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Best St. Louis County Grants for Nonprofits in Missouri

Find the perfect St. Louis County grants for nonprofits on Instrumentl. 9,000+ St. Louis County grants for nonprofits in the United States.

9,000+

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$2.60B

Total funding

$5K

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9,000+ grants
$2.60B total
$5K median

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9,221 Results based on applied filters

AARP Community Challenge Grant: Capacity-Building Microgrant

AARP Foundation
Association/Society
Puerto Rico, United States +1 more
US $2,500
The AARP Community Challenge Grant: Capacity-Building Microgrant offers $2,500 to support projects that enhance community livability for residents aged 50 and older. Initiated in 2017, it has funded over 1,700 projects nationwide, focusing on immediate improvements and long-term progress. Eligible organizations include nonprofits and government entities, aiming to implement innovative programs in areas like disaster preparedness, walkability, and home modifications. This initiative fosters inclusive communities and empowers older adults.
Senior Services

AARP Community Challenge Grant: Demonstration Grant

AARP Foundation
Association/Society
Puerto Rico, United States +1 more
US $10,000 - US $25,000
The AARP Community Challenge Grant supports innovative projects that enhance community livability for people aged 50 and older. Funded by the AARP Foundation, these demonstration grants range from $10,000 to $25,000 and aim to improve pedestrian safety, expand broadband access, and reconnect divided communities. Since 2017, AARP has awarded over $20 million in grants, fostering immediate improvements and long-term progress across the United States, including Puerto Rico and the U.S. Virgin Islands.
Senior Services

NCI Pathway to Independence Award (K99/R00 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NCI Pathway to Independence Award (K99/R00) aims to support talented postdoctoral researchers in their transition to independent faculty positions. This program provides essential NCI research funding to help awardees establish competitive, independent research careers. Applications must be submitted by 5:00 PM local time of the applicant's organization, ensuring timely consideration for this critical funding opportunity.
Medical Education & Professional Training Cancer / Oncology

UCAR Next Generation Fellowship

University Corporation for Atmospheric Research
Private
Canada, Mexico +1 more
US $40,000
The UCAR Next Generation Fellowship offers graduate students a unique opportunity to engage in Earth System Science research while addressing societal impacts. With a $40,000 fellowship over two years, participants can expect mentorship from UCAR leaders and professional development training. This program encourages interdisciplinary exploration, allowing fellows to collaborate closely with experts, attend conferences, and build lasting networks. It aims to empower diverse students as future change-makers in the field, fostering a commitment to equity and innovation.
Earth Science Public Policy Atmospheric Sciences +6 more

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NCDDG program supports innovative research aiming to discover and develop new treatments for mental disorders, including substance use and alcohol use disorders. This initiative encourages collaborations between academic and industry partners to advance neurostimulation techniques and drug/device development. Applicants are invited to submit proposals that focus on specific projects utilizing the U01 mechanism, with a clear emphasis on rationally designed candidate agents and cutting-edge technologies. Letters of Intent are encouraged 30 days prior to the submission deadline.
Pharmacology Neuroscience Mental Health & Psychiatric Diseases +5 more

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Cooperative Drug/Device Discovery/Development Groups (NCDDG) program invites applications to foster innovative research in treating mental disorders and substance use issues. This initiative promotes collaboration between academia and industry, supporting diverse, multidisciplinary projects aimed at developing rational therapies and neurostimulation techniques. Applicants are encouraged to submit Letters of Intent 30 days before the proposal deadline to enhance project alignment with funding goals.
Pharmacology Neuroscience Mental Health & Psychiatric Diseases +5 more

Conservation Connect Fellowship Program

National Forest Foundation (NFF)
Private
United States
Up to US $6,870
The Conservation Connect Fellowship Program, offered by the National Forest Foundation, invites graduate students to engage in hands-on conservation projects. This fellowship provides practical experience, mentorship from conservation professionals, and training in collaborative leadership. Fellows will gain a deep understanding of forest management and expand their professional networks. With a focus on developing future conservation leaders, the program seeks students passionate about public lands and community engagement.
Law Forestry Natural Resources +5 more

Mishler Brown Fund Grant

Community Foundation of Elkhart County
Private
United States
Unspecified amount
The Mishler Brown Fund Grant, managed by the Community Foundation of Elkhart County, supports nonprofits dedicated to agriculture and historic preservation. Applications are accepted annually from October 1 to December 31, with funds awarded in January. Organizations must have a 501(c)(3) status but do not need to be located in Elkhart County. The fund honors Helen Mishler's legacy by preserving farming heritage, including her family's historic homestead.
Agriculture Historic Preservation Farms & Farming +1 more

Health Equity and Inclusiveness Research Fellow Award

LUNGevity Foundation Inc
Private
United States
US $50,000 - US $100,000
The Health Equity and Inclusiveness Research Fellow Award by LUNGevity supports physician-scientists conducting lung cancer research aimed at addressing health disparities. Funded projects will focus on early detection and improved outcomes for lung cancer, particularly among underserved communities. Awards can reach up to $100,000 over two years, with payments contingent on project milestones. This initiative aims to foster innovative research and enhance individualized treatment approaches for lung cancer.
Lung Cancer Health Disparities & Social Determinants of Health

LUNGevity VA Research Scholar Award

LUNGevity Foundation Inc
Private
United States
US $50,000 - US $100,000
The LUNGevity VA Research Scholar Award supports innovative lung cancer research within the Department of Veterans Affairs, with a focus on early detection and treatment methods relevant to veterans. The maximum award is $100,000, distributed over two years, contingent upon satisfactory progress. Applications are now open for the 2025 cycle, with funding aimed at improving outcomes and developing individualized treatment strategies, including targeted therapies and immunotherapies.
Lung Cancer Military & Veterans Services

LUNGevity Career Development Award

LUNGevity Foundation Inc
Private
United States
US $100,000 - US $300,000
The LUNGevity Career Development Award supports emerging research leaders focused on lung cancer. It funds innovative projects aimed at enhancing early detection and personalized treatments, including targeted therapies and immunotherapy. With a maximum award of $300,000 over three years, this opportunity is limited to US applicants. The funding is contingent upon annual progress reviews, with the first payment expected after November 1, 2025. This award aims to foster groundbreaking advancements in lung cancer research.
Lung Cancer

ASTRO-LUNGevity Residents / Fellows in Radiation Oncology Seed Grant

LUNGevity Foundation Inc
Private
United States
Up to US $50,000
The ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed Grant aims to enhance the research careers of residents and fellows focused on radiation oncology, specifically benefiting lung cancer patients. This initiative supports basic, translational, and clinical research endeavors. With a maximum award amount of $50,000 for one year, it provides essential funding to foster innovative projects that can lead to significant advancements in lung cancer treatment.
Cancer / Oncology Lung Cancer Biomedical Imaging

Capacity Accelerator for Tribal Offshore Wind Engagement

United States Department of Energy (DOE)
Federal Government
United States
Up to US $565,000
The Capacity Accelerator for Tribal Offshore Wind Engagement, launched by the U.S. Department of Energy, aims to empower Tribal Nations in offshore wind energy decision-making. This initiative offers up to $7.1 million in cash prizes and technical assistance through three phases: Capacity Needs, Capacity Development, and Engagement. Each phase is designed to support Tribes in outlining their priorities, building capacity, and implementing impactful projects in offshore wind energy.
Renewable/Sustainable Energy Native American Services Wind Energy +1 more

Stanley C. Israel Regional Award for Advancing Diversity in the Chemical Sciences

American Chemical Society
Association/Society
United States
US $1,250 - US $2,750
The Stanley C. Israel Regional Award for Advancing Diversity in the Chemical Sciences recognizes individuals or institutions promoting inclusiveness in the chemical sciences. This award includes a medal, a $1,250 grant, and reimbursement for travel expenses up to $1,500 for attending the ACS regional meeting where the award is presented. Eligible nominees must foster programs that increase participation from diverse groups in the chemical enterprise.
Chemistry Diversity, Equity & Inclusion

CLRA Research Grant Program

Childrens Leukemia Research Assn Inc
Private
United States
Up to US $30,000
The CLRA Research Grant Program, led by the Children’s Leukemia Research Association, focuses on funding innovative research aimed at uncovering the causes of leukemia and improving treatment options. Grants totaling $30,000 are awarded to U.S.-based researchers, with the intention of advancing scientific understanding and ultimately finding a cure. The program has made significant contributions to the high cure rates for childhood leukemia, showcasing the importance of continued research in this field.
Leukemia

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) (357604)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $475,000
This funding opportunity encourages applications for clinical observational studies focused on musculoskeletal, rheumatic, and skin diseases. It aims to gather essential data for designing future clinical studies, enhancing understanding of disease symptoms, progression, and patient outcomes. Observational studies supported by this initiative will contribute to the development of objective biomarkers and effective outcome measures. Applicants are invited to address key challenges in clinical project design, ensuring a robust foundation for subsequent clinical trials.
Musculoskeletal Diseases Neurological Diseases & Disorders Skin Diseases & Dermatology +1 more

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) (357602)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required) aim to support clinical trials that can be completed within a limited timeframe. This funding opportunity encourages a variety of exploratory studies that align with the NIAMS mission, focusing on interventions such as drugs, biologics, devices, and various therapies. Applications are due by 5:00 PM local time of the applicant organization.
Musculoskeletal Diseases Neurological Diseases & Disorders Skin Diseases & Dermatology +1 more

The Ono Initiative Grant

Ono Pharma Foundation
Private
Canada, United States
Up to US $1,035,000
The Ono Initiative Grant by the Ono Pharma Foundation supports innovative research in Chemical Biology, aiming to transform human health. It welcomes proposals from Principal Investigators (PIs) at nominated institutions, focusing on groundbreaking solutions and promoting the development of young scientists. Grants of up to $1,035,000 over three years are available, fostering collaboration and transformative research aligned with the foundation's mission.
Biochemistry Chemistry Biology

Patterson Foundation: Assistance Dog Program Grants

Patterson Dental Foundation
Private
Alabama, Alaska +46 more
Up to US $35,000
The Patterson Foundation offers Assistance Dog Program Grants to support organizations providing service animals to veterans and individuals with disabilities. Funding is available for projects that expand capacity, personnel costs related to puppy training, and program support aimed at improving client experiences. Eligible organizations must be 501(c)(3) non-profits and can request grants up to $35,000 for capital projects or $10,000 for program support. Applications are accepted through a two-step process.
Service Animals

Patterson Foundation Scholarship

Patterson Dental Foundation
Private
Canada, United Kingdom +1 more
US $4,750 - US $19,000
The Patterson Foundation Scholarship offers $4,750 annually to children and legal dependents, aged 24 and under, of full-time employees at Patterson Companies in the U.S., U.K., and Canada. Renewable for up to four years, this scholarship can total $19,000 for higher education at accredited institutions. All undergraduate degrees are eligible, and students can reapply even if they have previously been denied. A selection committee from Scholarship America, Inc. reviews applications each summer.
All fields of work

Limited Competition: Mentored Research Career Development Program Award in Clinical and Translational Science Awards (CTSA) Program (K12 Clinical Trial Optional) (357632)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,500,000
The Limited Competition K12 Mentored Research Career Development Program aims to support institutions in developing innovative career pathways for later-stage postdoctoral fellows and junior faculty. This initiative encourages applicants from those with existing Clinical and Translational Science Awards (CTSA) to foster independent research careers. By creating diverse opportunities across academia, industry, and government, the program enhances engagement in clinical and translational science research, ultimately contributing to significant advancements in health outcomes.
Medical Education & Professional Training Science Biology +1 more

U.S. Writers Aid Initiative Grant

PEN America
Private
United States
Unspecified amount

U.S. Writers Aid Initiative

PEN America is an organization of writers and their allies, and that solidarity is never more important than when members of our literary community face crises. PEN America’s U.S. Writers Aid Initiative, part of the PEN America Writers Emergency Fund, offers grants for writers in the United States facing acute financial need following an emergency situation.

The U.S. Writers Aid Initiative is intended to assist fiction and nonfiction authors, poets, playwrights, translators, and journalists in addressing short-term financial emergencies. To be eligible, applicants must be professional writers based in the United States, and be able to demonstrate that this one-time grant will be meaningful in helping address a short-term emergency situation. The fund is limited, and not every application can be supported.

Grant decisions are made on a quarterly basis by a volunteer committee of literary peers in consultation with PEN America staff, using the following guidelines to evaluate professional credentials:

  • Publication of one or more books. (Writers who are only self-published or published by a press that charges for publication are not eligible.)
  • Multiple essays, short stories, or poems appearing in literary anthologies or literary journals (either online or in print) in the last two years.
  • A full-length play, performed in a theater by a professional theater company. Productions in academic settings qualify if the author is not a student at the time of the production.
  • Employment as a full-time professional journalist, columnist, or critic, or a record of consistent publication on a freelance basis in a range of outlets during the last two years.
  • Contracted forthcoming books, essays, short stories, poems, or articles for which the name of the publisher can be provided.
  • Other qualifications that support the applicant’s professional identity as a writer.
Writing & Literature

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund B)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty in digestive disease research. This award aims to support independent careers in pancreatic cancer research by protecting a significant portion of the recipient's time for research activities. Eligible applicants must hold an MD, PhD, or equivalent and work at a North American institution, with AGA membership required. Strong encouragement is given to underrepresented groups.
Pancreatic Cancer

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund A)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty focused on independent research in pancreatic cancer. This award aims to protect at least 50% of the recipient's time for research activities. Eligible applicants must hold an MD or PhD and be classified as early-career. The award encourages physician-scientists and underrepresented groups in biomedical research to apply, supporting innovative research that can lead to significant advancements in understanding pancreatic cancer.
Pancreatic Cancer

AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award in Gastric Cancer

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award provides $100,000 annually for three years to early-career faculty dedicated to gastric cancer research. Eligible candidates must have an MD, PhD, or equivalent and a full-time faculty position in North America. The award supports research in various areas related to gastric cancer, ensuring a minimum of 50% time commitment to the project, thus fostering independent careers in digestive diseases.
Gastrointestinal Cancers

Postdoctoral Fellowships

American Diabetes Association Inc
Private
American Samoa, Guam +4 more
US $84,008 - US $252,024
The American Diabetes Association's Postdoctoral Fellowship Awards aim to foster emerging leaders in diabetes research. With a focus on innovative research, these fellowships provide up to three years of funding, including a stipend and allowances. Eligible applicants must hold a recent advanced degree and conduct research at U.S. affiliated institutions. This initiative not only supports career development but also contributes significantly to the mission of preventing and curing diabetes.
Diabetes

Zuckerman Postdoctoral Scholars Program: Joint North American-israel Postdoc Track

Mortimer B Zuckerman Foundation
Private
Canada, Israel +1 more
Up to US $126,000
The Zuckerman Postdoctoral Scholars Program fosters collaboration between leading scientific institutions in the U.S. and Israel by attracting top postdoctoral researchers. With a focus on STEM leadership, this program offers a unique two-year scholarship, allowing scholars to conduct research at participating Israeli universities and North American institutions. The initiative aims to strengthen academic ties, enhance research capabilities, and support the return of talented Israeli scholars to their home institutions, ultimately enriching the global scientific community.
Engineering Mathematics Science +1 more

St. Louis County Grants for Nonprofits Highlights

Looking for St. Louis County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all St. Louis County grants recommended for your specific programs in Missouri.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : St. Louis County Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ St. Louis County grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

16 St. Louis County grants for nonprofits over $25K in average grant size

6 St. Louis County grants for nonprofits over $50K in average grant size

19 St. Louis County grants for nonprofits supporting general operating expenses

88 St. Louis County grants for nonprofits supporting programs / projects

4,000+ Grants on Instrumentl focused on Academic Scholarship Programs

400+ Grants on Instrumentl focused on Early Childhood Development

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for St. Louis County grants for Nonprofits?

Most grants are due in the first quarter.

Q1
27.7%
Q2
22.3%
Q3
23.2%
Q4
26.8%

Typical Funding Amounts

What's the typical grant amount funded for St. Louis County Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$27,026 $27 K Average
$775,000 $775 K Max.

Average Grant Size

What's the typical amount funded for Missouri?

Grants are most commonly $101,542.

$101,542

Total Number of Grants

What's the total number of grants in St. Louis County Grants for Nonprofits year over year?

In 2024, funders in Missouri awarded a total of 44,064 grants.

2022 39,922

2023 39,688

2024 44,064

Top Grant Focus Areas

Among all the St. Louis County Grants for Nonprofits given out in Missouri, the most popular focus areas that receive funding are Philanthropy, Voluntarism & Grantmaking Foundations, Education, and Human Services.

1. Philanthropy, Voluntarism & Grantmaking Foundations

2. Education

3. Human Services

Funding Over Time

How is funding for St. Louis County Grants for Nonprofits changing over time?

Funding has increased by -15.61%.

2022 $4,698,402,122

2023 $5,287,874,816
12.55%

2024 $4,462,369,205
-15.61%

Missouri Counties That Receive the Most Funding

How does grant funding vary by county?

St Louis County, Jackson County, and St Louis City receive the most funding.

County Total Grant Funding in 2024
St Louis County $2,185,711,864
Jackson County $1,234,679,326
St Louis City $1,054,441,922
Greene County $223,079,775
Clay County $178,423,081

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