Best Grants for Science Research in California

The DanPaul Foundation aims to enhance early childhood development by training teachers and parents, protecting children from abuse, and promoting social responsibility. They provide grants to non-profits for programs that focus on education, health, and welfare of youth. Key initiatives include scholarships, environmental education, and support for underprivileged children. Grant amounts range from a few hundred dollars to $15,000 annually, with a focus on impactful, community-driven projects.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

Mission

The Social Science Research Council (SSRC) is an independent, international, nonprofit organization founded in 1923. The Council fosters innovative research, nurtures new generations of social scientists, deepens how inquiry is practiced within and across disciplines, and mobilizes necessary knowledge on important public issues.

Driving University Impact: Expanding the Public Exchange Network

With generous support from the William and Flora Hewlett Foundation, the Social Science Research Council is pleased to invite U.S. R1 research universities in SSRC’s College and University Fund for the Social Sciences to apply for funding to join the Public Exchange Network. Public Exchange is a new network that turns university research expertise into real-world action and impact. Foundedat the University of Southern California in 2020 and expanded to Washington University in St. Louis in 2025, Public Exchange connects researchers with government, nonprofit, and industry partners to tackle pressing challenges—from disaster recovery and climate solutions to food insecurity and homelessness prevention. Since its founding, Public Exchange has developed high-impact collaborations between 48 partners and 142 researchers including:

• CLEAN LA and CLEAN STL: One of the largest free soil testing programs for lead in Los Angeles County following the January 2025 wildfires, and a related program in St. Louis to test soil and air for contaminants following the May 2025 EF-3 tornado;
• The California Solar Canal Initiative: An ambitious public-private research collaboration to advance solar panel infrastructure along California’s 4,000 miles of open aqueduct, conserving water and generating renewable energy;
• Food Base LA: LA County’s first food systems data dashboard, helping LA County and non-profit partners target distribution of millions of pounds of food and related resources to families experiencing food insecurity;
• ShadeLA: A people-powered campaign to cool Los Angeles ahead of the 2028 Olympics and Paralympics by advancing natural and built shade cover in the region.

Partners have included the City and County of Los Angeles, the State of California, the City of St. Louis, Yelp, Solar AquaGrid, the United Nations Foundation, Keck Medicine of USC, the Southern California Association of Governments, Santa Clarita Valley Water Agency, the Sustainable Entertainment Alliance, the Los Angeles Regional Food Bank, Department of Angels and many more. In addition to real-world impact positively affecting millions of lives, Public Exchange collaborations have resulted in over $18m in research funding, some helping to incubate new centers or areas of research, more than 40 academic journal publications, hundreds of media hits, and dozens of student career opportunities. 

The Public Exchange Model

Public Exchange is a partner-driven program, working collaboratively with external partners to: (1) define a research scope, timeline, and deliverables; (2) identify the right team of multidisciplinary academic experts to analyze the problem; (3) provide project management from concept and strategy development to project outputs and tools delivery; and (4) manage the public and stakeholder engagement related to the project, as well as communications and design needs. Public Exchange staff are not researchers, but come from government, industry, and non-profit backgrounds, uniquely equipping project teams to understand partners’ needs and lead projects to action. Staff oversee activities including partnership and proposal development, funder cultivation, research translation, dissemination, and communications, impact and scaling strategy, administrative support, cross-sector convening, and more, to maximize the real-world impact of university expertise. Public Exchange builds results-driven teams that deliver measurable impact and lasting solutions for partners.

How the Public Exchange Network Works

No single university – even a large R1 – has enough faculty expertise available to meet the needs of every partner. The Public Exchange Network was designed to help universities work together seamlessly to build robust partnerships and generate more collective impact. Universities joining the network are independent but affiliated members, with full control over their own program and project portfolios. As a national network with local, on-the-ground capacity, Public Exchange Network members can also share approaches that work, scale solutions to common problems, and build cross-regional partnerships together. 

As an institutional partner in the Public Exchange Network, universities will build capacity to develop, test and implement solutions to the most urgent problems in their regions and beyond. Universities joining the Public Exchange Network get:

• The tools, templates and training they need to start right away;
• A shared brand they can plug into on day one;
• A network of faculty, past and potential partners and philanthropic relationships, benefitting everyone in the network. 

SSRC Public Exchange Network Expansion Grants

Public Exchange Network Expansion grants will cover 75-80% of the minimum estimated annual costs for two years to launch a new Public Exchange. To launch a Public Exchange, universities must have the following in place: (1) a staff executive director with experience launching and leading social impact partnerships, (2) a project seed fund, and (3) a modest operations budget. We also recommend some in-kind project management support from an existing university staff member. The grant includes a two-year Public Exchange Executive Director (ED) compensation subsidy of $300,000 to launch the Public Exchange on campus, and a 2-year license to use the Public Exchange brand. New Public Exchange Network members will also receive ongoing support and guidance from current Public Exchange leadership and staff at USC and WashU, including recruitment support and intensive training for hiring and onboarding an executive director, a sub-site on the Public Exchange website, incubation and project management support from current Public Exchange staff, and a suite of tools for developing and implementing Public Exchange projects.

In addition, every university in the Public Exchange Network benefits from central communications support (currently housed at USC), and access to a collaborative network of project partners, researchers, and funder relationships. Separately, SSRC will select a local research fellow to study and document how the Public Exchange model develops within and between host institutions during the grant term, and how the Public Exchange Network universities work together to effect larger-scale change. 

Expectations

Institutions selected to join the Public Exchange Network are expected to:

• Hire an Executive Director who can launch and lead efforts to incubate social impact projects with public and private sector partners;
• Have in place before public launch: (1) an executive director, (2) a seed fund, (3) a modest operations budget, and (4 – recommended) some in-kind project management support. 
• Develop and sustain at least three high-impact research partnerships during the two-year grant tenure;
• Invest modest resources during the grant term that demonstrate commitment to continuing the Public Exchange model after the end of philanthropic support. This is estimated at approximately $85-$90k annually (with some variation considering local labor markets) to support an operations and project seed fund and any additional capital needed for the Executive Director hire beyond the subsidy. 
• Coordinate with the SSRC research fellow who will examine the impact of Public Exchange at their university and across the network. 
• Work with faculty across their university. Public Exchange can live anywhere within a university at the school or central level. The majority of Public Exchange projects to date at USC and WashU have included researchers from two or more schools, and grantees must be able to work with faculty university-wide. 

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The Mayer and Morris Kaplan Foundation Environment Grant aims to support initiatives that combat climate change, prioritizing efforts to reduce fossil fuel consumption and enhance climate education for young adults. The foundation emphasizes innovative solutions and partnerships to address both immediate and long-term environmental challenges. Areas of focus include climate and clean energy policy, as well as providing scientifically accurate climate change education. By leveraging data and research, the foundation seeks to empower organizations dedicated to creating impactful change.

The Ocean Drilling Grant, supported by the National Science Foundation (NSF), facilitates research in marine geosciences through the International Ocean Discovery Program (IODP). Proposals for pre- and post-expedition studies are accepted, particularly during the expedition moratorium period. This grant aims to enhance scientific understanding of climate and geological processes through innovative drilling techniques and collaborative international efforts, ensuring the scientific community has access to valuable data and research outcomes.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Saw Island Foundation offers grants focusing on education, science, and health, primarily targeting nonprofit organizations in the San Francisco Bay Area. Their education grants support scholarships and program partnerships, while science and health grants aim to enhance life experiences through improved health outcomes. Eligible applicants must be 501(c)(3) organizations, and the foundation emphasizes innovative collaborations that demonstrate measurable impact in their communities.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

The Georgia-Pacific Foundation Grant supports organizations in the Metro Atlanta area, focusing on education, entrepreneurship, community enrichment, and environmental sustainability. Established in 1958, the foundation prioritizes investments that align with its mission and values, promoting long-term well-being within communities where Georgia-Pacific operates. Eligible applicants include 501(c)(3) nonprofits, public schools, and local government entities located within 30 miles of GP manufacturing sites.

The Lawrence Foundation is a private family foundation established in 2000, dedicated to granting funds for environmental and human services causes. Eligible organizations include 501(c)(3) nonprofits and public schools, with grants typically ranging from $5,000 to $10,000. The foundation supports unrestricted grants for various projects, including disaster relief and environmental programs, but does not fund individuals or for-profit entities. Applications are evaluated based on alignment with the foundation's priorities.

The A.P. Giannini Foundation offers a Postdoctoral Research Fellowship and Leadership Award to support innovative biomedical research. Since 1945, the Foundation has funded nearly $50 million in research aimed at translating scientific discoveries into effective treatments for various diseases. This fellowship program not only provides financial support but also includes leadership training and a collaborative learning community, preparing fellows for impactful careers in academia and industry.

The California Institute for Regenerative Medicine (CIRM) is offering a funding opportunity through EDUC 1.12 to manage the Annual Trainee Network Conference. This initiative aims to support CIRM's Research Training programs by selecting a qualified applicant to develop and oversee the conference scheduled between May and August 2026. This effort aligns with CIRM's mission to promote equitable regenerative medicine advancements and enhance education and training across diverse communities.

The California Institute for Regenerative Medicine (CIRM) invites applications for the EDUC 1.5 Funding Opportunity to manage the SPARK Annual Meeting. This initiative aims to support the development and management of the 2026 meeting, promoting advancements in regenerative medicine. With a funding limit of $118,000 for eligible costs, this opportunity seeks a qualified applicant to enhance CIRM's education and training programs, ultimately delivering transformative treatments equitably to diverse communities.

The Amateur Radio Digital Communications Grants support projects that enhance digital communication and promote amateur radio. The California-based ARDC foundation funds initiatives focusing on education, research, and the growth of amateur radio, including scholarships and community engagement programs. Eligible applicants include U.S. nonprofits, educational institutions, and international charities. Emphasizing open access, funded projects must make their outcomes available to the public, fostering innovation in communication technology.

The DISC5 Awards, funded by the California Institute for Regenerative Medicine, aim to support innovative research in stem cell technologies that enhance patient care. Grants of up to $1.5 million for individual projects and $3 million for team efforts are available, with a project duration of up to three years. These awards encourage collaboration and focus on addressing critical knowledge gaps in regenerative medicine, promoting diversity and inclusivity in research.

The NNLM Region 5 Professional Development Award offers funding for individuals at member institutions to enhance their knowledge and skills in health-related areas. This initiative aims to support meetings, workshops, and training that focus on health literacy, public health, and evidence-based practices. By fostering professional development, the NNLM seeks to improve healthcare services and access to health information across various communities, ultimately contributing to better public health outcomes.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

The Community Ties Giving Program by Union Pacific Foundation offers local grants aimed at enhancing community well-being through diverse funding priorities. These include safety initiatives, workforce development, community vitality, and environmental sustainability. The program emphasizes supporting organizations that promote diversity, equity, and inclusion, aiming to create impactful projects that resonate with Union Pacific's heritage and mission. Eligible applicants must be nonprofit organizations serving Union Pacific communities and demonstrate a clear need and capacity to deliver effective programming.

The Effectiveness Monitoring Committee (EMC) is inviting project proposals aimed at evaluating the effectiveness of California's Forest Practice Rules and natural resource protections. This initiative targets key issues such as watershed health, wildlife habitat, and wildfire management. Proposals should address specific research themes and critical monitoring questions identified by the EMC, contributing to enhanced scientific understanding and improved forest resilience in California.

The Pacific Power Foundation offers Community Enhancement and Environmental Respect Grants to support nonprofit organizations in the Pacific Power and Rocky Mountain Power service areas. Since 2019, the foundation has contributed over $13 million to promote community resilience, affordable housing, and environmental conservation. Eligible candidates include 501(c)(3) nonprofits and educational institutions. Grants aim to address local needs while ensuring responsible environmental stewardship, enhancing community vitality, and fostering sustainable development.

The mission of the California Institute for Regenerative Medicine (CIRM) is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a diverse California and world. In support of this mission, CIRM’s governing board approved a structured, data-driven Strategic Allocation Framework (SAF) in 2024 to prioritize resources and maximize the impact of CIRM’s funding.

Designed in response to this framework, CIRM’s new Discovery Programs include complementary funding opportunities that support research at different scales and levels of maturity, emphasizing multidisciplinary innovation, knowledge sharing and leveraging synergies across CIRM-funded programs. These new funding opportunities support comprehensive, discovery research across a diverse range of diseases and bottlenecks to accelerate the development of potential therapeutics and biomarkers in regenerative medicine.

DISC4 Awards

Supporting Multidisciplinary, Collaborative Research

DISC4 supports expansive, cross-disciplinary and integrated studies led by collaborative teams applying a range of technologies and approaches to accelerate foundational insights in disease biology. 

Expected Outcomes

Funded projects are expected to achieve one or more of the following outcomes:

• Discovering novel mechanistic insights or advance our understanding of human diseases;
• Extending understanding of disease mechanisms to all affected human populations;
• Identification and validation of novel therapeutic strategies, targets, and/or biomarker(s).

Focus Area (Fiscal Year 2026/2027): Immune-Tissue Interplay in Disease, Homeostasis, and Repair

CIRM is seeking multidisciplinary proposals focused on elucidating the molecular and cellular mechanisms by which the human immune system interacts with and influences tissues, particularly in the context of pathology, injury or regeneration. See PA for illustrative examples. While priority will be given to proposals aligned with this focus area, proposals outside this area may be considered if they represent a compelling opportunity to advance DISC4 program goals.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

The California Department of Food and Agriculture is inviting proposals for the Adaptive IPM for Invasive Agricultural Pests grant program. This initiative aims to develop integrated pest management strategies that can be implemented swiftly when new invasive pests threaten California's agriculture. With $500,000 available for one award, the program seeks to enhance existing IPM strategies and explore new control measures to combat pesticide resistance and ensure a sustainable agricultural environment.