pressing local issues in Springfield by funding impactful projects. With a total of $120,000 available, grants of $30,000 will be awarded to one agency in each of four categories: early childhood development, child abuse prevention, mental health support, and affordable housing. This initiative fosters community collaboration and empowers organizations to create meaningful change.

The AWWA Abel Wolman Fellowship, established in 1984, supports highly qualified students conducting meaningful research in water supply through doctoral programs. Named after Dr. Abel Wolman, this prestigious award recognizes excellence and creativity in the water sector. The fellowship provides up to two years of financial support, with an initial award of $30,000 for the first year, aimed at fostering the next generation of water professionals in the U.S., Canada, and Mexico.

The Natural History Research Experiences (NHRE) is a prestigious 10-week summer internship program at the Smithsonian's National Museum of Natural History. It offers undergraduates the chance to engage in independent research across various disciplines including Earth Science and Anthropology. Participants receive a stipend of $8250, travel support, and free housing, while benefiting from mentorship by leading scientists. This program aims to cultivate future leaders in natural history research.

The Amcor Community Support Grants Program, administered by the Amcor Cares Foundation, provides funding for projects that benefit local communities. Grants are available to 501(c)(3) organizations and accredited educational institutions that serve Amcor Flexibles North America facility communities. Focus areas include fighting hunger, supporting disaster relief, expanding STEM education, and enhancing health and wellness. Applications are reviewed quarterly, and grant amounts typically exceed $1,000.

The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.

The Adtalem Global Education Foundation, established in 2010, is dedicated to enhancing education and community development. Based in Chicago, it focuses on expanding educational access, particularly for underrepresented minorities in the healthcare sector. The foundation prioritizes initiatives that promote economic growth through skills-based workforce development, address healthcare disparities, and increase access to quality education for underserved populations. Its commitment to civic engagement and equality reflects its mission to empower communities.

The Community Connect Grants Program provides financial assistance to eligible applicants aiming to deliver broadband services in rural areas where access is limited. This initiative fosters economic growth and enhances educational, healthcare, and public safety benefits, improving the quality of life in underserved communities. By supporting projects that create better market opportunities and promote equitable access, the program plays a vital role in advancing rural development and addressing environmental justice.

The Office of National Drug Control Policy is inviting applications to create a surveillance system that connects drug toxicology testing results and interviews from emergency department patients with the illicit drug supply in various U.S. communities. This project aims to enhance drug consumption surveillance, identify deficiencies in current drug testing methods, and promote collaboration among public health and safety organizations to effectively tackle the ongoing drug crisis.

The LASC Foundation offers grants to nonprofit organizations in the Greater Metropolitan St. Louis Area focusing on poverty relief through targeted partnerships. Eligible projects include food security, youth development, and education initiatives. First-time applicants should contact the foundation’s program officer before applying, while unsolicited proposals are accepted year-round. The foundation aims to foster sustainability and self-determination within communities, supporting both faith-based and non-faith-based organizations.

Theresa Alessandra Russo Foundation Inc

The Theresa Foundation honors the memory of Theresa Alessandra Russo by touching the lives of children with special needs and their families. The Foundation fosters each child’s unique abilities by supporting programs focusing on art, music, dance, drama, and recreation.

The Theresa Foundation has a vision of the world where artistic expression and physical recreation are just as important to adults as they are to children. We believe in a world where every child, regardless of ability or challenging conditions, is free to communicate through and participate in every art or recreational activity. A society without art is a society without soul. Art enables us to express our inner thoughts, fears, joys, and sadness.  

The Theresa Foundation Grant Program

The Theresa Foundation Grant Program is committed to providing financial support for programs in art, music, dance, drama, or recreation that are designed specifically for children with special needs in order to ensure that no one is excluded from these activities. 

We believe that every individual should have the opportunity to participate in art, music, dance, drama or recreation if they so choose. Our grant program works to provide direct funding for the success of these activities, while also promoting an environment of acceptance and inclusiveness where all can take part without judgment or fear. 

As of 2026, the Theresa Foundation has provided over $3,300,000 in grant funding for over 200 programs in 29 states throughout the country and 4 international grants. With your help we can continue to make a difference in the lives of those with special needs by providing them access to enriching experiences that would otherwise be out of reach. 

The Udall Undergraduate Scholarship, awarded by the Morris K. Udall and Stewart L. Udall Foundation, supports future leaders in environmental, tribal public policy, and health care fields. With 55 scholarships of $7,000 each expected in 2025, this highly competitive program requires students to participate in their schools' internal competitions. Scholars benefit from networking opportunities and access to the Udall Alumni Network, fostering collaboration and growth in their respective fields.

Brooks Brothers, founded in 1818, is committed to social responsibility through its donation program. The company partners with local and national non-profits focused on health issues and education. They seek to enhance community well-being while maintaining a commitment to inclusivity. Notably, they do not support organizations that discriminate based on protected categories. Their donations are aimed at fostering positive change in society, reflecting their belief in the importance of community engagement.