Best Large Grants for Nonprofit Organizations in South Carolina

The Norfolk Southern In-Kind Donation Grant supports organizations seeking physical donations of materials that align with their focus areas, including safety, sustainability, workforce development, and thriving communities. This grant is available year-round, with no application deadline. Recipients must be located within Norfolk Southern territory and are encouraged to apply for resources that will enhance their community projects and initiatives, fostering growth and resilience.

The David, Helen and Marian Woodward Fund, established by Marian Woodward Ottley in 1974, aims to support non-profit organizations in Georgia and neighboring states. The fund prioritizes capital projects and educational programs that enhance graduation rates, particularly those with religious affiliations. Grants are awarded exclusively to 501(c)(3) organizations, while governmental agencies can also apply. The foundation's mission underscores a commitment to improving the world for future generations.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Karen Colina Wilson Foundation Grant supports programs for children, youth, and women, enhancing their health and well-being through education, art, literature, and music. Established in 2006, the foundation aims to make a positive difference in their lives, particularly in Southern and Western Wayne County, Michigan. Grants typically range from $500 to $10,000, often as matching funds, fostering broader fundraising efforts by local nonprofit organizations.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Vulcan Materials Company Foundation Grant focuses on enhancing community quality of life through education, environmental stewardship, and employee involvement. Established in 1988, the Foundation supports public charities and government units, prioritizing proposals that improve public education and promote sustainable practices. Special consideration is given to initiatives that engage Vulcan employees and integrate multiple focus areas, ensuring a positive impact in the local communities where Vulcan operates.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

Kids' Chance of South Carolina offers educational scholarships to children whose parents have been seriously injured or killed in work-related accidents. This initiative aims to alleviate the financial burdens these children face, enabling them to pursue their educational goals. Eligible applicants must be between 16-25 years old, have completed the FAFSA, and be accepted into an accredited educational program. This scholarship is vital for supporting the educational aspirations of those affected by workplace tragedies.

The Wallace F. Pate Scholarship, established by the Hampton Wildlife Fund in 2004, awards $2,500 annually to a South Carolina resident pursuing higher education in natural resource disciplines. This scholarship honors Wallace F. Pate, a pioneer in offshore big game fishing. Eligible applicants must be seniors in South Carolina high schools, planning to major in fields such as wildlife biology or environmental science. The scholarship aims to support future conservation leaders and promote educational growth in South Carolina.

The Duke Endowment's Child and Family Well-Being Grant provides implementation support to public and private agencies in North and South Carolina. This funding aims to adopt and sustain evidence-based programs that prevent and treat child maltreatment. Eligible organizations must have two years of audited financial statements and work with accredited groups. The grant prioritizes innovative solutions and advocacy to improve child welfare systems, ensuring effective support for children and families at risk.

The Kids’ Chance of South Carolina Scholarship provides financial assistance to children of South Carolina workers who have been killed or seriously injured in work-related incidents. Ranging from $500 to $3,000, these scholarships aim to alleviate the financial hardships faced by these families, empowering students aged 16-25 to pursue post-secondary education. Eligible applicants must demonstrate financial need and be accepted or enrolled in an educational institution, ensuring support for their educational aspirations.

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

Crime Victim Assistance Grants

The mission of the Department of Crime Victim Assistance Grants (DCVAG) is to enhance South Carolina’s capacity to assist crime victims and to provide leadership in the promotion of justice and healing. Through grant funding, victims can receive services including:

• Victim Advocacy
• Counseling
• Residential Shelter
• Forensic Interviews and Forensic Nurse Examination
• Emergency Assistance

Victims of Crime Act (VOCA)

DCVAG is responsible for the administration of four grant programs including the Victims of Crime Act (VOCA), a 1984-Public Law 98-473 established the Victims of Crime Act (VOCA) - Federal Fines, Fees, and Assessments

The primary purpose of VOCA is to support the provision of direct services to victims of violent crime. The program goal is to provide federal funding through grant awards to certified private non-profit organizations and public/government agencies for projects that will provide, enhance, improve, and expand direct services to victims of violent crime. 

According to the 2016 VOCA Program Rule, direct services or services to victims of crime are defined as those efforts that (1) respond to the emotional, psychological, and physical needs of crime victims, (2) assist victims to stabilize their lives after victimization, (3) assist victims to understand and participate in the criminal justice system, or (4) restore a measure of safety and security for the victim.

Funding cannot be used for the investigation of crimes or collection of evidence to further the prosecution of crimes.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

The CIF Capacity Builder Awards by Endeavor Health focus on enhancing community health through strategic investments. With over $38.5 million allocated to local partnerships, these awards aim to address critical areas like healthcare access, food insecurity, and workforce development. Designed for nonprofit organizations, the awards range from $100,000 to $500,000 annually for 1-2 years, fostering long-term community impact and advancing health equity in the service areas.

About

Being deeply connected to the community means more than providing access to excellent healthcare. It means understanding, and investing in, the health needs of our community.

Through our Community Investment Fund (CIF), Endeavor Health has awarded more than $38.5 million to 59 local partnerships dedicated to enhancing community health and wellbeing, advancing health equity and supporting local economic growth. Together, we’re committed to helping everyone in our communities be their best.

Award categories

Through the CIF, we will make meaningful and intentional investments through impact awards and capacity builder awards. These awards are intended to meaningfully advance the health of our community over time towards three bold aspirations through investments in five areas of focus.

We aspire to a future where:

• A person’s zip code does not determine how long they will live
• Hunger and homelessness in our communities are history
• The healthcare workforce is thriving and representative of the communities we serve

To help advance these aspirations, the CIF will invest in the following areas:

• Access to healthcare
• Behavioral health
• Food insecurity
• Housing insecurity
• Workforce development for careers in healthcare

Impact awards

• Designed for 5-year initiatives where organizations come together to drive measurable impact and longer-term change in the communities we serve by improving existing systems and innovation
• Emphasize strategic cross-sector and/or intra-sector partnerships between community-based organizations
• Uplift community members of greatest need
• Directly align with CIF areas of focus and meaningfully contribute to CIF goals
• Award amount: $1 million per year, up to 5 years

Arbor Rising Grant, established in 2010, is a NYC-based nonprofit providing unrestricted multi-year funding and capacity-building support to nonprofits focused on alleviating poverty. The grant process occurs every three years, with the next round in 2025 being invitation-only. Eligible organizations must demonstrate high potential and effective leadership, typically operating on a modest budget. Arbor Rising prioritizes applicants from the NYC metro area while expanding to cover the lower 48 US states.

The FJ Brotherton Charitable Trust Grant aims to support charitable organizations, focusing on arts, education, and social services primarily in the northeastern United States. Established in 2024, the Trust continues the legacy of the Fred J. Brotherton Charitable Foundation. It emphasizes funding for programs that assist the needy or disabled, while adhering to strict eligibility criteria, including a requirement for tax-exempt status under I.R.C. Section 501(c)(3).

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.

The South Carolina Commodity Supplemental Food Program (CSFP) aims to enhance the health of individuals aged 60 and above by providing nutritious USDA food packages. Administered by the South Carolina Department of Agriculture, the program helps eligible participants with limited income access essential nutrients. Local agencies distribute food and offer nutrition education while connecting them to additional support services like SNAP and Medicaid. This initiative addresses dietary deficiencies in the senior population of South Carolina.

South Carolina State Firefighters’ Association

The South Carolina State Firefighters’ Association was founded in 1905 by a group of determined fire service leaders committed to strengthening the fire service through education, training, benefit provision, and legislative representation. Today, our mission stands: to serve the membership as the leader in fire service advocacy, benefits, education, and safety, while acting as the steward of the Firemen’s Insurance and Inspection Fund.

To fulfill this mission, the Association is supported by a family of programs and organizations that extend our reach and impact. These include the South Carolina Firefighters Foundation, the South Carolina Burned Children’s Fund (operating under the Foundation), the South Carolina Firefighters Insurance Services, and the South Carolina Firefighters Assistance Team.

Lieutenant Taylor A. Graham Memorial Scholarship

Lieutenant Graham served in the fire service for more than 30 years, dedicating his career to protecting citizens across Greenville and Spartanburg Counties. He proudly served 22 years with the City of Greer Fire Department as a Lieutenant and was also a member of the Greenville County Emergency Response Team (ERT). Beyond his years of service, Lieutenant Graham was deeply passionate about mentoring and teaching future firefighters. As an instructor at the fire academy, he took great pride in helping develop the next generation of fire service professionals and was honored to share his knowledge and experience with others entering the profession.

The Graham family has established an annual scholarship in remembrance of Lieutenant Taylor A Graham’s dedication and passion for the citizens of Greenville and Spartanburg Counties, and South Carolina’s fire service.

Applicants must complete the application, offer a letter of support from the applicant’s Fire Chief, and provide a general reference letter of support from a person of the applicant’s choosing. 

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

About QuikTripQuikTrip believes in investing in the communities in which our employees live and work. Every year, QuikTrip donates 5% of our annual net profit to qualified 501c3 non-profit agencies, which includes our United Way campaign match, support for National Safe Place agencies, Folds of Honor scholarships and many other agencies that support at-risk youth and early childhood education.Mission: To wisely invest dollars in community efforts that will help impact (in measurable terms) individuals in our society who are dependent on the charitable support of others. We believe the most effective way to do that is to invest our contribution dollars and volunteers in strategic efforts that help those at risk reach their functional capacity as successful, independent citizens.About QuikTrip Charitable GrantsQuikTrip funds 501c3 agencies located in the cities in which we have stores and our employees live and work. Funding can include: “in-kind” products (coupons, gift cards or product donation), formal grants, fundraiser/event sponsorships and employee volunteer time.Focus Areas:

• Creating Safe Communities
  • First Responders: QuikTrip is proud to partner with law enforcement and first responders in every market we serve, making sure that they have the tools, training and support they need to keep our communities safe and to return home safely to their families after each shift.
  • Homeless Outreach & Alternatives to Police Response: To significantly reduce non-emergency calls and help people in crisis get back on their feet, QuikTrip funds dedicated homeless outreach teams across our communities. These teams engage individuals experiencing homelessness and living in encampments – connecting people to services, shelter, detox and long-term care.

• Creating Strong Communities
  • Ending Homelessness: We support emergency, transitional and permanent supportive housing, diversion and prevention programs, and more.
  • Mental Health & Substance Abuse : We know that healthy communities are safe communities, which is why we invest in detox and substance abuse treatment centers, and behavioral health centers and services to end the perpetuation of cycles of trauma and addiction.
  • At-Risk Youth: We especially prioritize services for at-risk youth – those aging out of foster care, justice-involved or without stable support systems.
• Additional Community Commitments
  • United Way: Employee donation matching in all markets.
  • Folds of Honor: Scholarships for families of fallen or wounded service members and first responders.
  • National Safe Place: QT stores serve as Safe Place locations for youth in crisis, with trained staff ready to assist.

The NHLBI Career Transition Award (K22) program supports postdoctoral fellows in transitioning their research to extramural institutions. The program includes a mentored intramural phase (up to two years) followed by an extramural phase (three years), totaling five years of support. Applications have multiple deadlines, including October 12, 2024, and February 12, 2025, among others. Successful transition depends on the awardee's progress during the mentored phase, evaluated by NHLBI.

The Summer Reading Camp Community Partnership Grant aims to support students struggling with reading proficiency by providing quality instructional services and engaging learning experiences. With approximately $700,000 available, the grant encourages partnerships with community organizations to enhance student achievement. Applicants are urged to ensure regular attendance and parental involvement. The South Carolina Department of Education will award 10-15 grants based on the quality of applications received, with final budgets subject to negotiation based on needs.

2026-27 Career Cluster Partnership Program

Description

The South Carolina General Assembly has provided funds to the South Carolina Department of Education (SCDE) through a legislative proviso (H. 5126 General Appropriations Bill, Proviso 1A.27) for one year to award grants on a competitive basis to private-sector statewide trade associations that provide nationally certified programs in career and technical education representing the automotive, construction, engineering, healthcare, mechanical contracting/construction, and hospitality and tourism career clusters. The purpose of this program is to support instructor/student training and student testing in industry clusters to increase the state’s skilled workforce. The SCDE administers the program through its Office of Career Readiness (OCR).