Best Human and Social Service Grants in South Carolina

Focused on innovative human services, Creag Foundation invites South Carolina 501(c)(3) nonprofits to seek support for new approaches to social problems. Organizations that have held 501(c)(3) status for at least one year and are addressing existing or previously unaddressed social issues may be considered, starting with a letter of inquiry.

501(c)(3) nonprofits supporting youth health, education, development, or welfare in South Carolina can apply for DanPaul Foundation grants, with awards up to US $15,000. Funding supports child advocacy, homelessness and poverty services, early childhood development, refugee enrichment, environmental education, and related human and social service programs for children and youth, with no geographic restrictions nationwide.

Early-stage, impact-first nonprofits and mission-driven for-profits tackling major social or environmental challenges can access funding and intensive capacity-building support to scale their solutions, including in South Carolina. Grants from Draper Richards Kaplan Foundation help human and social service innovators grow proven models for underserved communities, with awards up to US $300,000 over three years.

Nonprofit and NGO programs using technology to tackle human and social service challenges in South Carolina and worldwide can apply for Global Impact Cash Grants, with awards up to US $100,000. Cisco Systems Foundation supports initiatives in crisis response, education access, and economic empowerment that primarily serve economically underserved communities.

South Carolina human and social service organizations can access funding through State Farm Companies Foundation for safety, education, and community development initiatives. Eligible applicants include 501(c)(3) nonprofits, educational institutions, government programs, and volunteer fire companies in the U.S. Projects may address disaster preparedness, affordable housing, food insecurity, financial literacy, or K-12 and higher education success.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

South Carolina human and social service nonprofits and other 501(c)(3) organizations can receive support for health, education, and community programs through Labcorp Charitable Foundation. The foundation funds efforts such as food pantries, healthcare and patient services for underserved populations, STEM programming, and healthy lifestyle initiatives, with requests reviewed in March and September.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

Human and social service nonprofits working on health, education, or disaster relief in South Carolina and globally can seek support for programs serving marginalized communities. Semnani Family Foundation provides flexible funding for initiatives such as healthcare access, child welfare, domestic violence services, literacy, and humanitarian aid, and has a track record of work in the U.S. and multiple countries.

Nonprofit 501(c)(3) organizations providing human and social services, education, scientific, or medical programs in South Carolina can seek support for charitable activities that benefit U.S. communities. With a mission to advance charitable, scientific, medical, and educational work, Sidney Stern Memorial Trust provides funding to soundly managed organizations that significantly improve general welfare.

South Carolina 501(c)(3) nonprofits addressing human and social service needs like housing, hunger, workforce development, and community development can seek sponsorship support through Bank of America Foundation. Additional priorities include arts and culture, environmental initiatives, and diversity and inclusion programs, which may benefit organizations serving low- and moderate-income communities.

Nonprofit 501(c)(3) organizations offering human and social services in South Carolina may be eligible for funding to advance community services, peacebuilding, and environmental initiatives. Focused on broad, future-oriented change, the Dudley T Dougherty Foundation invites applicants working to improve quality of life for people and communities.

Human and social service 501(c)(3) organizations in South Carolina can apply for funding to support operations, programs, capital needs, or endowments. Grants from Patrick Family Foundation also support arts, healthcare, higher education, and conservation, and must be used for charitable, scientific, literary, or educational purposes as outlined in the approved proposal.

Nonprofit 501(c)(3) organizations providing basic needs, youth enrichment, workforce readiness, or domestic violence services in South Carolina may be eligible for funding if located within 15 miles of a TJX site. The TJX Foundation supports programs helping vulnerable families and children build better futures through community-based human and social services.

Nonprofit 501(c)(3) organizations, public schools, and libraries can seek funding for environmental, human services, and related programs, including in South Carolina. With a mission to support environmental and human services causes, Lawrence Foundation provides unrestricted US $5,000 - US $10,000 operating or program grants to eligible organizations without geographic restrictions.

South Carolina human and social service 501(c)(3) organizations can access funding through the Philip L Van Every Foundation for special projects and capital needs, with awards ranging from US $10,000 - US $50,000. Eligible nonprofits work in areas like human and community services, healthcare and rehabilitation, education, and arts, culture, and history, with one request accepted per 12-month cycle.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

Eligible 501(c)(3) organizations and government units in Greenville County, South Carolina can apply for Community Foundation of Greenville’s Greenville Women Giving grants, awarding US $50,000 - US $100,000 for high-impact projects. Funding supports arts, education, environment, health, and human services initiatives that address community needs and demonstrate measurable results.

The Spark Good: Strengthening Community Local Grants program by the Wal-Mart Foundation empowers local organizations through grants ranging from $250 to $5000. This initiative aims to enhance community welfare by supporting diverse projects, including animal shelters and educational programs. Eligible organizations must have a verified Spark Good account, ensuring funds are allocated effectively to meet local needs and foster community development. Together, we can create lasting impacts through small yet significant actions.

Ameriprise Community Grants focus on supporting nonprofits that enhance community vitality and meet basic needs. With over 120 years of commitment to philanthropy, Ameriprise Financial engages employees in volunteerism and grantmaking. Key giving areas include hunger relief, housing stability, and community development. Priority is given to organizations with active volunteer engagement from Ameriprise advisors and employees, creating a meaningful impact on financial independence and community resilience.

The Nordstrom Community Grant focuses on supporting youth and families by providing over $1 million in grants annually. It aims to assist grassroots organizations that address essential community needs such as food, shelter, and clothing, as well as creating opportunities for economic mobility through mentorship and workforce development. Eligible organizations must be 501(c)(3) nonprofits located in areas where Nordstrom operates. Applications are encouraged for those meeting these criteria.

Human and social service nonprofits in South Carolina can apply for Dr Scholl Foundation grants of US $5,000 - US $25,000 to support program work. Grants from Dr Scholl Foundation help organizations in areas such as social services, health care, education, civic and cultural projects, and environmental initiatives on a one-year funding basis.

Human and social service nonprofits in South Carolina can seek project, general operating, or capital support for programs improving economic stability, workforce readiness, health, and disaster relief. Grants from O'Reilly Automotive Foundation help U.S.-based 501(c)(3) organizations in O’Reilly Auto Parts communities serve underserved and underrepresented individuals and families.

Human and social service nonprofits in South Carolina can receive up to US $50,000 to support community-focused programs through the People Helping People Awards. BECU Foundation funds 501(c)(3) organizations impacting areas like basic needs, health, education, economic opportunity, and community strengthening, including work in Charleston County nominated by BECU members.

South Carolina human and social service nonprofits supporting youth, families, housing, food access, or environmental stewardship can access funding through Chick Fil A Foundation’s True Inspiration Awards. U.S. 501(c)(3) organizations may apply for US $30,000 - US $350,000 to expand programs in education, hunger relief, housing support, community services, and related environmental initiatives.

South Carolina human and social service nonprofits can access funding through the Robinson Foundation for programs serving children and families, poverty relief, disaster relief, veterans, education, health, and related needs. Eligible applicants are 501(c)(3) charities active more than three years, serving communities below the Mason-Dixon line, seeking single-year, program-focused support rather than capital projects.

Nonprofit organizations across the U.S., including those serving South Carolina communities, can apply for Mutual of America Foundation’s Community Partnership Award to recognize exemplary cross-sector collaborations addressing significant social issues. Awards honor partnerships that measurably improve lives, operate in multiple communities, or demonstrate strong potential for replication and scalable social impact.