Best Large Grants for Nonprofit Organizations in Missouri

The Sergeant John Basilone Memorial Graduate Scholarship, offered by the UNICO Foundation, provides two awards of $3,000 each for graduate students of Italian descent. Eligible applicants must be U.S. citizens, enrolled full-time in accredited programs, and reside in specified states. The scholarship supports students pursuing graduate studies in the academic year 2026-2027. UNICO promotes Italian American heritage and community service, making this scholarship a valuable opportunity for deserving students.

Quality Improvement Grant Request for Proposals

Optimizing Maternal RSV Immunization Delivery: A Systems-Based Quality Improvement Initiative to Improve Uptake, Equity, and Newborn Outcomes

Pfizer, in collaboration with the Society for Maternal-Fetal Medicine (SMFM), is pleased to announce a competitive grant opportunity to support independent Quality Improvement (QI) initiatives focused on advancing maternal immunization, with a specific emphasis on Respiratory Syncytial Virus (RSV) vaccination during pregnancy.

This initiative builds upon insights generated from the Maternal Immunization Needs Assessment (MINA) project, a multi-stakeholder collaboration that identified persistent clinical, behavioral, and system-level gaps in the delivery and uptake of maternal vaccines.

We seek to fund projects that implement measurable, evidence-based interventions to improve real-world delivery of maternal RSV immunization across healthcare systems and care settings. Proposed initiatives should aim to optimize access, strengthen provider–patient communication training and tools, enhance care coordination, and address structural and behavioral barriers impacting vaccine uptake and equity.

Pfizer Global Medical Grants (GMG) supports the global healthcare community’s independent initiatives (e.g., research, quality improvement or education) to improve patient outcomes in areas of unmet medical need that are aligned with Pfizer’s medical and/or scientific strategies. Pfizer’s GMG competitive grant program involves a publicly posted Request for Proposal (RFP) that provides detail regarding a specific area of interest, sets timelines for review and approval, and uses an expert review panel (ERP) to make final grant decisions. Organizations are invited to submit an application addressing the specific gaps in clinical practice or care as outlined in the specific RFP.

For all QI grants, the applicant (and ultimately the grantee) will be solely responsible for the design, implementation, and conduct of the proposed initiative. Pfizer will have no involvement in project development, execution, or outcomes.

The Dunkin' Joyful Spaces Grant supports children's hospitals and community health centers in creating joyful environments for pediatric patients. Launched in 2022, this initiative helps fund play areas, healing gardens, and other kid-friendly spaces, enhancing the hospital experience. Grants typically range from $25,000 to $65,000 annually, with a maximum of $150,000 over three years. This opportunity encourages creativity in designing spaces that provide comfort and joy to children and their families during hospital stays.

The Tree Campus Higher Education Program, initiated by the National Arbor Day Foundation, empowers colleges and universities to cultivate their green spaces and enhance their community forests. By adhering to five standards, institutions can earn recognition while promoting environmental stewardship among students and faculty. Participating schools benefit from reduced energy consumption, improved mental health, and a commitment to sustainability. This program not only beautifies campuses but also fosters a sense of pride among students and the wider community.

The UNICO Foundation's Ralph J. Torraco Scholarship provides two scholarships of $2,500 each to students pursuing a degree. Open to all ethnicities, applicants must be U.S. citizens, attend an accredited college full-time, and maintain a minimum GPA of 3.0. They should continue their studies in the 2026-2027 academic year and may apply if sponsored by a UNICO chapter from specific states. This initiative underscores UNICO's commitment to supporting educational opportunities for deserving students.

The Historic Preservation Tax Credit Program (HTC) in Missouri incentivizes the rehabilitation of historic commercial and residential structures. Small Projects, which seek under $275,000 in tax credits, allow for significant renovations while adhering to caps based on Qualified Rehabilitation Expenditures (QREs). For instance, a project eligible for a 25% tax credit requires less than $1.1 million in QREs, ensuring broad access for smaller rehabilitation efforts.

The Terry and Deborah Mitchel Scholarship provides a $1,000 scholarship to undergraduate students entering their second, third, or fourth year at a Missouri college or university. Applicants must have a minimum GPA of 2.5 and submit a transcript along with an essay. This scholarship is offered by the Community Foundation of the Ozarks, which aims to enhance the quality of life in the region through resource development and community engagement.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5416 - Innovative Approaches to Extend Lifetime and Minimize O&M for Nature-based Installations

Grant Information

• Identify and evaluate innovative design, construction, and management approaches that extend the functional lifetime of nature-based installations and reduce ongoing operations and maintenance (O&M) requirements.
• Develop practical guidance on key factors affecting nature-based solution (NbS) longevity, including hydraulic optimization, engineered media selection and replacement, plant selection, sediment management, and construction-phase best practices.
• Survey utilities and other NbS owners to document current maintenance practices, costs, and hours, and establish benchmarks to inform targets for improvement.

Home Repair Assistance (HeRO) Program

Home Repair Assistance (HeRO) Program provides home repair grants for income-qualifying Missouri residents of single-family homes. MHDC does not award funds directly to households. Interested households should contact a participating agency to apply for the program. 

All project expenses must be within the following limitations:

• The total hard cost must not exceed $25,000 per project;
• The total soft cost that is covered by MHDC must not exceed $2,000 per project; and
• The total administration cost that is covered by MHDC must not exceed 10% of the total cost covered by MHDC per project.

The California Casualty Thomas R. Brown Athletics Grant aims to support public middle and high school sports programs facing funding challenges due to budget cuts. Established by California Casualty, this grant provides financial assistance for purchasing equipment and covering travel costs for competitions. Eligible applicants must be active employees of public schools and members of affiliated education associations. Awards cannot be used for individual student recognition or fundraising projects.

Upward Momentum is a collaborative fund aimed at transforming economic mobility in Missouri. By investing in community-driven initiatives, it seeks to address systemic inequities and foster opportunities for all. The fund emphasizes partnerships and innovative strategies to create lasting change, focusing on the unique diversity of Missouri's communities. With a commitment to inclusivity and collaboration, Upward Momentum is poised to drive impactful solutions that enhance economic well-being across the state.

The THCF Community Grants program offers funding for up to three years for eligible 501(c)(3) nonprofits and local government organizations in Eastern Jackson County. Proposals can focus on areas such as arts, education, community betterment, and health services. Notably, applicants may only seek funding from one grant program, either Community Grants or the Jelley Family Foundation Grants, starting in 2024. This initiative aims to foster community growth and support diverse local projects.

The MEEA Environmental Educator Mini-Grant supports educators in Missouri by providing funding for innovative environmental education projects. Established in 2013, this grant program awards eight grants of $250 each annually to enhance sustainability education. Open to all MEEA professional members, it prioritizes proposals that engage underrepresented groups in environmental learning. Funded by Debby Barker in memory of her husband, Lou Clairmont, this initiative aims to inspire and educate while promoting conservation efforts across the state.

The DGLF Youth Literacy Grants, established by the Dollar General Literacy Foundation, aim to enhance literacy among underperforming students in K-12. Organizations such as schools and libraries can apply for funding to implement or expand literacy programs, purchase necessary materials, and acquire technology. With over $159 million awarded to date, the foundation supports efforts that provide equitable education opportunities, ensuring every child has the chance to learn and succeed, regardless of their background.

The Dollar General Literacy Foundation offers the DGLF Summer Reading Grants, which support the development and expansion of summer reading programs aimed at Pre-K to 12th grade students, particularly new and below-grade-level readers, including those with learning disabilities. Eligible organizations, such as nonprofits, schools, and libraries within 15 miles of a Dollar General store, can apply for grants up to $3,000 to foster literacy and education initiatives.

The Bonnycastle Fellowship for Wetland and Waterfowl Research supports graduate students in advancing conservation efforts. Offered by Ducks Unlimited, this fellowship provides up to $17,000 annually for research and personal support. The fellowship emphasizes the importance of research originality, ecological contributions, and feasibility. It is open to all North American graduate students, with a preference for doctoral candidates. The award is renewable for PhD students up to two years, and once for Master's students, contingent on satisfactory progress.

The MEM Safety Grants program, offered by Missouri Employers Mutual, provides critical funding to enhance workplace safety. With one-to-one matching funds available from $500 to $10,000, it supports policyholders in acquiring necessary safety equipment. Applications are accepted year-round, with decisions made monthly. To qualify, applicants must maintain an active policy and clearly demonstrate the need for safety improvements. This initiative aims to foster safer work environments across Missouri, reflecting the company’s commitment to worker safety.

The CHS Foundation supports initiatives that benefit the agriculture industry, focusing on 501c3 organizations within specific states. Their funding is aimed at empowering cooperative growth and sustainable practices. Local projects may also be eligible through the CHS Seeds for Stewardship program. However, funding is not available for individuals, sports teams, or religious groups, ensuring that the support remains directed towards community and cooperative development.

The Patterson Foundation offers Oral Health Grants to support programs that enhance access to dental care for underserved communities. Eligible 501(c)(3) non-profit organizations can apply for funding up to $35,000 for capacity expansion, $10,000 for personnel support, or $10,000 for program support. The foundation prioritizes projects led by volunteer dental professionals and requires follow-up reports for continued funding. Applications are accepted year-round through a two-step process.

The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.

The Preschool Development Grant Birth Through Five (PDG B-5) SMART Grant aims to enhance early care and education systems in the U.S. by supporting targeted investments in technology and data analytics. This initiative, led by the Administration for Children and Families, encourages states to improve program quality, family choice, and data-driven decision-making for children from birth to five years old. The funding is designed to create measurable outcomes and strengthen coordination within the mixed-delivery system.

The Helen E. Nash, M.D. Educational Trust Fund Scholarship honors Dr. Helen Nash's legacy in St. Louis by providing need-based financial support up to $7,000 annually for qualifying high school seniors. Applicants must be residents of St. Louis City, rank in the top third of their class, and intend to enroll in a four-year college or university in Missouri. This scholarship aims to empower students to pursue higher education, reflecting Dr. Nash's commitment to equality and education.

Ava’s Grace Scholarship, founded in 2010, provides vital educational support to students with incarcerated parents or caregivers in Missouri and parts of Illinois. Offering scholarships up to $5,000 annually, it renews through graduation. This initiative promotes hope and community, transforming lives through education. Eligible applicants must demonstrate financial need and maintain a minimum GPA of 2.0, while also planning to pursue an accredited degree. This program, part of The Scholarship Foundation of St. Louis, aims to foster a brighter future.

The rootEd Undergraduate Scholarship, established by rootEd Alliance in 2018, supports high school seniors from rural Missouri and Idaho in pursuing higher education. This renewable scholarship provides up to $12,000 annually for students attending accredited nonprofit colleges or universities. Eligible applicants must demonstrate financial need, maintain a minimum GPA of 2.0, and be committed to completing a bachelor’s degree program. This initiative aims to enhance educational opportunities and promote success for students in rural America.

The F26AS00104 State ANS Management Plan 2026 aims to combat aquatic nuisance species through pre-proposals followed by full applications. Managed by the US Department of the Interior's Fish and Wildlife Service, this initiative requires a 25% cost-share and limits administrative costs to 5%. Applications are due by October 14, 2026, though the funding opportunity closes on December 16, 2026. The plan is crucial for maintaining biodiversity and supporting a coordinated national approach to invasive species management.

The Missouri State Library advances the development and improvement of library services throughout the state, provides direct library and information service in support of the Missouri state government, and strives to ensure all Missourians have equal access to library services.

Project Lead The Way is offering a rolling grant for schools to implement the PLTW Biomedical Science program for the 2026-2029 academic years. Eligible schools can receive up to $14,000 to cover participation fees and training costs. This grant encourages public, private, and charter schools across the U.S. to enhance their science curriculum, supporting students with engaging, hands-on learning experiences. Schools must commit to offering specific courses during the grant period to qualify for funding.