Upcoming Webinar
How Funders Feel About AI, and What Keeps Them Saying Yes.
Wed, Oct 14 @ 2PM ET

Skip to main content
Main content

Best Large Grants for Nonprofit Organizations in Missouri

Find the perfect Large Grants for Nonprofit Organizations in Missouri on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Missouri in the United States.

10,000+

Available grants

$2.59B

Total funding

$5K

Median grant

10,000+ grants
$2.59B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,667 Results based on applied filters

Costco Wholesale Charitable Contributions

Costco Wholesale Corporation
Corporate
United States
Unspecified amount
The Costco Wholesale Charitable Contributions program prioritizes support for children, education, and health services within local communities. Nonprofit organizations seeking assistance must be 501(c)(3) certified and focus on monetary requests. Applications are reviewed within 4-6 weeks, factoring in community needs and collaboration. However, Costco limits grants to 10% of the program budget and typically restricts organizations to one request per fiscal year. They do not fund individuals or direct aid for various specific purposes.
Youth Services Child Welfare Services Education +4 more

Kyndryl Foundation Grant

Kyndryl Charitable Foundation
Private
Czech Republic, Hungary +5 more
Unspecified amount
The Kyndryl Foundation Grant aims to empower communities through investments in education, technology, and workforce development. With a focus on cybersecurity and AI skills for underrepresented learners, the foundation fosters balanced partnerships and innovation. It prioritizes transparency and integrity, ensuring grants support long-term impact. This initiative aligns with Kyndryl's mission to create a sustainable future by enhancing access to opportunities and resources for all, thereby promoting diversity and inclusivity in economic growth.
Cybersecurity Workforce Preparation & Job Readiness Career / College Preparation +2 more

Drug-Free Communities (DFC) Support Program – Competing Continuation (Year 6)

US HHS: Substance Abuse and Mental Health Services Administration (SAMHSA)
Federal Government
American Samoa, Guam +4 more
Up to US $125,000
The Drug-Free Communities (DFC) Support Program aims to foster collaboration among community coalitions to combat youth substance use. Established by the Drug-Free Communities Act of 1997, it encourages partnerships among various stakeholders, including governmental and non-profit agencies. The program focuses on reducing substance use among youth and promoting protective factors within communities. This funding opportunity is available for those who have completed the initial funding cycle or experienced funding interruptions, supporting their ongoing efforts to create a healthier environment for youth.
Addiction & Substance Use Disorders Drug Use Disorder Community / Public Safety

CDV5 Foundation Grant

Cdv5 Foundation
Private
United States
Unspecified amount
The CDV5 Foundation Grant supports charitable organizations, churches, and government entities that meet IRS 501(c)(3) requirements. This grant aims to nurture successful children, foster stronger families, and cultivate healthier communities. Through partnerships, the foundation provides resources to help individuals reach their full potential. Applicants may submit one request annually for operating, capital, or program support, while event sponsorships are also considered. The foundation encourages applicants to consider their budget and history with the foundation when requesting funding.
Early Childhood Development Youth Development & Leadership Education - Preschool / Early Learning +6 more

Golden Goldman Fund

Foundation For Jewish Philanthropies
Private
United States
US $2,000 - US $20,000

Our Mission

Empower donors to fulfill their passions and dreams by establishing charitable vehicles designed to create a positive and enduring impact on Jewish Buffalo, Western New York and the World.

Golden Goldman Fund

The Golden Goldman Philanthropic Fund’s mission is to maximize local impact in support of: Women’s issues including reproduction and choice; Arts and Culture; Literacy; Reducing Income Inequality; and Judaism.

Funding will be awarded based on your proposal's potential impact. We will be looking at the applying organizations' fiscal viability and their ability to reach out to underserved individuals as part of our evaluation process. We do not usually provide funding for ongoing, existing programs.

Reproductive Health Women's Health Reproductive Rights +5 more

Thriving Community Impact Fund: Support Grants

GUNDERSEN LUTHERAN MEDICAL FOUNDATION INC
Private
United States
Up to US $2,499
The Thriving Community Impact Fund offers grants up to $2,499 to support local programs that enhance community health and well-being. This initiative by Gundersen Health emphasizes collaboration, focusing on areas such as physical and mental health, poverty alleviation, and neighborhood improvements. Organizations like non-profits and government agencies can apply for funding during a rolling application period, with decisions made monthly. The fund aims to empower communities and address health inequities through impactful partnerships.
Mental Health & Psychiatric Diseases Wellness & Healthy Living Poverty Alleviation & Services +5 more

Modernizing Violent Death and Suicide Surveillance Using the National Violent Death Reporting System (NVDRS)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Up to US $966,085
The National Violent Death Reporting System (NVDRS) is a crucial surveillance initiative by the CDC aimed at understanding violent deaths and suicides. This funding opportunity supports state and local entities in modernizing NVDRS, enhancing data collection and reporting processes. Key activities include timely data updates, modernization assessments, and pilot projects for improved data systems. The goal is to create a sustainable national surveillance system that provides reliable data to inform public health actions and enhance violence and suicide prevention efforts.
Computer Science & Engineering Suicide Prevention Violence Prevention

Alma Gibbs Donchian Foundation Grants

Alma Gibbs Donchian
Private
United States
Up to US $10,000
The Alma Gibbs Donchian Foundation provides grants primarily to support institutions in Vermont, focusing on issues such as elderly welfare, educational assistance for learning disabilities, and community preservation. Emphasizing partnerships and innovative program models, the Foundation prefers applicants with a strong financial management background. Grants typically range from a few thousand dollars to $20,000, with larger amounts considered for significant impact projects. Eligibility is limited to tax-exempt organizations.
Special Needs Education Communication Disorders Learning Disabilities +4 more

Walter Blackburn Scholarship

Central Indiana Community Foundation
Private
United States
Unspecified amount
The Walter Blackburn Scholarship, established by Alpha Blackburn in memory of her husband, supports Marion County residents pursuing degrees in design, architecture, fine arts, performing arts, or construction management. Eligible students must demonstrate financial need and maintain a GPA of 3.0 or higher. Preference is given to public school and minority students. Awards cover educational expenses at accredited institutions, including tuition, fees, and sometimes room and board, fostering educational opportunities in Central Indiana.
Architecture Fine Art Performing Arts +4 more

FRS: Community Grant Program

Foundation for Rural Service
Private
United States
US $250 - US $5,000
The FRS Community Grant Program supports rural communities served by NTCA members, offering grants up to $5,000 for various local initiatives. Priority is given to projects that promote economic development, education, health, and public service. Eligible applicants must secure a 10% match of the grant amount requested. Ineligible projects include overhead expenses, individuals, and those without secured funding. FRS aims to foster sustainable and engaged rural communities through these efforts.
Rural Development Business Development Economic Services & Development +2 more

Howard Brown Rickard Scholarship

National Federation Of The Blind Inc
Private
District of Columbia, Puerto Rico +1 more
US $10,000

About Us

Who We Are

The National Federation of the Blind is the oldest and largest nationwide organization of blind Americans. Founded in 1940 and currently headquartered in Baltimore, the NFB consists of affiliates, chapters, and divisions in all fifty states, Washington, DC, and Puerto Rico.

What We Do

Through our network of blind members, we coordinate many programs, services, and resources to defend the rights of blind Americans, provide information and support to blind children and adults, and build a community that creates a future full of opportunities.

What We Believe

We are the only organization that believes in the full capacity of blind people and has the power to transform our dreams into reality. We believe in blind people because we are blind people—from our democratically elected leaders to our diverse nationwide membership.

Scholarship Program

Thanks to our generous partners, there are thirty $10,000 merit-based scholarships currently available. All scholarships are awarded on the basis of academic excellence, community service, and leadership. The finalists are announced every spring. They then attend our national convention in July when the winners of each individual scholarship are selected. 

Howard Brown Rickard Scholarship

The Howard Brown Rickard Scholarship, first granted in 1965, is awarded to post-secondary full time students studying law, medicine, engineering, architecture, or the natural sciences.

Education - Higher Education Vision Impairment Care & Services College Success / Persistence +5 more

Community Advocacy & Partnership Engagement (CAPE) Grant

National Education Association Staff Organization
Private
United States
Unspecified amount
The NEA Community Advocacy & Partnership Engagement (CAPE) Grant aims to support local affiliates in mobilizing community organizations to enhance student achievement, particularly for students of color. Key priorities include fostering initiatives for racial justice in education, engaging NEA members trained in leadership, and creating union roles for community engagement. This grant encourages collaboration between educators and community leaders to build capacity and drive positive change.
Education - K through 12 Social Justice / Human Rights Academic Success & Enrichment +4 more

The Rosalie Out of the Ordinary Scholarship

Childrens Brain Tumor Foundation Inc.
Private
United States
US $1,000

About

The Children’s Brain Tumor Foundation (CBTF) was founded in 1988 by a group of dedicated parents, physicians, and friends to improve the treatment, quality of life, and the long term outlook for children with brain and spinal cord tumors through research, support, education, and advocacy to families and survivors. In addition to providing funds to research a cure, the organization is the nation’s leader in quality of life programs for families impacted by brain and spinal cord tumors. We support families from the day of diagnosis and throughout the brain tumor journey.

CBTF believes in the importance of being responsive to the needs of everyone in the brain tumor community regardless of their racial/ethnic background. We believe in the importance of a culture that values people of all racial/ ethnic backgrounds. We value the many identities that an individual brings to the community and honor and appreciate the intersections of these identities. Our practice values respect, integrity and honesty. We are committed to inclusiveness. 

The Rosalie Out of the Ordinary Scholarship

Thank you for applying for the Rosalie Out of the Ordinary Scholarship. This opportunity is given in memory of Rosalie Ou, a brain tumor survivor who brought positive energy and creativity everywhere she went. Her passions were fashion, art, and friendship. Rosalie taught many of us the art of origami and at the same time instilled in us lessons about how to live a life filled with joy. Rosalie was not able to complete her degree at the Fashion Institute of Technology. In her memory we dedicate this scholarship to a student who wants to fulfill their dream of a career in fashion or art.

Art & Culture Education - Higher Education Vocational & Trade Education +4 more

The Jandy Ammons Foundation Grant

The Jandy Ammons Foundation
Private
United States
Unspecified amount
The Jandy Ammons Foundation, established in 2012, is committed to enhancing local communities through innovative, project-driven initiatives. Focused on 'shovel ready' projects, it supports wildlife conservation, educational efforts, artistic installations, and Christian mission endeavors. By providing resources to IRS-recognized 501(c)(3) charities, the foundation aims to inspire community engagement and sustainable growth. The foundation reflects the collaborative spirit of its founders, Andy and Jan Ammons, who believe in hard work, integrity, and maximizing available resources.
Community Development & Revitalization Land / Habitat Conservation Environmental Conservation +5 more

Target Community Engagement Funds Grant

Target Foundation
Corporate
U.S. Territories, United States
US $1,000 - US $15,000

Target Foundation

At Target Foundation, we envision a world where all families and communities have the resources they need to determine and realize their own joy in life. It’s a reality that is out of reach for far too many families as they struggle for access to economic opportunity, financial stability and the kind of empowerment that lifts up their communities. We believe we have a responsibility to work to remove barriers and to help create that access, resulting in a world where all families can thrive.

Community Engagement Funds

Community Engagement Funds (CEF) is a community grant program that empowers Target stores and distribution center leaders to make meaningful, localized giving decisions that meet the needs of the communities where our team members and guests live, work, and thrive.

  • Organizations cannot apply for the same program in both grant cycles.
  • Organizations are encouraged to apply during the cycle that best aligns with their program timing.
  • A maximum of 10 applications is allowed per organization at any time.

CEF will prioritize nonprofit programs and initiatives aligned to its focus areas:

  • Thriving Families; Basic needs and youth development..
  • Vibrant Neighborhoods: Community vitalization; Community and green spaces.
  • Emerging Creative & Culture: Cultural partnerships and creative programming.
  • Economic Opportunity: Workforce development.

Workforce Preparation & Job Readiness Basic Human Needs Youth Development & Leadership +3 more

Greater St. Cloud Public Safety Foundation Scholarship

CommunityGiving
Private
United States
US $2,000
The Greater St. Cloud Public Safety Foundation Scholarship, offered by CommunityGiving, aims to support high school seniors, college students, and non-traditional students from Benton, Stearns, or Sherburne County in Minnesota. Eligible applicants should have a GPA of 2.5 or higher and pursue a degree in Criminal Justice or First Responder programs. This scholarship fosters leadership and community involvement, ensuring a lasting impact on public safety and local services.
Academic Scholarship Programs Education - Higher Education Emergency Medical Care & Services +4 more

LHGM General Operating Grant

Larry H Miller & Gail Miller Family Foundation
Private
Arizona, Colorado +5 more
Up to US $10,000
The Larry H. & Gail Miller Family Foundation offers General Operating Grants aimed at 501(c)(3) nonprofits that serve the west side of Salt Lake City. Grants of up to $10,000, with an average of $5,000, support initiatives in health, shelter, education, economic self-reliance, and cultural enrichment. Applications are reviewed monthly. Organizations must be registered as nonprofits and align with the Foundation's focus areas to be eligible for funding.
Community Culture & Heritage Basic Human Needs Religion & Spirituality +3 more

Career Development Grants

American Association of University Women (AAUW)
Association/Society
United States
Up to US $8,000
The Career Development Grants, offered by the American Association of University Women (AAUW), support women with bachelor's degrees seeking to advance or change careers, particularly in high-growth STEM fields. These grants fund post-bachelor's coursework, including master's degrees or certifications, at accredited institutions. Applicants must demonstrate a commitment to their educational pursuits and meet specific eligibility criteria, such as being enrolled in accredited programs that promote women's participation in underrepresented fields.
Workforce Preparation & Job Readiness Career / College Preparation Education +7 more

MCFA Grant

Mitsubishi Corporation Foundation for the Americas
Corporate
Americas
Unspecified amount
The Mitsubishi Corporation Foundation for the Americas (MCFA) supports environmental initiatives across the Americas, focusing on biodiversity conservation, environmental education, justice, and sustainable development. They prioritize programs that align with these aims, particularly those involving 501(c)(3) organizations. MCFA seeks to empower marginalized communities, promote ecological stewardship, and encourage sustainable economic practices, ensuring that environmental burdens are shared equitably across all communities.
Sustainability Environmental Conservation Environmental Justice & Advocacy +2 more

Baughman Family Foundation Grants

The Baughman Family Foundation
Private
United States
US $1,000 - US $3,000

Our Mission

The Baughman Family Foundation aims to make an impact on our local communities by supporting organizations nominated by family members. The goal of the foundation is twofold: to make a meaningful impact on our selected charitable organizations and to encourage family members to become active in charitable giving.

Submission Guidelines

When submitting an application, please keep the following guidelines in mind:

The focus of the Baughman Family Foundation is on supporting local charities where the Foundation can make a direct, tangible impact on causes that matter to our family.

Art & Culture Humanities & Social Science Education +7 more

Rural Communities Opioid Response Program - Child and Adolescent Behavioral Health

Health Resources and Services Administration
Federal Government
American Samoa, Guam +7 more
Up to US $1,000,000
The Rural Communities Opioid Response Program focuses on enhancing behavioral health care services for children and adolescents in rural areas. By providing essential funding, this initiative aims to tackle mental health and substance use disorders, ensuring that young individuals receive the support they need. The program, administered by the Health Resources and Services Administration, is crucial in addressing the unique challenges faced by rural communities, promoting healthier outcomes for future generations.
Community Services Addiction & Substance Use Disorders Drug Use Disorder

El Dorado Springs Affiliate Grantmaking Program

Community Foundation of the Ozarks Inc.
Private
Cedar County, Missouri
US $2,500
The El Dorado Springs Affiliate Grantmaking Program, managed by the Community Foundation of the Ozarks, supports 501(c)(3) organizations and IRS-approved entities serving Cedar County. With a funding limit of $3,000, this program addresses vital community needs through flexible grantmaking. The foundation prioritizes projects that enhance the lives of local residents while ensuring non-discrimination in funding use. Applications are accepted periodically, reflecting the community's most pressing requirements.
Community Services Health & Medicine Human & Social Services +7 more

Graduate Education Fund: AUKUS Scholarships

American Australian Association
Private
Australia, United States
Up to US $40,000
The Graduate Education Fund: AUKUS Scholarships, established by the American Australian Association, supports American and Australian citizens pursuing full-time graduate studies in security, technology, and diplomacy. With up to $40,000 in funding for tuition and living expenses, this scholarship encourages innovative research in critical fields, particularly in relation to the AUKUS initiative. Applications are open biannually, fostering educational exchange and collaboration between the two nations.
Domestic / Homeland Security International Security Emerging Technology Development +3 more

Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The Mechanism for Time-Sensitive Substance Use Research (R21 Clinical Trial Optional) invites applications that address urgent research needs in substance use epidemiology and health services. This funding opportunity encourages pilot studies focusing on emerging drug issues, unexpected prescription drug abuse trends, and timely medical system challenges. Letters of Intent are recommended 30 days before the proposal deadline, emphasizing the necessity for rapid review and funding to address pressing scientific questions.
Addiction & Substance Use Disorders Drug Use Disorder

HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $140,000
The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.
Drug Use Disorder Addiction & Substance Use Disorders

NAMM Foundation: Music Research Grants

Namm Foundation
Private
United States
US $5,000 - US $25,000
The NAMM Foundation Global Grantmaking Program provides music research grants aimed at enhancing music education and career mobility. With a focus on eliminating barriers for underrepresented communities, grants range from $5,000 to $25,000. The foundation supports high-impact organizations that demonstrate measurable outcomes and align with its mission of fostering music makers. Eligible applicants include those with a strong research track record and innovative project proposals that do not duplicate existing studies.
Music Workforce Preparation & Job Readiness Music Education +1 more

See, Test & Treat Grant - Multiyear Funding

College Of American Pathologists Foundation
Private
United States
Up to US $50,000
The See, Test & Treat Grant offers vital funding for cancer screening and health education programs targeting medically underserved communities. This pathologist-led initiative aims to reduce healthcare barriers, empower preventive care, and connect patients with local resources. Eligible organizations can apply for up to $50,000 over three years, fostering sustainable health improvements. The program emphasizes same-day results for screenings and culturally appropriate education, ensuring equitable access to essential healthcare services.
Reproductive Health Breast Cancer Reproductive Education +1 more

Large Grants for Nonprofit Organizations in Missouri Highlights

Looking for large grants for nonprofit organizations in Missouri?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Missouri recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Missouri

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Large Grants for Nonprofit Organizations in Missouri grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Large Grants for Nonprofit Organizations in Missouri over $25K in average grant size

29 Large Grants for Nonprofit Organizations in Missouri over $50K in average grant size

25 Large Grants for Nonprofit Organizations in Missouri supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in Missouri supporting programs / projects

600+ Grants on Instrumentl focused on Food Access & Hunger

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Missouri?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Missouri?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Missouri year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Missouri given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Missouri changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081