Best Beaufort County Grants for Nonprofits in South Carolina

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Delta Dental of Missouri Grant Program aims to improve oral health in Missouri by funding initiatives that reduce oral disease, enhance access to quality dental care, and raise awareness, particularly among underserved populations. Grants range from over $5,000 to $100,000 and are awarded for one year, focusing on projects that increase access to care and demonstrate matching funds from other sources.

Delta Dental of Missouri's Community Donation Program aims to enhance community health through charitable contributions, focusing on organizations that serve Missouri and South Carolina. Preference is given to those with an oral health component. Eligible organizations must be 501(c)(3) registered, address the needs of at-risk populations, and be represented by an authorized member for support requests. This initiative underlines Delta Dental's commitment to community well-being and support.

Charlie's Heart Foundation Annual Grant Program supports small nonprofits focusing on mental well-being for families in underserved communities. Grants between $5,000-$30,000 are available, prioritizing organizations based in North Carolina. Eligible applicants must be 501(c)(3) tax-exempt and demonstrate alignment with the Foundation's mission, organizational need, and program sustainability. The Foundation does not fund individuals, private foundations, or religious organizations, ensuring a strong focus on impactful community programs.

The Craig Newmark Philanthropies Grants, established in partnership with the Bob Woodruff Foundation, aim to support military and veteran communities through funding initiatives that enhance health and well-being. Since 2020, this program has positively impacted over 1.6 million veterans, service members, and their families. The grants focus on improving health determinants, increasing access to healthcare, and facilitating veterans' successful transitions to civilian life.

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

The Covenant Foundation's Signature & Ignition Grants celebrate excellence in Jewish education by funding innovative projects that enhance educational practices. The Foundation supports diverse institutions across North America, inviting applications for creative programs that can adapt and disseminate effective practices. While Signature Grants may reach up to $150,000 over three years, Ignition Grants focus on untested ideas with funding up to $20,000 for one year. One application per cycle is permitted.

The Wadsworth Golf Charities Foundation Program Grants aim to promote self-discipline, culture, and etiquette through golf, enriching lives and fostering charity. The foundation focuses on providing grants exclusively to 501(c)3 organizations, ensuring that only one application per organization is accepted each year. By encouraging youth and individuals of all ages to engage with the game, the foundation aspires to instill valuable life lessons and a sense of community, making golf a powerful teacher.

The Barbara McDowell and Gerald S. Hartman Foundation Grant supports social justice litigation in the U.S. by providing funding to organizations involved in systemic legal cases. Since 2009, the foundation has awarded over $1.4 million to 49 organizations, enhancing the lives of disadvantaged groups through impactful legal advocacy. The foundation prioritizes cases that align with its focus areas, including children's rights, discrimination, and homelessness, ensuring comprehensive support for societal improvement.

The Life Comes From It Grant, funded by the Tides Foundation, supports grassroots initiatives focused on restorative, transformative, and indigenous justice. It prioritizes projects led by communities of color, emphasizing alternatives to incarceration and community-led solutions. Applicants must be 501c3 organizations based in the United States. This grant fosters a collaborative approach to healing and justice, aiming to shift power dynamics and promote inclusive practices across generations.

The Humanity United Grant focuses on addressing human exploitation and violent conflict through a strategic approach. It emphasizes support for registered charities and initiatives globally, particularly in regions like Asia-Pacific and South Sudan. The grant fosters collaboration among partners to promote human dignity, racial justice, and peacebuilding. Interested organizations are encouraged to align their proposals with the outlined themes and engage with the funder for potential support.

The Native American Agriculture Fund (NAAF) offers grants to support Native farmers and ranchers through business assistance, agricultural education, technical support, and advocacy services. Established from the Keepseagle v. Vilsack settlement, NAAF is committed to providing essential resources to eligible organizations, including 501(c)(3) nonprofits, educational institutions, and tribal governments. Special focuses include inflation assistance and market access, ensuring a holistic approach to agricultural support.

The Security and Preparedness (SAP) Program, supported by the National Science Foundation, promotes fundamental research addressing global and national security issues. It emphasizes intellectual merit and broader impacts, encouraging projects that are methodologically sound and empirically driven. Research areas include international relations, political violence, and peace science, among others. The program also fosters undergraduate research experiences and methodological innovations, while strictly avoiding applied research.

The Civic Engagement Microgrant Grant Program, funded by Research!America, aims to enhance public engagement skills among early-career scientists. By providing financial support for innovative projects, this initiative encourages collaborations across various STEM disciplines. Grantees will develop essential skills in communication and policy-making to strengthen community ties and promote science as a national priority. This program addresses the critical need for scientists to connect with local communities and policymakers to ensure the relevance and impact of scientific research.

The Rachael Ray No-Kill Excellence Grants, funded by the Rachael Ray Foundation, support Best Friends Network partners in maintaining a 90% Save Rate for animals. These grants encourage innovative projects that enhance community partnerships and mentorships, helping organizations achieve sustainable lifesaving outcomes. Eligible organizations can apply for grants up to $60,000, with a focus on scalable programs that benefit animals and promote no-kill initiatives across the United States.

The Brave Heart Foundation Grant aims to uplift underserved populations, focusing on children and families through education, health, and community action. With a commitment to funding impactful programs in Indiana, the Foundation prioritizes organizations that demonstrate clear community benefits. Larger funding requests are accepted from previously funded agencies, ensuring continuity and accountability. This grant serves as a vital resource for initiatives that enhance the well-being of those in need, fostering positive change within local communities.

The Monsignor Leo Adamiak Trust Grant provides financial assistance to Ukrainian Catholic parishes in the U.S. and Ukraine, aiming to support their educational and operational needs. Eligible organizations must demonstrate a commitment to community service with a history of at least three years. The trust favors projects with measurable impacts and sustainable outcomes, while not supporting general operating costs or for-profit entities. Interested parishes should contact for application materials, as online applications are not accepted.

The NALAC Fund for the Arts offers organization grants focused on supporting Latinx artists and arts organizations in the U.S. and Puerto Rico. This funding initiative has invested over $6 million in the arts community, nurturing creativity and social change. Eligible applicants include organizations with a mission centered on Latinx arts. The program aims to enhance artistic excellence and community engagement, making it a vital resource for cultural production and social justice efforts.

The Science of Science: Discovery, Communication, and Impact (SoS:DCI) program fosters research that enhances the public value of scientific endeavors. It invites proposals that explore mechanisms of scientific discovery, improve understanding of communication outcomes, and assess societal benefits of science. Emphasizing interdisciplinary approaches, the program prioritizes proposals that broaden participation in science, engage diverse teams, and support America's leadership in global scientific innovation. The goal is to create impactful, evidence-based policies and advance the science of science.

The Mark Wahlberg Youth Foundation, established in 2001 by Mark and Jim Wahlberg, aims to support youth service programs that eliminate barriers to success for inner city youth. By providing financial and community support, the foundation empowers young individuals to achieve their potential and dreams, fostering a nurturing environment reminiscent of the Boys and Girls Clubs of America, where Mark spent his formative years.

The Dennis Schuman Charitable Foundation Grant supports qualified Jewish organizations and charities in the United States, focusing on arts, education, health, human services, public benefit, and religion. Established by Dennis Schuman, the foundation continues his philanthropic legacy, providing funding exclusively for charitable, religious, scientific, literary, or educational purposes. Organizations must be exempt under Section 501(c)(3) of the Internal Revenue Code to qualify for funding.

The Father's Table Foundation Grant aims to glorify God by addressing the immediate and future needs of women and children globally. This selective grant process emphasizes building self-sufficiency and resilience among beneficiaries, focusing on proven partners capable of expanding their impact. The foundation supports a diverse range of projects, including employment assistance, education, humanitarian aid, and health care, ensuring that aid not only meets urgent needs but also fosters long-term sustainability.

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

The AACAP Educational Outreach Program for General Psychiatry Residents offers a unique opportunity for residents to gain insights into child and adolescent psychiatry. Participants will network with mentors and peers, attend the 71st AACAP Annual Meeting from October 14-19, 2024, and receive a stipend of up to $1,200 post-meeting. This program prioritizes first-time applicants, ensuring a valuable experience in a supportive environment while expanding professional connections.

Family Medicine Cares USA offers grants up to $25,000 to support the establishment of new free clinics. Eligible applicants must either have opened or plan to open within six months of the application deadline and hold the National Association of Free and Charitable Clinics Seal of Excellence. Priority is given to clinics with an AAFP member as medical director and those engaging Family Medicine residents or medical students as volunteers. Applications are accepted annually from March 15 to July 15.

The Family Medicine Cares USA Free Health Clinic Grants support existing clinics in providing care to the uninsured. Grants of up to $10,000 are available if funds permit, prioritizing clinics with AAFP members in leadership roles. The program emphasizes the involvement of Family Medicine residents or medical students as volunteers, aiming to enhance healthcare access in underserved communities.

The Gilead Research Scholars Program in Oncology supports innovative research from emerging investigators worldwide, focusing on scientific understanding and progress in cancer treatment. Launched in 2008, it offers financial support of up to $180,000 over two years to junior faculty who meet eligibility criteria. The program emphasizes diversity and aims to reduce barriers for underrepresented groups in research, fostering a more inclusive landscape in addressing unmet medical needs.