Best Large Grants for Nonprofit Organizations in California

The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.

Community Foundation of the Fox River Valley

The Community Foundation of the Fox River Valley is a collection of individual funds and resources given by local citizens to enhance and support the quality of life in the Fox River Valley of Illinois.

We are a tax-exempt public charity that allows individuals, businesses, and non-profit organizations to establish permanent endowments and temporary funds within the confines of one large foundation.

Foundation funds are used to provide grants to non-profit organizations and scholarships to area students. The Foundation also hosts a Youth Engagement in Philanthropy (YEP) program, which helps high school students learn more about philanthropy and empowers them to make a difference in the community.

The Community Foundation of the Fox River Valley serves the City of Aurora, Kane County, and Kendall County within the State of Illinois.

Irene & Marie Oberweis Nursing Scholarship Endowment Fund

This scholarship was created by Marie Oberweis as a loving tribute to her sister Irene.

Marie Oberweis (1921-2007) graduated from Madonna High School in 1939.

That year, she started her career with Oberweis Dairy where she later became a partner with her father Peter Oberweis and her brother Joseph Oberweis.

Irene Oberweis (1924-1996) attended Annunciation School in Aurora. She spent many years of her life in hospitals due to fragile health.

In gratitude for the exemplary care her sister received throughout her lifetime from those in the nursing profession, Marie Oberweis created a permanent scholarship fund to support area students entering the nursing field.

The Metropolitan Water District of Southern California's Innovative Conservation Program (ICP) has funded innovative water savings projects since 2001, with $250,000 available biannually. The program aims to evaluate and demonstrate the reliability of new water-saving technologies. Nearly 400 proposals have sought $36 million in funding. The ICP, supported by multiple agencies, encourages projects that can benefit Southern California's water efficiency, inviting proposals from outside its service area to enhance regional water management.

The Biophysical Society offers Travel Awards for scientists within 10 years of their terminal degree, promoting excellence in biophysics at their Annual Meeting. These awards support students, postdoctoral researchers, and professionals, with amounts up to $750 based on travel distance. Eligible applicants must be members of the Society and presenting authors of accepted abstracts. Additional funding opportunities exist for those from low-income countries and members facing funding lapses, ensuring broader participation and diversity in the scientific community.

The Y & H Soda Foundation Grant Program supports organizations in the East Bay focused on equity and social change. Prioritizing immigrant rights and economic justice, the foundation seeks initiatives that address systemic barriers and foster community engagement. Eligible applicants include 501(c)(3) organizations serving Alameda and Contra Costa Counties. The foundation emphasizes advocacy and local solutions that empower marginalized voices, aiming for lasting impact in promoting inclusivity and prosperity for all residents.

The Stem Cell Grants: Travel Award supports students, postdocs, and faculty attending scientific conferences and workshops related to stem cell research. Up to $1,200 is available for each application, with a maximum of two applications per PI lab each calendar year. Priority is given to those presenting at stem cell meetings and workshops. All applications must be submitted at least one week before travel to ensure funding consideration.

The Travel Awards offered by the Biophysical Society target scientists with over 10 years of professional experience. These awards aim to promote engagement and excellence in biophysics by supporting members attending the Society's Annual Meeting. Eligibility requires applicants to submit an abstract and be a paid member. Awards vary based on travel distance, providing up to $750. Special funds are available for those from low-income countries, enhancing diversity and inclusion within the scientific community.

The Biophysical Society offers Travel Awards for members, including students and postdoctoral researchers, to attend its Annual Meeting. These awards recognize outstanding contributions in biophysics and promote global engagement among scientists. Applicants must submit an abstract and meet specific eligibility criteria, with funding up to $750. Additionally, Low-Income Country Travel Awards are available, providing $3,000 in travel funds for members from eligible countries, ensuring diverse participation in scientific discussions.

• Innovative: An approach that brings fresh thinking, tools, or models to homeownership in ways that challenge the status quo and demonstrate a disruptive, future-oriented vision with potential to inspire or shift broader field practice.
• Impactful: A solution with meaningful potential to expand homeownership through knowledge and action, featuring clear and measurable progress indicators that demonstrate capacity to shift trajectories for low- and moderate-income households.
• Bridge-Building: An initiative that effectively connects and unifies a wide range of stakeholders, fostering meaningful collaboration across sectors or perspectives. The strongest submissions will reflect strong community partnerships across the housing ecosystem.
• Durable: A sustainable pathway that addresses root causes of homeownership barriers rather than just symptoms, with compelling evidence of potential to elicit robust support from broad private, philanthropic, and public funding sources over time.

The Trail Accelerator Grants aim to enhance mountain bike trail communities by providing essential planning and design services. With funding between $10,000 to $30,000, these grants support local organizations in creating sustainable trail systems. The initiative encourages projects that increase access and promote community engagement, particularly focusing on diversity and inclusion. Applicants must demonstrate the capacity to match funds, ensuring collaborative efforts to improve trail networks and experiences for all riders.

The Alice M. Ditson Fund offers organizational support for summer festivals and conferences focused on contemporary American classical music. This funding opportunity encourages the appreciation of works by younger, relatively unknown American composers. Eligible applicants include performing organizations and institutions that promote artistic excellence. The Fund emphasizes supporting living composers at various career stages, ensuring a broader recognition of their contributions to classical concert music. It is crucial for applicants to align their projects with the Fund's mission of enhancing public knowledge and appreciation.

Troutville Volunteer Fire Department Scholarship Fund

Fund provides higher educational scholarship assistance to deserving students.

Amount

• $1,000+
• non-renewable

The HEAL Initiative aims to address the complex interplay between chronic pain and opioid use disorder (OUD), affecting 40-60% of OUD patients. Through the IMPOWR initiative, this funding opportunity seeks to develop integrated care strategies that enhance treatment delivery at health systems levels. By identifying effective interventions and collaborative care models, the initiative strives to improve patient outcomes in managing both chronic pain and OUD, while emphasizing the roles of various healthcare professionals in this integrated approach.

The Desert Tortoise Recovery Partnership aims to restore and protect the Mojave desert tortoise populations in California's western Mojave Desert. Formed by the National Fish and Wildlife Foundation and various military and environmental agencies, this initiative seeks to address urgent conservation needs and enhance habitat through a funding opportunity of up to $1 million. The partnership exemplifies a collaborative effort to balance species recovery with military operations, ensuring both ecological and operational sustainability.

The Sociedad Amigos de Colombia de Indiana (SADCO) Scholarship, managed by the Central Indiana Community Foundation, supports Latinx and Hispanic students pursuing post-secondary education. Applicants must be Indiana residents with a GPA of 3.0 or higher, demonstrating financial need and community service. Preference is given to first, second, or third generation Latinx and/or Hispanic students. Scholarship funds assist with tuition, fees, and other educational expenses, reinforcing the foundation's mission to build inclusive opportunities.

The Jack Feldt Ambucs Memorial Scholarship, established in 1997, supports students in the Tri-Cities area pursuing a degree in Physical Therapy. Funded by the Grand Haven Area Community Foundation, this scholarship prioritizes applicants demonstrating financial need. It considers college juniors and graduating high schoolers, reflecting the spirit of community and collaboration championed by Ambucs. Eligible candidates need to provide transcripts and additional required documents to complete their application.

The Senate Bill 1 Sea Level Rise Adaptation Planning Grant Program in California provides vital funding for local governments to develop sea level rise adaptation plans. With $17.18 million available, this program aims to enhance coastal resilience against the impacts of climate change. The program supports jurisdictions in creating consistent and effective strategies to address rising sea levels, ensuring public safety and safeguarding infrastructure and biodiversity along California's coastline.

The NANFA Conservation Research Grant, offered by the North American Native Fishes Association, supports research focused on conserving North America's indigenous fish species, particularly those that are threatened or endangered. With a maximum funding of $1,000 per proposal, this grant is open to academia, conservation groups, and independent researchers. Since 2001, NANFA has aimed to enhance knowledge about native fishes and promote their conservation through scientific research and community engagement.

Generally the Community Foundation's scholarships are awarded to applicants who have high financial need. Applicants with household income exceeding $100,000 are less likely to be awarded, but applying will allow you to be considered for targeted scholarships.

Virginia Valk Fehsenfeld Scholarship

Open to full time undergraduate students who are Kent County residents studying education, dietetics, nutrition, or human services and have a minimum 3.4 GPA.

The Women's Club of Grand Haven Grant, established in 2001, offers scholarships to non-traditional students from the Tri-Cities seeking further education. Funded through community efforts such as an annual Used Book Sale, this grant prioritizes financial need and is open to applicants residing in Northern Ottawa County or those who graduated from local school districts. Preference is given to female applicants aged 21 and older, supporting educational advancement for those whose academic journeys have been interrupted.

The SAF Technology Transfer Award honors exceptional contributions to technology transfer in forestry by an SAF member. It recognizes leaders who have significantly impacted forestry practices through innovation and quality work. The award includes a $1,000 honorarium, complimentary registration for the SAF convention, and up to $500 for travel costs. Presented at the SAF national convention, it emphasizes the importance of effective technology transfer for sustainable forest management.

The Marisla Foundation, established in 1986, offers a Human Services Grant aimed at supporting women in crisis in Orange County and Los Angeles, California. This grant focuses on enhancing physical, emotional, and financial wellbeing through stable housing, addiction treatment, and vocational training. Eligible organizations must possess 501(c)(3) tax-exempt status. The foundation does not support individual applications or multiple submissions from the same organization within a year, ensuring a fair and equitable distribution of resources.

About NABT

Since its establishment in 1938, the National Association of Biology Teachers (NABT) has been the recognized "leader in life science education." Thousands of educators have joined NABT to share experiences and expertise with colleagues from around the globe; keep up with trends and developments in the field; and grow professionally.

NABT Mission

The National Association of Biology Teachers empowers educators to provide the best possible biology and life science education for all students.

Climate Education Action Award

Sponsored by NCSE, this award recognizes excellence in classroom/community education that specifically supports and promotes the accurate and robust teaching of climate science and the impact of the changing climate on society beyond the classroom. This award is presented to K-12 teachers in odd-numbered years and undergraduate and/or informal educators in even-numbered years. NCSE’s sponsorship of this award includes a $1,000 honorarium. The recipient also receives a recognition plaque to be presented at the NABT Professional Development Conference and one year of complimentary membership to NABT.

Reader’s Digest Partners for Sight Foundation

The Reader’s Digest Partners for Sight Foundation is a philanthropic organization dedicated to improving the lives of individuals who are blind or visually impaired by fostering independence and self-sufficiency. Its mission is to support programs that help people with vision loss lead independent, productive lives, while its vision is an accessible and inclusive world where individuals have the tools, resources, and opportunities to fully participate in society.

The Foundation’s funding priorities focus on supporting nonprofit organizations and initiatives that provide education, training, and rehabilitation services, assistive technology innovations, vision care and access to aids, and capacity building for professionals serving the visually impaired community. It also invests in programs that enhance employment opportunities, promote independence, and improve service delivery systems for people with vision loss, emphasizing practical, community-based solutions and long-term impact.

Small Discretionary Grants

The Reader’s Digest Partners for Sight Foundation (RDPFS) Track #3 Small Discretionary Grants provide flexible, year-round funding for smaller-scale initiatives that support individuals who are blind or visually impaired. Grant requests are accepted on a rolling basis and awarded at the discretion of the Executive Director. Awards are made until available funds are exhausted, allowing the Foundation to respond to timely or emerging needs.

The Reader’s Digest Partners for Sight Foundation offers Single Program Grants to support impactful programs for individuals who are blind or visually impaired. These grants, ranging from $25,000 to $50,000, prioritize initiatives that enhance independence and service delivery. Eligible organizations must be US 501(c)(3) non-profits, and unsolicited proposals are not accepted. The foundation emphasizes community-based solutions and invites qualified applicants to submit a Letter of Inquiry followed by a full proposal.

The Celine Wyatt Memorial Scholarship honors a remarkable young athlete who embodied determination and leadership. This scholarship is aimed at empowering high school senior girls from Ohio, Kentucky, West Virginia, or Pennsylvania who excel in softball and aspire to pursue higher education. By supporting these young women, the scholarship continues Celine's legacy of positivity, resilience, and encouragement, ensuring that her spirit of hard work and dedication inspires future generations of student-athletes.

The Little Giraffe Foundation, a national non-profit based in Chicago, provides NICU Support Grants ranging from $100 to $1,000. Since 2011, they have positively impacted countless families by delivering over 32,000 gift bags and funding essential research. These grants aim to enhance the experience for parents and patients in neonatal intensive care units, supporting initiatives like holiday gift bags and resources for bonding with babies. Applications are welcomed from eligible U.S.-based institutions.