Best Large Grants for Nonprofit Organizations in South Carolina

The Jobs Plus NOFO for FY2026, issued by the US HUD's Office of Public and Indian Housing, aims to enhance job opportunities for public housing residents. This initiative encourages innovative programs that prepare individuals for employment in high-demand fields, ultimately fostering economic stability within communities. By focusing on workforce development, this funding opportunity seeks to empower residents through education and training, paving the way for long-term success and self-sufficiency.

The David Kelby Johnson Memorial Foundation offers grants to 501(c)(3) organizations focused on sight preservation, children's services, and environmental conservation, primarily in Utah. Established in memory of David Kelby Johnson, who tragically lost his life at a young age, the foundation aims to honor his legacy by supporting impactful charitable initiatives. Grants range from $5,000 to $100,000, with a commitment to improving communities both locally and globally.

The Loretta Morris Memorial Grants support individuals with cystic fibrosis in California who wish to engage in physical activities such as swimming, horseback riding, dance, or golf. Established in memory of Loretta Morris, this fund aims to help recipients enjoy the benefits of an active lifestyle. Applications are welcomed from both children and adults, promoting inclusivity and well-being within the CF community. Note that certain items, like memberships or accessories, are not eligible for funding.

The Science Policy Fellowship, offered by the American Chemical Society, provides a unique opportunity for trained scientists to engage in public policy. This program enhances understanding of the policy-making process, allowing Fellows to work alongside experienced Government Affairs staff. The Fellowship focuses on key areas such as federal research funding, education in STEM, and environmental policies. Candidates with a strong background in chemical sciences or engineering are encouraged to apply, regardless of holding a doctorate.

The Earth Rising Foundation Grants provide financial support ranging from $200 to $20,000 for grassroots climate initiatives. The foundation emphasizes empowering Indigenous communities, advocating for sustainable agricultural practices, and addressing social justice issues linked to climate change. By fostering youth involvement and supporting innovative projects, the foundation aims to create a vision for a sustainable future that respects both people and the planet. Applications must be submitted through a US-based nonprofit organization.

The Enterprise Mobility™ Philanthropic Giving program focuses on enhancing community engagement through grants aimed at supporting health, education, arts, and disaster relief initiatives. Only Enterprise Mobility team members and their spouses or domestic partners who volunteer with a nonprofit can apply for funding. The program prioritizes sustainable projects that uplift local communities and address pressing social issues, fostering a culture of responsibility and giving back to society.

Patagonia’s Corporate Grant supports grassroots organizations focused on bold, direct-action campaigns that address the root causes of environmental issues. The program emphasizes equity, inclusivity, and long-term change, targeting communities affected by environmental exploitation. Grants are awarded to innovative groups within the US and Canada, fostering civic engagement and measurable objectives. Patagonia prioritizes funding for initiatives that confront systemic bias and promote environmental justice, ensuring that diverse voices are represented in the environmental movement.

The Blake-Nuttall Fund Grants, offered by the Nuttall Ornithological Club Inc, support vital ornithological research, conservation, and education efforts focused on the birds of New England and the Northeast. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code, while applications from individuals or private foundations are not considered. This initiative aims to foster a deeper understanding and protection of avian species in the region.

The Hathaway Family Foundation Grant aims to enhance the lives of individuals in need within Greenville, South Carolina. This private foundation focuses on improving food security, access to quality healthcare, conservation efforts, and addressing homelessness. By supporting organizations that provide temporary shelters, mental health care, and food distribution, the foundation ensures targeted assistance for the most vulnerable populations. The foundation's commitment reflects a dedication to fostering community well-being and positive change.

The Ornis Birding x Lost Birds Expedition Grant aims to inspire skilled young birders, aged 18-30, to explore remote regions and rediscover species that have evaded scientific detection for over a decade. Funded by Ornis Birding Expeditions, this grant offers up to $5,000 for innovative expeditions, encouraging participants to submit detailed observations and engage with local communities. The initiative seeks to fill critical gaps in ornithological knowledge while promoting conservation and ecotourism.

The GSF Foundation Grant supports 501(c)(3) non-profit organizations that enhance the lives of children and families in need. Applications must be submitted by a current GSF Associate who nominates the organization and its project. Since 2002, the foundation has funded over 600 organizations nationwide. It emphasizes personal involvement and contributions from associates, focusing on essential needs such as education tools, food, and shoes for children. Grants are reviewed at local and national meetings.

The Eastern Bank Foundation (EBF) is dedicated to empowering communities through its Neighborhood Donations initiative. By investing over $16 million in local organizations, EBF aims to support vital services and promote equity in Eastern Massachusetts, Southern New Hampshire, and Rhode Island. This program allows contributions to non-501(c)(3) organizations, reinforcing EBF's commitment to partnership and community-driven solutions, with donations typically ranging from $100 to $1,000.

The Catalyze Challenge Grant, managed by Catalyze, is an opportunity for organizations to receive funding for innovative solutions that enhance career-connected learning for youth aged 11-22. With over $4 million available in Round 5, finalists can secure up to $300,000 to implement their ideas. The grant seeks proposals that empower underserved learners through hands-on experiences and meaningful employer partnerships, ultimately impacting over 65,000 young people across the U.S.

The Kadel & Gerhardt Internships, funded by the Point Foundation, aim to enhance the representation of LGBTQ+ individuals in HIV/AIDS research and advocacy. These internships support academically talented students pursuing unpaid opportunities in the summer of 2025, addressing the critical need for culturally competent care within the community. By investing in future leaders, the program seeks to combat the stigma surrounding HIV and increase access to essential services for those affected.

The Mumford & Keller Grant and Scholarship Program, initiated by Indiana Audubon in 2010, offers financial support for projects focusing on natural resources and Indiana's birdlife. With grants ranging from $500 to $5,000, it aims to promote conservation, research, and education. Priority is given to initiatives targeting key species and habitats within Indiana. This program honors the legacy of Russell Mumford and Charles Keller, enhancing bird conservation efforts for future generations.

Wilson Ornithological Society

The earliest stages of the Wilson Ornithological Society’s development began with the formation of the “Young Ornithologists’ Association,” initiated in 1886 under the leadership of L. O. Pindar and J. B. Richards. They began as a corresponding group of naturalists interested in birds, with notes published in The Oölogist.

Soon after, the Society acquired a constitution and established itself in December 1888 as the Wilson Ornithological Chapter of the Agassiz Association. The fledgling group was named in honor of Alexander Wilson, considered the Father of American Ornithology. Its original purpose was “the study of birds, their nests, and eggs.”

Over the subsequent decades, the group—eventually becoming known as the Wilson Ornithological Club—published its proceedings and articles under a series of diverse titles, culminating in The Wilson Bulletin after 1894 and, most recently, The Wilson Journal of Ornithology. The Club adopted its Constitution and Bylaws in 1930 and became the Wilson Ornithological Society in 1955.

Early Professional Avian Conservation and Community Impact Award

The Early Professional Avian Conservation and Community Impact Award recognizes outstanding contributions by Wilson Ornithological Society (WOS) members working in applied, non-research careers that advance the conservation of birds and their habitats. This award also celebrates professionals whose work fosters a stronger and more inclusive conservation community, through management, education, communication, advocacy, or community engagement.

Purpose

This award highlights the diverse pathways through which people contribute to lasting ornithology and avian conservation beyond academic research. It honors those whose efforts build bridges between science, management, and the public; inspire action for birds; provide mentorship or leadership to build capacity; and promote equity, inclusion, and accessibility within the bird conservation community.

Examples of Qualifying Contributions

• Developing and implementing habitat management or conservation plans.
• Creating tools, educational materials, or outreach programs that promote bird conservation.
• Leading advocacy, communications, or storytelling that inspires conservation action.
• Building partnerships or community engagement initiatives that strengthen conservation impact.
• Advancing conservation policy or planning at local, regional, or national scales.

Award and Presentation

The recipient will be recognized at the 2026 Wilson Ornithological Society Annual Meeting, where they will be invited to share their work with attendees. The award includes:

• A monetary honorarium
• An original piece of artwork from an early-career artist
• Coverage of meeting registration, travel, lodging, and per diem expenses

The KTGF Fellowship Programs, funded by the Klingenstein Third Generation Foundation, offer $100,000 over two years to support post-doctoral and junior faculty research on ADHD and depression in children, particularly from low-income and under-resourced backgrounds. This initiative aims to foster promising early-career scientists while producing impactful research that benefits affected children and families. Applications are accepted from September 1 to December 15, with specific eligibility criteria outlined for candidates.

The Jim and Margie Fegley Orchestral String Scholarship Fund, established in 2013 by Marjorie Fegley, honors her late husband, James E. Fegley. This fund supports Berks County residents pursuing music education, particularly in orchestral strings. Applicants must maintain a GPA of 3.0 or higher and have participated in music programs. The Berks County Community Foundation manages this fund, which contributes significantly to the local arts and education landscape, fostering musical talent in the community.

The MMUF Dissertation Grant, funded by the Mellon Foundation, supports doctoral candidates who are alumni of the Mellon Mays Undergraduate Fellowship. This grant aids scholars in completing their dissertations, ensuring diverse perspectives are represented in academia. With up to $30,000 for a 12-month period, the program encourages candidates to secure additional funding from their institutions. The initiative aims to bolster access to education and foster understanding among varied backgrounds, ultimately enhancing the academic landscape.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

The Friends of Reservoirs: Large Grant supports fish habitat enhancement projects in manmade reservoirs, promoting conservation and partnerships. With approximately $250,000 in Federal funding and $500,000 from Bass Pro Shops, grants up to $75,000 are available. Projects must match funding and can be multi-year, with specific caps on subsequent funding. This initiative aims to address habitat impairments and enrich community quality of life through improved fishing opportunities.

The National Estuarine Research Reserve System (NERRS) Land Acquisition and Construction Program for Fiscal Year 2026, funded by NOAA, aims to enhance research and education by supporting land acquisition and construction projects. With approximately $8.5 million available, the program prioritizes strategic expansions of Reserve boundaries and facility enhancements, ensuring sustainable design standards. Funding will support 5-20 projects over 12-36 months, with potential extensions for complex projects, contingent on available funds and negotiations.

The Goldberg, Joseph and Ruth Scholarship, offered by the Beatrice Educational Foundation, aims to support students pursuing medical professions, such as nursing, dental, and physical therapy. Established in 1987, the Foundation provides over $55,000 annually in scholarships to Beatrice High School seniors. Eligible applicants must be in the top quarter of their class and complete the application independently. This scholarship is part of the Foundation's commitment to enhancing educational opportunities in the Beatrice School District.

The Affirm Cares Employee Foundation Grant, established by Affirm, aims to support non-profit organizations making a significant impact in financial literacy, community enrichment, and technology education. Grants range from $1,000 to $10,000, focusing on sustainable initiatives that empower communities and alleviate housing insecurity. Eligible applicants must be 501(c)(3) designated non-profits operating within the U.S. The foundation prioritizes measurable outcomes in its funding efforts, fostering civic engagement and vibrant communities.

The BTCF: Simple Gifts Fund Grant supports young artists aged 13-19 in the Berkshire Taconic region, providing financial assistance for summer enrichment programs in the arts. Established in 1998 in memory of folk singer Bill Crofut, the fund aims to empower youth through small grants that can cover costs for tuition, art supplies, or living expenses. The grant fosters creativity and personal growth, ensuring that young individuals have opportunities to pursue their passions.

The Purple Martin Conservation Association offers the PMCA Research and Conservation Grant to support research on Purple Martins. This grant aims to promote conservation efforts and may cover expenses such as travel and supplies, though it does not fund salaries or overhead. Eligible applicants include students and professionals engaged in Purple Martin research, with a focus on projects that enhance the species' habitat and well-being.

The H. Branch Howe Grant, offered by the Georgia Ornithological Society, supports graduate students conducting ornithological research in Georgia. This grant encourages the scientific study of birds and conservation efforts, providing funding for research that enhances knowledge of avian life. Eligibility is limited to graduate students in Georgia, and preference is given to projects within state boundaries. The GOS aims to foster collaboration and knowledge sharing among those passionate about birds and nature.