Best Grants for Nonprofit Healthcare Programs in California

Nonprofit public charities in California seeking support for healthcare, health care access and delivery, social services, and related programs can apply for the Harold McAlister Charitable Foundation’s grants. With a mission to support effective organizations in bettering the lives of others, the foundation also considers education, animal welfare, arts and culture, and environmental initiatives.

California nonprofit 501(c)(3) organizations providing practical support that helps pregnant people access abortion care can receive funding for transportation, lodging, childcare, meals, wage replacement, and related services. California healthcare access groups can access funding through the California Department of Health Care Access and Information, administered by Essential Access Health, with awards ranging from US $100,000 - US $750,000.

Nonprofit organizations in California focused on health care and human services may be eligible for funding that supports community-focused healthcare access and related programs. Focused on arts, education, youth, community, and global food and agriculture, J R Simplot Company Foundation invites U.S. nonprofits to apply; requests are reviewed quarterly.

Grants from Astrazeneca Foundation help California nonprofit healthcare and community organizations address health equity through nutrition and food security, healthcare access, STEM education, and climate and nature initiatives. U.S.-based 501(c) groups serving historically excluded or disenfranchised communities in California can apply for up to US $30,000 for community-based programs, excluding capital projects, salaries, and hospitals.

First- and second-year medical students conducting health-related research in California can access funding through Alpha Omega Alpha’s Carolyn L. Kuckein Student Research Fellowship, which awards US $7,000 for 2–12 month projects. Eligible projects include clinical investigation, basic laboratory research, epidemiology, health services, social science, leadership, or professionalism studies at schools with active AΩA chapters.

Nonprofit organizations in California working on health care access, mental health, or education for underserved populations can apply for US $10,000 - US $75,000 in program funding from L B Research and Education Foundation. The foundation supports established 501(c)(3)s expanding proven, research-informed programs for adolescents, post-secondary students, and adult vocational learners through a rolling, concept-paper-first process.

Early- through growth-stage U.S.-incorporated companies improving health care access and delivery for low-income Californians can apply for up to US $400,000 to scale technology and innovation solutions. Grants from California Health Care Foundation help California-focused healthcare innovators build partnerships with providers, health systems, payers, and patients, which may benefit nonprofit healthcare programs statewide.

Nonprofit 501(c)(3) small or rural health facilities in California can apply for low-interest loans from the California State Treasurer's Office; awards US $25,000 - US $1,500,000 for facility expansion and equipment. Funds may support construction, renovation, furnishings, feasibility studies, pre-construction costs, or refinancing a single existing debt, with a 5% borrower contribution required.

Nonprofit organizations improving community access to quality healthcare in California can apply for the Astrazeneca Foundation’s CHANGE grants, awarding US $200,000 - US $220,000 in general operating support. Programs using innovative, collaborative approaches to address health care access, delivery, and related equity issues may be considered, with potential for multi-year renewal based on performance.

Nonprofit 501(c)(3) organizations running healthcare and health equity projects in California can seek funding for defined community health improvement initiatives. With a mission to improve health and advance social justice, Commonspirit Health provides grants up to US $150,000 through participating hospitals to address needs identified in community health needs assessments.

Nonprofit 501(c)(3) organizations in California working on health care access and delivery, early childhood education, conservation, or family services can seek capital or special project funding that supports community programs. Grants from James M Cox Foundation help U.S. nonprofits in Cox service areas, with preference for groups engaged with local Cox businesses.

About CommonSpirit

A calling that defines and unites

At CommonSpirit Health, we passionately care for the most vulnerable, relentlessly innovate how and where healing can happen and believe in uniting to benefit the common good. Our expansive network spans diverse communities, uniquely positioning us to meet their changing needs, improve population health and help chart the path to health equity.

Our mission, vision and values inform every aspect of our work each day and remind us that we serve our patients, their families, our communities – and each other. Our community health, research and home health programs help us address the primary barriers to healthier communities.

Sponsorship requests

We’re proud to support nonprofits that expand access to care, advance health equity and healthier communities. Learn more about our priorities.

Supporting our communities

CommonSpirit Health and our local facilities support nonprofit organizations that share our mission, vision and values. We give priority to programs that improve access to care and promote health equity and healthier communities.

CommonSpirit is proud to support nonprofit organizations that help improve the health and well-being of our communities. Guided by our mission, vision and values, we prioritize projects that focus on advancing health equity, improving access to care and improving community wellness.

California 501(c)(3) nonprofits offering healthcare, education, or arts programs for children and women can apply for project or capital funding that excludes most operating costs. Grants from Douglas Foundation help organizations in California, with preference for Los Angeles County, expand equitable access to health care and related community services.

California community development financial institutions (CDFIs) supporting affordable housing, health care, small business lending, and other services in low- and moderate-income communities can use these grants for working capital and to increase net assets. With a mission to strengthen community development, California State Treasurer's Office provides California CDFIs with up to US $200,000 based on recent lending activity.

Nonprofit organizations in California offering health care access, wellness, mental health, or related services can apply for John Jordan Foundation’s John Jordan Foundation Grant to support programs improving quality of life for vulnerable communities. Funding may also benefit initiatives serving youth, seniors, families, and under-resourced populations alongside healthcare-focused work.

The Domanica Foundation Grant provides funding to IRS-qualified charitable 501(c)(3) organizations in San Diego and Denver. Established in 1994, the foundation focuses on social services addressing hunger, homelessness, healthcare for the uninsured, and scholarships for non-traditional students. While first-time recipients typically receive between $1,000 and $5,000, there is no set application schedule. Proposal summaries can be submitted at any time for consideration by the board.

Nonprofit and other organizations supporting community health workers in California can apply for California Health Care Foundation’s Amplifying Impact Initiative, which funds scaling of CHW/P/R Medi-Cal providers. Over 18 months, 28 providers receive grants, technical assistance, and tools to expand culturally responsive health and social services and strengthen CHW/P/R jobs.

The Henry L. Guenther Foundation Grants support charitable organizations in California, focusing on improving social conditions and human welfare. Funding is aimed at diverse projects including medical services, youth opportunities, and community programs. Grants are awarded for 12 months, and any unspent funds must be returned. Eligible applicants include qualified tax-exempt organizations, while individuals and changes to grant scopes are not accepted. This foundation enhances the quality of life for Southern California residents by backing impactful initiatives.

The DGLF Youth Literacy Grants, established by the Dollar General Literacy Foundation, aim to enhance literacy among underperforming students in K-12. Organizations such as schools and libraries can apply for funding to implement or expand literacy programs, purchase necessary materials, and acquire technology. With over $159 million awarded to date, the foundation supports efforts that provide equitable education opportunities, ensuring every child has the chance to learn and succeed, regardless of their background.

Homecare Assistance Grant

MS Focus understands the daily needs and challenges that must be met by both those with MS and their caregivers. In order to meet these needs in the most timely and efficient way possible, our Homecare Assistance Grant connects you to the best available local services. Should resources within your community not be available, direct support may be provided on a temporary basis.

Available Services include:

• Home Care - Personal hygiene services, light housekeeping, grocery shopping, meal preparation, and transportation to and from appointments are all services that can be provided for a limited time.
• Therapy Visits - Based upon individual need, an appointment with an occupational, physical, or speech therapist can be arranged. Through education and training, these therapists can help to foster independence, self-esteem, and better quality of life for the person living with MS.
• Respite Care - Respite allows primary caregivers the opportunity to tend to themselves, or other family business, with the assurance that their loved one is being cared for by a properly trained individual. This service is provided on a short-term basis for a scheduled period of time. 
• Coming Home - Returning home from a stay at the hospital can be a difficult time of transition. We offer a four-hour visit from an aide who will meet the patient at the hospital, provide transportation home, and then get the patient settled comfortably at home.

Ventura County Community Foundation

Nearly 40 years ago, we set out to make life better for the people of Ventura County.

Initially, we wanted to help nonprofits become more sustainable and give donors a way of leaving complicated gifts, like real estate and stocks. In 1990, we began giving people the chance to fund scholarships. Then, in 2000, we provided community grantmaking where donors could give together towards a common cause.

Now, we convene large numbers of residents to work together as agents of change.

Swift Memorial Health Care Foundation Charitable Fund

The Swift Memorial Health Care Foundation Charitable Fund was established following the dissolution of the Swift Memorial Health Care Foundation (SMHCF). SMHCF was named in honor of Dr. Floyd J. Swift and his wife, Ida Swift, in recognition of their significant contributions to improving the quality of life in Ventura County.

The Swift Memorial Health Care Foundation Charitable Fund will carry on the Foundation’s legacy by supporting nonprofit organizations that assess health care needs or provide health care services to Ventura County residents through community-focused programs, projects, or events. Grants are typically awarded to support specific projects that are expected to be achieved within a defined timeframe—often within one year—and for projects with the potential to extend beyond the grant period, generating lasting impact and long-term multiplier effects.

Healthcare Assistance Grant

The MS Focus Healthcare Assistance Grant assists uninsured individuals with the cost of visiting their MS specialist as well as dental assistance. The grant, which can pay for one visit and one follow-up, is designed to assist those already diagnosed with MS who may need a visit to their treating physician to renew a prescription or handle other important needs. 

Applicants give MS Focus staff authorization to negotiate costs directly with the provider, and the fee is paid directly to the doctor. 

Working together with IE Nonprofits to Advance Vibrant Health

We support organizations that serve families with children across the Inland Empire. We invest in strengthening nonprofit infrastructure, increasing access to basic needs, and building healthier community environments. Our goal is simple: help trusted local leaders do their work better, reach more people and create lasting change where it’s needed most.

Responsive Grants

As part of our responsive grantmaking strategy, IEHPF offers two types of responsive grants – and . Both grant opportunities allow organizations to submit funding requests for projects and activities that advance Vibrant Health for Inland Empire community members and align with IEHPF’s mission, vision, and priorities.

Healthy Communities Grant Summary

Healthy Communities grants provide funding and support to nonprofit organizations, collaboratives or networks addressing regional health needs, social drivers of health (SDPH) and systems change efforts for Inland Empire community residents who are experiencing the poorest health outcomes in low income communities, rural or remote areas and/or communities with a Healthy Places Index (HPI) score lower than 25. The grant focuses on supporting projects and activities that improve the organization or network’s capacity to effectively advocate for better health policies, strengthen regional workforce development efforts (especially in health, social services and for the purposes of Medi-Cal retention) and focus on improving population health outcomes that can be sustained beyond the one-year lifecycle of the grant.

Healthy Communities grants are awarded twice a year and have a one-year grant lifecycle. Awards will range from $20,000 - $75,000, although exceptions may apply. Organizations may only apply once per calendar year and must address at least one of the IEHPF’s priority Vital Conditions.

Working together with IE Nonprofits to Advance Vibrant Health

We support organizations that serve families with children across the Inland Empire. We invest in strengthening nonprofit infrastructure, increasing access to basic needs, and building healthier community environments. Our goal is simple: help trusted local leaders do their work better, reach more people and create lasting change where it’s needed most.

Responsive Grants

As part of our responsive grantmaking strategy, IEHPF offers two types of responsive grants – and. Both grant opportunities allow organizations to submit funding requests for projects and activities that advance Vibrant Health for Inland Empire community members and align with IEHPF’s mission, vision, and priorities.

Healthy Organizations Grant Summary

The Healthy Organizations grants provides funding and support to nonprofit organizations addressing the social drivers of health (SDOH) for Inland Empire community residents who are experiencing the poorest health outcomes in low-income communities, rural or remote areas and/or communities with a Healthy Places Index (HPI) score lower than 25. These investments focus on supporting projects and activities that improve the nonprofit’s internal capacity to work effectively and develop strong programs, finances, leadership and infrastructure that will be sustained beyond the one-year lifecycle of the grant.

Healthy Organizations grants are awarded twice a year and have a one-year grant lifecycle. Awards will range from $5,000 - $20,000, although exceptions may apply. Organizations may only apply once per calendar year and must address at least one of the IEHPF’s priority Vital Conditions.

To apply, organizations will complete a brief Eligibility Quiz to determine eligibility and submit a Letter of Inquiry (LOI) with a brief description of the project or activity they hope to fund with the Healthy Organizations grant. IEHPF staff members will then will review the LOI and determine if the organization will be invited to the full application on a rolling basis, but by the invitation deadline below.

Please note that organizations are encouraged to submit their LOIs early to allow for greater time to complete an application, if invited. However, as long as an organization submits an LOI by the deadline, their project will be considered for funding.

The NIH is set to release a funding opportunity for pragmatic and implementation trials aimed at evaluating the effectiveness of interventions in real-world healthcare settings. This initiative encourages collaborations across various health systems to assess the effectiveness and feasibility of interventions. By focusing on commonly encountered conditions in everyday clinical care, the trials aim to provide actionable insights for patients, clinicians, and policymakers. Interested investigators are encouraged to start developing their project proposals.

FY25 Veterans Treatment Court Program

Executive Summary

This NOFO will support the implementation and enhancement of veterans treatment court (VTC) operations. VTCs connect veterans who come in contact with the justice system to treatment for substance use disorders (SUD), mental health disorders (MHD), co-occurring mental health and substance use disorders (MHSUD), post-traumatic stress disorder (PTSD), and traumatic brain injury (TBI). Funding supports service coordination, and recovery support services. VTCs integrate mandatory drug testing, incentives and sanctions, and transitional services in judicially supervised criminal court settings that have jurisdiction over veterans with behavioral health treatment needs. These courts aim to reduce recidivism and overdose fatalities, while increasing access to treatment and recovery support that leads to long-term recovery.

Category 3 supports state applicants to improve, enhance, or expand VTC services statewide. Activities include expanding treatment and services; audits of program policies and procedures; and data collection and analysis to assess program practices and track recidivism. These are intended to be one-time projects to enhance capacity that can be sustained.

Program Description

Statewide grants are available to state applicants to improve, enhance, or expand veterans treatment court services statewide. Activities include expanding treatment and services; reviewing programs’ policies and procedures; and data collection and analysis to assess program practices and track recidivism. This could include training to address staff turnover and offer operational skills updates and to expand treatment resources in locations with critical substance use needs. These are intended to be one-time projects to enhance capacity that can be sustained

The Centers of Excellence in Healthcare Quality and Safety program aims to establish a collaborative network of healthcare systems and public health partners to enhance patient and healthcare worker safety. This initiative focuses on improving the quality and resilience of U.S. healthcare delivery across various settings, including hospitals and outpatient facilities. By fostering partnerships, the program seeks to effectively detect, respond to, and prevent safety threats, ensuring a higher standard of care and safety for all.