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Best St. Louis city Grants for Nonprofits in Missouri

Discover active funding opportunities in St. Louis city Grants for Nonprofits. 36,000+ grants are available for a wide range of missions and programs with additional grants in St. Louis County, Jackson County, and St. Charles County.

9,000+

Available grants

$2.60B

Total funding

$5K

Median grant

9,000+ grants
$2.60B total
$5K median

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Alex Shives Scholarship

Midlands Community Foundation
Private
United States
US $1,250 - US $2,500

About Us

Midlands Community Foundation (MCF) is here to serve and add value to donors’ philanthropic needs by providing them an opportunity to “invest in the power of community.” It is our goal to identify current and emerging issues, channel resources to address community needs, and help prepare for the future.

MCF Mission

The mission of Midlands Community Foundation is to be a catalyst for lasting impact in Sarpy and Cass counties and to give opportunities to organizations and individuals to pursue their charitable goals.

Scholarships Through MCF

Midlands Community Foundation is committed to the futures of communities in Sarpy and Cass Counties, and across the country. Supporting higher education of students is a direct investment in the futures of these communities.

Alex Shives Scholarship Application Guidelines

The purpose of the Fund is to distribute scholarships to assist qualified recipients in their pursuit of higher education who have graduated or will be a graduating senior from either Papillion LaVista or Papillion LaVista South High School and who have participated on the boys or girls golf team at either high school.

The Fund shall annually distribute one (1) scholarship in the total amount of $2,500, split evenly per semester (i.e., $1,250 Fall Semester, and $1,250 Spring Semester).

Education - Higher Education Golf

Patrick J. Kiley / Houston AGC Scholarship

Greater Houston Community Foundation
Private
United States
Unspecified amount

Patrick J. Kiley / Houston AGC Scholarship

Benefiting employees, dependents of employees, and/or interns of AGC Houston member firms OR students involved in AGC Student Chapters.

Award Amounts

Multiple awards are given each year. Scholarship award amounts will vary for each selected scholarship recipient.

Vocational & Trade Education

Investigating the Benefit of Early Treatment with Ritlecitinib in Alopecia Areata: A Real-World Evidence Approach

Pfizer, Inc.
Corporate
United States
Up to US $100,000

Investigating the Benefit of Early Treatment with Ritlecitinib in Alopecia Areata: A Real-World Evidence Approach

Alopecia Areata (AA) is a chronic, immune-mediated condition causing nonscarring hair loss that affects about 2% of the global population and can lead to substantial psychosocial burden if disease is severe and untreated. The treatment landscape has recently evolved with the approval of ritlecitinib, a systemic therapy for severe AA in adults and adolescents aged 12 years and older, based on efficacy demonstrated in the ALLEGRO phase 2b/3 program.

Despite this advance, important questions remain regarding the optimal timing of therapy initiation. Emerging post-hoc analyses from the ALLEGRO program indicate that patients with shorter disease duration and lower baseline severity achieve higher response rates, suggesting that earlier intervention with ritlecitinib may lead to improved outcomes.

Geographic Scope

United States 

Funding Range and Project Length

Individual projects requesting up to $100,000 USD will be considered.

Maximum project length is 24 months.

Skin Diseases & Dermatology

Hemophilia Fellowship

Pfizer, Inc.
Corporate
United States
Up to US $100,000

Hemophilia Fellowship

This competitive grant program seeks to support an institution-based fellowship that emphasizes shared decision making (SDM), patient education, and multidisciplinary team-based care. The intent is to strengthen the hemophilia care through equitable education, and patient-centered shared decision making in a rapidly evolving treatment landscape.

Geographic Scope

  • United States 

Funding Range and Project Length

  • Grant funding is available to support a one year fellowship up to $100.000 USD. 
Hematological Systems

Accelerating the Development of Combined CGM–Pump Devices

Breakthrough T1D ( Formally JDRF International)
Private
United States
Up to US $900,000

Accelerating the Development of Combined CGM–Pump Devices

A combined continuous glucose monitor (CGM) and insulin pump device represents an innovative approach to simplifying diabetes management by integrating two essential technologies into a single device. This approach has the potential to improve quality of life for people with type 1 diabetes (T1D) by reducing the burden associated with wearing and managing multiple devices.

Despite this promise, the development of combined CGM–pump devices presents technical and commercialization challenges. These include the need for further advances in device compatibility and lifespan, system reliability, and scalable manufacturing, while maintaining affordability and broadaccessibility. In addition, a potential insulin dilution effect may require adjustment of the CGM algorithm.

Breakthrough T1D invites applications for research and development projects that address key technical, clinical, and translational challenges related to combined CGM–pump devices, with the goal of accelerating their development and improving outcomes for people living with T1D.

In response to this announcement, applications may request up to a total of $900,000 USD for up to three years. 

Diabetes

OREF/Musculoskeletal Transplant Foundation Research Grant

Orthopaedic Research and Education Foundation
Private
United States
US $100,000

OREF/Musculoskeletal Transplant Foundation Research Grant

Solicits investigator-initiated proposals focusing on research in the science of biologic – reconstruction, bone regeneration, transplantation - allografts, and including stem cells for graft transplantation.

Orthopedics

NEA Arts and Artifacts International Indemnity Program 1, FY2027 (9/26)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $1,000 - US $100,000
The NEA Arts and Artifacts International Indemnity Program, administered by the National Endowment for the Arts, provides financial protection for museums exhibiting significant art and artifacts. Launched in 1975, it minimizes insurance costs for international exhibitions. The program allows U.S. entities to receive indemnity for works of art while on display in the U.S. Applications are assessed by expert panels, ensuring a thorough review process before approvals or conditional notices are issued.
Art & Culture Arts / Culture Access & Participation

FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN)

DOT Federal Highway Administration
Federal Government
United States
Up to US $12,000,000
The FY25-FY26 Advanced Transportation Technology and Innovation (ATTAIN) grant program aims to enhance transportation through the deployment of innovative technologies. It focuses on improving safety, mobility, and efficiency while fostering economic competitiveness. Projects funded will prioritize core infrastructure improvements and address roadway congestion, aligning with the Trump Administration's goals. The program emphasizes economic opportunities and community benefits, ensuring that selected projects contribute positively to families and communities, ultimately enhancing their quality of life.
Public Transportation & Mass Transit Systems Pedestrian & Bike-Friendly Infrastructure Automotive Safety +1 more

NEA Arts and Artifacts International Indemnity Program 2, FY2027 (3/27)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $100,000
The NEA Arts and Artifacts International Indemnity Program, established in 1975, supports the exhibition of significant art and artifacts by minimizing insurance costs for international exhibitions. Administered by the National Endowment for the Arts, it covers U.S. owned art during exhibitions in the country. The program evaluates applications through advisory panels and the Federal Council on the Arts and Humanities, ensuring that vital cultural works are accessible while providing necessary financial protections.
Art & Culture Arts / Culture Access & Participation

NEA Arts and Artifacts Domestic Indemnity Program 1, FY2027 (12/26)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $100,000
The NEA Arts and Artifacts Domestic Indemnity Program, administered by the National Endowment for the Arts, ensures that U.S. museums can exhibit significant art and artifacts without the burden of high insurance costs. Established in 1975, it provides indemnity against loss or damage, promoting access to cultural heritage. The program evaluates applications through expert advisory panels and typically meets three to six months after deadlines to decide on indemnity requests, thereby supporting the arts and enriching public engagement.
Art & Culture Arts / Culture Access & Participation

NEA Arts and Artifacts Domestic Indemnity Program 2, FY2027 (12/26)

National Endowment for the Arts
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $100,000
The NEA Arts and Artifacts Domestic Indemnity Program provides museums and cultural institutions in the U.S. with financial protection against loss or damage to significant artworks during exhibitions. Established in 1975 and expanded in 2007, the program aims to enhance public access to art by minimizing insurance costs. Managed by the National Endowment for the Arts, it involves thorough evaluations by expert panels to ensure eligibility and compliance, facilitating the safe display of invaluable cultural treasures.
Art & Culture Arts / Culture Access & Participation

Health and Extreme Weather Research Coordination and Data Center (U2C - Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Environmental Health Sciences (NIEHS) is seeking applications for research coordination and data support under the Health and Extreme Weather initiative. This funding opportunity aims to engage NIH grantees and the broader community by sharing best practices, developing training resources, and facilitating access to health and environmental data. The initiative will enhance collaboration, reduce duplication, and promote data standards to support impactful research and infrastructure activities.
Health & Medicine Atmospheric Sciences Data Science & Digital Information Systems +1 more

Health and Extreme Weather Solutions-Focused Research Hubs (U54 - Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The National Institute of Environmental Health Sciences (NIEHS) is launching a funding opportunity for research hubs focused on the health impacts of extreme weather. This initiative encourages multidisciplinary teams to engage with community partners on issues such as wildfire smoke and extreme heat. Emphasizing collaboration, the program aims to develop scalable solutions and measurable public health outcomes, leveraging resources and expertise across institutions to address climate-related health challenges effectively.
Health & Medicine Atmospheric Sciences Climatology +2 more

Limited Competition: Supporting Programs to Advance Research Knowledge in Environmental Health Sciences (SPARK-EHS) (UE5/T32 - Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $20,000
The SPARK-EHS initiative aims to broaden the reach of NIEHS training by launching innovative environmental health programs for predoctoral trainees at institutions without recent NIEHS T32 funding. This initiative focuses on research regarding the impact of the environment on biological systems and seeks to translate findings into practical health solutions. Eligible institutions will receive support for developing and implementing these targeted training programs, fostering advancements in environmental health research.
Environmental Health

Dan Pheil Scholarship Fund

Community Foundation of Washington County Maryland
Private
United States
Unspecified amount

What is a Community Foundation?

We are one of more than 750 similar tax-exempt public charities throughout the United States that work to make their community a better place to live. We are a local organization staffed by residents of the community and led by a board of trustees who have an in-depth knowledge of the issues that shape our County.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Dan Pheil Scholarship Fund

Created in honor of Dan Pheil, this scholarship awards a deserving graduating high school senior residing in Washington County who plans to major in business.

Education - Higher Education Career / College Preparation

Lawrence and Genevieve Martin Scholarship Fund

Community Foundation of Washington County Maryland
Private
United States
Unspecified amount

What is a Community Foundation?

We are one of more than 750 similar tax-exempt public charities throughout the United States that work to make their community a better place to live. We are a local organization staffed by residents of the community and led by a board of trustees who have an in-depth knowledge of the issues that shape our County.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Lawrence and Genevieve Martin Scholarship Fund

This scholarship honors Larry and Geney Martin by assisting a young man or woman graduating from a Washington County, MD public high school who plans to pursue a career in the building industry.

Education - Higher Education Career / College Preparation

FOP Lodge #88 Criminal Justice Scholarship

Community Foundation of Washington County Maryland
Private
United States
Unspecified amount

What is a Community Foundation?

We are one of more than 750 similar tax-exempt public charities throughout the United States that work to make their community a better place to live. We are a local organization staffed by residents of the community and led by a board of trustees who have an in-depth knowledge of the issues that shape our County.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

FOP Lodge #88 Criminal Justice Scholarship

Established by the FOP Thomas Pangborn Lodge #88, this scholarship shall provide awards to deserving students pursuing an education in criminal justice.

Education - Higher Education Career / College Preparation Criminal Justice System Reform

Hub City Ravens Roost Inc. #124 “4th and 29” Scholarship Fund

Community Foundation of Washington County Maryland
Private
United States
Unspecified amount

What is a Community Foundation?

We are one of more than 750 similar tax-exempt public charities throughout the United States that work to make their community a better place to live. We are a local organization staffed by residents of the community and led by a board of trustees who have an in-depth knowledge of the issues that shape our County.

This Community Foundation was created by and for the people of Washington County MD, and exists to improve the quality of life for all of our citizens, now and for generations to come, by building community endowments, addressing needs through grant making and providing leadership on key community issues.

Hub City Ravens Roost Inc. #124 “4th and 29” Scholarship Fund

Named for a legendary Baltimore Ravens miracle play, this scholarship recognizes one student’s effort in any area (personal, academic, music, sports, art, etc.) that has led to a brighter future.

Education - Higher Education Career / College Preparation

AD Osherman Scholarship

Greater Houston Community Foundation
Private
United States
US $2,500 - US $3,500

AD Osherman Scholarship

Benefiting first-generation students in Texas.

Funding

Four (4) scholarships awarded out:

  • $3,500 for students pursuing a 4-year degree
  • $2,500 for students pursuing a 2-year degree

One-time award. Previous recipients may reapply as long as all eligibility requirements are met.

Education - Higher Education Vocational & Trade Education Career / College Preparation

Clinical Data, Safety and Statistical Centers (CDSSC)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Clinical Data, Safety and Statistical Centers (CDSSC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance clinical research through comprehensive support. This includes statistical analysis, protocol development, and oversight of safety monitoring in studies related to asthma, autoimmune diseases, and transplantation. By coordinating these efforts, the program seeks to facilitate impactful research outcomes and improve public health outcomes through informed data-driven decisions.
Immune System Diseases Allergies & Allergic Diseases

Translational Transplantation Tolerance Cooperative Study Group

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Translational Transplantation Tolerance Cooperative Study Group, supported by the National Institute of Allergy and Infectious Diseases, aims to advance transplant tolerance strategies that promote long-term graft survival without lifelong immunosuppression. This initiative focuses on developing, optimizing, and evaluating methods to induce immune tolerance in allogeneic transplants through collaborative efforts across multiple centers, utilizing translationally relevant models to ensure effective outcomes.
Infectious & Parasitic Diseases Organ And Tissue Banks

Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAID aims to enhance our understanding of the interplay between chronic and infectious diseases through innovative precision systems biology research. By utilizing advanced technologies such as multi-omics and artificial intelligence, the initiative focuses on uncovering critical pathways that connect infections to chronic health issues. This multidisciplinary approach leverages longitudinal patient data to inform and improve prevention and treatment strategies, ultimately seeking to provide insights into disease progression and host-pathogen interactions.
Health & Medicine Infectious & Parasitic Diseases Chronic Illnesses

Asthma and Allergic Diseases Cooperative Research Centers

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) program, supported by the National Institute of Allergy and Infectious Diseases (NIAID), aims to enhance research on asthma and related allergic diseases. This initiative fosters multi-center, multidisciplinary research to explore disease mechanisms and treatment responses. By promoting clinical trials and observational studies, the AADCRC seeks to advance understanding and improve interventions for conditions such as asthma and food allergies, ultimately benefiting public health.
Respiratory Diseases & Systems Asthma

Clinical Trials in Organ Transplantation in Children and Adults

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is advancing organ transplantation outcomes through the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. This initiative supports multicenter clinical trials and mechanistic studies related to heart, lung, kidney, liver, and intestinal transplants, as well as non-hematopoietic cellular transplantation. By exploring immune mechanisms and innovative therapies, the program aims to enhance the success and efficacy of organ transplantation.
Infectious & Parasitic Diseases Organ And Tissue Banks

Translational Centers Using Microphysiologic Systems for Infectious Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIAID aims to enhance infectious disease research by supporting human microphysiologic systems (MPS) development. These in vitro platforms mimic human tissue functions, promoting drug and biological product development while reducing animal use. This initiative aligns with NIH’s commitment to innovative research practices and regulatory acceptance. By focusing on MPS in infectious disease contexts, NIAID seeks to streamline therapeutic advancements and establish robust human tissue models, addressing critical challenges in understanding and treating infections.
Infectious & Parasitic Diseases

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses

American Society for the Prevention of Cruelty to Animals (ASPCA)
Private
United States
US $10,000 - US $40,000

ASPCA Reimagining Racers: Grants for Adopting Out Retired Racehorses Grant

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and organizations actively participating in the warm-up ring (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) are invited to apply for a grant to support an increase in capacity and/or efficiency of programs aimed at adopting out retired Thoroughbred racehorses. 

Funding requests for this grant initiative should focus on:

Activities that increase capacity, decrease length of stay, reduce cost of care or increase efficiencies, and/or improve humane outcomes in other ways. Examples:

  • Training programs
  • Programs that engage new adopters and grow the market share for adoption
  • Medical make-ready or rehabilitation with a focus on innovation and/or sustainability
  • Collaborations with other equine industry organizations to increase support for retired racehorses

Proposals will be evaluated on their potential (within the 12-month grant term) to: 

  • Increase capacity (the number of horses that can be rehabilitated, trained, and placed)
  • Decrease length of stay
  • Decrease cost of care
  • Reduce risk, harm or suffering for retired racehorses

Requests may be for the creation of new programs or the expansion of existing programs. Programs that test innovative ideas are welcome.

Grant Amounts

Grants will generally range from $10,000-$40,000, with a maximum individual grant amount of $60,000. The total funding amount available for this grant opportunity is $200,000. 

Eligibility

ASPCA Right Horse Adoption Partners, ASPCA Right Horse Industry Partners, and active Warm-Up Ring participants (defined as groups that are actively working to achieve the 13 criteria for Partnership and are participating on myrighthorse.org) whose mission or operations focus significantly on serving retired Thoroughbred racehorses are eligible to apply for this grant opportunity. Adoption organizations must be up to date on reporting data biannually to the Equine Welfare Data Collective (EWDC). If you’re unsure about your eligibility, you may contact therighthorse@aspca.org to confirm before applying.   

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) was founded on the belief that animals are entitled to kind and respectful treatment by humans. We invite all voices to join us in working together to improve the lives of animals in need.

Animal Welfare - General Animal Welfare - Domestic Animals & Pets

ASPCA Right Horse Grants to Amplify Adoptions and Support Community Equines

American Society for the Prevention of Cruelty to Animals (ASPCA)
Private
United States
US $5,000 - US $50,000
The ASPCA Right Horse Grants aim to enhance equine adoptions and support community equines by funding programs that boost shelter capacity or assist in keeping owned equines in their homes. Grants between $5,000 and $50,000 are available, with a total funding pool of up to $750,000. Eligible applicants include ASPCA Right Horse Adoption Partners and organizations committed to the welfare of retired Thoroughbred racehorses. Proposals should clearly outline the objectives and expected impacts.
Animal Welfare - General Animal Welfare - Domestic Animals & Pets

St. Louis city Grants for Nonprofits Highlights

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Grant Insights : St. Louis city Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

94 St. Louis city grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

15 St. Louis city grants for nonprofits over $25K in average grant size

6 St. Louis city grants for nonprofits over $50K in average grant size

21 St. Louis city grants for nonprofits supporting general operating expenses

77 St. Louis city grants for nonprofits supporting programs / projects

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

4,000+ Grants on Instrumentl focused on Academic Scholarship Programs

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for St. Louis city grants for Nonprofits?

Most grants are due in the fourth quarter.

Q1
23.6%
Q2
26.2%
Q3
20.9%
Q4
29.3%

Typical Funding Amounts

What's the typical grant amount funded for St. Louis city Grants for Nonprofits?

Grants are most commonly $10,000.

$500 $500 Min.
$10,000 $10 K Median
$29,618 $29.6 K Average
$775,000 $775 K Max.

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in St. Louis city Grants for Nonprofits year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the St. Louis city Grants for Nonprofits given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for St. Louis city Grants for Nonprofits changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081

Related Grants in Missouri

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