Best Large Grants for Nonprofit Organizations in South Carolina

The Adtalem Global Education Foundation, established in 2010, is dedicated to enhancing education and community development. Based in Chicago, it focuses on expanding educational access, particularly for underrepresented minorities in the healthcare sector. The foundation prioritizes initiatives that promote economic growth through skills-based workforce development, address healthcare disparities, and increase access to quality education for underserved populations. Its commitment to civic engagement and equality reflects its mission to empower communities.

The Natural History Research Experiences (NHRE) is a prestigious 10-week summer internship program at the Smithsonian's National Museum of Natural History. It offers undergraduates the chance to engage in independent research across various disciplines including Earth Science and Anthropology. Participants receive a stipend of $8250, travel support, and free housing, while benefiting from mentorship by leading scientists. This program aims to cultivate future leaders in natural history research.

The Amy Adina Schulman Memorial Fund

The Amy Adina Schulman Memorial Fund is a Princeton, New Jersey-based endowment fund providing grants to individuals, young adults who volunteer or intern for progressive social action projects or programs in an area of their interest and commitment. The Amy Adina Fund also sponsors a lecture each year on a relevant and timely topic related to its educational mission.

The Amy Adina Schulman Memorial Fund was started in 1987 one year after Amy Adina, 20, died suddenly while a student and activist at Rutgers University. It is a realization of her family and her communities’ desire to celebrate her life, to fulfill her dreams and her potential. Since its inception, almost 1,500 grants have been awarded for work in Africa, Asia, Latin America, the Middle East, and the United States—nearly $1,000,000 in total. The Amy Adina Schulman Memorial Fund is a 501(c)3 nonprofit organization.

About Our Grants

Small grants (depending on length of service), are awarded to as many applicants as possible rather than giving larger amounts to fewer individuals. The number of awards has grown each year thanks to annual contributions as well as to gifts sent to the Fund to honor special occasions and life cycle events.

The Conservation Practitioner Award, presented by the American Ornithological Society, recognizes dedicated professionals at any career stage who address avian conservation issues at local or regional levels. This award includes a certificate and a $1,000 honorarium, acknowledging the critical work of individuals or groups in government or non-government organizations. The AOS aims to promote ethical standards and support a diverse community of ornithologists committed to bird conservation.

South Carolina Department of Commerce

From site selection to infrastructure improvement, we are here to help grow new and existing businesses.

SC Commerce promotes economic opportunity for individuals and businesses through initiatives like workforce training. As a national leader in foreign direct investment, the state extends its global reach with offices in Europe and Asia that help existing companies in developing export markets.

South Carolina Community Development Block Grant

The South Carolina Community Development Block Grant (“State CDBG Program”) is designed to aid units of general local government in improving economic opportunities and meeting community revitalization needs, particularly for persons of low- and moderate-income. The State CDBG Program has been funded through the State since 1982 by the U.S. Department of Housing and Urban Development (HUD) under the Housing and Community Development Act of 1974, as amended (Title I). 

CDBG Program Goals and Outcomes

The SC Department of Commerce seeks to improve the well-being of all South Carolinians in a manner that supports and enhances a high quality of life. The State CDBG Program supports the agency’s efforts to strengthen communities through revitalization and improvement of neighborhoods, public infrastructure, and the local economy. 

The three overarching goals of the HUD CDBG program are to provide decent housing, economic opportunities and a suitable living environment. Within the context of these goals, each project funded by the State must also meet one of three outcomes identified by HUD: affordability, accessibility, or sustainability. 

Local Match/Leveraging

CDBG projects are expected to leverage other public and private investments and serve as a catalyst for future development.

There must be a 10% match of the total CDBG request, unless otherwise approved, which can come from a variety of committed sources including other grants, loans, waiver of fees, public or private investments, and documented volunteer or in-kind contributions. Matching funds must be immediately available for the project at the time of application. 

Community Development Block Grant Categories

There are three broad grant program categories: Community Development, Business Development, and Regional Planning. The Community Development Program is further broken down into several subcategories to address infrastructure, community facilities, and local priorities.

Community Development Programs

Description

This program is designed to produce outcomes that improve citizens’ quality of life and create a competitive environment for jobs and investment by addressing priority community development needs. Activities should contribute to healthy, safe and sustainable neighborhoods and communities. These grants are designed to improve the quality of life for distressed and LMI communities. Community Development projects will compete within the following subcategories that have the same general submission requirements, except that the Ready to Go Program will not be funded in a competitive funding round.

Community Development Program Categories: Community Infrastructure; Community Enrichment; Local Priorities Program; and Ready to Go Program

Local Priorities Program

Outcome and Priorities

This program is designed to address unique local and regional needs and priorities for addressing those needs through community development, including projects that reflect priorities established in conjunction with the S.C. Department of Commerce Business Incentives & Community Development Division. Projects may reflect community development needs that are not typically funded through the other State CDBG programs and generally should not be funded by other HUD partner programs, such as HOME and NHTF (affordable housing), ESG (homelessness) or HOPWA (special needs). These funds will be used for alternative grant activities and partnerships that meet the community development needs of eligible municipalities. Local Priority projects could include historic preservation, innovation, energy conservation, parks, and trails/greenways. New or expanded public service activities are also eligible. Projects should leverage other funding or include local funding; impact identified needs and demonstrate strong community support while meeting a National Objective and all other requirements. 

About NCRC

The National Community Reinvestment Coalition (NCRC) is a nationwide network of nearly 800 organizations and champions working for a Just Economy, where all Americans can build wealth and provide for their families with stability and dignity.

Our vision: To solve America’s historic racial and socio-economic wealth, income and opportunity divides. This vision is the foundation of the Just Economy Pledge.

Fellowship for Equitable Development

The National Community Reinvestment Coalition matches top-level graduate degree students with premiere community development organizations.

NCRC is looking for fellowship projects that move the needle on housing, small business development, and workforce development. Projects may directly result in community outcomes in these focus areas, or involve work with community members to create plans or project pipelines that will solve local issues in these areas.

The NCRC Fellowship cultivates the next generation of community development leaders and empowers them to tackle the issues of tomorrow. The community development sector will face significant challenges in the coming decades from climate change, widening wealth gaps, food insecurities, extreme housing shortages and other needs. These challenges will disproportionately impact low-wealth communities and communities of color. Therefore, it is NCRC’s intention and pledge to uphold the values of community empowerment in the fellowship program.

Interested students and host organizations must apply for this fellowship opportunity.

Program Benefits for Student Fellows Include:

• High-quality training and support from regional leaders in the nonprofit, government, planning and community development fields
• A $20,000 stipend for the eight-month, part-time (20-hours per week) fellowship
• The opportunity to meet with leaders in the nonprofit, government, planning and community development fields
• Academic credit, in accordance with the policies of the Fellows’ respective universities
• Complimentary admission to the NCRC annual Just Economy Conference

Program Benefits for Host Organizations Include:

• Fresh, innovative talent to help advance organizational mission
• The opportunity to help shape the next generation of community development leaders
• Participation in a fellowship program at little to no cost

The Process

1. NCRC Members Apply; 2. NCRC Selects Member Projects; 3. Students Apply To Selected Projects; 4. Top Student Candidates Interviewed; 5. NCRC & Member Select Student Fellow; 6. NCRC Onboards Member & Student 7. Fellowship Commences

Student Fellow Applications

Fellow applications will open for eligible students once host projects have been reviewed and finalists selected. Students will apply to be considered for a specific host project. Top student candidates will be interviewed by NCRC as well as the host organization.

Fellow Requirements

• Must provide documentation confirming active enrollment (i.e. Letter of Enrollment from Registrar or transcript)
• Must commit to fellowship for full Period of September 14, 2026-May 14, 2027 academic school year
• Must commit to a 20 hour/week fellowship
• Must commit to a schedule with at least one day per week in-office of host organization

About NCRC

The National Community Reinvestment Coalition (NCRC) is a nationwide network of nearly 800 organizations and champions working for a Just Economy, where all Americans can build wealth and provide for their families with stability and dignity.

Our vision: To solve America’s historic racial and socio-economic wealth, income and opportunity divides. This vision is the foundation of the Just Economy Pledge.

Fellowship for Equitable Development

The National Community Reinvestment Coalition matches top-level graduate degree students with premiere community development organizations.

NCRC is looking for fellowship projects that move the needle on housing, small business development, and workforce development. Projects may directly result in community outcomes in these focus areas, or involve work with community members to create plans or project pipelines that will solve local issues in these areas.

The NCRC Fellowship cultivates the next generation of community development leaders and empowers them to tackle the issues of tomorrow. The community development sector will face significant challenges in the coming decades from climate change, widening wealth gaps, food insecurities, extreme housing shortages and other needs. These challenges will disproportionately impact low-wealth communities and communities of color. Therefore, it is NCRC’s intention and pledge to uphold the values of community empowerment in the fellowship program.

Interested students and host organizations must apply for this fellowship opportunity.

Program Benefits for Student Fellows Include:

• High-quality training and support from regional leaders in the nonprofit, government, planning and community development fields
• A $20,000 stipend for the eight-month, part-time (20-hours per week) fellowship
• The opportunity to meet with leaders in the nonprofit, government, planning and community development fields
• Academic credit, in accordance with the policies of the Fellows’ respective universities
• Complimentary admission to the NCRC annual Just Economy Conference

Program Benefits for Host Organizations Include:

• Fresh, innovative talent to help advance organizational mission
• The opportunity to help shape the next generation of community development leaders
• Participation in a fellowship program at little to no cost

The Process

1. NCRC Members Apply; 2. NCRC Selects Member Projects; 3. Students Apply To Selected Projects; 4. Top Student Candidates Interviewed; 5. NCRC & Member Select Student Fellow; 6. NCRC Onboards Member & Student 7. Fellowship Commences

Host Partnerships

Fellowship host partners must be NCRC members. If your organization would like to participate in the Fellowship but is not a member, you can join here and then apply.

Host Requirements

• A compelling project to provide a challenging assignment for fellows with real world application.
• Must commit to a schedule with at least one day per week in office for both fellow and host supervisor.

South Carolina Department of Commerce

From site selection to infrastructure improvement, we are here to help grow new and existing businesses.

SC Commerce promotes economic opportunity for individuals and businesses through initiatives like workforce training. As a national leader in foreign direct investment, the state extends its global reach with offices in Europe and Asia that help existing companies in developing export markets.

South Carolina Community Development Block Grant

The South Carolina Community Development Block Grant (“State CDBG Program”) is designed to aid units of general local government in improving economic opportunities and meeting community revitalization needs, particularly for persons of low- and moderate-income. The State CDBG Program has been funded through the State since 1982 by the U.S. Department of Housing and Urban Development (HUD) under the Housing and Community Development Act of 1974, as amended (Title I). 

CDBG Program Goals and Outcomes

The SC Department of Commerce seeks to improve the well-being of all South Carolinians in a manner that supports and enhances a high quality of life. The State CDBG Program supports the agency’s efforts to strengthen communities through revitalization and improvement of neighborhoods, public infrastructure, and the local economy. 

The three overarching goals of the HUD CDBG program are to provide decent housing, economic opportunities and a suitable living environment. Within the context of these goals, each project funded by the State must also meet one of three outcomes identified by HUD: affordability, accessibility, or sustainability. 

Local Match/Leveraging

CDBG projects are expected to leverage other public and private investments and serve as a catalyst for future development.

There must be a 10% match of the total CDBG request, unless otherwise approved, which can come from a variety of committed sources including other grants, loans, waiver of fees, public or private investments, and documented volunteer or in-kind contributions. Matching funds must be immediately available for the project at the time of application. 

Community Development Block Grant Categories

There are three broad grant program categories: Community Development, Business Development, and Regional Planning. The Community Development Program is further broken down into several subcategories to address infrastructure, community facilities, and local priorities.

Community Development Programs

Description

This program is designed to produce outcomes that improve citizens’ quality of life and create a competitive environment for jobs and investment by addressing priority community development needs. Activities should contribute to healthy, safe and sustainable neighborhoods and communities. These grants are designed to improve the quality of life for distressed and LMI communities. Community Development projects will compete within the following subcategories that have the same general submission requirements, except that the Ready to Go Program will not be funded in a competitive funding round.

Community Development Program Categories: Community Infrastructure; Community Enrichment; Local Priorities Program; and Ready to Go Program

Community Enrichment Grants

Outcome and Priorities

This program is designed to fund public facilities, services and other activities that strengthen existing communities and support a high quality of life within the following state priority areas:

• Economic competitiveness and resiliency
• Education and workforce development
• Safe and healthy communities

Project investments should contribute to quality of life and the long-term vitality of communities. Activities must have the broad support of citizens and local businesses. Buildings and brownfield sites should be owned by the local government. Note that costs for operating or maintaining public facilities are not eligible for CDBG, so building projects must demonstrate financial viability. Equipment for public service activities must be for new or expanded services and generally associated with a significant capital investment in facilities. Only major pieces of equipment that have a durable life of five years will be considered for funding.

Brooks Brothers, founded in 1818, is committed to social responsibility through its donation program. The company partners with local and national non-profits focused on health issues and education. They seek to enhance community well-being while maintaining a commitment to inclusivity. Notably, they do not support organizations that discriminate based on protected categories. Their donations are aimed at fostering positive change in society, reflecting their belief in the importance of community engagement.

The Social Impact Fund - Nationwide Grant supports innovative solutions addressing health care access, food security, and economic empowerment. Funded by the American Heart Association, this grant prioritizes community-led projects from organizations with under $10M in revenue. Eligible entities include both for-profit and nonprofit organizations based in the U.S. and Puerto Rico. Grants can provide up to $250,000 to initiatives that demonstrate measurable impact, fostering sustainable change in health and wellness.

The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.

Theresa Alessandra Russo Foundation Inc

The Theresa Foundation honors the memory of Theresa Alessandra Russo by touching the lives of children with special needs and their families. The Foundation fosters each child’s unique abilities by supporting programs focusing on art, music, dance, drama, and recreation.

The Theresa Foundation has a vision of the world where artistic expression and physical recreation are just as important to adults as they are to children. We believe in a world where every child, regardless of ability or challenging conditions, is free to communicate through and participate in every art or recreational activity. A society without art is a society without soul. Art enables us to express our inner thoughts, fears, joys, and sadness.  

The Theresa Foundation Grant Program

The Theresa Foundation Grant Program is committed to providing financial support for programs in art, music, dance, drama, or recreation that are designed specifically for children with special needs in order to ensure that no one is excluded from these activities. 

We believe that every individual should have the opportunity to participate in art, music, dance, drama or recreation if they so choose. Our grant program works to provide direct funding for the success of these activities, while also promoting an environment of acceptance and inclusiveness where all can take part without judgment or fear. 

As of 2026, the Theresa Foundation has provided over $3,300,000 in grant funding for over 200 programs in 29 states throughout the country and 4 international grants. With your help we can continue to make a difference in the lives of those with special needs by providing them access to enriching experiences that would otherwise be out of reach. 

Hispanic Heritage Foundation

Established by the White House in 1988, the Hispanic Heritage Foundation—a 501(c)(3) nonprofit organization—continues to advance its mission through award winning programs that adapt to the needs, aspirations, and vision of our community while delivering a strong value proposition for the country.

HHF’s mission and programs have been recognized by The White House, US Congress, Fortune 500 Companies, US Army, other nonprofits, and even the Government of Mexico, in five areas of focus: education, workforce development, societal impact, and leadership, with culture serving as the cornerstone of its mission.

Youth Awards

The 28-year-old Youth Awards have recognized thousands of high school students from all 50 states, Puerto Rico, and Washington, D.C., for their achievements in the classroom, community, and focus on career paths in STEM fields, entrepreneurship, media, public service, and other categories.

Gold, Silver, and Bronze recipients are selected in each category and receive a one-time innovation grant to fund their college education or support a community service effort addressing a social issue. Additionally, one national awardee is selected in each category.

Once selected, recipients are celebrated in virtual ceremonies and become part of the LOFT (Leaders On Fast Track) Network, a collective of 300,000+ students and young professionals with access to mentors, resources, networking opportunities, workshops, symposia, summits, internships, and full-time positions with Fortune 500 companies.

The Harry Chapin Foundation grants support 501(c)(3) organizations in the U.S. focused on self-sufficiency. They prioritize grassroots programs in the arts, community education, and environmental sectors, with a budget cap of $750,000. Grants are typically awarded for one year, with renewals requiring a new proposal each year. Organizations using fiscal agents or applying for individuals are not eligible. The foundation is dedicated to improving lives through sustainable initiatives.

The Connected Communities Grants aim to enhance the quality of life in the Midlands by funding innovative projects that foster community attachment and satisfaction. Eligible organizations must be 501(c)(3) registered and located in specified counties. Grants range from $10,000 to $60,000, requiring a challenge match of funds raised. Priority is given to projects promoting equity and community involvement, making it vital for applicants to present novel ideas that strengthen local connections and address community needs.

The Community Connect Grants Program provides financial assistance to eligible applicants aiming to deliver broadband services in rural areas where access is limited. This initiative fosters economic growth and enhances educational, healthcare, and public safety benefits, improving the quality of life in underserved communities. By supporting projects that create better market opportunities and promote equitable access, the program plays a vital role in advancing rural development and addressing environmental justice.

Delaney Family Foundation 

The Delaney Family Foundation is a private family foundation focused on making grants to support Wildlife and Land Conservation, Education, Healthcare and Community Betterment.

The Delaney Family Foundation was established in 2013. We make both program and operating grants and do not have geographical restrictions.  

Grant Information

Grants are awarded annually. The following criteria will be used in confirming that grant requests match the goals of The Delaney Family Foundation.

• Clarity of Purpose – the request should be clearly defined with a specific description of how goals/tasks will be achieved and how funds will be spent.
• Potential for Success – the organization must demonstrate that they have funding sources, manpower, and community support as well as the time to achieve their goals. Projects must be realistic.
• Leadership – stability in the organization is a requirement, as well as a well-deserved reputation for results.
• Site Visits – While not always possible, site visits by board members prior to gifting, during gifting or following may be considered.

 We may consider multi-year grants.

Tyson Foods invites sponsorship proposals that reflect its core values and contribute to community welfare, particularly in Springdale, Arkansas, and Dakota Dunes, South Dakota. Proposals should demonstrate clear community benefits, visibility of the event, and outline how funds will be utilized effectively. Organizations are encouraged to apply if they align with Tyson's mission of integrity and stewardship, ensuring that funding can support primary objectives while considering tax-deductible options.

The Robert and Joan Dircks Foundation Grant Program supports non-profit organizations in New Jersey that provide opportunities for disadvantaged individuals. With grants ranging from $1,000 to $15,000, the foundation focuses on innovative programs that solve critical issues rather than operational needs. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code. The foundation does not fund political activities, cultural projects, or operating budgets, ensuring resources directly benefit those in need.

The GCCF Community Impact Grants for Youth and Education aim to enhance the educational landscape in Greenwood County. These grants support initiatives that address educational attainment, reduce dropout rates, and foster early childhood development. Organizations with 501(c)(3) status can apply for up to $5,000 to fund specific programs that demonstrate collaboration and community value. This funding opportunity is vital for empowering youth and ensuring access to quality education for all residents.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5411 - Practical Playbook for Adaptive Utility Capital Improvement Planning Under Deep Uncertainty

Grant Information

• Assess current utility practices for incorporating adaptive or flexible decision making into capital improvement planning (CIP) at the portfolio or programmatic level.
• Identify where deep uncertainty most affects CIP decision points, including investment areas prone to lock-in or points of no return.
• Document the institutional processes, frameworks, and governance structures that have enabled utilities to embed adaptive and flexible investment strategies.
• Quantify how adaptive capital strategies compare to traditional CIP approaches in terms of lifecycle costs, rate stability, financial risk exposure, and avoided or deferred capital investments across a range of plausible future conditions.
• Establish practical criteria to help utilities determine which types of capital investments are well suited for adaptive approaches.
• Develop a practitioner-focused playbook that equips utilities to apply adaptive CIP in practice, including case studies, decision trees, trigger points, vulnerability assessment tools, financial and risk insights, and governance guidance.
• Produce tiered recommendations that allow utilities to adopt adaptive CIP practices incrementally.

The Mike & Sofia Segal Foundation Grant provides vital funding to nonprofit organizations focused on intellectual freedom, medical research for rare diseases, Jewish heritage preservation, elder care, and climate change initiatives. By supporting innovative projects that align with their mission, the foundation aims to uplift communities and foster meaningful societal contributions. Organizations must be 501c-3 compliant and demonstrate a clear plan for engagement with beneficiaries and measurable objectives to be eligible for funding.

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5426 - Investigation of Non-Point Sources of PFAS in Sewersheds and Potential Mitigation Strategies

Grant Information

Evaluate the impact of non-point or dispersed sources of per- and polyfluoroalkyl substances (PFAS) in the sewershed (including PFAS-contaminated groundwater infiltration) on PFAS mass loading to wastewater treatment plants.

Assess how PFAS loading from non-point or dispersed sources of PFAS in the sewershed may affect treatment efficiency and reuse water quality.

Improve understanding of PFAS precursor contributions.

Identify potential strategies to mitigate PFAS loading from non-point or disbursed sources of PFAS in the sewershed.

The MMUF Dissertation Grant, funded by the Mellon Foundation, supports doctoral candidates who are alumni of the Mellon Mays Undergraduate Fellowship. This grant aids scholars in completing their dissertations, ensuring diverse perspectives are represented in academia. With up to $30,000 for a 12-month period, the program encourages candidates to secure additional funding from their institutions. The initiative aims to bolster access to education and foster understanding among varied backgrounds, ultimately enhancing the academic landscape.

The NIDA Mentored Clinical Scientist Development Program Award aims to foster research independence in clinician scientists by providing intensive supervised research training and career development in the field of substance use and substance use disorder. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submission for this essential funding opportunity.

The J. Larry Landers Student Research Award, offered by the Gopher Tortoise Council, provides funding for undergraduate and graduate students conducting research on gopher tortoise biology or upland habitat conservation. With an average award of $1,000, applicants must submit a four-page proposal, including project details and a budget. This grant aims to support original student-led research within the southeastern U.S., where the gopher tortoise is native, thus promoting vital ecological studies.

The Healthy Harbors Fund, launched by Charleston Waterkeeper and the South Carolina Coastal Conservation League with support from Coastal Community Foundation, aims to enhance water quality in the Charleston Harbor area. The fund, bolstered by a $1 million settlement from a pollution lawsuit, will provide grants to local nonprofits focusing on critical issues such as plastics, bacteria, and climate resilience. This initiative encourages community engagement and aims to tackle pressing environmental challenges in the Lowcountry.