Best Large Grants for Nonprofit Organizations in Missouri

The Coaching Enhancement Grant - Division II aims to enhance diversity in NCAA coaching by providing financial support for new assistant coaching positions. This grant specifically targets increased representation of ethnic minorities and women in athletics. Selected schools receive funding for three years to cover salaries and benefits, totaling $370,000 annually for up to 21 institutions. Eligible schools must be active NCAA Division II members committed to these diversity efforts.

The Recreational Trails Program Grants, offered by the Missouri State Parks Foundation, aim to enhance both motorized and nonmotorized recreational trails through federal funding. These grants support local governments, school districts, and nonprofits in projects such as trail construction, maintenance, and facility development. A minimum 20% matching contribution is required from project sponsors. This initiative fosters partnerships to improve Missouri's park systems, ensuring accessibility and sustainability for public enjoyment.

The CHS Foundation's Ag Leadership Grant aims to enhance agricultural leadership and cooperative education. This program supports projects that cultivate a diverse pipeline for future agricultural leaders, focusing on education and career training for high school students to young professionals. Priority is given to initiatives that impact multiple states within the CHS trade area, thereby fostering a deeper understanding of the cooperative business model in agriculture.

The NRP Research Grant Program offers up to $50,000 for healthcare professionals to explore optimal neonatal resuscitation methods. It encourages innovative research addressing gaps in transitional physiology and effective teaching of resuscitation skills. Applications must focus on evidence-based practices and demonstrate potential for meaningful impact in delivery room care. Researchers from Canadian and US institutions are eligible, though applications primarily focused on quality improvement without a research emphasis will not be considered.

The Growing Tribal Economies Through Forest Market Innovations grant program, initiated by First Nations Development Institute, aims to empower Tribes and Alaska Native Villages to engage in emerging markets that enhance forest health and resilience. With funding of $200,000 to $500,000 per grant, this initiative supports projects focusing on sustainability, innovation, and traditional knowledge. Eligible applicants are encouraged to develop forest products, certifications, and practices that contribute positively to biodiversity and ecosystem management.

The New Era Scholarship, offered by The Scholarship Foundation of St. Louis, provides up to $12,000 annually for eligible students from select youth development agencies and high schools in the St. Louis area. This renewable scholarship supports those aiming to attend accredited colleges or technical schools in Missouri and select Illinois institutions. Applicants must demonstrate financial need and meet academic criteria, making this an essential opportunity for local high school seniors.

The Virginia H. Glasson Charitable Trust Grant supports Christian charitable organizations and preferred beneficiaries. It funds projects in areas such as education, scientific research, religious activities, and arts and culture. Eligible applicants are nonprofit organizations recognized under section 501(c)(3) of the IRS tax code, located in states such as California, Colorado, Florida, Missouri, North Carolina, and Washington D.C. However, individuals cannot apply for funding.

Patterson Family FoundationThe Patterson Family Foundation, based in Kansas City, Missouri, is a family-led foundation that extends the legacy of Neal and Jeanne Patterson. The Foundation’s mission, “Working together to help rural communities thrive,” is carried forward through strategic grantmaking and other collaborative initiatives that serve rural counties across Kansas and western Missouri. At the Patterson Family Foundation, we believe that thriving rural communities aren’t just about the numbers—they’re about the people who choose to live there. A strong and engaged community is built on essentials like access to good jobs, quality healthcare, educational opportunities, and a sense of belonging. But keeping rural communities strong doesn’t happen on its own—it takes all of us working together. That’s why we focus on working with local leaders, businesses, and organizations to invest in the areas that matter most, ensuring that rural places don’t just get by but thrive for generations to come.Maternal Health GrantsThis opportunity expands maternal and child health services in rural communities by increasing access before, during, and after pregnancy. Projects should strengthen the maternal health workforce, improve care availability, and support families through enhanced training, equipment, and service options. Applicants should plan to report on services expanded, residents served, workforce growth, and improvements in access to maternal and child health care. Eligible use of funds include:  

• Expanding the maternal-child health workforce
• Training and education on specialized equipment
• Creating opportunities for maternal health professionals to practice in rural settings
• Equipment  

Enterprise Community Partners

Enterprise Community Partners is a national nonprofit that exists to make a good home possible for the millions of families without one.

We support community development organizations on the ground. We aggregate and invest billions to improve housing and strengthen communities across the U.S. We advance housing policy at every level of government. We build and manage communities ourselves. Everything we do is informed by the residents we serve. Since 1982, we have invested $80.9 billion and created 1 million homes across all 50 states, the District of Columbia, Puerto Rico, and the U.S. Virgin Islands. We do all this to make home and community places of pride, power, and belonging.

Southwest Tribal Resilience Academy - Resilience Capacity Grant

Enterprise Community Partners (Enterprise) is seeking Requests for Proposals (RFPs) from eligible tribal entities, Community Development Corporations (CDCs), and Community Housing Development Organizations (CHDOs) that have participated in the Southwest Tribal Resilience Academy.

The Academy provides cohort-based learning opportunities for Southwest Tribal housing organizations to connect with one another, engage with subject-matter experts, and collaborate with local stakeholders to address the unique climate-related hazards facing their region.

To build on the knowledge and technical assistance gained through the Academy, Enterprise will award grant funding to participants of the Southwest Tribal Resilience Academy to support the implementation of resilient, community-driven solutions.

Entergy’s Open Grants Program aims to enhance community well-being through funding initiatives in arts, education, social services, and community improvement. The program prioritizes support for organizations that serve diverse populations, including children and low-income communities. Eligible entities must have 501(c)(3) status or equivalent nonprofit recognition. Applications should be submitted three months in advance, allowing ample time for review. Entergy focuses on projects that foster self-sufficiency and enrich local neighborhoods.

The Strategic Alliance Matching Grant by the NCAA Division III aims to bolster ethnic minority and gender representation in senior athletics administration roles. With an annual budget of $1.6 million, it supports up to 46 schools and conferences over five years. Eligible institutions must be active NCAA Division III members and meet various requirements. This grant encourages diversity in leadership, fostering an inclusive environment for student-athletes.

The Stimulating Hematology Investigation: New Endeavors (SHINE) program aims to enhance nonmalignant hematology research aligned with the goals of the NIDDK, NIA, and NHLBI. It invites R01 grant applications focused on innovative and early translational hematology topics, fostering growth in this critical research area. Key deadlines for applications span from February 2025 to October 2027, allowing for both standard and renewal submissions.

The Regional Touring Grant Program, funded by the Mid-America Arts Alliance, supports organizations in the M-AAA region to showcase touring artists from outside their state. Grants up to $5,000 are available, with organizations eligible for matching funds and the capacity to submit multiple applications. Projects are designed to enhance arts programming and engage underserved audiences through public-facing events, including performances and outreach activities. This initiative aims to foster cultural exchange and deepen community connections through the arts.

The Waste Management Charitable Contributions Program supports initiatives that enhance environmental stewardship, sustainability education, and community vitality. With a commitment to civic pride and economic development, the program prioritizes organizations that address local needs and promote sustainable practices. Eligible applicants include 501(c)(3) organizations that focus on public purposes, while ineligible requests include funding for operating costs and individual fundraising events. This initiative fosters a collaborative approach to community betterment.

Our Mission

The Community Foundation’s mission is to improve the quality of life in Greater Kansas City by increasing charitable giving, educating and connecting donors to community needs they care about, and leading on critical community issues.

Scholarships

We offer hundreds of different scholarships for students in and around Kansas City.

I-70 Community Hospital Education Foundation Scholarship Fund

To enhance the hospital and community by providing scholarships in the healthcare field, with an emphasis on rural healthcare, and in other ancillary fields deemed appropriate by the scholarship advisory committee.

The Coaching Enhancement Grant by the NCAA Division III aims to increase diversity in assistant coaching roles by providing financial support to member institutions. Over two years, selected schools receive $15,000 to cover salaries, requiring a matching contribution. This initiative encourages ethnic minority and gender representation, allowing up to 11 institutions to benefit annually, thus enhancing inclusivity in collegiate sports.

Community Foundation of the Ozarks

The Community Foundation of the Ozarks (CFO) provides philanthropic leadership to build stronger communities. Our mission is to enhance the quality of life in our region through resource development, community grantmaking, collaboration and public leadership.

We help donors achieve their philanthropic goals through professional management and investment of charitable funds. We work with nonprofit organizations to help them fulfill their missions through fund administration, grantmaking and learning opportunities. We award scholarships to deserving students to help them achieve their educational goals.

Cardinals Fly Together Fund — School Matching Grants

The Springfield Cardinals Fly Together Fund has been created to provide grants to area schools to give students the opportunity to attend a Springfield Cardinals (AA Affiliate of the St. Louis Cardinals) home baseball game. Educational Day Field Trips are an excellent opportunity to incorporate learning through various pre-game educational topics along with the experience of attending a live sporting event.   

Matching grants may be awarded as full or partial requests to provide an amount equal to the amount contributed by the school for a Springfield Cardinals educational day field trip. For example, a full grant will cover 50% of the ticket cost for tickets requested through the grant. A partial grant will cover 25% of the ticket cost for tickets requested through the grant. (Transportation costs and food & beverage expenses are the responsibility of the school and not included in the grant.)

The Asian Cultural Council's New York Fellowship offers a transformative six-month program for artists, scholars, and arts professionals from Asia. Participants engage deeply with New York City's vibrant cultural landscape, attending performances, exhibitions, and workshops while building networks with local communities. This unique opportunity fosters peer-learning and individual artistic development, encouraging fellows to incorporate their experiences into their practices and contribute to their home cultures. The fellowship emphasizes exploration, exchange, and support, culminating in a rich cultural immersion.

The Anderson-Rogers Foundation Grant supports U.S.-based 501(c)(3) organizations focused on environmental protection, animal welfare, climate change mitigation, and social support. Established in 2001, this family foundation prioritizes innovative projects and general operating support for small organizations facing financial constraints. Note that applicants must first submit a letter of inquiry, as the foundation does not fund scholarships or grants to individuals or religious organizations, nor does it support organizations outside the U.S.

The Albert G. and Olive H. Schlink Foundation, established in 1966, has significantly impacted Ohio's nonprofit sector by increasing its annual grant distribution from an initial $500 to over $1.4 million in 2023. The Foundation prioritizes organizations with ties to Erie and Huron Counties and emphasizes thoughtful evaluation of all grant applications. With a focus on community needs, it continues to honor the founders' legacy while adapting to the evolving demands of local nonprofits.

The Share the Bounty Grant, offered by The Andersons Inc Charitable Foundation, aims to enhance the quality of life in communities through support for agriculture, social services, civic engagement, education, arts, and health initiatives. By investing in these key areas, The Andersons seeks to foster environments where individuals and families can thrive, ensuring a sustainable and vibrant future for all residents in the regions they serve.

The Call for Kindness Grant, offered by Riley's Way Foundation, empowers young leaders aged 13-23 to launch impactful social projects focused on kindness and community connection. With grants up to $5,000, recipients receive essential mentorship, coaching, and community support. This initiative has already benefited over 3,500 youth nationwide, promoting values of empathy and social change. Applicants can pursue projects in diverse areas, including environmental justice, ensuring a broad impact in their communities.

The Missouri State Parks Bus Grant Program provides funding to schools and nonprofit organizations to cover transportation costs for field trips to state parks and historic sites. This initiative aims to enhance outdoor learning experiences for children, connecting them with nature while promoting cultural and recreational opportunities. Eligible costs include bus mileage, charter services, and driver wages. The program supports a maximum of two grants per school district to ensure broad access to these valuable educational resources.

The Dana Brown Charitable Trust Grant supports organizations in the St. Louis area that aid financially disadvantaged children, focusing on health, education, and welfare. It encourages programs that expand children's knowledge of nature and wild animals. The Trust favors collaborative, high-impact projects and prioritizes immediate needs over long-term funding. Notably, individual grants are not awarded directly to individuals, and only one Letter of Intent is permitted per year.

The NRA Foundation offers grants in Missouri aimed at promoting charitable purposes under IRS regulations. Eligible applicants include IRS 501(c)(3) organizations, government entities, and recognized nonprofits. The funding supports initiatives in firearms education, safety, and marksmanship, fostering community engagement in these areas. However, labor organizations, private businesses, and individuals are ineligible. The foundation emphasizes compliance with its mission to advance the shooting sports and enhance public safety.

The CHS Foundation offers funding for innovative projects in precision agriculture and data analytics. This annual grant program supports colleges and universities focusing on enhancing agronomy and ag mechanics curriculum. Applications are accepted from April 15 to May 31, with priority given to initiatives that foster hands-on learning and technology development. Eligible projects should emphasize data analysis and improve students' understanding of agricultural technology, while adhering to funding guidelines.

Missouri Prairie Foundation

The Missouri Prairie Foundation is a private, nonprofit, 501(c)(3) land trust governed by a volunteer board of directors. MPF was founded in 1966 by a small group of conservation professionals and volunteers who were concerned about the rapid decline of greater prairie-chickens and the degradation and loss of grassland habitat throughout the state of Missouri. Since that time, MPF has grown and developed with several goals in mind, including the permanent protection of prairie habitat and the need for greater understanding of the role of native grasslands in wildlife conservation, energy security and carbon storage. 

The mission of MPF is to protect and restore prairie and other native grassland communities through land acquisition, management, education, and research; to promote the use of native plants through its Grow Native! program; and to support the control of invasive plants through its administration of the Missouri Invasive Plant Council. 

Prairie Garden Grants Program 

Gardening and other conservation groups, parks, schools, and other entities in Missouri and immediately surrounding states are invited to submit proposals to MPF’s Prairie Garden Grants Program. In 2026, MPF would like to award several grants to help fund the establishment or improvement of public prairie gardens or plantings using Midwest native plants. Grants will not exceed $800 each. Those with smaller projects are encouraged to apply as well. Matching funds are not required, but proposals with secured matching funds may be evaluated higher than others.