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Best Madison County Grants for Nonprofits in North Carolina

Looking for grants for 501(c)(3) nonprofit organizations working in Madison County, North Carolina? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

Available grants

$2.69B

Total funding

$5K

Median grant

9,000+ grants
$2.69B total
$5K median

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9,365 Results based on applied filters

Pathways to Enable Secure Open-Source Ecosystems

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $1,500,000
The Pathways to Enable Secure Open-Source Ecosystems (PESOSE) program, funded by the National Science Foundation, aims to transform open-source research into sustainable ecosystems that tackle national and societal challenges. This initiative promotes innovation across various sectors, including AI and cybersecurity, by fostering strong governance and broad user engagement. PESOSE invites proposals to establish and enhance open-source ecosystems, ensuring their safety, security, and effectiveness in meeting emergent needs.
Engineering Computer Science & Engineering Emerging Technology Development

Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.
Children’s Health & Pediatrics Genetic Conditions & Birth Defects Pediatric Cancers

Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a Notice of Funding Opportunity (NOFO) under the NIH HEAL initiative to enhance research on joint health and pain. This initiative aims to refine the understanding of joint tissues and pain mechanisms, expand clinical phenotyping, and support preclinical testing of novel therapies. Collaborations among experts in neurobiology, pain science, and rheumatic diseases are encouraged to foster innovative solutions for joint pain management.
Musculoskeletal Diseases Arthritis

BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative's BBQS Program aims to revolutionize the study of brain function by facilitating high-resolution tracking of complex behaviors alongside neural activity. This transformative research opportunity seeks to develop innovative tools for minimally intrusive measurements of various biobehavioral functions while accounting for environmental variables. Emphasizing transdisciplinary collaboration, it focuses on creating new analytical frameworks that model neurobehavioral function as dynamic systems influenced by an organism's surroundings, thereby advancing our understanding of behavior at the organismal level.
Neuroscience Neurological Diseases & Disorders

Genomic Community Resources (U24 Clinical Trials Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Human Genome Research Institute (NHGRI) is launching a Notice of Funding Opportunity (NOFO) aimed at enhancing genomic research through the development and distribution of high-value resources. This initiative encourages collaborative efforts in genomic resource development and the integration of data science in clinical applications. While applications are not currently being accepted, prospective applicants are urged to prepare meaningful collaborations and projects ahead of the formal solicitation.
Cancer / Oncology Genetics & Genomics Human Genome & Genetics

Medical Scientist Training Program (MSTP)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Medical Scientist Training Program (MSTP) aims to cultivate skilled clinician-scientist leaders to meet the nation's biomedical research demands. It supports domestic organizations in developing dual-degree training that integrates clinical and research education, leading to both a clinical degree (e.g., M.D., D.O.) and a Ph.D. Through comprehensive mentoring and career development, MSTP prepares trainees for impactful careers in health-related research, ensuring a robust pipeline of qualified scientists.
Science Medical Education & Professional Training

Native American Research Centers for Health (NARCH)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The Native American Research Centers for Health (NARCH) program supports federally-recognized American Indian and Alaska Native Tribes and organizations in advancing health-related research. It aims to enhance research careers and infrastructure through a competitive application process. Funded by the US Dept. of Health & Human Services, this initiative invites eligible entities to apply, ensuring that only high-quality proposals undergo peer review for potential funding.
Native American Services Native American Culture & Heritage Indigenous Services

Network of the National Library of Medicine Regional Medical Libraries (UG4 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $600,000
The National Library of Medicine (NLM) is seeking applications to establish Regional Medical Libraries within the Network of the National Library of Medicine (NNLM). Since 1965, the NNLM has enhanced public health information access through partnerships with libraries and health organizations. The initiative aims to improve community engagement, disseminate NIH research findings, and foster collaborations to promote health literacy and access to biomedical data, thereby supporting local clinical research efforts.
Health & Medicine Library & Information Science Library Services

Network of the National Library of Medicine Training Center (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The National Library of Medicine (NLM) is seeking applications for a Training Center under the Network of the National Library of Medicine (NNLM). This initiative aims to enhance professional development for librarians, community engagement, and access to health information. By fostering partnerships and disseminating NIH resources, the NNLM will broaden its impact and improve public understanding of health data and information. The NTC will develop innovative training curricula and materials to meet diverse audience needs.
Health & Medicine Library & Information Science Library Services

Network of the National Library of Medicine Coordinating Center (U24 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $1,500,000
The National Library of Medicine (NLM) is inviting applications for its Coordinating Center within the Network of the National Library of Medicine (NNLM). Established in 1965, the NNLM enhances public access to health information through collaboration with libraries and community organizations. The NCC will oversee network administration and evaluation, fostering partnerships and supporting local clinical research. This initiative aims to expand NIH engagement and improve public understanding of health resources and information available through the NNLM.
Health & Medicine Library & Information Science Library Services

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $800,000
The HEAL Initiative Whole Joint Health Program aims to advance research on the biological mechanisms of joint pain by exploring the interactions of various tissues within the joint. This innovative program will support clinical studies that focus on non-pharmacological interventions to enhance healing and improve quality of life for individuals suffering from chronic joint pain. By fostering a comprehensive understanding of joint health, the initiative aligns with the NIH's broader goals to reduce chronic pain and opioid dependency.
Musculoskeletal Diseases Orthopedics

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Limited Competition Small Grant Program for the NCATS CTSA Program aims to empower KL2 scholars by funding diverse clinical and translational research projects. These grants support short-term studies, methodology development, and preliminary data collection, facilitating the transition to independent research careers. Applications will undergo NIH peer review, ensuring only high-quality proposals receive funding. This initiative fosters innovation in research methodologies and technology, ultimately enhancing the capabilities of emerging translational scientists.
Science Biology Health & Medicine +2 more

Collaborative Program Grant for Multidisciplinary Teams

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Collaborative Program Grant for Multidisciplinary Teams, funded by the US Dept. of Health & Human Services: National Institutes of Health (NIH), supports integrated teams of researchers tackling ambitious projects that individual efforts cannot achieve. This program promotes collaboration among experts with complementary skills, aiming for significant advancements in their fields. Teams are encouraged to pursue innovative objectives that have the potential to transform research landscapes.
Science Biology Health & Medicine

HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The HEAL Initiative's new program aims to generate comprehensive datasets on human pain networks through advanced 'omics and physiology research. Utilizing primary human tissues, the initiative promotes collaboration among diverse experts to enhance the understanding of pain mechanisms. This cooperative agreement will foster best practices and data sharing, ensuring integrated approaches across various pain conditions. While applications are not currently being accepted, the initiative encourages multidisciplinary teams to prepare for future opportunities in pain research.
Human Physiology Human Genome & Genetics

Robert and Diane Turrell Family Scholarship

Community Foundation of the Endless Mountains (CFEM)
Association/Society
United States
Unspecified amount

Community Foundation of the Endless Mountains

Our mission at the Community Foundation of the Endless Mountains is to improve the region’s quality of life through the power of philanthropy. We do this by offering individuals, families, and businesses the most effective charitable giving tools available in the marketplace today. Founded in 1998, the Community Foundation of the Endless Mountains is honored to work with hundreds of donors, nonprofits, advisors, and civic leaders to achieve dreams for making the Endless Mountains region of Northeastern Pennsylvania an even better place to live for everyone.

Scholarships

Many generous individuals, families, and businesses have established scholarship funds to provide support to graduates in our region. Scholarships are available to graduating high school seniors.

Robert and Diane Turrell Family Scholarship

Established by Robert and Diane Hill Turrell. Provides a post-secondary scholarship to a high school graduate who is a student of good moral character and who demonstrates financial need through their Student Aid Report. Students from Lackawanna Trail, Tunkhannock, Elk Lake, Homeschooled and Wyalusing Valley High Schools may apply. Priority will be given to students living in Habitat for Humanity Housing. The recipient may re-apply during each of the remaining years of undergraduate study until reaching the age of 25.

Education - Higher Education

Scholarships for Careers Endowment

Community Foundation of the Endless Mountains (CFEM)
Association/Society
United States
Unspecified amount
The Scholarships for Careers Endowment, established by a local family in connection with the Community Foundation of the Endless Mountains, aims to support graduates of Elk Lake School District and the Susquehanna County Career & Technology Center. This scholarship prioritizes students with financial need and promise for future success, assisting them in pursuing vocational, technical, academic, or other post-secondary programs. Additionally, it contributes to special projects within the school district and community.
Education - Higher Education Vocational & Trade Education

Nicholls Family Scholarship

North Carolina Community Foundation Inc
Private
North Carolina
Unspecified amount
The Nicholls Family Scholarship, provided by the North Carolina Community Foundation, supports students pursuing a master’s degree within the College of Humanities and Social Sciences at North Carolina State University. Eligible applicants must demonstrate financial need. This scholarship reflects the Foundation's commitment to enhancing educational opportunities and fostering community growth through philanthropy, ensuring diverse students can achieve their academic goals.
Education - Higher Education College Success / Persistence

Larry and Diane Stone Scholarship Endowment

North Carolina Community Foundation Inc
Private
North Carolina
Unspecified amount
The Larry and Diane Stone Scholarship Endowment, established by the North Carolina Community Foundation, supports Wilkes County high school seniors pursuing higher education within the University of North Carolina system. This initiative aims to empower local students by providing them with essential financial assistance, thereby fostering academic achievement and community development. The Foundation's commitment to philanthropy ensures that resources are allocated effectively to meet the educational needs of students across North Carolina.
Education - Higher Education Career / College Preparation College Success / Persistence

Cody Blue Pilkington Scholarship Fund

North Carolina Community Foundation Inc
Private
North Carolina
More than US $1,000
The Cody Blue Pilkington Scholarship Fund honors a gifted student dedicated to education and community service. Available to North Carolina residents entering their Freshman or Sophomore year at NC State University pursuing engineering, science, or math, applicants must maintain a 2.8 GPA, be at least 18 years old, and participate in community service. This scholarship supports the legacy of Cody Pilkington, who tragically lost his life while studying engineering.
Education - High School Academic Scholarship Programs STEM / STEAM Education

Fred and Betty Worsh Scholarship Fund

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The Fred and Betty Worsh Scholarship Fund, managed by the North Carolina Community Foundation, offers financial support to residents of New Hanover and Brunswick Counties who are U.S. citizens attending accredited four-year colleges or universities. Scholarships are available to undergraduates, graduates, and adult re-entry students, and may be renewed annually based on academic performance and financial need. Applications open on December 16, 2025, and close on March 3, 2026.
Education - High School Academic Scholarship Programs STEM / STEAM Education

Grayce Wills MacDonald and Ivan A. MacDonald Endowment

North Carolina Community Foundation Inc
Private
United States
More than US $1,000

Scholarships

We partner with donors to administer scholarships for students across the state. Most NCCF scholarships open for applications on Dec. 16, 2025, and close on March 3, 2026.

Undergraduates, graduates, medical and professional school students and adult re-entry students who are attending community colleges, four-year universities, career/technical schools, teaching credential programs and graduate, medical or professional schools in the United States are eligible for scholarships offered at NCCF.

Each scholarship has specific eligibility requirements defined by the donor when the scholarship was established. Be sure to read the requirements of each scholarship carefully as directed through the universal application and address those elements as needed in your application.

Grayce Wills MacDonald and Ivan A. MacDonald Endowment

Shall support students who attended high school in Cherokee, Graham, Clay, Swain, Macon, Jackson, Haywood, Buncombe, and Henderson counties, and who are pursuing a college or post-graduate level degree in the field of nutrition with emphasis on the study of natural foods and the vegetarian lifestyle. Scholarships may be based on both need and merit.

Education - Higher Education Education - High School Academic Scholarship Programs +2 more

JADE Learning Electrical Technologies Scholarship

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The JADE Learning Electrical Technologies Scholarship supports students enrolled in North Carolina technical or occupational schools focused on electrical systems technologies. Eligible candidates include undergraduates, graduates, and apprentices who demonstrate financial need and strong academic performance. The scholarship application requires careful attention to specific donor-defined eligibility criteria. Applications open on December 16, 2025, and close on March 3, 2026, with preference given to those pursuing a two-year associate’s degree.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

Joyce Price Johnson’s Samaritan Fund

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The Joyce Price Johnson’s Samaritan Fund provides scholarships for young people in North Carolina who are exiting foster care or facing poverty. Eligible candidates include undergraduates, graduates, and adult re-entry students attending various accredited institutions. Applications for NCCF scholarships open on December 16, 2025, and close on March 3, 2026. Preference is given to applicants from Wayne County and adjacent areas, ensuring support for those with exceptional financial need.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

Jecholiah Dinkins Hollar Legacy Scholarship

North Carolina Community Foundation Inc
Private
North Carolina
Unspecified amount
The Jecholiah Dinkins Hollar Legacy Scholarship, offered by the North Carolina Community Foundation, supports high school graduates from Yadkin County pursuing undergraduate degrees at private colleges in North Carolina. Preference is given to those attending Duke University. Selection is based on academic achievement, moral character, and community service. Established in honor of Jecholiah Dinkins Hollar, this scholarship emphasizes the importance of education and fostering a love of learning for future generations.
Education - Higher Education Career / College Preparation College Success / Persistence

CASL Scholarship Fund in Memory of Lane Meyer

North Carolina Community Foundation Inc
Private
North Carolina
Unspecified amount
The CASL Scholarship Fund in Memory of Lane Meyer, managed by the North Carolina Community Foundation, awards scholarships to high school seniors actively participating in the Capital Area Soccer League at the Challenge Level or above. Applicants are evaluated on their academic excellence, soccer skills, sportsmanship, and community involvement, reflecting the values exemplified by Lane Meyer. This initiative not only honors Lane's legacy but also fosters leadership and teamwork among young athletes across North Carolina.
Education - Higher Education Career / College Preparation College Success / Persistence

Judy Moore Memorial Scholarship Endowment

North Carolina Community Foundation Inc
Private
North Carolina
More than US $1,000
The Judy Moore Memorial Scholarship Endowment supports students in nursing programs in North Carolina, emphasizing Judy's commitment to education and community health. The scholarship prioritizes residents of Macon County and considers financial need. Applications open on December 16, 2025, and close on March 3, 2026. Eligible candidates include undergraduates, graduates, and adult re-entry students attending accredited institutions across the state. This scholarship honors Judy's legacy of compassion and dedication to nursing.
Education - High School Academic Scholarship Programs STEM / STEAM Education +2 more

NC Alpha Delta Kappa Student Achievement Scholarship

North Carolina Community Foundation Inc
Private
North Carolina
More than US $1,000
The NC Alpha Delta Kappa Student Achievement Scholarship supports North Carolina high school seniors pursuing education degrees. Eligible applicants should have a GPA between 2.5 and 3.5 and SAT scores ranging from 900 to 1050. The selection committee considers academic performance, community service, integrity, and leadership potential. Applications will be accepted from December 16, 2025, to March 3, 2026, providing a valuable opportunity for future educators to advance their studies.
Education - Higher Education Education - High School Academic Scholarship Programs +1 more

Madison County Grants for Nonprofits Highlights

Looking for Madison County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Madison County grants recommended for your specific programs in North Carolina.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in North Carolina

Average Grant Size

What's the typical amount funded for North Carolina?

Grants are most commonly $131,121.

$131,121

Total Number of Grants

What's the total number of grants in Madison County Grants for Nonprofits year over year?

In 2024, funders in North Carolina awarded a total of 70,602 grants.

2022 63,850

2023 62,335

2024 70,602

Top Grant Focus Areas

Among all the Madison County Grants for Nonprofits given out in North Carolina, the most popular focus areas that receive funding are Education, Human Services, and Philanthropy, Voluntarism & Grantmaking Foundations.

1. Education

2. Human Services

3. Philanthropy, Voluntarism & Grantmaking Foundations

Funding Over Time

How is funding for Madison County Grants for Nonprofits changing over time?

Funding has increased by 15.49%.

2022 $7,927,620,616

2023 $7,987,830,464
0.76%

2024 $9,224,796,270
15.49%

North Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Durham County, Orange County, and Mecklenburg County receive the most funding.

County Total Grant Funding in 2024
Durham County $2,942,551,198
Orange County $2,549,339,233
Mecklenburg County $1,468,677,341
Wake County $1,122,908,782
Buncombe County $444,853,701

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