Best Large Grants for Nonprofit Organizations in South Carolina

Summer Medical Internship Program (SMIP)

Fosters an interest in research by funding a summer research project conducted by a medical student.

The SIR Foundation Summer Medical Internship Program introduces medical students to interventional radiology research and medical device development. The goal of this program is to foster an interest in research by funding a summer research project conducted by a medical student.

Students applying for the program must show strong potential for a career in IR with proven academic success. Selected students will have an opportunity to intern with an interventional radiologist research mentor or corporate research and development mentor for 8 weeks during the summer.

SIR Foundation will provide a $6,000 stipend to help ease the financial burdens throughout their internship experience.

• Budget: Up to $6,000
• Grant Length: Eight weeks

The Gilead Research Scholars Program in Oncology supports innovative research from emerging investigators worldwide, focusing on scientific understanding and progress in cancer treatment. Launched in 2008, it offers financial support of up to $180,000 over two years to junior faculty who meet eligibility criteria. The program emphasizes diversity and aims to reduce barriers for underrepresented groups in research, fostering a more inclusive landscape in addressing unmet medical needs.

Investigating the Benefit of Early Treatment with Ritlecitinib in Alopecia Areata: A Real-World Evidence Approach

Alopecia Areata (AA) is a chronic, immune-mediated condition causing nonscarring hair loss that affects about 2% of the global population and can lead to substantial psychosocial burden if disease is severe and untreated. The treatment landscape has recently evolved with the approval of ritlecitinib, a systemic therapy for severe AA in adults and adolescents aged 12 years and older, based on efficacy demonstrated in the ALLEGRO phase 2b/3 program.

Despite this advance, important questions remain regarding the optimal timing of therapy initiation. Emerging post-hoc analyses from the ALLEGRO program indicate that patients with shorter disease duration and lower baseline severity achieve higher response rates, suggesting that earlier intervention with ritlecitinib may lead to improved outcomes.

Geographic Scope

United States 

Funding Range and Project Length

Individual projects requesting up to $100,000 USD will be considered.

Maximum project length is 24 months.

Hemophilia Fellowship

This competitive grant program seeks to support an institution-based fellowship that emphasizes shared decision making (SDM), patient education, and multidisciplinary team-based care. The intent is to strengthen the hemophilia care through equitable education, and patient-centered shared decision making in a rapidly evolving treatment landscape.

Geographic Scope

• United States 

Funding Range and Project Length

• Grant funding is available to support a one year fellowship up to $100.000 USD. 

The SPARK-EHS initiative aims to broaden the reach of NIEHS training by launching innovative environmental health programs for predoctoral trainees at institutions without recent NIEHS T32 funding. This initiative focuses on research regarding the impact of the environment on biological systems and seeks to translate findings into practical health solutions. Eligible institutions will receive support for developing and implementing these targeted training programs, fostering advancements in environmental health research.

The Oak Foundation's Learning Differences Grant Programme aims to foster equitable educational experiences for students with learning differences, particularly those marginalized by racism and poverty. Through strategic partnerships with not-for-profit organizations, the program enhances understanding of diverse learners' needs, translates knowledge into effective practices, and influences systemic changes to create supportive learning environments. The initiative emphasizes the importance of community involvement, ensuring that students' voices are heard and their educational needs are met.

Clinical Research Training Scholarship in Autoimmune Neurology

This award recognizes the vital importance of rigorous clinical and translational research and aims to inspire and support early-career investigators pursuing clinical studies in autoimmune neurology — specifically immune-mediated diseases of the nervous system other than multiple sclerosis.

The scope of this award encompasses research on autoimmune neurologic disorders, including neural antibody-associated diseases of the nervous system, autoimmune encephalitis, immune-mediated epilepsy, autoimmune movement disorders, inflammatory myelopathies, NMOSD, MOGAD, paraneoplastic neurological syndromes, neurological complications of cancer immunotherapies, and inborn errors of immunity/autoinflammatory syndromes affecting the nervous system.

This award will consist of a commitment of $65,000 per year for two years, plus a $10,000 per year stipend to support education and research-related costs for a total of $150,000. Supplementation of the award with other grants is permissible, but to be eligible to apply for this award, the other grant source(s) cannot exceed $75,000 annually.

The Shared Instrumentation Grant (SIG) Program supports NIH-funded investigators in acquiring high-cost, specialized instruments, with a minimum award of $50,000 and a maximum of $750,000. Eligible instruments include light microscopes, mass spectrometers, and DNA sequencers, among others. This program aims to enhance research capabilities by enabling the purchase or upgrade of essential equipment for scientific advancement.

The Limited Competition: Basic Instrumentation Grant (BIG) Program offers funding to NIH-supported researchers for purchasing specialized instruments or integrated systems, with minimum awards of $25,000 and maximum awards reaching $350,000. Eligibility is restricted to institutions that have not received significant S10 funding in recent years. This program aims to enhance research capabilities by providing access to essential technology, thereby fostering scientific innovation and collaboration within the NIH community.

The Pulitzer Center offers U.S. Local News Reporting Grants aimed at supporting freelance and staff journalists in producing in-depth investigative reporting for local news outlets. This initiative seeks to amplify underreported stories crucial to community engagement, particularly those addressing systemic issues. The grants are available on a rolling basis, encouraging diverse voices in journalism. Applicants must provide a project description, budget estimate, and distribution plan to qualify for funding that covers essential reporting costs.

Dave Dupont Memorial Scholarship

The family remembers Dave as a very kind hearted, loving husband, father, and friend. He and his wife Sandi were married 35 years, and had 2 children Kyle and Danielle DuPont.

Dave loved to give back to his community, and attend as many fundraisers as he could. Dave would be proud to be able to give back to the kids in his community.

Dr. Sonny Rush Memorial Scholarship

Dr. Sonny Rush was a pioneering orthopedic surgeon and a kind friend to all his patients. He encouraged all students interested in healthcare to pursue their passion in the medical field. This scholarship was established by his family in his memory and is designed to help jumpstart a career in the healthcare field. 

Amount

• 1500

Carol J. Kenagy Nursing Education Scholarship

In memory of Carol J. Kenagy, RN and through the wonderful generosity of our donors, Silverton Health Foundation is able to offer continuing education scholarships for Legacy Silverton staff pursuing nursing degrees.

The Carol J. Kenagy Nursing Education Scholarships will be awarded on an annual basis.

All clinical programs are eligible and encouraged to apply.

Amount of Award:

• up to $5,000 annually 
• Number of Awards: 2-3

The James B. Linsmayer Foundation Grant supports programs in arts, culture, education, health, and human services primarily within the Twin Cities of Minnesota. Established in memory of James B. Linsmayer, the foundation aims to be a strategic partner in these vital areas. Eligible grantees include public charities recognized under IRC guidelines, with no geographic limitations but a preference for local organizations. While start-ups may be considered, funding for organizational expenses is not permitted.

The Frances M. Culbertson Travel Grant provides essential funding for women from developing countries at the beginning of their psychology careers. This grant helps address the challenges posed by limited resources, allowing recipients to attend international and regional conferences. Eligible applicants must hold a doctoral degree and be within ten years postdoctoral, promoting diversity in the field. Preference is given to those attending key psychology conferences, fostering professional growth and networking opportunities.

The TIP Office of the US Department of State invites applications for projects aimed at combating human trafficking, adhering to the Trafficking Victims Protection Act. This initiative prioritizes prosecuting traffickers, protecting victims, and preventing trafficking through strategies outlined in the National Security Strategy, executive orders, and the annual Trafficking in Persons Report, while aligning with America First Foreign Policy priorities.

Family Medicine Cares USA offers grants up to $25,000 to support the establishment of new free clinics. Eligible applicants must either have opened or plan to open within six months of the application deadline and hold the National Association of Free and Charitable Clinics Seal of Excellence. Priority is given to clinics with an AAFP member as medical director and those engaging Family Medicine residents or medical students as volunteers. Applications are accepted annually from March 15 to July 15.

The Morton B. Duggan, Jr. Memorial Education Recognition Award, provided by the American Respiratory Care Foundation, honors a student enrolled in an accredited respiratory care program. This award, which can reach up to $1,000, includes a certificate of recognition, travel expenses, and registration for AARC Congress. Eligible applicants must verify their enrollment and GPA, and provide letters of recommendation. Preference is given to candidates from Georgia and South Carolina.

The BRAIN Initiative seeks to develop innovative tools and approaches for neuroscience research, focusing on cell-specific and circuit-specific processes within the central nervous system. This initiative encourages projects that enhance our understanding of brain architecture and function through novel technologies for characterizing neural components and advancing methods for recording and modulating neural activity. Applications are invited to address significant challenges and promote transformative breakthroughs in neuroscience.

The Family Medicine Cares USA Free Health Clinic Grants support existing clinics in providing care to the uninsured. Grants of up to $10,000 are available if funds permit, prioritizing clinics with AAFP members in leadership roles. The program emphasizes the involvement of Family Medicine residents or medical students as volunteers, aiming to enhance healthcare access in underserved communities.

The Adult Learn-to-Swim Grants, offered by the USA Swimming Foundation in collaboration with U.S. Masters Swimming, aim to enhance swimming safety for adults aged 18 and over. This initiative provides funding to programs that promote swim education, targeting underserved communities. Grants can be used for expenses like pool rentals and scholarships, with a maximum award of $5,000. The goal is to reduce drowning risks and encourage ongoing participation in swimming activities.

The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.

The Placement and Coordination Program, administered by the Office of Refugee Resettlement, invites eligible organizations to enhance refugee resettlement services. By diversifying service providers, the program aims to strengthen the national resettlement framework. Key responsibilities include managing the Program of Initial Resettlement and Intensive Case Management for vulnerable refugees, ensuring comprehensive support from arrival through initial resettlement, and addressing barriers to self-sufficiency.

The Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging offer MD, DO, PhD, or combined-degree students the opportunity to conduct research on aging. Established by Diana Jacobs Kalman, a leader in aging science, the program addresses the challenges of an aging population. By awarding up to ten scholarships, it aims to foster innovative research and improve the quality of life for older adults. Proposed projects should focus on specific areas like immune function, inflammation, and genetic control of longevity.

The AFAR Grants for Junior Faculty and Glenn Foundation for Medical Research offer up to $160,000 for one- to two-year research projects focusing on the biology of aging. Aimed at early career faculty, these grants support innovative studies not limited to age-related diseases but rather the fundamental mechanisms of aging. Approximately 10 grants will be awarded in 2026, with funding starting July 1. Applicants must be independent investigators within 10 years of their postdoctoral training.

The Rocky Talkie Search and Rescue Award, sponsored by the American Alpine Club, provides $75,000 annually to support underfunded Search and Rescue (SAR) teams in the U.S. and Canada. The initiative aims to enhance community awareness of the vital contributions made by volunteer SAR members. Grants include $10,000 for five selected teams and a special $25,000 award for the Featured Rescue of the Year, spotlighting exceptional volunteer-led rescue operations and their impact on mountain safety.

The FY26 Neurofibromatosis Research Program's Synergistic Idea Award supports innovative research on neurofibromatosis (NF) through collaborative efforts of two or three Principal Investigators (PIs). By leveraging their unique perspectives, these PIs will tackle significant questions in NF research. Applicants must provide relevant preliminary or published data to support their proposals, ensuring a strong foundation for impactful research outcomes.