Best Grants for 501(c)(3) in South Carolina

The Spencer T. and Ann W. Olin Foundation Wetlands and Waterfowl Research Fellowship supports graduate students in North America conducting research on waterfowl or wetland biology. The fellowship, offering up to $9,500 annually, emphasizes applicant qualifications, research proposal soundness, originality, and potential contributions to conservation efforts. This competitive opportunity is renewable for up to two additional years for PhD students and once for Masters students, pending satisfactory progress reports.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) supports innovative, hypothesis-driven clinical studies with a focus on diseases relevant to NIDDK. This initiative facilitates early peer review and assessment of study designs while providing essential support for operational documents. Applicants are encouraged to consult with NIDDK staff before submission to enhance the chances of success.

The Rheum for Kids: Pediatric Skin and Joint Grant, offered by the Arthritis National Research Foundation, is aimed at early-career researchers focused on pediatric joint and skin diseases. This grant provides funding of up to $50,000 for one year to support innovative research projects. It encourages applications from diverse fields to advance the understanding and treatment of rheumatic diseases in children, fostering new insights and potential breakthroughs in pediatric healthcare.

Indigo Hope Foundation: Addiction Recovery Programs Grant

Funding programs that offer treatment, counseling, recovery support services, and harm reduction for individuals battling addiction.

Key Focus Areas:

• Treatment Services
• Recovery Support
• Harm Reduction
• Family Programs

Example Programs We Fund:

• Outpatient counseling programs
• Peer recovery support
• Addiction Recovery Residential Programs
• Family therapy services

About

Community Foundation of Greenville bridges philanthropy and purpose in Greenville County, helping people make their charitable giving simpler and more powerful for 70 years. We strategically match diverse needs and opportunities in Greenville County with philanthropic resources.

Vision:

Community Foundation of Greenville will be the leading catalyst for developing assets and unlocking potential to meet the needs of an inclusive and equitable community.

Mission:

Community Foundation of Greenville improves the lives of Greenville County residents through strategic philanthropy, community investment, and collaborative leadership.

New Leaf Fund

Community Foundation of Greenville administers grants to preserve parks, open spaces, and historical and cultural assets through the New Leaf Fund.

The New Leaf Fund was established in 2025 by a Greenville native with a passion for conservation.

Established 501c(3) organizations and local municipalities are invited by the New Leaf Fund Committee to apply online through Community Foundation’s website during the spring, summer, and/or winter grant cycles.

The Foundation encourages grant requests that include the protection of land and waterfront areas, increased tree cover and access to green spaces, and the protection and restoration of historical properties, in the City of Greenville, in Greenville County, and, to a lesser degree, in the Upstate.

The Special Emphasis Limited Project Grant from the American Society of Colon and Rectal Surgeons aims to address health disparities in colorectal surgery. It focuses on improving care for racial/ethnic minorities, women, LGBTQ+ populations, and individuals with disabilities. Proposals should concentrate on patient-oriented interventions and may explore quality improvement, access to services, and enhancing workforce diversity. Funding of up to $20,000 is available for innovative projects that promote equity in colorectal healthcare.

The AWWA Scholarship Program, administered by the American Water Works Association, offers a $5,000 scholarship to graduate-level students pursuing careers in the water industry. Recognizing the vital role of future professionals, AWWA aims to support education in water supply and wastewater management through this scholarship initiative. Founded in 1886, American Water is the largest U.S. investor-owned water utility, emphasizing the importance of investing in education for sustainable water solutions.

About Patient Advocate Foundation

Patient Advocate Foundation is the nation’s most comprehensive nonprofit dedicated to helping patients navigate, access, and afford the care they need—while improving the healthcare system for all.

Who we are and our impact

Patient Advocate Foundation provides financial assistance to help patients afford treatment and cost of living needs, personalized case management to navigate complex healthcare and social needs challenges, and a wide array of resources to empower people to take charge of their health. Since our founding in 1996—and joining forces with the PAN Foundation in 2026—we have helped 3.8 million patients navigate and access care, granted over $7 billion in financial assistance, served 350,000 people through personalized case management and elevated the patient’s voice to drive improvements in the healthcare system.

HIV, AIDS, and prevention

Help with healthcare costs for HIV, AIDS, and prevention

This TotalAssist fund helps you pay for out-of-pocket healthcare costs, including medication copays, coinsurance, and deductibles, health insurance premiums, and other expenses.

About the disease

HIV, also known as human immunodeficiency virus or acquired immunodeficiency syndrome, is a virus that attacks the immune system. When left untreated, it can develop into AIDS. HIV is a chronic disease that affects the immune system.

Every Kindness is a Gift

Dollar Tree Gift Card Program 2026

Every Kindness is a Gift is a gift card grant program made possible through the generosity of Dollar Tree and managed by the team here at Gift Card Bank. We are a nonprofit organization that specializes in the distribution of gift cards and our mission is to improve well-being and build financial stability by supporting people through their time of need.

Through Every Kindness is a Gift, nonprofit organizations and Title I schools located in the 48 contiguous states may apply to receive a grant of Dollar Tree gift cards.

Gift cards received through these grants are meant to be distributed directly to individuals and families in need. A primary goal of the program is to give gift card recipients the dignity of choice by empowering them to shop for what they need themselves. By putting gift cards directly in the hands of our neighbors in need, we are able to increase access to essentials like food, school supplies, paper products, cleaning products, and hygiene items.

In 2026, there will be two rounds of grant distributions. In each round, we will award a number of grants between $2,500 and $10,000.

Round One is a summer distribution. Gift cards awarded in Round One will arrive in late June, while kids are on break and back-to-school is around the corner. Round Two is a holiday distribution. Gift cards awarded in Round Two will arrive in early November, as the end-of-year holidays approach.

We know that these are times of year when budgets are tight. Through these gift card grants, we hope to connect individuals and families directly to the essential resources they need during difficult months.

About Us

Our team is working tirelessly to heal the planet and ensure that a just and livable future prevails.

With three decades of clean energy industry experience, our leadership team draws upon a long track record of environmental stewardship and meaningful throughput to confidently navigate today's unprecedented challenges.

We are teaming up with local philanthropists, nonprofit organizations, advocates and elected officials to implement effective solutions towards stopping the climate crisis.

Solar Moonshot Program Grant

The Solar Moonshot Program is helping nonprofit organizations across the United States afford the switch to clean energy.

Grants up to $25,000 are typically awarded, with grant amounts dependent on various factors, including the organization’s need for funding. 

In addition to grants given through the program, we also offer short-term, low-interest recoverable grants to help cover the project costs offset by the Investment Tax Credit.

Grants for 2026 are made possible by the BQuest Foundation and two anonymous donors, and the program is managed by Hammond Climate Solutions Foundation. Learn more about the program's status and participants below! 

The NIDDK Disease Research and Translational Core Centers (P30 Clinical Trial Optional) program invites applications to support innovative biomedical research focused on cystic fibrosis, diabetes, and other chronic diseases. These centers foster collaboration, provide essential resources, and mentor early-stage investigators, enhancing the research landscape. Funding will support pilot programs and access to shared services, ensuring efficient use of resources while promoting a robust scientific community dedicated to advancing health outcomes.

The 2026 Vilcek Prizes for Creative Promise in Biomedical Science will award three $50,000 prizes to exceptional young immigrant scientists in the U.S. This prestigious prize recognizes innovative research contributions in biomedical science. Eligible candidates must be under 38 years old, hold a doctoral degree, and have made significant achievements in their field. The Vilcek Foundation aims to highlight the impact of immigrant scientists on the advancement of biomedical research, fostering diversity and excellence.

The Lynde and Harry Bradley Foundation Grant supports organizations dedicated to preserving American exceptionalism through a commitment to individual liberty, free markets, and civic responsibility. It prioritizes proposals from 501(c)(3) organizations that promote informed citizenship and strong communities. With ongoing acceptance of Letters of Inquiry, the Foundation seeks to empower initiatives that align with its principles of limited government and the rule of law, fostering a rich community culture.

About Us

The Youth Climate Justice Fund aims to support climate justice young leaders with trust-based funding, resources, and capacity strengthening, enabling them to amplify their voices and to keep their vision and influence alive.

Collectively, we have the power to ignite meaningful change and build equitable and sustainable futures. Despite the challenges posed by the current crisis, youth climate justice organizers remain determined to address current issues and explore new approaches.

Mission & Purpose

We work to strengthen existing organizing efforts and support emerging youth-led initiatives with a focus on bridging funders and organizers to enable flexible and impactful support. Through capacity strengthening and resource sharing, we empower and support young people to drive change and build a just and sustainable future.

How To Apply

The Youth Climate Justice Fund provides funding to emerging youth-led climate justice and socio-environmental groups through a participatory decision-making process.

The AWWA Scholarship Program offers the GFT Forces of Change Scholarship, providing $5,000 to undergraduate or graduate engineering students passionate about advancing the water industry. This scholarship underscores AWWA's commitment to nurturing future professionals who will tackle critical infrastructure challenges. By investing in education, AWWA aims to empower the next generation to innovate and lead in water supply solutions. This initiative highlights the importance of skilled engineers in shaping a sustainable future.

The John Goddard Prize offers microgrants to empower youth-led environmental initiatives across the nation. This competitive cash prize supports ambitious young leaders seeking funding for innovative projects that promote environmental sustainability. Applications are welcomed from young people dedicated to making a positive impact on the planet. By fostering creativity and action, the prize aims to inspire the next generation of environmental stewards.

The Brower Youth Awards for Environmental Leadership honors young leaders aged 13 to 22 in North America who excel in environmental initiatives. Awardees receive a $3,000 cash prize, training, and networking opportunities to enhance their impact. This prestigious program fosters youth leadership and amplifies diverse voices within the environmental movement, encouraging innovative solutions to pressing ecological challenges. Over the past 25 years, the awards have celebrated over 100 emerging leaders dedicated to making a difference in their communities.

The Johnson Controls Foundation Grants support nonprofit organizations dedicated to creating smarter, healthier, and more sustainable communities. Since 1952, the Foundation has contributed over $77 million to U.S. charities, emphasizing initiatives in education, health, and environmental protection. Eligible organizations should align with the Foundation’s priorities and demonstrate community impact, particularly in areas with a strong Johnson Controls presence. Each year, approximately $7 million is distributed to support these vital programs.

Over our more than 100-year history, we've been fighting heart disease and stroke, striving to save and improve lives.

Our Mission

To be a relentless force for a world of longer, healthier lives.

Rapid Impact Research Award

Purpose

The American Heart Association continuously seeks innovative ideas to address the most pressing issues impacting cardiovascular and brain health. To that end, the Association is pleased to announce the Rapid Impact Research Award program, which will support early and mid-career investigators proposing innovative research that aligns with the Association’s mission. Novel basic, clinical and/or population health proposals are invited in the following three priority areas of research.

• Sudden cardiac arrest/resuscitation science
• Cardiovascular Kidney Metabolic Syndrome
• Stroke and/or vascular dementia

Applicants will be asked to indicate alignment of their proposal with one or more of the topic areas listed above. 

The FY26 Tick-Borne Disease Research Program (TBDRP) Therapeutic/Diagnostic Research Award aims to foster innovative therapeutic and diagnostic research for Lyme disease and other tick-borne conditions. This award supports early-stage drug discovery and evaluation studies, as well as novel diagnostic methods that can be seamlessly implemented in clinical environments, ultimately enhancing patient care and quality of life.

The ANR Foundation Postdoctoral Fellowship offers financial support to researchers focusing on arthritis and related autoimmune diseases. This initiative aims to cultivate future leaders in the field by providing fellowships that foster innovative research and exceptional training opportunities. Open to various research areas, including osteoarthritis and lupus, the fellowship seeks to empower physicians to advance their work and make impactful contributions to understanding these conditions.

The AAAAI Allied Health Recognition Award honors non-physician members who have significantly contributed to allergy and immunology education or research. As part of the American Academy of Allergy, Asthma & Immunology, this award emphasizes the importance of allied health professionals in advancing patient care. Eligible recipients include AAAAI Allied Health members who demonstrate excellence in their field, ensuring that contributions to the specialty are recognized and celebrated.

The Hope APFED/AAAAI Grant Award aims to support innovative research projects related to Eosinophilic Disorders, excluding asthma, rhinitis, and eczema. This initiative encourages collaboration between the American Academy of Allergy, Asthma & Immunology and the American Partnership for Eosinophilic Disorders, providing a platform for independent researchers to secure future funding. Applicants must be AAAAI members and hold relevant academic positions, ensuring a commitment to advancing knowledge in allergy and immunology.

The NIHCM Journalism Grants support projects that enhance health reporting and education, targeting critical issues such as healthcare affordability, pharmaceutical pricing, provider market dynamics, and chronic disease management. This initiative emphasizes the importance of informing policymakers and the public on how to improve healthcare quality and access in the U.S. Proposals may also explore the role of artificial intelligence in healthcare delivery. Applications are welcome from journalists, nonprofits, and universities.

The Lowcountry Land Conservation Grant, offered by the Gaylord & Dorothy Donnelley Foundation, focuses on enhancing land conservation efforts in the Lowcountry region through a climate resiliency, diversity, equity, and inclusion lens. This grant supports non-profit organizations in their general operations and projects aimed at protecting natural and working lands, fostering collaboration among diverse communities, and advocating for sustainable policies. Eligible applicants must be 501(c)(3) organizations with a connection to land conservation.

The 15 and the Mahomies Foundation Grants aim to enhance the lives of children by supporting health, wellness, and community initiatives. This private foundation seeks to fund 501(c)(3) non-profit organizations, focusing on charitable causes. Grant requests are reviewed quarterly, and applicants must meet eligibility criteria. However, the foundation does not accept applications from individuals or for non-charitable items such as autographs or game tickets.

The H. Hovnanian Family Foundation Grant supports the Armenian community in Armenia and the U.S., focusing on Monmouth and Ocean Counties, New Jersey. The Foundation prioritizes education, healthcare, arts, and youth development through grants to registered non-profits. Proposals should demonstrate sustainability and community impact, with favorable consideration given to projects that engage local stakeholders and foster collaboration. Applications are accepted year-round, with a maximum funding limit of $10,000 for operational expenses.