Best Foundation Grants for Nonprofits in Ohio

The Amgen Foundation, established in 1990, focuses on enhancing science education and strengthening communities. It supports nonprofit organizations that align with its mission, emphasizing teacher development and hands-on science experiences. Grants are awarded annually, with a commitment of $180 million to impactful programs. Eligible organizations include public schools and libraries, while ineligible requests involve individual support, religious organizations, and political activities. This approach aims to inspire the next generation of innovators through quality educational opportunities.

The Lubrizol Foundation Grants support nonprofit organizations that align with community investment priorities and the United Nations Sustainable Development Goals, focusing on quality education, health, and sustainable communities. Established in 1952, the foundation emphasizes support for initiatives in Cleveland, Ohio, and Houston, Texas. Grant applications are evaluated based on alignment with Lubrizol's investment pillars, with a commitment to fostering social impact and community well-being through financial support.

The Makulinski Family Foundation Grant supports nonprofit and charity organizations, emphasizing sustainable community development. With a commitment to lasting change, MFF actively matches investments to amplify their impact, ranging from 10:1 to 1:2 based on beneficiary needs. The foundation welcomes proposals from various regions, including Ohio, Michigan, and South Carolina, and encourages applications that align with their mission. Interested parties can access the grant request form to submit their proposals.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

The Valero Energy Foundation Grants support nonprofit organizations that align with their mission to improve the quality of life in communities where Valero operates. With a focus on basic needs, health care, education, and civic initiatives, the foundation prioritizes funding requests from 501(c)(3) organizations. In 2019, it provided approximately $40 million to support disadvantaged children and families, emphasizing a commitment to corporate citizenship and community well-being.

The Elevance Health Foundation's Maternal and Child Health Grant supports community-based nonprofit organizations aiming to enhance maternal and infant health outcomes. The foundation prioritizes funding programs that address disparities, improve care access, and promote health throughout the pregnancy journey. Focus areas include reducing pre-term birth rates and severe maternal morbidity. This initiative encourages scalable solutions for measurable impact across various states, ensuring comprehensive support for mothers and infants alike.

The EQT Foundation Grant Program supports nonprofits with a focus on community enrichment, education, and environmental preservation in areas aligned with EQT Corporation's business operations. Since 2003, it has awarded over $74 million, emphasizing impactful, evidence-based proposals that foster safe and sustainable communities. Eligible organizations must be tax-exempt and demonstrate effective resource management. The foundation prioritizes projects that promote STEM education, community engagement, and conservation efforts to enhance quality of life in the regions it serves.

The Joyce Foundation's Education & Economic Mobility Grants aim to close income and race disparities in college and career success. The foundation prioritizes equitable access to high-quality education, supporting policies for effective educators, high school graduation, and affordable college credentials. Focused on racial equity and economic mobility, it addresses the needs of historically underserved young people in the Great Lakes region and invests in research, policy development, and advocacy to help them recover from the COVID-19 pandemic.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000

The Sam J. Frankino Foundation is dedicated to enhancing the quality of life for children and families in need through monetary grants for education, health care, and community support. With a focus on initiatives that empower disadvantaged youth and support the Italian-American community, the Foundation aims to foster growth and development in Northeast Ohio. Guided by philanthropic excellence, it seeks to create lasting change through strategic partnerships and innovative programs for social betterment.

The Elsa Heisel Sule Foundation Grant supports 501(c)(3) organizations in the Greater Cincinnati area, focusing on education, health, arts, and community welfare. Established in 2004, the foundation prioritizes projects that enhance community well-being, ensuring grants are awarded to nonprofits with operating budgets under $10 million. Organizations must apply annually and adhere to specific eligibility criteria, including geographical and operational restrictions. The foundation aims to empower local initiatives that promote positive societal impact.

The Toledo Rotary Club Foundation provides traditional grants to support nonprofit, 501(c)3 tax-exempt organizations focused on community and international projects. Each year, approximately 20 grants are awarded, with funding capped at $10,000, except for camperships which are limited to $750. The foundation prioritizes projects benefiting disadvantaged citizens, particularly youth, the disabled, and the elderly, within the Toledo area and Northwest Ohio.

The Ruth Danley and William Enoch Moore Charitable Fund Grant is a private foundation based in Pittsburgh, established in 1992. It focuses on philanthropy, specifically supporting K-12 education for Native American children living on reservations. The foundation directs its grants primarily to regions preferred by donors, including several states in the Northeast and Midwest, aiming to improve educational opportunities and foster community development in underserved populations.

The Penn National Gaming Foundation Grants support various community initiatives across North America, emphasizing education, health services, and cultural affairs. Launched post-Hurricane Katrina, the foundation aids local nonprofits, enhancing community development, public safety, and veteran support. The grants cater to organizations that address the needs of children, senior citizens, and disadvantaged populations, ensuring a broad impact in areas where Penn National Gaming operates. This commitment reflects the foundation's dedication to uplifting communities and fostering resilience.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

The Environment Pillar Award by Honda supports nonprofit organizations and schools in the U.S. focused on sustainability. Grants aim to reduce environmental impact through programs in decarbonization, clean energy, and efficient resource use. Eligible projects must align with Honda's mission and primarily benefit communities where Honda associates live and work. Organizations can apply for up to two grants, provided they meet specific eligibility criteria, including tax-exempt status under the IRS.

The Honda USA Foundation's Mobility Pillar Award aims to empower individuals with disabilities by funding programs that enhance access and mobility. The foundation supports nonprofit organizations and schools that provide therapeutic, adaptive, and comprehensive care programs, as well as mobility modifications and assistive technology. Applications are accepted from U.S.-based organizations with 501(c)(3) status or fiscal sponsors, ensuring that the joy of mobility is accessible to all.

The Fifth Third Foundation offers grants to nonprofit organizations in the Greater Cincinnati area, focusing on education, arts, community development, and health services. It aims to enhance community vibrancy and provide opportunities, supporting various funding interests from several benefactors. Eligible organizations must be 501(c)(3) nonprofits operating in Cincinnati, Dayton, or Northern Kentucky. The foundation prioritizes initiatives that empower women, support children, and promote environmental conservation, among other charitable purposes.

The Daniel and Susan Pfau Foundation, established in 1994, focuses on enhancing education, health, cultural experiences, and social welfare for youth with disabilities and economic challenges in the Greater Cincinnati area. It supports arts organizations and recreation initiatives, prioritizing programs that help young individuals realize their potential. Eligible applicants must be recognized 501(c)(3) nonprofits and demonstrate benefits to specific counties in Ohio, Kentucky, and Indiana. The Foundation encourages collaboration with other donors for project funding.

The Elevance Health Foundation's Behavioral Health Grant aims to address significant challenges in mental health and substance use disorders. With a commitment of up to $90 million over three years, the Foundation seeks partnerships with nonprofits to enhance treatment access, promote prevention strategies, and alleviate loneliness among affected individuals. This initiative emphasizes innovative solutions and measurable outcomes, targeting both national and local programs, particularly in states with pressing health disparities.

The MGM Resorts Foundation Community Grant Fund supports nonprofit agencies providing essential services in areas such as affordable housing, education, and health. Grants are awarded for a one-year period and focus on regions where MGM Resorts employees live and work. Eligible applicants must comply with diversity policies and serve individuals or families. The foundation does not fund governmental agencies or projects exclusively for medical research. This initiative aims to enhance community well-being through targeted support.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Donald C. and Laura M. Harrison Family Foundation, established in 2006, aims to enhance educational opportunities for underprivileged students in the Greater Cincinnati area. With a focus on innovative programs and scholarships, the foundation supports initiatives in primary, secondary, and adult education. Grants range from $5,000 to $15,000 annually, promoting sustainability and collaboration with other donors. Eligible applicants must be IRS-designated 501(c)(3) organizations, prioritizing local community impact.

The Elevance Health Foundation's Food as Medicine Grant aims to enhance access to nutritious foods and improve health outcomes for individuals facing diet-related conditions. This initiative invites qualified nonprofits to submit proposals focused on scalable solutions that address food insecurity and promote health equity. The foundation prioritizes programs that demonstrate measurable outcomes and support whole-person health, particularly for populations at high social risk. Grants will be awarded for a term of 1-3 years, with funding based on program needs.