Best Private Grants for Nonprofits

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For concepts with preliminary feasibility evidence that are ready to advance from prototype toward an integrated workflow—optimizing performance, broadening assay or pathogen coverage, and generating more robust cost-reduction and performance data.

The Patient-Centered Outcomes Research Institute (PCORI) will announce the Phased Large Awards for Comparative Effectiveness Research on December 2, 2025. This funding aims to support high-quality, patient-centered comparative clinical effectiveness research projects. The initiative encourages applicants to engage with patients and stakeholders to address critical healthcare dilemmas and improve decision-making. Projects should compare established clinical alternatives with evidence of efficacy, targeting vital health issues across diverse populations.

The Reusable Beverage Containers Infrastructure Grant Program, offered by CalRecycle, aims to fund infrastructure and start-up costs for a deposit-return system for glass reusable containers in California. This initiative, established under AB 179, seeks to enhance the Beverage Container Recycling Program and promote a circular economy by establishing a processing stream for reusable glass containers. Eligible projects include equipment, technology, and training necessary for implementing this sustainable system.

The Jack Feldt Ambucs Memorial Scholarship, established in 1997, supports students in the Tri-Cities area pursuing a degree in Physical Therapy. Funded by the Grand Haven Area Community Foundation, this scholarship prioritizes applicants demonstrating financial need. It considers college juniors and graduating high schoolers, reflecting the spirit of community and collaboration championed by Ambucs. Eligible candidates need to provide transcripts and additional required documents to complete their application.

The Creative Entrepreneur Accelerator Program provides financial resources and consulting services to creative entrepreneurs in Pennsylvania, especially focusing on BIPOC individuals and those in low-income communities. By reserving 55% of funds for these groups, the program aims to foster diversity, equity, and inclusion within the creative sector, empowering entrepreneurs to grow their businesses and reach wider audiences while enhancing their revenues.

Cupertino Electric, established in 1954, is dedicated to supporting communities through donations and volunteerism. Our giving program focuses on addressing hunger, homelessness, and early education (K-8). With substantial annual contributions and a commitment to service, we aim to make a meaningful impact in the areas where our employees live and work. By fostering a culture of giving back, we believe that enhancing community well-being is as vital as our business operations.

The Conservation Partners Legacy Grant Program, managed by the Minnesota Department of Natural Resources, offers competitive grants ranging from $5,000 to $500,000 for projects that restore, protect, or enhance vital habitats like prairies and wetlands. Applicants must provide a 10% match of non-state funds and the total project cost cannot exceed $1,000,000. Focused on habitat benefits, the program emphasizes conservation easements and public ownership for funded projects.

The Detlev and Mary Ellen Preissler Fund for the Arts, Music, Design, and Nature supports arts education in Jefferson, Berkeley, and Morgan County. Grants from $1,000 to $10,000 are available for 501(c)(3) nonprofits and public schools that focus on inspiring children through art, music, design, and nature. Eligible applicants are encouraged to propose specific programs that enhance children's learning experiences, particularly those integrating nature into their curriculum.

The Junior League of Houston is introducing the Community Assistance Pilot Program to support early-stage organizations in the greater Houston area. This program will provide up to three agencies with $10,000 annually for three years, aiming to enhance their capacity in key focus areas: Children’s Education, Health and Well-Being, and Basic Needs. Eligible organizations must be 501(c)(3) non-profits with a clean legal record and less than $1 million in assets.

Toby L. Mapes: Fire Protection Technology Scholarship

Funding Amount:

• $1500
• Active

This scholarship is to provide financial assistance for a student pursuing a higher education in a Fire Protection Technology degree at an accredited institution, with preference given to students attending Blue Ridge Community College or AB Technical College in a fire protection technology field. A second preference is given to students pursuing nursing. 

The Community Support Team Grant Program by the Illinois Department of Human Services aims to enhance services for Northwest Crisis Care System consumers who lack funding in specific counties. This initiative will promote access to vital nursing and psychiatric treatment, responding to individual needs identified in assessments. The program prioritizes diversity and equity, addressing systemic barriers to ensure inclusivity across all demographics and fostering a supportive environment for those facing socioeconomic challenges.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.

The Delaney L. Wykle Nursing Scholarship, managed by the Beckley Area Foundation, aims to support nursing students from Raleigh and Summers counties in West Virginia. Applicants must demonstrate financial need, possess a minimum 3.0 GPA, and be enrolled in an accredited four-year nursing program. This scholarship helps empower students to achieve their educational goals while enhancing community health services in Southern West Virginia.

N.C. Forest Service - Urban and Community Forestry Financial Assistance Program

The goal of the North Carolina Urban and Community Forestry (U&CF) Program is to help municipalities reach a level of sustainable U&CF management that matches their goals and capacity. We define urban and community forestry as follows:

Urban forestry is defined as the management of the planting, maintenance and protection of tree populations in urban settings to enhance the economic and ecosystem services trees provide to the community.

Community forestry is a branch of forestry that engages the community in the completion of urban forestry practices in support of local government, serves broader community needs and works for positive change.

When municipalities and partners accomplish urban and community forestry practices and activities in an ordered manner, they enhance the level of management in the community, leading to sustainable program success.

We use the accomplishment of six specific standards to measure and classify the development status of a community’s U&CF program into one of four management classifications. This helps a community measure its progress, celebrate accomplishments, and allows us to best serve each community’s individual needs.

The Urban and Community Forestry Project Financial Assistance Program is designed to help communities climb this sustainable management hierarchy. The program accomplishes this by providing financial assistance and guidance in the development and completion of U&CF projects comprised of urban and community forestry practices and activities. A Request for Applications (RFA) process is offered several times a year to help you plan and apply for these assistance opportunities. Definitions of the practices, activities and project deliverables can be found in the following document: NCFS U&CF FAP Glossary of Deliverables and Requirements

Financial Assistance Program Packages

We offer the following packages of specific practices and activities, each designed to help move a community up the management hierarchy or address a specific need.

• Climb to Tree City USA Package (Consolidated Program Grant (CPG); Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))
• Climb to Managing Community Package  (Consolidated Program Grant (CPG); Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))
• Tree Maintenance and Planting Packages: i) Tree maintenance and planting project (Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA)) and ii) Bad tree bounty project);
• Professional Staff Development Assistance
• N.C. Arbor Day Celebration Assistance
• Special Projects: Climb to Tree City USA Services (Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))

Climb to Tree City USA Package

This assistance package is designed to help municipalities that have not met all the Tree City USA standards complete select urban forestry practices and community forestry activities that are foundational in the management of public trees and to achieve Tree City USA designation. The RFA opens in January each year.

Funding Program Options

A grant will be funded by one of the three funding programs. You will need to select one. (Contact NCFS U&CF program staff for guidance, if needed):

• Consolidated Program Grant (CPG)
• Hurricane Helene Recovery (HHR)
• Inflation Reduction Act (IRA)

Inflation Reduction Act (IRA)

• 100% of the Tribal government or municipality’s incorporated lands fall within the boundaries of NCFS U&CF Financial Assistance Program Inflation Reduction Act project areas.
• Cost share %: Reimbursement of 100% of eligible purchased goods and services.
• Indirect administration – 20% de minimis/total purchased goods and services.
• $5.6 million of assistance is available for award of all IRA funded RFAs.

The Betty and Davis Fitzgerald Foundation Grant aims to enhance education and mental health access for low-income families in the 21-county Metro Atlanta area. The foundation focuses on supporting organizations that strengthen talent pipelines and promote systemic solutions. With four grant cycles annually, applications are accepted year-round, and the foundation prioritizes initiatives that foster equity and collaboration, benefiting historically marginalized communities. This commitment drives their funding strategy and helps ensure effective resource allocation.

N.C. Forest Service - Urban and Community Forestry Financial Assistance Program

The goal of the North Carolina Urban and Community Forestry (U&CF) Program is to help municipalities reach a level of sustainable U&CF management that matches their goals and capacity. We define urban and community forestry as follows:

Urban forestry is defined as the management of the planting, maintenance and protection of tree populations in urban settings to enhance the economic and ecosystem services trees provide to the community.

Community forestry is a branch of forestry that engages the community in the completion of urban forestry practices in support of local government, serves broader community needs and works for positive change.

When municipalities and partners accomplish urban and community forestry practices and activities in an ordered manner, they enhance the level of management in the community, leading to sustainable program success. 

We use the accomplishment of six specific standards to measure and classify the development status of a community’s U&CF program into one of four management classifications. This helps a community measure its progress, celebrate accomplishments, and allows us to best serve each community’s individual needs.

The Urban and Community Forestry Project Financial Assistance Program is designed to help communities climb this sustainable management hierarchy. The program accomplishes this by providing financial assistance and guidance in the development and completion of U&CF projects comprised of urban and community forestry practices and activities. A Request for Applications (RFA) process is offered several times a year to help you plan and apply for these assistance opportunities. Definitions of the practices, activities and project deliverables can be found in the following document: NCFS U&CF FAP Glossary of Deliverables and Requirements

Financial Assistance Program Packages

We offer the following packages of specific practices and activities, each designed to help move a community up the management hierarchy or address a specific need.

• Climb to Tree City USA Package (Consolidated Program Grant (CPG); Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))
• Climb to Managing Community Package (Consolidated Program Grant (CPG); Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))
• Tree Maintenance and Planting Packages: i) Tree maintenance and planting project (Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA)) and ii) Bad tree bounty project);
• Professional Staff Development Assistance
• N.C. Arbor Day Celebration Assistance
• Special Projects: Climb to Tree City USA Services (Hurricane Helene Recovery (HHR); and Inflation Reduction Act (IRA))

Climb to Tree City USA Package

This assistance package is designed to help municipalities that have not met all the Tree City USA standards complete select urban forestry practices and community forestry activities that are foundational in the management of public trees and to achieve Tree City USA designation. The RFA opens in January each year.

Funding Program Options

A grant will be funded by one of the three funding programs. You will need to select one. (Contact NCFS U&CF program staff for guidance, if needed):

• Consolidated Program Grant (CPG)
• Hurricane Helene Recovery (HHR)
• Inflation Reduction Act (IRA)

Hurricane Helene Recovery (HHR)

• Tribal government or a municipality located in Alleghany, Ashe, Avery, Buncombe, Caldwell, Henderson, Madison, Mitchell, Polk, Rutherford, Transylvania or Yancey counties.
• Cost share %: Reimbursement of 100% of eligible purchased goods and services.
• Indirect administration – 15% de minimis/total purchased goods and services.
• $2.2 million in assistance is available for award of all HHR funded RFAs.

The Community Foundation of South Lake County offers the CFSLC Community Impact Grants to support local non-profits in various focus areas such as affordable housing, education, and health. With over $9 million granted in the past 27 years, the foundation emphasizes the importance of serving residents in the South Lake County tax district. Eligible organizations must have 501(c)(3) status and a minimum of three years of program data to apply for funding.

The National Sea Grant Law Center is inviting proposals for the Coastal Resilience Program to research laws and policies addressing coastal resilience challenges such as sea level rise and flooding. With a funding cap of $150,000 over two years, this initiative aims to assess the effectiveness of existing policies and promote informed decision-making in coastal management. Up to two projects will be selected for funding, supporting innovative solutions to enhance community resilience against environmental threats.

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

Tennessee Department of Transportation

The Department of Transportation provides citizens of Tennessee and travelers with one of the best transportation systems in the country. TDOT consistently wins awards for its projects, highway design and innovative approach to transportation.

TDOT is a multimodal agency with responsibilities in aviation, public transit, waterways, railroads and cycling and walking. Our involvement ranges from airport improvements to funding transit buses to planning for river ports.

Transportation Planning Grants

The Transportation Planning Grant (TPG) is intended to assist jurisdictions (both municipalities and counties) with transportation planning efforts that determine strategies to support improvements in traffic flow, safety, mobility, and overall efficiency of the transportation system. Since 2015, TDOT has awarded 145 planning grants across the state, many of which have resulted in implementation funding.

The TPG funds transportation plans only.

Goals of the Transportation Planning Grant

• Assist Tennessee communities with multimodal transportation planning
• Bridge the gap between land use planning and transportation planning
• Aid with the creation of planning documents that support improvements in traffic flow, safety, and overall efficiency of the transportation system
• Provide planning resources to achieve community visions that promote future economic growth

Matching

• The TPG is 80% federal, 10% state, and 10% local match
• Distressed and At-Risk Counties as determined by TNECD (and municipalities within) as of FY26 qualify for 0% local match

Planning Opportunities

Planning opportunities include, but are not limited to: Complete Streets Plans; Bicycle and Pedestrian Master Plans; Transportation System Management and Operations (TSMO) Plans; Corridor Studies; Resurfacing Plans; Community Mobility Plans

We also welcome any creative and innovative transportation planning ideas.

Bicycle and Pedestrian Master Plans

A Bicycle & Pedestrian Plan can assist communities in prioritizing non-motorized transportation investments. As demand for alternative transportation options continue to grow, communities are increasingly recognizing the need for these facilities to help achieve their desirable quality of life. See more here.

Administrative Process

Through the Transportation Planning Grant program, your community will be paired with a consultant currently under contract with TDOT that will guide you through the planning process and bring your plan to life. The community is responsible for actively participating in the plan by establishing a Steering Committee, providing the match, and ensuring local support for the proposed study recommendations.

The Jacquelin Goldman Congressional Fellowship offers developmental and clinical psychologists a unique opportunity to gain public policy experience while enhancing the application of psychological knowledge in government. Funded by the American Psychological Foundation, this fellowship supports one fellow annually with a stipend of $75,000 to $90,000, along with health insurance reimbursement and professional development funds. Applicants must demonstrate expertise in child psychology and policy issues, and have strong communication skills.

Overview

The Submerged Lands Harbor Management and Access Grant (HMA) is administered by the Submerged Lands Program (SLP), a program of the Bureau of Parks and Lands (BPL) within the Maine Department of Agriculture, Conservation and Forestry (DACF). The SLP works to balance the public’s right to access state waters with demand for private and commercial use of those waters. The SLP administers the Submerged Lands Leasing Program which provides limited leases and easements that allow piers and other structures to be built on or over publicly owned submerged lands. Lease and easement revenues are used to support harbor planning and public access improvements through grants to municipalities and state agencies. Maine’s submerged lands include:

• Coastal waters:
  • All land from the mean low-water mark out to the three-mile territorial limit (including islands).
• Tidal Rivers:
  • All land below the mean low-water mark of tidal rivers upstream to the farthest natural reaches of the tides.
• Great Ponds:
  • All land below the natural low-water mark of ponds that are 10 or more acres in size in their natural state.
• Boundary Rivers:
  • Land lying between the banks of rivers that form Maine's border with Canada.

The Delores and Jerry Etter Graduate Research Scholarships, offered by the Tulsa Community Foundation, support master's and doctoral students conducting impactful research at the Joseph H. Williams Tallgrass Prairie Preserve. Established to promote diverse research topics, these scholarships aim to enhance conservation efforts in the region. Selection is based on the potential impact of the projects, evaluated by a committee comprising foundation staff and academic professionals. This initiative fosters academic excellence and ecological stewardship in Oklahoma.

The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.

The Larry L. Hillblom Foundation offers the Start-Up Grant to support early-career researchers in California focused on diabetes and age-related brain and vision disorders. Grants of up to $120,000 per year for three years are available for projects that demonstrate innovative approaches to medical research. The foundation prioritizes funding for those affiliated with California institutions and encourages applications from those who have not held faculty positions for over a year.

The Conservation Opportunity Fund Grant provides up to $1,500 to private landowners in Cheshire County, NH, to enhance wildlife habitats on small tracts of land (25 acres or less). Eligible projects include pollinator habitats, rain gardens, and vegetated buffers that promote ecological integrity and sustainability. Priority is given to projects with long-term maintenance plans and landowner involvement. This initiative supports environmental stewardship and aims to improve biodiversity in the region.

The Sociedad Amigos de Colombia de Indiana (SADCO) Scholarship, managed by the Central Indiana Community Foundation, supports Latinx and Hispanic students pursuing post-secondary education. Applicants must be Indiana residents with a GPA of 3.0 or higher, demonstrating financial need and community service. Preference is given to first, second, or third generation Latinx and/or Hispanic students. Scholarship funds assist with tuition, fees, and other educational expenses, reinforcing the foundation's mission to build inclusive opportunities.