Best Raleigh Grants for Nonprofits in North Carolina

The NIH Stroke Clinical Trials Network (StrokeNet) aims to enhance stroke treatment and recovery through a robust national infrastructure. Funded by the National Institutes of Health, this initiative focuses on clinical trials that evaluate innovative therapies for stroke patients and those at risk. The program is currently not soliciting applications but encourages the development of collaborations to support the national coordinating center and data management efforts, ultimately improving outcomes for individuals affected by stroke.

The NIDA Avenir Program aims to cultivate innovative leaders in addiction science by funding exceptional early stage investigators (ESIs) embarking on pioneering research. Launched in 2015, this initiative encourages high-risk, high-reward mechanistic studies related to Substance Use Disorders (SUDs) across diverse scientific domains. Applications from new investigators and those outside addiction research are welcomed, fostering interdisciplinary approaches that enhance understanding of SUD mechanisms. The program supports ESIs who may lack preliminary data but demonstrate potential for impactful contributions.

The BRAIN Initiative aims to advance innovative neurotechnologies by funding early-stage clinical studies for devices that record or stimulate the human central nervous system. This initiative encourages collaborations between clinical researchers and device manufacturers to facilitate groundbreaking studies. By addressing the challenges of obtaining safety and utility data, this program supports both non-invasive and significant risk devices, providing essential insights into their functionality and design. Applications are currently not being solicited, allowing time for meaningful project development.

The BRAIN Initiative, led by the NIH, aims to advance neurotechnologies at institutions with limited NIH funding. This funding opportunity encourages collaboration and knowledge transfer to integrate innovative neurotechnologies into research and training programs. While applications are currently not being solicited, potential applicants should start developing partnerships and projects in preparation for future submissions. This initiative will enhance the dissemination of BRAIN technologies and support novel research practices.

Stars, Stripes & Skilled Trades

General Motors invites eligible 501(c)(3) nonprofit organizations to submit proposals for Stars, Stripes & Skilled Trades, a workforce development initiative designed to support veterans, transitioning service members, and military-connected family members—including spouses—in building lasting careers in manufacturing, automotive, and skilled trades. GM is seeking scalable, results-driven programs that create clear pathways to quality careers while recognizing the experience and leadership that veterans and military families bring to American industry. 

We're looking for existing initiatives that:

• Serve career-transitioning service members, veterans, and military-connected family members
• Provide industry-recognized training, certifications, or credentials
• Connect participants to mentorships, quality jobs, and long-term career pathways in manufacturing, automotive technician roles, or skilled trades.

Grant Range

• $100,000 | $250,000 | $500,000

Mellon Foundation

The Andrew W. Mellon Foundation was established in 1969 to strengthen, promote, and defend the arts and humanities as essential to democratic societies. Throughout our history, Mellon has held true to our founding commitments, secure in our conviction that the arts and humanities are essential to the health of a multivocal and democratic society. From our earliest days, we have aspired to build partnerships with our grantees, offering expertise and counsel in addition to funding

In recent years, Mellon has expanded on these core principles by actively prioritizing social justice across all of our grantmaking. This strategic shift builds on our long history of advocating for and investing in expanded access to higher education, humanities, and the arts, and addressing historical inequities in these fields. Our vision for Mellon’s future includes a focus on justice for all in all that we do—rooted in the Foundation’s long-held historic belief in the impact and power of the arts and humanities. At Mellon, we make grants to actively support communities and ideas that unlock the power in the arts and humanities that helps connect us all.

Humanities in Place Grant Program

The Andrew W. Mellon Foundation actively works with our grantee partners and we are deeply immersed in the fields in which we invest. Our grants are designed to activate the spirit of learning through the creation and sharing of bold new ideas and the inspiration felt in art, expression, spaces, and scholarship. 

From Alaska to Guam and the Borderlands to the Midwest, America is a constellation of unique heritages, traditions, and stories. In communities of all sizes, people are striving to expand the ways we can understand and authentically engage with the history that is all around us. Our Humanities in Place grants fund place keepers, artists, institutions, and storytellers who shine a spotlight on historically overlooked sites, and the communities and stories that surround them. In doing so, they help broaden our shared understanding and open new paths to discover what unites us, what makes us unique, and what we can learn from one another.

Company culture at Clark Associates emphasizes responsibility, sharing our success with others, and the importance of building strong communities. To help fulfill these goals, Clark Associates Charitable Foundation (CACF) was incorporated in 2001 and provides funding to organizations serving people in need and those delivering positive experiences for youth. CACF supports non-profits operating in and around its business locations and those where our employees volunteer and actively contribute. To date, CACF has distributed over $44 million in charitable contributions.

Organizations must be registered 501c3 charities serving three basic categories: people in need, innovative youth educational programs, and youth programs in music and the arts. People in need represents the largest giving category and includes homelessness, food insecurity, individuals with disabilities, victims of abuse, and people in recovery. Examples of other grant recipients include those assisting veterans, senior citizens, at-risk youth, academic enrichment, mentorship, leadership development, and those focused on the performing and visual arts.CACF evaluates grant applications submitted by non-profit organizations every month of the year.

Melton Foundation

The Melton Foundation is an international 501(c)(3) non-profit organization registered in the USA, and a leading proponent of Global Citizenship education and practice worldwide. Established nearly thirty years ago with the credence that collaborations across boundaries can forge sustainable solutions to the world’s most pressing challenges, today, our programs reach millions of young leaders, having crystallized into a network of over 750 life-long Melton Fellows spread across 40+ countries. Our primary operations are in Chile, China, Germany, Ghana, India, and the United States of America, with legal subsidiaries in Bangalore, India; Jena, Germany; Temuco, Chile; and Accra, Ghana. 

Through our fellowship and collaborative programs we promote and enable global citizenship as a way for individuals and organizations to work together across boundaries of place and identity to solve challenges in an interconnected world.

Melton Foundation Action Grants

The Melton Foundation offers grants year-round to support Melton Fellows in developing skills, perspective and wider networks to further their capacity as global citizens and contribute towards building an equitable, sustainable, and peaceful world.

In almost 10 years of granting, more than 100 Fellows’ initiatives have been awarded with a Melton Foundation grant to

• Build awareness and/or further awareness raising around global issues and the Sustainable Development Goals (SDGs),
• Develop individual and collective responsibility for sustained, collaborative action,
• Grow capacity to collaboratively drive and sustain social impact at the local and/or global level,
• Further the design, implementation and evaluation of collaborative actions that embody the spirit of global citizenship practice and further social impact, or
• Support coordinated social-impact efforts in a particular or across (emerging) Melton Foundation Hub regions to promote global citizenship practice (s) and the organization’s mission.

The Climate Program Office (CPO) FY2026 Earth System Science and Services Partnership (ESSSP) aims to enhance NOAA's mission through collaborative research and activities. It focuses on understanding changes in Earth's systems and their impacts on ecosystems and communities. Eligible applicants include academic institutions offering doctoral degrees in NOAA-related sciences. The total funding available is approximately $10 million, supporting initiatives that encompass research, data evaluations, and stakeholder engagement.

The R3PEATS Grassroots Rigor Projects, funded by the NIH, aim to enhance research practices through two project types: Metascience and Laboratory Capacity-Building. Metascience projects focus on creating tools and metrics to promote high-quality research, while Laboratory Capacity-Building projects help labs adopt new techniques and share data that influence research outcomes. This initiative is part of a broader effort to improve rigor, replicability, and reproducibility in scientific research.

The R3PEATS Multi-Team Triangulation initiative supports collaborative research teams to explore a central biomedical question using diverse methods and model systems. It emphasizes the importance of identifying biological variability and ensuring the robustness of findings through replication strategies. This program is part of the NIH Common Fund's Rigor, Replicability, & Reproducibility to Promote Excellence in Science, aiming to enhance the accuracy and translation of scientific discoveries.

The R3PEATS Rigor Scholar Cohort Awards (K12) are designed to empower early-career researchers by enhancing their skills in rigorous scientific practices. This initiative promotes collaboration across institutions to develop best practices in research methodologies, including preregistration and randomization. Participants will gain essential training to ensure excellence and transparency in scientific research, aligning with the NIH's commitment to improve replicability and reproducibility in the field.

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Nehemiah Atkinson Humanitarian Grant

This grant reflects the Foundation’s dedication to giving and serving others. It is awarded to individuals who have shown an extraordinary commitment to enhancing the lives of those around them.

The Foundation supports projects that promote and preserve the legacy, vision, and spirit of our founder, Dennis Van der Meer. We will only consider funding for educational, life enrichment, mentoring, and tennis programs.

Dennis Van der Meer Tennis Foundation

A 2021 International Tennis Hall of Famer, Dennis was the founder of the Professional Tennis Registry Foundation (PTR Foundation), now called Dennis Van der Meer Tennis Foundation, Professional Tennis Registry (PTR), and the Van Der Meer Tennis University.

Dennis Van der Meer Tennis Foundation is a nonprofit organization exempt from federal income tax under Section 501(c)(3) of the Internal Revenue Code. The Dennis Van der Meer Tennis Foundation provides support to deserving individuals and organizations globally. The foundation is also focused on bringing tennis within reach to countless people worldwide.

Natural Disaster Relief Request

The Foundation stands with tennis professionals affected by the devastating hurricanes and other natural disasters in the U.S. in 2024. If you are a tennis pro facing hardships due to recent storms, we are here to help you get back on your feet. Our assistance program provides relief and resources specifically for tennis professionals affected by these events. Together, we can rebuild stronger.

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Patient Travel Grant Program

A mesothelioma diagnosis and treatment often require the patient and their family to incur numerous expenses as part of their treatment. Travel to treatment, alone, can cause a significant financial burden on the patient, which might even cause the patient to not seek treatment away from home, even it’s their best option. To ensure that all patients have the ability to seek specialized help and treatments, the Mesothelioma Applied Research Foundation administers its Travel Grant Program.

The Meso Foundation’s Patient Travel Grant Program, founded by Mary and Bob Cosentino, provides travel grants to patients and one caregiver traveling for an initial consult and/or for clinical trial treatments.

• The type of eligible travel must fall into at least one of these two categories:
  • One trip for one initial consultation with a mesothelioma specialist.
  • Multiple trips to participate in an interventional clinical trial (found on clinicaltrials.gov).

Mesothelioma Applied Research Foundation Inc

The Mesothelioma Applied Research Foundation is the only nonprofit charity organization dedicated to ending mesothelioma, and the suffering caused by this cancer, by:

• funding research to improve treatment options;
• providing treatment support and education for patients and their families;
• and advocating for federal funding of research.

The mission of the Mesothelioma Applied Research Foundation spans across four distinct areas: through research, education, support, and advocacy the Foundation seeks to eradicate the vicious effects of mesothelioma. Led by the Board of Directors, our team works collaboratively to develop and administer our programs, and to fundraise to pay for those programs (the Foundation is funded by private individual and corporate contributions only — it does not receive any government funding).

Bret A. Rosenthal Patient Assistance Fund

Patients diagnosed with cancer at a younger age often face greater financial burdens. This is a time in a patient’s life when they are raising a family, starting a career, or have not accumulated savings. For patients 49 and under, the Foundation administers the Bret A. Rosenthal Patient Assistance Fund grant program. This program is made possible by the generosity of the Rosenthal family.

Utilizing the Full Power of Empire AI Request for Applications

The Simons Foundation (SF) intends to support cutting-edge mathematics and basic science research, drawing on the advanced computational power of the Empire AI.

Toward this goal, SF plans to initiate a new program to fund six to 12 proposals through a competitive open call to the Empire AI research community.

A successful proposal will outline an ambitious two-year research program in one of the following fields, or at their intersections: computational astrophysics and physics, computational biology, mathematics, neuroscience and computational physical chemistry. Each proposal will necessarily rely on the development and utilization of foundational machine learning models, aimed at solving problems of fundamental importance in the above-listed disciplines.

Computational biophysics, neuroscience, ecology and evolution, plant biology, optimal transport, multiscale physics, fluid dynamics and numerical general relativity are representative examples of fields that could use multinode clusters of GPUs of Empire AI, which is a requirement of the program. All submitted proposals should detail how their work will use multinode clusters of GPUs in Empire AI. Proposals focused on data curation and creation of datasets can be considered in exceptional cases, as long as the attained data will be used by the proposers for solving scientific problems as part of the same proposal.

The program’s total budget is expected to be $6 million USD over a two-year period.

Funding

Award Amount: There is no maximum budget total for an individual award. The total amount requested should reflect the proposed research. All award amounts are inclusive of indirect costs (see our grant policies). Please note that we anticipate funding six to 12 applications. The total program’s budget of $6 million USD over two years will be spread across all awards.

Award Duration: June 1, 2027, through May 31, 2029.

Number of Awards: We expect to select six to 12 applications for funding.

The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.

The BJA FY 2026 Paul Coverdell Forensic Science Improvement- Competitive Grants Program aims to enhance forensic science and medical examiner/coroner services across the U.S. This funding opportunity supports state and local government laboratories in improving their capabilities to ensure justice and public safety. Applications are due by November 5, 2026, at 8:59 p.m. ET, promoting advancements in forensic practices to better serve law enforcement and communities.

The BJA FY26 Paul Coverdell Forensic Science Improvement - Formula Grants Program supports state agencies in enhancing forensic science capabilities. The program aims to improve public safety by funding initiatives that strengthen forensic science and support law enforcement efforts. Eligible applicants can submit their full applications through JustGrants by November 6, 2026. This funding is crucial for addressing ongoing challenges in the justice system, including violent crime and public safety concerns.

The OJJDP FY 2026 Multistate Mentoring Programs aims to provide crucial mentoring services to at-risk youth, helping them avoid delinquency and victimization. This funding opportunity emphasizes the importance of one-on-one, group, and peer mentoring approaches. The program aligns with the U.S. Department of Justice's commitment to public safety and juvenile justice reform, addressing the needs of vulnerable populations and fostering positive youth development.

The OJJDP FY 2026 Strengthening Internet Crimes Against Children (ICAC) program aims to enhance the technological investigative capacity of ICAC task forces nationwide. Through this funding opportunity, the program will support the development and refinement of investigative tools and methods to combat child sexual abuse material, exploitation, and trafficking. The deadline for application submission is November 5, 2026, at 8:59 p.m. ET, emphasizing the urgency of addressing these critical issues.

The FY 2027 Department of War Multidisciplinary Research Program (MURI) funds U.S. academic teams engaged in innovative basic research addressing future defense challenges. Established in 1985, MURI emphasizes collaboration across multiple scientific disciplines to tackle complex, DoW-relevant issues. By fostering partnerships among faculty, postdoctoral researchers, and students, the program aims to advance the U.S. defense industrial base and nurture a skilled scientific workforce, contributing to significant breakthroughs in military technology and economic growth.

The OJJDP FY 2026 Victims of Child Abuse Act Training and Technical Assistance program aims to enhance the skills of child abuse professionals. This initiative will promote coordinated investigations and improve intervention strategies for child abuse victims. By providing essential training on effective interviewing, investigative techniques, and interagency collaboration, the program seeks to elevate the quality of care and support available to affected children and families. Applications are due by November 5, 2026.

The BJA FY 2026 Rural Violent Crime Reduction Initiative aims to empower local law enforcement in rural areas to combat violent crime effectively. This funding opportunity provides resources for personnel, technology, and data analytics to enhance crime prevention strategies. Eligible applicants can utilize updated equipment and training to address specific violent crime challenges, ensuring safer communities through innovative approaches and strategic resource allocation. Applications are due by November 6, 2026.

The Fiscal Year 2027 Department of War Multidisciplinary Research Program aims to fund innovative research teams from U.S. universities. Established in 1985, this initiative addresses complex challenges faced by the Department of War, fostering collaboration across various scientific disciplines. By integrating world-class faculty and graduate students, the program seeks to cultivate a skilled workforce poised to enhance the U.S. defense capabilities and contribute to the advancement of the defense industrial base.

The BJA FY 2026 Students, Teachers, and Officers Preventing (STOP) School Violence Program aims to enhance school safety by funding initiatives that train staff and students, develop threat assessment teams, and implement technology solutions like anonymous reporting systems. This program supports effective strategies to identify and mitigate risks of school violence, ensuring students have the tools necessary to foster a secure learning environment while adhering to the guidelines set forth by the STOP School Violence Act.