Best Large Grants for Nonprofit Organizations in South Carolina

Greater Toledo Community Foundation

Greater Toledo Community Foundation transforms generosity into lasting impact. With over $510 million in assets across 1,000+ funds, we've granted more than $370 million to strengthen education, health, arts, and social services throughout our region.

We connect donors with causes they care about while bringing together leaders, organizations, and resources to tackle our community's biggest challenges. What began with Walter E. Terhune's vision in the 1920s continues today as we help individuals, families, and businesses create positive change that will benefit our region for generations.

Ottawa County Community Foundation Grants

The Ottawa County Community Foundation, Inc. (OCCF) is a public charitable organization created by the citizens of Ottawa County to enrich the quality of life for individuals and families in Ottawa County. Grants from unrestricted funds support a variety of programs in the fields of education, health and social services, economic development, natural resources and the arts.

The Knight Foundation Advised Fund supports innovative projects that enhance democracy and community engagement in Columbia, SC. With grant amounts typically not exceeding $75,000, it focuses on revitalizing downtown areas and riverfront development. Eligible organizations must be 501(c)(3) charities or similar entities serving Columbia or Richland County. The foundation prioritizes civic engagement, smart design, and the arts to foster inclusive public life, while avoiding funding for debt reduction, capital campaigns, or projects with discriminatory practices.

The See, Test & Treat Grants, offered by the College of American Pathologists Foundation, aim to enhance community health by providing free breast and cervical cancer screenings. Since 2011, nearly 9,000 women have benefited from these programs, which will expand in 2026 to reach more underserved populations. This initiative empowers pathologists to reduce healthcare disparities through accessible screenings and follow-up care, ensuring prompt results and comprehensive health education for participants.

The NIDA Mentored Clinical Scientist Development Program Award aims to foster research independence in clinician scientists by providing intensive supervised research training and career development in the field of substance use and substance use disorder. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submission for this essential funding opportunity.

The U.S. Fish and Wildlife Service's Coastal Program offers vital technical and financial support for projects aimed at protecting and restoring fish and wildlife habitats in priority coastal ecosystems. Collaborating with conservation partners, the program ensures that all projects are scientifically sound and align with the missions of the Department of the Interior. Applicants must contact a local office for guidance before applying, ensuring projects meet strategic conservation goals.

The Richard King Mellon Foundation invites innovative proposals that align with their 2021-2030 Strategic Plan, aiming to invest over $1.2 billion to enhance opportunities in southwestern Pennsylvania. Their funding focuses on conservation, economic development, economic mobility, health and well-being, organizational effectiveness, and social-impact investments. The General Application offers flexibility without deadlines, allowing for a variety of support types, including project-specific and general operating funding, aimed at enriching community vitality and environmental stewardship.

The Aerie Real Foundation™ Community Grant aims to enhance confidence, inclusion, and sustainability among young women while supporting non-profit organizations in the US and Canada. Grants of up to $10,000 are available to programs focused on mental well-being, fostering inclusive communities, and environmental protection. Applications are accepted from certified 501c3 nonprofits, with funding allocated for projects that align with the Foundation's mission. The goal is to empower the next generation and create a positive impact in local communities.

The NIAAA Integrative Neuroscience Initiative on Alcoholism (INIA) aims to renew support for two research consortia focusing on the biological mechanisms of excessive alcohol consumption and Alcohol Use Disorder (AUD). By utilizing advanced technologies and fostering collaboration across multiple sites, this initiative seeks to standardize neurofunctional measures and enhance reproducibility in findings. Investigators are encouraged to prepare for future applications to this NOFO, which will utilize the U24 activity code.

The Dell Scholars Program, established by the Michael & Susan Dell Foundation, provides scholarships and support to empower students in their journey towards college graduation. It offers flexible funding for tuition, housing, and essential expenses, ensuring students can focus on their education. Alongside financial aid, scholars receive academic coaching, career guidance, and mental health resources, fostering resilience and success. Since 2004, it has helped over 6,000 scholars, including 4,500 graduates, achieve their academic goals.

The Richard and Mary Myerly Scholarship, offered by the Community Foundation of Washington County, MD, supports low-income students pursuing careers in photography or fine arts at accredited institutions. Established in memory of Richard and Mary Myerly, this scholarship invites applications from students in Washington County and surrounding areas, promoting educational opportunities and honoring community values. With over 100 scholarships available, this initiative aims to empower the next generation of artists and photographers.

The Ittleson Foundation, established in 1932, focuses on enhancing mental health, AIDS prevention, and environmental initiatives. It funds not-for-profit organizations aiming to improve public policy and the lives of citizens. The Foundation is particularly interested in innovative projects addressing mental health stigma, advancing preventative efforts, and supporting underserved populations. While it funds new initiatives, it does not typically support capital projects, endowments, or direct service programs outside New York City.

The Lasher-Bottorff Award, established by the American Association of Avian Pathologists, recognizes outstanding contributions to poultry health. It honors Dr. Hiram N. Lasher and Dr. C. A. Bottorff, pivotal figures in avian medicine. The award, valued at $1,000, is presented annually to a veterinarian who has made significant advancements in avian diagnostics or technical services over the past decade, promoting the health and productivity of poultry in North America.

The Lundbeck US Charitable Fund focuses on enhancing brain health through sponsorships that support various initiatives. These sponsorships are available to both non-profit and for-profit organizations, provided they align with Lundbeck's mission. Funds are primarily allocated for educational or awareness events, with an emphasis on community outreach and collaboration to address gaps in care, especially for vulnerable populations. By fostering innovative strategies, the Fund aims to drive meaningful change in the field of brain health.

The Lundbeck US Charitable Fund focuses on enhancing brain health through impactful donations. Established to support organizations dedicated to brain health, it addresses pressing needs by funding innovative strategies and community collaborations, particularly for at-risk populations. The Fund aims to transform lives and improve mental health care, with a commitment to responsible giving. With over 20 organizations supported in 2023, it drives meaningful change in communities affected by brain disorders.

The AISES Stellantis Scholarship aims to enhance the representation of Indigenous peoples in STEM fields. Funded by Stellantis, this scholarship offers $20,000 for full-time students enrolled in colleges with Mopar Career Automotive Programs. Eligible candidates must be current AISES members and either enrolled citizens or descendants of recognized Indigenous groups. The program not only supports education but also fosters a diverse and inclusive workforce within the automotive industry.

The GCCF Community Impact Grants for Youth and Education aim to enhance the educational landscape in Greenwood County. These grants support initiatives that address educational attainment, reduce dropout rates, and foster early childhood development. Organizations with 501(c)(3) status can apply for up to $5,000 to fund specific programs that demonstrate collaboration and community value. This funding opportunity is vital for empowering youth and ensuring access to quality education for all residents.

The Fair Housing Initiatives Program (FHIP), established by Congress in 1988, aims to fund organizations to combat discriminatory housing practices. The Education and Outreach Initiative (EOI) educates stakeholders about their rights under fair housing laws. Key components include the National Media Campaign, which promotes fair housing awareness nationally, and local programs that support community-based outreach. HUD oversees the process, ensuring compliance and monitoring of funded initiatives to enhance fair housing practices.

The AISES Indian Motorcycle Academic Scholarship offers $5,000 annually to support Native students pursuing degrees in STEM fields. Sponsored by the American Indian Science and Engineering Society, this scholarship aims to empower Indigenous students and enhance diversity in STEM. Eligible applicants must be current AISES members, full-time students, and enrolled citizens or descendants of recognized Native tribes. This scholarship not only provides financial assistance but also fosters community and innovation within the STEM landscape.

The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.

The Horton PhD Research Grant supports up to three Ph.D. students annually in hydrology and related fields, funded by the Robert E. Horton Fund. It provides a maximum of $10,000 for research and travel, along with $500 for U.S. and Canadian applicants participating in AGU's annual meeting. Eligible students must be active AGU members, enrolled for the award's duration, and meet all application requirements. This grant promotes excellence in hydrological sciences.

The See, Test & Treat Grant offers funding for a pathologist-led cancer screening program aimed at underserved communities. With a focus on health education, the program provides vital cervical and breast cancer screenings, ensuring same-day results and follow-up care. Eligible institutions can apply for funding up to $20,000 for single-year projects or up to $50,000 over three years. This initiative addresses health disparities, empowers communities, and enhances the visibility of pathology in healthcare.

The Hawk Watch Fund Grant, established by the Hawk Migration Association of North America (HMANA), supports hawk watch sites in North America facing funding challenges. Grants of up to $1000 are available for volunteer-based projects that align with HMANA's mission of promoting raptor conservation and migration study. Funding is sourced from HMANA's annual Raptorthon and donations. This initiative aims to enhance educational resources, equipment acquisition, and operational support for hawk watch groups.

The Lazarus Family Scholarship in Bioethics and Humanities, offered by the AMA Foundation, supports students engaged in bioethics or the humanities, including art, music, and literature. This scholarship aims to foster the next generation of physician leaders by providing financial assistance to those who are committed to advancing health equity and community service. By recognizing diverse fields of study, it emphasizes the importance of interdisciplinary approaches in medicine and the humanities.

The Alice M. Ditson Fund provides organizational support for professional performing ensembles and institutions committed to advancing the work of younger and relatively unknown living American composers. Grants are available for general operating or project support, emphasizing contemporary American classical concert music. Eligibility includes organizations without non-profit status if sponsored by a 501(c)(3) entity, while projects featuring American music are prioritized. This funding opportunity encourages innovative performances and fosters greater recognition of emerging talents in the classical music sphere.

Biogen General Grants

Funding to support a project or program that does not fit any of the other defined grant categories.

The Mayer and Morris Kaplan Foundation Environment Grant aims to support initiatives that combat climate change, prioritizing efforts to reduce fossil fuel consumption and enhance climate education for young adults. The foundation emphasizes innovative solutions and partnerships to address both immediate and long-term environmental challenges. Areas of focus include climate and clean energy policy, as well as providing scientifically accurate climate change education. By leveraging data and research, the foundation seeks to empower organizations dedicated to creating impactful change.

Common Waters: Strengthening Community-based Coastal and Riverine Stewardship

Opportunity Overview

Projects supported by this RFP must be community-based stewardship initiatives (including but not limited to stewardship driven by Indigenous and descendant communities); they should be led by an individual with a strong connection to and/or an existing track record of work in the community(ies) where the project will take place, or by a member of the community themselves, and be designed in response to community needs. Projects can focus on a wide range of specific issues, including (but not limited to) local conservation and ecosystem restoration, climate change adaptation and resilience, or sustainable fishing/agriculture. The RFP will prioritize projects in National Geographic-Lindblad Expeditions destinations, including the Arctic, Asia, Baja California, Costa Rica and Panama, Europe and the Mediterranean, Patagonia, the Peruvian Amazon, the Pacific Northwest, Southeast Alaska and British Columbia, the South Pacific, and the United Kingdom and Ireland. For more detailed information on targeted areas within these regions, please refer to the targeted areas document.