Best Grants for Science Research in California

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

State Farm's Good Neighbor Citizenship Company Grants aim to enhance community safety, development, and education. Focused on long-term impact, they support initiatives in auto and home safety, disaster preparedness, affordable housing, and educational programs. Eligible recipients include nonprofits, educational institutions, and government entities. However, funding is not available for individuals, religious programs, or organizations outside the U.S. By addressing critical community needs, these grants foster safer and more resilient neighborhoods.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Mayer and Morris Kaplan Foundation Environment Grant aims to support initiatives that combat climate change, prioritizing efforts to reduce fossil fuel consumption and enhance climate education for young adults. The foundation emphasizes innovative solutions and partnerships to address both immediate and long-term environmental challenges. Areas of focus include climate and clean energy policy, as well as providing scientifically accurate climate change education. By leveraging data and research, the foundation seeks to empower organizations dedicated to creating impactful change.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

The Ocean Drilling Grant, supported by the National Science Foundation (NSF), facilitates research in marine geosciences through the International Ocean Discovery Program (IODP). Proposals for pre- and post-expedition studies are accepted, particularly during the expedition moratorium period. This grant aims to enhance scientific understanding of climate and geological processes through innovative drilling techniques and collaborative international efforts, ensuring the scientific community has access to valuable data and research outcomes.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Saw Island Foundation offers grants focusing on education, science, and health, primarily targeting nonprofit organizations in the San Francisco Bay Area. Their education grants support scholarships and program partnerships, while science and health grants aim to enhance life experiences through improved health outcomes. Eligible applicants must be 501(c)(3) organizations, and the foundation emphasizes innovative collaborations that demonstrate measurable impact in their communities.

The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.

Wells Fargo Community Giving supports nonprofit organizations focusing on financial health, housing affordability, small business growth, and sustainability. The grant cycle runs from February to October, inviting organizations with 501(c)(3) status or equivalent to apply. Funding is prioritized for programs addressing critical community needs, while limited support is available for local initiatives like disaster relief and arts. Organizations must demonstrate fiscal stability and potential impact to be considered for funding.

The Amateur Radio Digital Communications Grants support projects that enhance digital communication and promote amateur radio. The California-based ARDC foundation funds initiatives focusing on education, research, and the growth of amateur radio, including scholarships and community engagement programs. Eligible applicants include U.S. nonprofits, educational institutions, and international charities. Emphasizing open access, funded projects must make their outcomes available to the public, fostering innovation in communication technology.

The Full Community-Partnered Participatory Research Award (Full CPPRA) supports research targeting tobacco-related health disparities through community-academic partnerships. With a maximum award of $600,000 per year for up to three years, this funding encourages the development and testing of tobacco prevention interventions. Applicants must include both a Community Co-PI and an Academic Co-PI from California-based institutions, fostering collaboration to enhance research efficacy and community impact.

The Pilot Community-Partnered Participatory Research Award (Pilot CPPRA) aims to support collaborative research addressing tobacco-related health disparities. With a funding cap of $500,000 per year for up to two years, this award encourages partnerships between community and academic researchers. Projects should focus on enhancing the feasibility of methods for interventions, developing collaborative relationships, and collecting preliminary data to improve future funding opportunities. This initiative fosters community engagement in tobacco research.

The California Department of Food and Agriculture is inviting proposals for the Adaptive IPM for Invasive Agricultural Pests grant program. This initiative aims to develop integrated pest management strategies that can be implemented swiftly when new invasive pests threaten California's agriculture. With $500,000 available for one award, the program seeks to enhance existing IPM strategies and explore new control measures to combat pesticide resistance and ensure a sustainable agricultural environment.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.

The A.P. Giannini Foundation offers a Postdoctoral Research Fellowship and Leadership Award to support innovative biomedical research. Since 1945, the Foundation has funded nearly $50 million in research aimed at translating scientific discoveries into effective treatments for various diseases. This fellowship program not only provides financial support but also includes leadership training and a collaborative learning community, preparing fellows for impactful careers in academia and industry.

The California Institute for Regenerative Medicine (CIRM) is offering a funding opportunity through EDUC 1.12 to manage the Annual Trainee Network Conference. This initiative aims to support CIRM's Research Training programs by selecting a qualified applicant to develop and oversee the conference scheduled between May and August 2026. This effort aligns with CIRM's mission to promote equitable regenerative medicine advancements and enhance education and training across diverse communities.

The California Institute for Regenerative Medicine (CIRM) invites applications for the EDUC 1.5 Funding Opportunity to manage the SPARK Annual Meeting. This initiative aims to support the development and management of the 2026 meeting, promoting advancements in regenerative medicine. With a funding limit of $118,000 for eligible costs, this opportunity seeks a qualified applicant to enhance CIRM's education and training programs, ultimately delivering transformative treatments equitably to diverse communities.

The DISC5 Awards, funded by the California Institute for Regenerative Medicine, aim to support innovative research in stem cell technologies that enhance patient care. Grants of up to $1.5 million for individual projects and $3 million for team efforts are available, with a project duration of up to three years. These awards encourage collaboration and focus on addressing critical knowledge gaps in regenerative medicine, promoting diversity and inclusivity in research.

The NNLM Region 5 Professional Development Award offers funding for individuals at member institutions to enhance their knowledge and skills in health-related areas. This initiative aims to support meetings, workshops, and training that focus on health literacy, public health, and evidence-based practices. By fostering professional development, the NNLM seeks to improve healthcare services and access to health information across various communities, ultimately contributing to better public health outcomes.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Effectiveness Monitoring Committee (EMC) is inviting project proposals aimed at evaluating the effectiveness of California's Forest Practice Rules and natural resource protections. This initiative targets key issues such as watershed health, wildlife habitat, and wildfire management. Proposals should address specific research themes and critical monitoring questions identified by the EMC, contributing to enhanced scientific understanding and improved forest resilience in California.

The Pacific Power Foundation offers Community Enhancement and Environmental Respect Grants to support nonprofit organizations in the Pacific Power and Rocky Mountain Power service areas. Since 2019, the foundation has contributed over $13 million to promote community resilience, affordable housing, and environmental conservation. Eligible candidates include 501(c)(3) nonprofits and educational institutions. Grants aim to address local needs while ensuring responsible environmental stewardship, enhancing community vitality, and fostering sustainable development.

The mission of the California Institute for Regenerative Medicine (CIRM) is to accelerate world class science to deliver transformative regenerative medicine treatments in an equitable manner to a diverse California and world. In support of this mission, CIRM’s governing board approved a structured, data-driven Strategic Allocation Framework (SAF) in 2024 to prioritize resources and maximize the impact of CIRM’s funding.

Designed in response to this framework, CIRM’s new Discovery Programs include complementary funding opportunities that support research at different scales and levels of maturity, emphasizing multidisciplinary innovation, knowledge sharing and leveraging synergies across CIRM-funded programs. These new funding opportunities support comprehensive, discovery research across a diverse range of diseases and bottlenecks to accelerate the development of potential therapeutics and biomarkers in regenerative medicine.

DISC4 Awards

Supporting Multidisciplinary, Collaborative Research

DISC4 supports expansive, cross-disciplinary and integrated studies led by collaborative teams applying a range of technologies and approaches to accelerate foundational insights in disease biology. 

Expected Outcomes

Funded projects are expected to achieve one or more of the following outcomes:

• Discovering novel mechanistic insights or advance our understanding of human diseases;
• Extending understanding of disease mechanisms to all affected human populations;
• Identification and validation of novel therapeutic strategies, targets, and/or biomarker(s).

Focus Area (Fiscal Year 2026/2027): Immune-Tissue Interplay in Disease, Homeostasis, and Repair

CIRM is seeking multidisciplinary proposals focused on elucidating the molecular and cellular mechanisms by which the human immune system interacts with and influences tissues, particularly in the context of pathology, injury or regeneration. See PA for illustrative examples. While priority will be given to proposals aligned with this focus area, proposals outside this area may be considered if they represent a compelling opportunity to advance DISC4 program goals.