Best Large Grants for Nonprofit Organizations in South Carolina

The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.

The Ralph J. Torraco Food Bank/Shelter Fund Grant, offered by the UNICO Foundation Inc., aims to combat hunger and provide shelter for the homeless and indigent. Eligible applicants include registered non-profit food pantries, soup kitchens, and shelters in 13 U.S. states. The grant focuses on direct services, ensuring that all funds are used for food and shelter, not for operating expenses, thereby promoting effective community support for vulnerable populations.

The Horton PhD Research Grant supports up to three Ph.D. students annually in hydrology and related fields, funded by the Robert E. Horton Fund. It provides a maximum of $10,000 for research and travel, along with $500 for U.S. and Canadian applicants participating in AGU's annual meeting. Eligible students must be active AGU members, enrolled for the award's duration, and meet all application requirements. This grant promotes excellence in hydrological sciences.

The Yamaha Outdoor Access Initiative supports outdoor enthusiasts and promotes responsible use of off-highway vehicles (OHVs). Its mission includes educating the public on land use and wildlife conservation while protecting access to public lands. Applications are accepted quarterly from nonprofit organizations and community groups focused on land stewardship and access improvements, ensuring a safe and sustainable outdoor experience for all.

The ASTR Targeted Research Area Grant supports projects by scholars focusing on under-represented areas in theatre, dance, and performance studies. This includes research on Asian, African, Latin American, and Middle Eastern disciplines, as well as pre-1900 studies and essential translations. The grant, offering up to $3000, encourages recipients to publish their findings and collaborate with Theatre Survey editors. Eligibility extends to scholars with terminal degrees and graduate students, provided they are ASTR members.

The Trout and Salmon Foundation Grant offers matching funds up to $5,000 to support projects aimed at restoring and enhancing trout and salmon habitats in North America. Established in 1969, the foundation prioritizes partnerships with local watershed organizations focused on habitat improvement. Grants are provided for projects that physically restore streams and fisheries, with on-site labor recognized in certain cases. The foundation seeks to diversify funding across various watersheds and regions, ensuring a broad impact in conservation efforts.

The NIHCM Foundation is seeking innovative research proposals that address critical issues in U.S. health care, particularly focusing on drug pricing, provider consolidation, health care delivery, chronic disease management, and the role of artificial intelligence. Projects should aim to improve affordability and quality of care. We welcome submissions from a variety of researchers and organizations, with a preference for studies that can be completed within one year.

The Richard King Mellon Foundation invites innovative proposals that align with their 2021-2030 Strategic Plan, aiming to invest over $1.2 billion to enhance opportunities in southwestern Pennsylvania. Their funding focuses on conservation, economic development, economic mobility, health and well-being, organizational effectiveness, and social-impact investments. The General Application offers flexibility without deadlines, allowing for a variety of support types, including project-specific and general operating funding, aimed at enriching community vitality and environmental stewardship.

The General Surgery Resident Research Initiation Grant aims to engage General Surgery Residents in research related to colorectal diseases. With an annual funding of $20,000, this grant supports both clinical and laboratory-based research. It is geared towards residents or recent graduates of approved General Surgery programs, prioritizing those with aspirations in Colon and Rectal Surgery. This initiative fosters innovative research to enhance patient care and surgical techniques in the field.

The Arthritis National Research Foundation supports early career researchers in their quest to advance understanding and treatment of arthritis and related autoimmune diseases. Annually, the foundation grants 10 to 20 awards of $125,000 each for two years. Focus areas include osteoarthritis, rheumatoid arthritis, lupus, and more. Eligible investigators must hold an M.D. or Ph.D., be affiliated with a U.S. nonprofit research institution, and commit significant research time. Applications from prior grant recipients or those with certain NIH grants are ineligible.

The Eugene Salvati, MD, Limited Project Grant, offered by the Research Foundation of the American Society of Colon and Rectal Surgeons, supports clinical research in colorectal surgery. This grant aims to honor Dr. Salvati's legacy by funding innovative projects that improve patient care. With a maximum funding of $25,000 for one year, it emphasizes investigator-initiated research conducted within the U.S. or Canada, encouraging collaboration among ASCRS members and adherence to ethical review board protocols.

The Research Foundation of the ASCRS offers the Limited Project Grant to support innovative research in colon and rectal surgery. With funding up to $25,000 for one year, this grant aims to foster investigator-initiated, hypothesis-driven projects conducted in the U.S. or Canada. Successful applicants may secure further funding from national agencies. ASCRS membership is required for principal investigators, ensuring a dedicated approach to advancing colorectal health and surgical techniques.

The Robotic Research Grant, offered by the American Society of Colon and Rectal Surgeons, provides up to $150,000 over two years for innovative research in colorectal surgery and robotics. Emphasizing education, health equity, and novel techniques, the grant supports projects conducted in the U.S. or Canada, with a focus on scientific rigor. Applications must be submitted by ASCRS members who are principal investigators, ensuring alignment with ethical research standards.

The Research Foundation of the American Society of Colon and Rectal Surgeons offers a Career Development Award to support early career investigators in colorectal surgery. With a funding of $75,000 per year for two years, this award emphasizes mentorship and career growth. Applicants must be within five years of their first faculty position and demonstrate innovative research in colon and rectal diseases. The award aims to enhance academic careers while fostering advancements in surgical techniques.

The Catalyze Challenge Grant, managed by Catalyze, is an opportunity for organizations to receive funding for innovative solutions that enhance career-connected learning for youth aged 11-22. With over $4 million available in Round 5, finalists can secure up to $300,000 to implement their ideas. The grant seeks proposals that empower underserved learners through hands-on experiences and meaningful employer partnerships, ultimately impacting over 65,000 young people across the U.S.

The Cameron Award supports field research on native rodents across the Americas, encouraging studies in ecology, behavior, physiology, and conservation. It is available to students in MS or PhD programs and postdoctoral researchers in the U.S. Applicants must be ASM members. Funds cover supplies, equipment, and travel, but not salaries or meeting travel. The award aims to enhance understanding of rodent ecology and their impact on ecosystems.

The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.

The DFO Research, Education, and Conservation Grant supports projects focused on birds and their habitats, prioritizing initiatives in the Denver area and Colorado's Front Range. Established in 1994, the fund encourages research, education, and conservation efforts with grants typically under $2,000. Recent funded projects include studies on owl habitats and educational programs for young birders. The fund aims to advance knowledge and appreciation of avian species through targeted financial support.

Biogen General Grants

Funding to support a project or program that does not fit any of the other defined grant categories.

The Kalamazoo Valley Chapter's Stanley Weber Projects Fund honors a dedicated member by supporting projects that enhance coldwater fisheries and their habitats. Offering grants up to $5,000 annually, the fund prioritizes non-profit initiatives that foster conservation, restoration, and public education while promoting volunteer engagement. Recognition through plaques or media announcements is requested for grant recipients, ensuring the legacy of Stanley Weber continues to impact the community positively.

The Donna J. Heinrich Environmental Education Grant, established by the Gopher Tortoise Council, aims to support educators and organizations in creating projects focused on the gopher tortoise and its habitat. This grant honors Donna June Heinrich, a dedicated environmental educator committed to wildlife conservation. By fostering educational initiatives, the grant seeks to enhance public understanding and appreciation of the gopher tortoise and promote its conservation across the southeastern United States.

Sodexo Stop Hunger Foundation

The Sodexo Stop Hunger Foundation goes beyond food aid to create lasting change. Through innovative programs, strategic partnerships and volunteer action, Stop Hunger tackles the root causes of food insecurity.

In 2025, Sodexo Stop Hunger Foundation and the Hunger Center awarded grants to 131 programs representing 118 communities in 37 states plus the District of Columbia. Collectively, these programs provided an estimated 22,000 backpacks full of shelf-stable food items for students to take home for the weekend or holidays when school meals are not served.

Since 2006, the Sodexo Stop Hunger Foundation has been a driving force behind weekend and holiday hunger relief for students across the U.S. Through support of food backpack programs, the Foundation partners with local food banks and schools to discreetly provide K-12 students with backpacks filled with nutritious, shelf-stable meals. These backpacks are distributed in safe, familiar settings – typically on the last school day before a weekend or school break – ensuring that all children who rely on free or reduced-price school meals don’t go hungry when school is out.

K-12 Backpack Grant

The K-12 Backpack Grant is an initiative launched by the Sodexo Stop Hunger Foundation and administered in partnership with the Congressional Hunger Center to support community backpack programs. Grants of $1,000 will be issued to community organizations with established backpack feeding programs that provide students with shelf-stable, nutritious meals when school is out of session.

South Carolina Department of Commerce

From site selection to infrastructure improvement, we are here to help grow new and existing businesses.

SC Commerce promotes economic opportunity for individuals and businesses through initiatives like workforce training. As a national leader in foreign direct investment, the state extends its global reach with offices in Europe and Asia that help existing companies in developing export markets.

South Carolina Community Development Block Grant

The South Carolina Community Development Block Grant (“State CDBG Program”) is designed to aid units of general local government in improving economic opportunities and meeting community revitalization needs, particularly for persons of low- and moderate-income. The State CDBG Program has been funded through the State since 1982 by the U.S. Department of Housing and Urban Development (HUD) under the Housing and Community Development Act of 1974, as amended (Title I). 

CDBG Program Goals and Outcomes

The SC Department of Commerce seeks to improve the well-being of all South Carolinians in a manner that supports and enhances a high quality of life. The State CDBG Program supports the agency’s efforts to strengthen communities through revitalization and improvement of neighborhoods, public infrastructure, and the local economy. 

The three overarching goals of the HUD CDBG program are to provide decent housing, economic opportunities and a suitable living environment. Within the context of these goals, each project funded by the State must also meet one of three outcomes identified by HUD: affordability, accessibility, or sustainability. 

Local Match/Leveraging

CDBG projects are expected to leverage other public and private investments and serve as a catalyst for future development.

There must be a 10% match of the total CDBG request, unless otherwise approved, which can come from a variety of committed sources including other grants, loans, waiver of fees, public or private investments, and documented volunteer or in-kind contributions. Matching funds must be immediately available for the project at the time of application. 

Community Development Block Grant Categories

There are three broad grant program categories: Community Development, Business Development, and Regional Planning. The Community Development Program is further broken down into several subcategories to address infrastructure, community facilities, and local priorities.

Community Development Programs

Description

This program is designed to produce outcomes that improve citizens’ quality of life and create a competitive environment for jobs and investment by addressing priority community development needs. Activities should contribute to healthy, safe and sustainable neighborhoods and communities. These grants are designed to improve the quality of life for distressed and LMI communities. Community Development projects will compete within the following subcategories that have the same general submission requirements, except that the Ready to Go Program will not be funded in a competitive funding round.

Community Development Program Categories: Community Infrastructure; Community Enrichment; Local Priorities Program; and Ready to Go Program

Community Infrastructure Grants

Outcome and Priorities

A Community Infrastructure application must contribute to creation of healthy and sustainable residential communities through water, sewer, roads, drainage or other activities that address one or more of the priorities listed in order of importance:

Significant improvements to existing infrastructure to address health concerns, meet required quality standards, ensure community sustainability or improve resiliency.

Projects that result in a more viable regional infrastructure solution or that provide new access to services near business centers where it is cost effective to address a documented health threat

Upgrades to infrastructure to address quality standards where there are only general health concerns or provide new services that are not near business centers when it is cost effective to address a documented health threat

The Kaiser Permanente Center for Gun Violence Research and Education Grant Program aims to transform the landscape of gun violence research and education by funding initiatives that address community firearm violence and suicide. This program focuses on partnering with affected communities, integrating healthcare approaches, and providing substantial funding to enhance research capacity and intervention effectiveness. With funding available in two categories, the initiative seeks to promote evidence-based solutions that foster community healing and well-being.

Mary Kay Ash Foundation

Guided by Mary Kay Ash’s dream to enrich the lives of women everywhere, the Mary Kay Ash Foundation® raises and distributes funds to invest in breakthrough cancer research and clinical trials to find a cure for women-related cancers and ending domestic violence.

Since 1996, the Mary Kay Ash Foundation®, a 501(c)3 organization, has contributed more than $100 million to organizations aligned with its two-fold mission. In addition, the Foundation supports awareness initiatives, community outreach programs, and advocates for legislation to ensure women are healthy and safe. Through our global charitable foundations in Brazil, Canada, China and the United States, we are collectively making a deeper impact on the lives of women around the world.

Mary Kay Ash Foundation: Cancer Research Grant

The Mary Kay Ash Foundation is a non-profit public foundation, which focuses on funding research for innovative grants for translational research of cancers affecting women (ovarian, uterine, breast, endometrial or cervical cancer among others). Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately, such research would lead to improvement in diagnosis, prognosis, prevention, or treatment of the cancer. Each year the Foundation extends invitations to NCI designated cancer institutes and accredited medical schools to apply. Only one application is accepted per institution.

Grant proposals are reviewed by a Scientific Research Review Committee comprised of notable members of the American medical and scientific community. Grants are awarded up to $100,000 (combined direct and indirect costs) for a two-year period. The Foundation anticipates funding between 10 and 15 grants annually. 

The See, Test & Treat Grants, offered by the College of American Pathologists Foundation, aim to enhance community health by providing free breast and cervical cancer screenings. Since 2011, nearly 9,000 women have benefited from these programs, which will expand in 2026 to reach more underserved populations. This initiative empowers pathologists to reduce healthcare disparities through accessible screenings and follow-up care, ensuring prompt results and comprehensive health education for participants.

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.