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Best Large Grants for Nonprofit Organizations in Florida

Find the perfect Large Grants for Nonprofit Organizations in Florida on Instrumentl. 10,000+ Large Grants for Nonprofit Organizations in Florida in the United States.

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$2.64B

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$5K

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10,000+ grants
$2.64B total
$5K median

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Smarter Water Governance with AMI: Conservation, Affordability, and Rate Design

Water Research Foundation
Private
North America
Up to US $275,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5409 - Smarter Water Governance with AMI: Conservation, Affordability, and Rate Design

Grant Information

  • Evaluate how utilities are currently leveraging advanced metering infrastructure (AMI) data to inform pricing, conservation programs (including emergency curtailment practices), affordability programs, and plans for future implementation.
  • Analyze AMI data and assess how the data can be leveraged to develop and/or enhance conservation programs, policies, rates, and affordability programs.
  • Investigate the potential for advanced analytics, including machine learning, of AMIdatasets to support adaptive or dynamic rate structures, early detection of hardship or atrisk households, categorization of customer classes, dynamic tiering based on household size, and better targeting of affordability and conservation interventions.
  • Identify the obstacles utilities and regulators face when balancing conservation, equity, and revenue stability, and how improved AMI data can clarify tradeoffs.
Environmental Conservation Water Resource Management Hydrology +1 more

United Company Foundation Grant

United Company Foundation
Private
United States
Unspecified amount
The United Company Foundation, established in 1986, provides grants to support charitable organizations in Bristol, VA, Bristol, TN, and Southwest Virginia. This private non-profit focuses on areas such as food, shelter, education, the arts, health, and youth services, emphasizing fiscal responsibility and innovative approaches. By prioritizing accountability and measurable outcomes, the Foundation aims to foster long-term improvements in the community it serves.
Child Welfare Services Education - K through 12 Food Access & Hunger +6 more

FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN)

DOT Federal Highway Administration
Federal Government
United States
Up to US $12,000,000
The FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN) grant program aims to enhance transportation through the deployment of innovative technologies. It focuses on improving safety, mobility, and efficiency while fostering economic competitiveness. Projects funded will prioritize core infrastructure improvements and address roadway congestion, aligning with the Trump Administration's goals. The program emphasizes economic opportunities and community benefits, ensuring that selected projects contribute positively to families and communities, ultimately enhancing their quality of life.
Public Transportation & Mass Transit Systems Pedestrian & Bike-Friendly Infrastructure Automotive Safety +1 more

Collections-Related Grants

Carl And Marilynn Thoma Foundation
Private
United States
Unspecified amount
The Carl & Marilynn Thoma Foundation offers Collections-Related Grants for Nonprofits, aimed at enhancing public interest in art through innovative projects. Grants support exhibitions, academic convenings, research, and catalog publication, focusing on art from the Spanish Americas, digital media, and more. The foundation prioritizes proposals from 501(c)(3) organizations in the U.S., particularly from New Mexico, Oklahoma, and Texas, fostering partnerships that advance art scholarship and cultural engagement.
Asian Art Folk Art / Traditional Art Media Arts +5 more

Systemic Sclerosis with Interstitial Lung Disease Fund

Healthwell Foundation
Private
United States
Up to US $9,000
The Systemic Sclerosis with Interstitial Lung Disease Fund, managed by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from systemic sclerosis. This rare autoimmune disease leads to excessive collagen production, causing serious health issues. The fund assists with prescription copays and insurance premiums to ensure patients receive necessary treatments. In 2024, HealthWell awarded over $1.2 billion in grants, supporting more than 1.1 million patients in accessing vital healthcare services.
Cardiovascular Diseases & Systems Neurological Diseases & Disorders Multiple Sclerosis +3 more

David Moses Bridges Scholarship

Maine Community Foundation
Private
United States
Unspecified amount
The David Moses Bridges Scholarship honors the legacy of a renowned Passamaquoddy artist and activist, providing essential support for individuals dedicated to the preservation of Wabanaki culture, traditional arts, and environmental stewardship. This scholarship aims to foster connections between master artists and apprentices, promote research on David's impactful life and work, and protect culturally significant natural spaces. It empowers artists and scholars to continue the vital work of preserving indigenous knowledge and practices for future generations.
Environmental Conservation Environmental Stewardship Native American Services +3 more

Center for Family Engagement Healthy Minds Fellowship

National Congress of Parents & Teachers
Corporate
United States
US $1,000
The Center for Family Engagement Healthy Minds Fellowship, organized by the National PTA, invites active PTA leaders to enhance their mental health expertise over a 12-month cohort starting January 2026. Participants will receive a $1,500 stipend and engage in developing actionable plans to improve mental health initiatives in schools. This fellowship aims to empower leaders through workshops and collaborative efforts, fostering a supportive environment for mental wellness in educational settings.
Child Welfare Services Children’s Mental Health Parenting Counseling & Education +2 more

Thalassemia Patient Incentive Award

Cooley’s Anemia Foundation Inc
Private
United States
US $250 - US $2,000
The Thalassemia Patient Incentive Award, sponsored by the Cooley’s Anemia Foundation, aims to support thalassemia patients in pursuing their educational and career aspirations. Awards ranging from $250 to $2,000 will be granted to students at various academic levels, with applications due in March 2026. This initiative not only encourages academic growth but also fosters a positive outlook among patients living with thalassemia, underscoring the Foundation's commitment to improving their quality of life.
Education - Higher Education Workforce Preparation & Job Readiness Vocational & Trade Education +3 more

Cancer-Related Behavioral Health Fund

Healthwell Foundation
Private
United States
Up to US $2,000
The Cancer-Related Behavioral Health Fund, established by the HealthWell Foundation, provides financial assistance to individuals diagnosed with cancer for behavioral health treatments. This fund covers costs associated with prescription drugs, counseling services, and transportation. Aiming to alleviate financial burdens, it ensures that underinsured patients can access necessary care without delay. In 2024, the foundation awarded over $1.2 billion, emphasizing its commitment to improving health outcomes for cancer patients across the United States.
Cancer / Oncology Crisis Intervention Health Care Access & Delivery +2 more

Educational Incentive Award Application for Children of Individuals with Thalassemia

Cooley’s Anemia Foundation Inc
Private
United States
US $500 - US $1,000
The Educational Incentive Award Application by the Cooley’s Anemia Foundation aims to support children of individuals with severe thalassemia in pursuing their educational and career aspirations. With a total funding of $10,000 for the 2025-2026 school year, awards range from $500 for two-year programs to $1,000 for higher degree studies. Eligible applicants must be diagnosed with specific thalassemia types and provide necessary documentation, including a 250-word essay detailing their educational goals.
Education - Higher Education Workforce Preparation & Job Readiness Hematological Systems +3 more

Park Foundation: Media Grants

Park Foundation, Inc.
Private
United States
Unspecified amount
The Park Foundation Grants: Media support public interest media that raises awareness of critical environmental and social issues. They prioritize funding for investigative journalism, media policy, public broadcasting, and documentary films to promote a better-informed citizenry. Eligible organizations must be 501(c)(3) certified, and funding is aimed at projects that ensure diverse perspectives and community engagement. The foundation is committed to fostering a robust democracy and independent media, reflecting its mission to advance a just and sustainable society.
Journalism Radio Television +2 more

Developing Regulated Therapeutic and Diagnostic Solutions for Patients Affected by Opioid and/or Stimulants use Disorders (OUD/StUD) (R41/R42 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,500,000
This funding opportunity invites Small Business Technology Transfer (STTR) grant applications aimed at developing FDA-regulated medical products for patients with opioid and stimulant use disorders. Projects may focus on pharmacotherapeutics or diagnostic devices, including software. The initiative seeks to address the ongoing opioid crisis by supporting innovations that enhance treatment options for individuals and communities affected by these disorders.
Drug Use Disorder Addiction & Substance Use Disorders Pharmacology +1 more

Jennie Wade Scholarship Endowment

Community Foundation of Wabash County
Private
United States
Unspecified amount

About Us

Our Mission

We create lasting impact through asset development, nonprofit capacity building, and community leadership. 

Our Vision

To enrich the lives of Wabash County residents by fostering opportunity, inspiring generosity, and building a thriving connected community. 

Our Scholarships

For High School Seniors & Non Traditional Students who are beginning college more than one year after high school.

The Community Foundation of Wabash County offers a wide variety of post-secondary education scholarships to traditional, non-traditional, and graduate students. With nearly 70 different scholarship endowments created through the generosity of our donors, many students are eligible to apply.    

Jennie Wade Scholarship Endowment

More than one hundred years ago, Jennie Wade created a scholarship in her words “to benefit mankind.” This scholarship is made to help young men and women continue their education after high school. Wabash County residents under the age of 21 are selected from among applicants who have done as much as possible in helping themselves obtain an education and whose families are unable to provide an education.

Workforce Preparation & Job Readiness Career / College Preparation Education - Higher Education +3 more

RMEF Grant Program- Hunting Heritage

Rocky Mountain Elk Foundation (RMEF)
Private
United States
Unspecified amount

The RMEF Grant Program lies at the core of advancing our mission.

RMEF established the program in 1986 to provide financial and logistical support to projects that align with our priorities and goals. Grant funds raised by RMEF members, volunteers and generous donors from across the country translate into significantly more conservation accomplishment when matched with partner funds. The RMEF Grant Program also aims to build recognition for RMEF’s work, grow engagement, and boost local fundraising efforts.

Governed by clear guidelines and criteria, the RMEF Grant Program seeks to foster meaningful collaborations and long-term impacts in the conservation of natural resources and outdoor traditions. Grant project partners include federal, state, local, and tribal wildlife and land management agencies, private landowners and local stakeholders, sportsmen and women, and conservation organizations, universities, foundations and the outdoor industry. Eligible projects primarily focus on habitat stewardship, land conservation and access, wildlife management, and hunting heritage.

We support organizations recognized by the Internal Revenue Service (IRS) as a 501(c)3 entity, federal, state, local, or tribal government entities, sportsmen’s organizations, or educational institutions. All applicants must have a Federal Employer Identification Number (EIN) issued by the IRS. RMEF does not offer grants to individuals.

Hunting Heritage

Ensuring our hunting heritage is central to RMEF’s mission. Hunters—America’s first conservationists—remain the driving force behind wildlife conservation. RMEF funds hunting heritage and conservation education to help more people experience the outdoors, learn the skills of hunting, and carry forward the traditions that define big game country, including outdoor skills programs/events, hunter or conservation outreach, mentored hunts, and other similar activities.

Land / Habitat Conservation Sport Shooting Outdoor Recreation +2 more

Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use initiative aims to enhance prevention services for infectious diseases among people who use drugs (PWUD). It encompasses two components: a biennial survey to assess service gaps and capacity, and increased support for testing and treatment services. The initiative seeks to improve data utilization in service provision, ultimately increasing testing for HBV, HCV, and HIV, and ensuring more PWUD engage in treatment and care.
Infectious & Parasitic Diseases Addiction & Substance Use Disorders Drug Use Disorder

National Girls and Women in Sports (NAGWS) Legacy Award

Society Of Health And Physical Educators
Private
United States
US $1,000
The National Girls and Women in Sports (NAGWS) Legacy Award, established by SHAPE America, honors exemplary contributions to increasing opportunities for women in sports. This annual award recognizes current SHAPE America members who submit impactful proposals related to women's sports, with a monetary prize of $1000. The award will be presented at the National Convention & Exposition, with a special deadline of November 1st. Nominations can include various initiatives aimed at empowering women in sports.
After School / Summer Educational Programs Women & Girl Services Sports & Athletics +5 more

NALMS Achievement Awards: Jim Flynn Outstanding Corporation Award

North American Lake Management Society (NALMS)
Association/Society
North America
Unspecified amount
The Jim Flynn Outstanding Corporation Award, presented annually by NALMS, honors the corporation that has made significant contributions to advancing lake management goals. This award emphasizes the importance of facilitating information exchange, promoting public awareness of lake ecosystems, and supporting management programs at all levels. Eligible nominations can come from any individual or entity, focusing on achievements in lake and reservoir management. Notably, current NALMS board members and awards committee members are excluded from eligibility.
Limnology Freshwater Conservation Water Resource Management

Oriental Trading Co. Corporate Giving Program

Oriental Trading Company
Corporate
United States
Unspecified amount
The Oriental Trading Company Corporate Giving Program focuses on enhancing the lives of children through education, youth programming, healthcare, and human services. With a commitment to making the world a better place, they support organizations that are tax-exempt under Section 501(c)(3) or public educational institutions. Their initiatives aim to foster community partnerships and provide essential resources to youth in need, ensuring they have access to vital services and opportunities for growth.
Youth Services Children’s Health & Pediatrics Children’s Mental Health +5 more

Smart Growth America: Community Connectors Grant Program

Smart Growth America
Private
American Samoa, Guam +4 more
Up to US $25,000
The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.
Pedestrian & Bike-Friendly Infrastructure Public Infrastructure Public Transportation & Mass Transit Systems +1 more

Ethel Strickarz Memorial Scholarship

Community Foundation of Elmira-Corning and the Finger Lakes, Inc.
Private
United States
Unspecified amount
The Ethel Strickarz Memorial Scholarship aims to address community needs through educational support in special education and related fields. Funded by the Community Foundation of Elmira-Corning and the Finger Lakes, it encourages students pursuing careers in human services, nursing, psychology, speech pathology, or therapy. This scholarship reflects a commitment to holistic community development by fostering future professionals dedicated to improving lives and addressing urgent societal challenges.
Psychology Nursing Physical Therapy +3 more

Quest for Healthy Communities Champions Grant

Quest Diagnostics Foundation Inc
Private
United States
US $10,000

Quest Diagnostics Foundation

Established as a 501(c)(3) nonprofit organization, the Quest Diagnostics Foundation is committed to addressing the systemic root causes of health disparities. By combining corporate resources with trusted community leadership, we fund and scale evidence-based initiatives that promote wellness, prevent chronic disease, and empower individuals.

We focus our resources on three critical, interconnected clinical and social interventions to build sustainable health improvement:

  • Strengthening the community health workforce
  • Addressing social drivers of health (SDoH)
  • Promoting the prevention, early detection, monitoring, and treatment of disease through diagnostic testing

About Quest for Healthy Communities Champions

The Quest for Healthy Communities Champion award was created to honor, uplift, and support outstanding organizations across the United States that are actively living our core purpose:

Working together to create a healthier world, one life at a time.

Whether you are expanding access to life-saving screenings, supporting maternal and family wellness, or addressing critical social drivers of health, your dedication is moving us closer to an equitable healthcare future. We want to recognize and celebrate your impact.

What we celebrate: Our core impact pillars

The Champions we look to honor are community-first organizations and coalitions tackling critical disparities head-on. We are especially excited to spotlight work that advances health, addresses social drivers of health, fosters community-clinical linkages and develops the community workforce. Examples of this work could include: 

  • Programs actively dismantling clinical barriers to ensure every individual—regardless of zip code, background, or income—has access to high-quality care
  • Innovators providing creative solutions for food security, transportation, health education, and maternal-child support networks
  • Organizations bringing critical care directly to those in need through mobile clinics, community health workers, and localized diagnostic screenings
  • Organizations finding creative ways to engage the communities they serve directly into the solutions they are delivering

The award: Selected organization champions will receive a $10,000 grant.

Health Policy & Advocacy Children’s Health & Pediatrics Maternal And Perinatal Health +3 more

NIH Brain Development Cohorts (NBDC) and Population Assessment of Tobacco and Health (PATH) Study Biospecimen Access

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH is offering access to biospecimens from the ABCD, HBCD, and PATH studies to promote research on health and disease across a lifetime. This initiative encourages projects that utilize these samples to deepen understanding of genetic and environmental influences, particularly substance exposure. Researchers can submit proposals to maximize the scientific utility of these resources, in alignment with the goals outlined under federal health regulations.
Addiction & Substance Use Disorders Drug Use Disorder Human Genome & Genetics

BFOA Monthly Grant

Broadcasters Foundation of America
Association/Society
United States
Unspecified amount
The Broadcasters Foundation of America Monthly Grant provides essential financial assistance to broadcasters facing acute hardships due to serious illnesses or accidents. This initiative aims to support those who have dedicated significant years to the broadcasting profession, ensuring they receive medical aid and relief from financial burdens. Eligible applicants can apply for monthly grants if they meet specific employment and hardship criteria, helping them navigate difficult times with dignity and support.
Children’s Health & Pediatrics Crisis Intervention Health Care Access & Delivery +4 more

NALMS Achievement Awards: Secchi Disk Award

North American Lake Management Society (NALMS)
Association/Society
North America
Unspecified amount
The NALMS Achievement Awards: Secchi Disk Award recognizes outstanding contributions to lake management by its members. NALMS aims to unite citizens, scientists, and professionals to ensure the protection and management of lakes and reservoirs. This prestigious award is open to NALMS members, with nominations encouraged from any individual or entity. However, current board and committee members are ineligible. The award celebrates those who significantly advance NALMS's goals and objectives in fostering lake ecosystem awareness and management.
Limnology Freshwater Conservation Water Resource Management

Validating Reverse Osmosis Conductivity Profiling for Pathogen Log Reduction Value Credit RFP

Water Research Foundation
Private
Up to US $500,000

About Us

advancing the science of water ®

Who We Are

The Water Research Foundation (WRF) is the leading research organization advancing the science of all water to meet the evolving needs of its subscribers and the water sector. WRF is a 501(c)(3) nonprofit, educational organization that funds, manages, and publishes research on the technology, operation, and management of drinking water, wastewater, reuse, and stormwater systems—all in pursuit of ensuring water quality and improving water services to the public.

5432 - Validating Reverse Osmosis Conductivity Profiling for Pathogen Log Reduction Value Credit

Grant Information

  • Validate conductivity profiling against pathogen removal by establishing the relationship between conductivity-profile response and MS2 bacteriophage removal under intact and controlled membrane integrity-defect conditions.
  • Demonstrate the robustness and applicability of conductivity profiling across representative reverse osmosis conditions, including new and aged membranes, different defect types and severities, operating conditions, variations in feedwater quality/composition/salinity, and temperature.
  • Develop a validation implementation framework that defines testing procedures, log removal value calculation methods, sensitivity and performance criteria, continuous monitoring, alarm/response thresholds, and operational requirements needed to support regulatory pathogen log removal values credit for reverse osmosis.
Sanitation & Clean Drinking Water Water Resource Management Hydrology

Gamma Mu Foundation Grant

Gamma Mu Foundation
Private
United States
Up to US $15,000
The Gamma Mu Foundation, established in 1988, aims to support the LGBT community in rural and underserved areas through various grants. Initially focused on HIV/AIDS projects, it now funds scholarships and services for diverse LGBT subpopulations. With over $2 million awarded, the Foundation prioritizes initiatives that enhance community support, public education, and health programs. It emphasizes projects that build organizational capacity and provide essential services where resources are limited, ensuring ongoing support for vital health and social services.
LGBTQIA+ Services HIV / AIDS Sexuality & LGBTQIA+ Rights

Quadratec Cares 'Energize The Environment' Grant Program

Quadratec
Corporate
United States
US $3,500
The Quadratec Cares 'Energize The Environment' Grant Program is dedicated to supporting individuals and organizations in the U.S. focused on environmental improvement. With two grants of $3,500 awarded annually, the program encourages initiatives like trail restoration and community educational projects. This grant aims to empower passionate individuals to enhance environmental awareness and stewardship, ensuring a healthier planet for future generations.
Trail Creation & Maintenance Greening & Beautification Parks & Public Spaces +3 more

Large Grants for Nonprofit Organizations in Florida Highlights

Looking for large grants for nonprofit organizations in Florida?


Read more about each grant below or start your 14-day free trial to see all large grants for nonprofit organizations in Florida recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations in Florida

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

300+ Large Grants for Nonprofit Organizations in Florida grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

64 Large Grants for Nonprofit Organizations in Florida over $25K in average grant size

49 Large Grants for Nonprofit Organizations in Florida over $50K in average grant size

41 Large Grants for Nonprofit Organizations in Florida supporting general operating expenses

200+ Large Grants for Nonprofit Organizations in Florida supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in Florida?

Most grants are due in the first quarter.

Q1
27.5%
Q2
26.3%
Q3
23.2%
Q4
23.0%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in Florida?

Grants are most commonly $12,500.

$100 $100 Min.
$12,500 $12.5 K Median
$487,658 $487.7 K Average
$40,331,313 $40.3 M Max.

Average Grant Size

What's the typical amount funded for Florida?

Grants are most commonly $127,766.

$127,766

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in Florida year over year?

In 2024, funders in Florida awarded a total of 120,990 grants.

2022 107,491

2023 109,840

2024 120,990

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in Florida given out in Florida, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in Florida changing over time?

Funding has increased by 4.30%.

2022 $14,150,322,449

2023 $14,761,745,220
4.32%

2024 $15,396,491,509
4.30%

Florida Counties That Receive the Most Funding

How does grant funding vary by county?

Miami Dade County, Orange County, and Hillsborough County receive the most funding.

County Total Grant Funding in 2024
Miami Dade County $5,036,107,623
Orange County $3,251,041,805
Hillsborough County $2,859,448,977
Broward County $2,438,211,409
Palm Beach County $2,225,921,170

Related Grants in Florida

Browse Other Nonprofit Operations & Capacity Grants in Florida

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