Best Large Grants for Nonprofit Organizations in Missouri

The Barney Family Foundation Grant focuses on improving early education and advancing medical research, particularly in cancer and Alzheimer’s. It supports organizations that demonstrate a clear plan to enhance children's life experiences and educational opportunities for those in grades K-8. Grants typically range from $5,000 to $50,000, prioritizing established entities while welcoming startups. Eligible applicants must have 501(c)(3) status, and the Foundation does not fund individual requests or political activities.

The AWWA Abel Wolman Fellowship, established in 1984, supports highly qualified students conducting meaningful research in water supply through doctoral programs. Named after Dr. Abel Wolman, this prestigious award recognizes excellence and creativity in the water sector. The fellowship provides up to two years of financial support, with an initial award of $30,000 for the first year, aimed at fostering the next generation of water professionals in the U.S., Canada, and Mexico.

The Quadratec Cares 'Energize The Environment' Grant Program is dedicated to supporting individuals and organizations in the U.S. focused on environmental improvement. With two grants of $3,500 awarded annually, the program encourages initiatives like trail restoration and community educational projects. This grant aims to empower passionate individuals to enhance environmental awareness and stewardship, ensuring a healthier planet for future generations.

The Rural Opioid Technical Assistance Centers program aims to provide essential training and technical assistance to combat opioid and stimulant misuse in rural areas. With 10 Regional Centers and a National Coordinating Office, the initiative focuses on high-quality prevention, treatment, and recovery support services for substance use disorders. This program anticipates awarding 11 new grants to enhance community health and safety in addressing polysubstance use challenges.

Loene Pooler Guthrie Scholarship Fund

The Loene P. Guthrie Scholarship fund benefits music students in Benton, Linn, and Lincoln counties who plan to engage in the teaching of piano, voice, and orchestral music.

This scholarship fund promotes the teaching of piano, voice and orchestral music by aiding music students in Benton, Linn, and Lincoln Counties who plan to engage in the teaching of piano, voice, and orchestral music. Students who will graduate from Linn, Benton, or Lincoln County high schools or graduates of those high schools currently studying music at an institution of higher learning may apply. The Linn-Benton Chapter of the Oregon Music Teachers Association reviews the applications and selects individuals to perform at an audition open to the public.

Hungry for Music

The Hungry for Music story began in 1992, when Founder and Director Jeff Campbell (in photo) organized a street musician concert to benefit the homeless. Within three years, he formed a 501(c)(3) nonprofit organization, dedicated to expanding opportunities in music for children.

Since then, Hungry for Music has placed more than 27,000 instruments into the hands of aspiring musicians. Children whose trajectory has been altered by the uplifting and life-changing gift of music.

We've delivered everything from guitars and trombones to violins and xylophones to kids in 50 states and 35 countries.

We collect and redistribute more than 2,000 instruments annually and, in our 31-year journey, we've become a full-time force for good in the musical community.

Request an Instrument

Hungry for Music collects and distributes instruments including brass, woodwinds, strings, electric keyboards, drums and other percussion, as well as amps and accessories.

Who Hungry for Music Helps

• Music teachers at Title One schools who identify children who cannot participate because of lack of funding.
• Music directors at innovative after-school music programs.
• Social workers who have young clients who would benefit from music therapy.

We only accept requests from public school music teachers, administrators, after-school/summer music program directors, and social workers. 

In our history, we have supported music programs in 40 different countries through stateside sponsors (i.e. business, school, church). We do not accept requests directly from international programs.

After-School & Summer Programs

Hungry for Music supports more than three dozen after-school/summer music programs annually across the United States. To be added to our distribution, a site visit is required.

Harry C. Anthony, Jr. Scholarship

Essay:

• Describe yourself and explain why you are interested in a career in medicine.

Awards:

• One-time award of $2,500

The Rare Impact Fund, founded by Selena Gomez, is dedicated to transforming mental health support for young people. With a commitment to mobilizing $100 million, the fund aims to enhance access to mental health services and promote a stigma-free community. Through public Requests for Proposals, the initiative seeks to strengthen the nonclinical youth mental health workforce, ensuring effective support systems that reflect the diverse backgrounds of youth. This innovative approach fosters lasting change in mental health care.

AARP Foundation

AARP Foundation strengthens financial resilience for and with older adults by empowering individuals and improving systems.

AARP empowers people to choose how they live as they age. There are 125 million Americans who are 50 or older, and people want their money, health and happiness to last as long as they do. We are a wise friend and fierce defender, focusing on the priorities of older Americans.

Purpose Prize® from AARP

Honoring extraordinary people 50-plus who put their purpose into action.

Purpose is a powerful force for good. The Purpose Prize from AARP honors extraordinary older Americans who put their purpose into action to support AARP’s mission of empowering people to choose how they live as they age. Winners receive $75,000 and a year of organizational support from AARP to grow the impact of their nonprofits. Examples of organizational support include data and evaluation, governance and succession planning, fundraising strategy, and prospectus development.

The AWWA Scholarship Program, specifically the Carollo Engineers Bryant L. Bench Scholarship, offers a $10,000 award to graduate students dedicated to advancing their careers in the water consulting engineering field. Established in honor of Bryant L. Bench, this scholarship aims to support future leaders who will enhance drinking water quality through innovative engineering solutions. The American Water Works Association emphasizes the importance of investing in students to secure the future of the water industry.

The Nicholas B. Ottaway Foundation offers grants through its Education Committee to support programs enhancing educational opportunities for economically disadvantaged students. These grants focus on initiatives like tutoring, college preparation, and internship programs. To qualify, organizations must be tax-exempt under 501(c)(3). Preference is given to projects that provide ongoing support to students post-graduation, particularly in specific geographic areas such as San Diego County and the New York Metropolitan Area.

NAFC Open Grant/Product Donation Applications

The National Association of Free and Charitable Clinics (NAFC) is the only nonprofit 501c(3) organization whose mission is solely focused on the issues and needs of the medically underserved throughout the nation and the more than 1,400 Free and Charitable Clinics that serve them. The NAFC has earned the Platinum Seal of Transparency from GuideStar and a 4-Star rating from Charity Navigator. Founded in 2001 and headquartered near Washington, D.C., the NAFC is working to ensure that the medically underserved have access to affordable quality healthcare and strives to be a national voice promoting quality healthcare for all. For more information about the NAFC, including how to become a member, please visit https://www.nafcclinics.org.

Healthcare Access Initiative

The Healthcare Access Initiative, supported by the McKesson Foundation and administered by the NAFC, aims to expand access to essential healthcare services for uninsured and medically underserved individuals. Free and charitable clinics and pharmacies play a critical role in ensuring that patients who fall outside traditional healthcare systems can receive timely, high-quality care. However, many clinics face barriers related to staffing, care coordination, technology, and patient outreach that limit their ability to meet growing community needs. Through this initiative, NAFC will provide $20,000 grants to member clinics and pharmacies to strengthen programs that increase access to primary care, specialty services, and preventive care. Funding will support innovative and practical approaches that reduce barriers to care, improve patient engagement, and expand the capacity of clinics to serve vulnerable populations.

The Adtalem Global Education Foundation, established in 2010, is dedicated to enhancing education and community development. Based in Chicago, it focuses on expanding educational access, particularly for underrepresented minorities in the healthcare sector. The foundation prioritizes initiatives that promote economic growth through skills-based workforce development, address healthcare disparities, and increase access to quality education for underserved populations. Its commitment to civic engagement and equality reflects its mission to empower communities.

Brooks Brothers, founded in 1818, is committed to social responsibility through its donation program. The company partners with local and national non-profits focused on health issues and education. They seek to enhance community well-being while maintaining a commitment to inclusivity. Notably, they do not support organizations that discriminate based on protected categories. Their donations are aimed at fostering positive change in society, reflecting their belief in the importance of community engagement.

Theresa Alessandra Russo Foundation Inc

The Theresa Foundation honors the memory of Theresa Alessandra Russo by touching the lives of children with special needs and their families. The Foundation fosters each child’s unique abilities by supporting programs focusing on art, music, dance, drama, and recreation.

The Theresa Foundation has a vision of the world where artistic expression and physical recreation are just as important to adults as they are to children. We believe in a world where every child, regardless of ability or challenging conditions, is free to communicate through and participate in every art or recreational activity. A society without art is a society without soul. Art enables us to express our inner thoughts, fears, joys, and sadness.  

The Theresa Foundation Grant Program

The Theresa Foundation Grant Program is committed to providing financial support for programs in art, music, dance, drama, or recreation that are designed specifically for children with special needs in order to ensure that no one is excluded from these activities. 

We believe that every individual should have the opportunity to participate in art, music, dance, drama or recreation if they so choose. Our grant program works to provide direct funding for the success of these activities, while also promoting an environment of acceptance and inclusiveness where all can take part without judgment or fear. 

As of 2026, the Theresa Foundation has provided over $3,300,000 in grant funding for over 200 programs in 29 states throughout the country and 4 international grants. With your help we can continue to make a difference in the lives of those with special needs by providing them access to enriching experiences that would otherwise be out of reach. 

The Harry Chapin Foundation grants support 501(c)(3) organizations in the U.S. focused on self-sufficiency. They prioritize grassroots programs in the arts, community education, and environmental sectors, with a budget cap of $750,000. Grants are typically awarded for one year, with renewals requiring a new proposal each year. Organizations using fiscal agents or applying for individuals are not eligible. The foundation is dedicated to improving lives through sustainable initiatives.

The LASC Foundation offers grants to nonprofit organizations in the Greater Metropolitan St. Louis Area focusing on poverty relief through targeted partnerships. Eligible projects include food security, youth development, and education initiatives. First-time applicants should contact the foundation’s program officer before applying, while unsolicited proposals are accepted year-round. The foundation aims to foster sustainability and self-determination within communities, supporting both faith-based and non-faith-based organizations.

The Natural History Research Experiences (NHRE) is a prestigious 10-week summer internship program at the Smithsonian's National Museum of Natural History. It offers undergraduates the chance to engage in independent research across various disciplines including Earth Science and Anthropology. Participants receive a stipend of $8250, travel support, and free housing, while benefiting from mentorship by leading scientists. This program aims to cultivate future leaders in natural history research.

The Amcor Community Support Grants Program, administered by the Amcor Cares Foundation, provides funding for projects that benefit local communities. Grants are available to 501(c)(3) organizations and accredited educational institutions that serve Amcor Flexibles North America facility communities. Focus areas include fighting hunger, supporting disaster relief, expanding STEM education, and enhancing health and wellness. Applications are reviewed quarterly, and grant amounts typically exceed $1,000.

The Amy Adina Schulman Memorial Fund

The Amy Adina Schulman Memorial Fund is a Princeton, New Jersey-based endowment fund providing grants to individuals, young adults who volunteer or intern for progressive social action projects or programs in an area of their interest and commitment. The Amy Adina Fund also sponsors a lecture each year on a relevant and timely topic related to its educational mission.

The Amy Adina Schulman Memorial Fund was started in 1987 one year after Amy Adina, 20, died suddenly while a student and activist at Rutgers University. It is a realization of her family and her communities’ desire to celebrate her life, to fulfill her dreams and her potential. Since its inception, almost 1,500 grants have been awarded for work in Africa, Asia, Latin America, the Middle East, and the United States—nearly $1,000,000 in total. The Amy Adina Schulman Memorial Fund is a 501(c)3 nonprofit organization.

About Our Grants

Small grants (depending on length of service), are awarded to as many applicants as possible rather than giving larger amounts to fewer individuals. The number of awards has grown each year thanks to annual contributions as well as to gifts sent to the Fund to honor special occasions and life cycle events.

The Community Connect Grants Program provides financial assistance to eligible applicants aiming to deliver broadband services in rural areas where access is limited. This initiative fosters economic growth and enhances educational, healthcare, and public safety benefits, improving the quality of life in underserved communities. By supporting projects that create better market opportunities and promote equitable access, the program plays a vital role in advancing rural development and addressing environmental justice.

The Udall Undergraduate Scholarship, awarded by the Morris K. Udall and Stewart L. Udall Foundation, supports future leaders in environmental, tribal public policy, and health care fields. With 55 scholarships of $7,000 each expected in 2025, this highly competitive program requires students to participate in their schools' internal competitions. Scholars benefit from networking opportunities and access to the Udall Alumni Network, fostering collaboration and growth in their respective fields.

The Conservation Practitioner Award, presented by the American Ornithological Society, recognizes dedicated professionals at any career stage who address avian conservation issues at local or regional levels. This award includes a certificate and a $1,000 honorarium, acknowledging the critical work of individuals or groups in government or non-government organizations. The AOS aims to promote ethical standards and support a diverse community of ornithologists committed to bird conservation.

Delaney Family Foundation 

The Delaney Family Foundation is a private family foundation focused on making grants to support Wildlife and Land Conservation, Education, Healthcare and Community Betterment.

The Delaney Family Foundation was established in 2013. We make both program and operating grants and do not have geographical restrictions.  

Grant Information

Grants are awarded annually. The following criteria will be used in confirming that grant requests match the goals of The Delaney Family Foundation.

• Clarity of Purpose – the request should be clearly defined with a specific description of how goals/tasks will be achieved and how funds will be spent.
• Potential for Success – the organization must demonstrate that they have funding sources, manpower, and community support as well as the time to achieve their goals. Projects must be realistic.
• Leadership – stability in the organization is a requirement, as well as a well-deserved reputation for results.
• Site Visits – While not always possible, site visits by board members prior to gifting, during gifting or following may be considered.

 We may consider multi-year grants.

Hispanic Heritage Foundation

Established by the White House in 1988, the Hispanic Heritage Foundation—a 501(c)(3) nonprofit organization—continues to advance its mission through award winning programs that adapt to the needs, aspirations, and vision of our community while delivering a strong value proposition for the country.

HHF’s mission and programs have been recognized by The White House, US Congress, Fortune 500 Companies, US Army, other nonprofits, and even the Government of Mexico, in five areas of focus: education, workforce development, societal impact, and leadership, with culture serving as the cornerstone of its mission.

Youth Awards

The 28-year-old Youth Awards have recognized thousands of high school students from all 50 states, Puerto Rico, and Washington, D.C., for their achievements in the classroom, community, and focus on career paths in STEM fields, entrepreneurship, media, public service, and other categories.

Gold, Silver, and Bronze recipients are selected in each category and receive a one-time innovation grant to fund their college education or support a community service effort addressing a social issue. Additionally, one national awardee is selected in each category.

Once selected, recipients are celebrated in virtual ceremonies and become part of the LOFT (Leaders On Fast Track) Network, a collective of 300,000+ students and young professionals with access to mentors, resources, networking opportunities, workshops, symposia, summits, internships, and full-time positions with Fortune 500 companies.

The Social Impact Fund - Nationwide Grant supports innovative solutions addressing health care access, food security, and economic empowerment. Funded by the American Heart Association, this grant prioritizes community-led projects from organizations with under $10M in revenue. Eligible entities include both for-profit and nonprofit organizations based in the U.S. and Puerto Rico. Grants can provide up to $250,000 to initiatives that demonstrate measurable impact, fostering sustainable change in health and wellness.

The William J. Brace Charitable Trust Grant supports educational, cultural, human services, and health care initiatives, focusing on the well-being of children and older adults, as well as hospitals in Kansas City, Missouri. Established in 1958, this private funder emphasizes general operating and program support for eligible organizations. Note that capital support requests are not considered. Grants typically last for one year, aiding community improvement and capacity building.