Best Large Grants for Nonprofit Organizations in South Carolina

The Mrs. Leon Camp Scholarship Fund, established by the San Antonio Area Foundation, supports students pursuing education degrees. Eligible applicants include high school seniors and current college students in the USA. The scholarship is renewable for up to three years, contingent upon maintaining a 2.5 GPA and full-time enrollment. This initiative aims to empower future educators and ensure financial accessibility for those dedicated to teaching, contributing to the community's educational growth.

The MLK Commission Scholarship Fund, managed by the San Antonio Area Foundation, supports current high school seniors from Bexar County who aspire to pursue higher education. This renewable scholarship is available for full-time or part-time undergraduate studies at accredited institutions in the U.S. Applicants must maintain a minimum GPA of 2.5 and demonstrate residency and citizenship requirements. The fund aims to empower youth and enhance community growth through educational opportunities.

The MHM Scholarship Fund, managed by the San Antonio Area Foundation, supports full-time students pursuing a career in healthcare. Eligible applicants include graduating Texas high school seniors who are U.S. citizens, exhibit strong academic performance in science, and demonstrate community involvement. The scholarship is renewable for up to four years, covering tuition, fees, and books. Since 1964, the foundation has contributed millions to enhance the quality of life in San Antonio through education and community support.

The Marshall O. Bell Scholarship Fund, managed by the San Antonio Area Foundation, offers financial assistance to current high school seniors in Bexar County. This scholarship supports students pursuing any area of study, requiring full-time enrollment in an accredited institution. Renewable for up to three years, it aims to alleviate the financial barriers to higher education, assisting students in achieving their academic goals and enhancing their community.

The Duncan Scholars Program Scholarship Fund, managed by the San Antonio Area Foundation, offers financial assistance for full-time students enrolled in various accredited institutions across the USA. This renewable scholarship is available to children of current Enterprise Products Company employees, ensuring that those with at least three years of service can support their child's educational pursuits. The program aims to enhance community well-being by investing in youth education and future leaders.

The DTRF + Thurgood Marshall College Fund Scholarship, offered by the Descendants Truth & Reconciliation Foundation, provides annual need-based scholarships of up to $10,000 for Certified Descendants of Jesuit slaveholding. This initiative aims to support educational advancement at Historically Black Colleges and Universities (HBCUs) and other post-secondary institutions, while promoting racial healing and minimizing the wealth gap within the Descendant community.

The Niagara Cares SkillPointe Scholarship offers $1,000 to $3,000 for individuals pursuing high-demand careers in manufacturing. Administered by the SkillPointe Foundation, this initiative addresses the skills gap by funding vocational training for candidates enrolled in post-secondary institutions. With over 1,000 scholarships awarded and a 97% employment rate among recipients, this program empowers workers and strengthens the economy by promoting essential skills without requiring a four-year degree.

The BISCUITS Grant, offered by Southern Vision Alliance, provides up to $5,000 to organizations with budgets under $300,000 that focus on building power through organizing and collective action. Recipients gain access to a supportive cohort and networking opportunities. Participation in two virtual gatherings and a $500 wellness stipend is included. This grant is aimed at new applicants or those who have submitted their final QMF reports, ensuring support for emerging grassroots organizations.

The AASM Foundation Disaster Relief Fund, established in 2005, provides essential financial aid to AASM accredited sleep centers impacted by natural disasters. By supporting these centers, the fund ensures that medical care remains accessible to patients during crises. Past funding has assisted centers after events like Hurricane Katrina and the 2010 Haiti earthquake, helping them recover and restore operations quickly. This initiative highlights the commitment to maintaining patient care in the face of adversity.

The Billye Suber Aaron Legacy Scholarship, supported by the United Negro College Fund, provides renewable, need-based scholarships for full-time undergraduate students at select HBCUs. Eligible students must have a minimum GPA of 2.5, be U.S. citizens or permanent residents, and demonstrate financial need. This initiative aims to empower minority students and promote educational attainment, reflecting UNCF's commitment to supporting academic excellence and leadership within the community.

The Getty Foundation's Connecting Art Histories initiative enhances global art historical scholarship by fostering intellectual exchange among scholars, particularly in underrepresented regions. This ongoing grant program supports seminars and workshops that connect over 1,000 early to mid-career researchers from diverse areas, including Africa and Latin America, to promote collaborative research and career development. The initiative not only builds professional networks but also aims to strengthen the discipline of art history by addressing geographic and political barriers.

The International Association of Minister's Wives & Widows Scholarship Program, supported by the United Negro College Fund, provides need-based scholarships to eligible students attending accredited four-year Historically Black Colleges and Universities (HBCUs). This initiative aims to empower deserving students, ensuring they have the financial support necessary to pursue their education and achieve their academic goals. By fostering educational opportunities, the program continues the legacy of advocating for minority education and community engagement.

The James J. and Margaret M. Kerrigan Endowed Scholarship, funded by the United Negro College Fund, provides essential financial support for juniors and seniors pursuing degrees in art and education at Historically Black Colleges and Universities. This scholarship aims to empower students with a minimum GPA of 2.5 who demonstrate unmet financial needs, contributing to a more equitable education landscape and fostering future leaders in these vital fields.

The Harry C. Moore Memorial Scholarship, offered by the Four County Community Foundation, supports high school seniors who have earned a varsity letter in any sport, including Quiz Bowl, and maintain a GPA of 3.00 or higher. Awardees will be honored at the Foundation Scholarship Celebration in May and recognized at their respective high school awards events. This scholarship exemplifies the Foundation's commitment to enhancing educational opportunities for local students.

The Montgomery County Scholars Program, established by the Municipality of Montgomery County, Ohio and the United Negro College Fund, offers need-based scholarships to residents pursuing higher education at accredited colleges or universities in the U.S. With a mission to support minority education, the program aims to empower students to achieve academic success and leadership roles in their communities. Eligible applicants must meet residency, GPA, and financial aid criteria.

The National Institute of Nursing Research (NINR) plans to publish a funding opportunity announcement for Community-Partnered Nursing Research Centers (P20 Clinical Trial Optional). This initiative aims to strengthen nursing-led programs that foster community-partnered research addressing significant health issues. By enhancing interdisciplinary research capacities, the program will establish centralized resources in nursing schools, build expertise in community partnerships, and support nurse-led teams in developing, implementing, and evaluating impactful research projects.

The Angela and Reginald Goins Endowed Scholarship, offered by the United Negro College Fund, provides vital financial support to full-time undergraduate students attending four-year historically Black colleges and universities (HBCUs). This need-based scholarship aims to assist students who possess a minimum GPA of 3.0 and demonstrate unmet financial need, fostering academic success and leadership among minority students in major urban areas like New York City, Chicago, and Detroit.

The NIDDK is expanding its Gastroparesis Consortium into the Disorders of Gastrointestinal Interoception Consortium (DGIC) to explore various GI disorders linked to interoceptive processing. This initiative aims to include multiple Clinical Research Centers and a Scientific Data Research Center, focusing on multidisciplinary approaches to uncover mechanisms connecting GI function to symptoms. The effort seeks to identify biomarkers and novel therapeutic targets for future clinical trials, enhancing understanding and treatment of complex gastrointestinal conditions.

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) aims to enhance understanding of inflammatory bowel diseases (IBD) through genomic research. By leveraging patient cohorts and advanced data science, the IBDGC seeks to identify genetic risk factors and develop predictive biomarkers for disease outcomes. This initiative will improve medical management and advance precision medicine for IBD patients, addressing the need for effective diagnostics and treatment strategies in this chronic condition.

Since 2002, the ACA has partnered with L.L. Bean to sponsor the Club Fostered Stewardship (CFS) Program. The CFS Program provides funding to local and regional paddling clubs and organizations that undertake stewardship projects on waterways in their area. The purpose of the program is to encourage paddling clubs to take an active role in protecting and improving the nation's waterways. 

Many of the stewardship needs of our nation's waters are best addressed at the local and regional level. Paddling clubs and watershed organizations are in an ideal position to lead these efforts. These paddlers are often willing to volunteer their time and assist with local stewardship projects. However, clubs often lack the funds needed to pay project expenses. As a result, they miss an opportunity to leverage dozens and sometimes hundreds of volunteer hours that could improve conditions on their favorite waterway.

CFS Grant Program

That is why L.L. Bean and the ACA have teamed up to sponsor the CFS Program.

CFS grants are available for projects that utilize volunteers in efforts to protect, maintain or restore recreational waterways, to provide for or improve public access, or to enhance safe navigation. 

Grant amounts range from $100-$1,000.

Past projects receiving CFS grants include:

• Removing heavy debris and trash from rivers and bays in numerous locations throughout the U.S.
• Improving access for local paddlers
• Establishing water trails 
• Water quality monitoring 
• Environmentally-sensitive woody debris removal 
• Riparian buffer restoration and improvement 
• Environmental education and outreach programs

ACA also offers additional assistance to clubs and organizations for waterway stewardship projects. Clubs and organizations concerned about liability for injuries that occur during stewardship projects may be able to obtain liability insurance coverage through the ACA. Clubs may request additional assistance using the It is not mandatory to be a paddling club to apply. In the past, grants have been awarded to conservation organizations and watershed groups.

Want to learn more about projects that have been funded through the CFS program? Review reports from past years!

The National Institute on Drug Abuse (NIDA) aims to establish a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics. This Center will educate researchers on product development for SUD therapies and provide technical and financial support for initial experiments. It encourages collaboration and outreach to enhance research efforts in drug addiction. Investigators with relevant expertise are invited to consider applying for future opportunities to develop impactful solutions in SUD pharmacotherapeutics.

The FY2026 ABPP Battlefield Land Acquisition Grant, offered by the US Department of the Interior's National Park Service, aims to preserve historic battlefields from the Revolutionary War, War of 1812, and Civil War. Grants, funded by the Land and Water Conservation Fund, require a dollar-for-dollar non-Federal match and support projects that enhance public access and enjoyment while maintaining preservation goals. Applications are accepted until December 30, 2026.

The WITH Foundation's upcoming RFP cycle opens on July 1, 2026, with decisions from the previous cycle made in February 2026. The foundation aims to improve healthcare for adults with developmental disabilities, emphasizing dignity and comprehensive care. Grants of up to $150,000 are available, with research-focused projects eligible for up to $250,000. Priority is given to applicants with 501(c)(3) status, addressing specific needs in healthcare delivery and advocating for systemic change.

The Danette Honesto Scholarship Program, administered by the San Antonio Area Foundation, offers financial assistance to current high school seniors and college students pursuing various degrees in the USA. Applicants must be dependents of Sonterra Medical Management Group employees and meet specific eligibility criteria. This scholarship aims to enhance educational opportunities and is a testament to the Foundation's commitment to community development, having distributed millions in grants and scholarships since 1964.

The CITGO Distinguished Scholars Program, offered by the San Antonio Area Foundation, is designed for junior high school students in the Alief, Houston, and Spring Branch ISDs. This program supports students planning to enroll in a 2- or 4-year college with funding for tuition, fees, and books. A cumulative GPA of 2.5 is required, and awards are granted to 40 students, empowering them to pursue higher education.

The Carvajal Educational Fund, managed by the San Antonio Area Foundation, aims to support current high school seniors from specified Texas counties in their pursuit of higher education. With a focus on Judeo-Christian institutions, this scholarship provides financial assistance for tuition, fees, and books, promoting academic achievement with a minimum GPA requirement of 2.5. Established to foster educational opportunities, the fund emphasizes the importance of community impact and leadership.

The Brian Morris College Gateway Scholarship Fund, managed by the San Antonio Area Foundation, supports full-time students pursuing a Bachelor's degree at accredited U.S. colleges. This renewable scholarship, available since 1964, is targeted at high school seniors from San Antonio, particularly those with financial need and a GPA of 3.33 or higher. The fund aims to empower students to achieve their educational goals, making a lasting impact on the community.