Best El Dorado County Grants for Nonprofits in California

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to uncover biological processes and disease mechanisms influenced by somatic mutations. Since its inception in 2023, it has produced valuable multi-omic datasets from diverse human tissues. The upcoming Stage 2 Genome Characterization Centers will focus on understanding the impact of these mutations in both healthy and clinically significant samples, enhancing our knowledge of somatic mosaicism's role in human health and disease.

In collaboration with Cummins Inc., the American Library Association (ALA) invites applications from U.S. public libraries to participate in A Year of STEM, 12 months of curated STEM programming to foster curiosity and STEM-mindedness in early childhood learners across the country. 

Twenty-five libraries will be chosen to participate in A Year of STEM, receiving professional development to prepare them for the project, copies of a newly created A Year of STEM programming guide developed by librarian advisors, a $5,000 programming stipend, four STEM kits (to be delivered quarterly), and support from ALA’s Public Programs Office staff throughout the project implementation period.

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

The DOE Quantum Genesis Q Competition aims to accelerate the development of fault-tolerant quantum computing capabilities essential for scientific research. This initiative invites proposals from domestic entities to create viable plans for the Quantum Genesis program, aligning with national scientific goals. The competition serves as a foundational effort to scale quantum technologies and enhance scientific workflows, fostering innovation and collaboration as the nation progresses into a new era of computational power.

The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.

The R21 Clinical Trial Not Allowed funding opportunity invites innovative research to develop and enhance research models and biological materials vital for studying human health and diseases. It emphasizes the need for new approach methodologies (NAMs) to improve the identification of confounding factors in biomedical research. Projects should have broad applicability across multiple NIH Institutes, focusing on various body systems and disease categories, ensuring relevance to a wide range of health issues.

The FY2026/2027 Community Compass Technical Assistance and Capacity Building Program provides competitive grants to organizations capable of delivering technical assistance (TA) to communities served by HUD. With up to $86 million available, recipients are expected to develop educational tools, collaborate with HUD, and show a strong record of performance. This initiative aims to enhance community systems, support high-priority projects, and ensure effective training delivery, fostering impactful outcomes across the nation.

The National Institute of Mental Health (NIMH) is launching a funding opportunity to establish a research network focused on rapid-acting psychotropic interventional drugs (RAPIDs), including ketamine and psilocybin. This initiative seeks to generate real-world evidence on the effectiveness and safety of these treatments for serious mental illnesses. By addressing critical questions around their implementation in clinical practice, the NIMH aims to facilitate the safe integration of RAPIDs into healthcare, ultimately improving mental health outcomes.

The National Endowment for the Humanities invites K-12 teachers and higher education faculty to apply for the Landmarks of American History and Culture and Summer Institutes program. This initiative aims to enhance humanities education through professional development opportunities, fostering a deeper understanding of historical and cultural landmarks. Participants will engage in enriching experiences designed to improve teaching practices and student learning outcomes in the humanities.

KBF Ski Racing Safety

The KBF helps alpine ski clubs around the country purchase safety equipment like netting and padding, and also contributes to venue improvement initiatives. Funding requests are reviewed through an annual grant cycle with an application process. Over the past decade, the Kelly Brush Foundation has purchased thousands of rolls of b-netting, supported trail widening projects, and helped with the purchase of other safety equipment. 

KBF Ski Racing Safety Equipment Grants are all matching grants–meaning that any grant awarded by the Kelly Brush Foundation will need to be matched by the ski club. We expect that clubs will join us in making safety a priority by fundraising or finding room in their budget for safety.

The BJA FY 2026 Second Chance Act Community-based Reentry Program aims to support community organizations and tribal governments in providing essential mentoring and transitional services for individuals returning from correctional facilities. This initiative targets those assessed as moderate to high risk for recidivism, addressing their needs both pre-and post-release. By fostering successful reintegration into society, the program contributes to public safety and reduces recidivism rates, aligning with the mission of the U.S. Department of Justice.

The BJA FY 2026 Capital Case Litigation Initiative aims to enhance legal representation in state capital cases. By providing essential funding, this initiative supports both prosecutors and defense attorneys to ensure equitable legal processes for indigent defendants. The U.S. Department of Justice emphasizes the importance of upholding the rule of law and protecting citizens' rights. Applications are due by November 5, 2026, at 8:59 p.m. ET, marking a critical opportunity for improvement in capital case litigation.

The BJA FY 2026 Upholding the Rule of Law and Preventing Wrongful Convictions Program aims to enhance justice by strengthening the capacity of entities that review wrongful convictions. By supporting partnerships among criminal justice and victims' services, the program seeks to effectively manage post-conviction claims of innocence and prevent future errors. This initiative will help identify actual perpetrators and ensure justice for victims, contributing to public safety and the integrity of the legal system.

The BJA FY 2026 DNA Capacity Enhancement for Backlog Reduction (CEBR)—Formula Grants Program aims to support states and local governments in enhancing their DNA analysis capabilities. By providing funding for existing crime laboratories, this initiative seeks to increase the processing capacity for DNA samples, thereby reducing the backlog in forensic DNA analysis and ensuring timely entry into the Combined DNA Index System (CODIS). Applications are due by November 5, 2026.

The BJA FY 2026 Adult Treatment Court Program aims to enhance Adult Treatment Court operations, focusing on preventing overdoses and reducing substance use among high-risk adults in the criminal justice system. The program integrates judicial supervision, substance use disorder treatment, and recovery support services to improve outcomes for participants. This funding opportunity from the U.S. Department of Justice highlights the commitment to public safety and addressing critical issues like the opioid crisis.

The BJA FY 2026 Comprehensive Opioid, Stimulant, and Substance Use Program (COSSUP) Training and Technical Assistance (TTA) aims to enhance the capacity of grantees through dedicated training. It addresses critical operational issues related to overdose responses, targeting illicit opioids and stimulants. The program underscores the U.S. Department of Justice's commitment to public safety, law enforcement support, and the fight against substance misuse. Applications are due by November 9, 2026.

The BJA FY 2026 Prosecuting Cold Cases Using DNA program aims to enhance public safety and justice by supporting prosecutors in the investigation and prosecution of violent cold case crimes with developed DNA profiles. This funding opportunity, provided by the US DOJ's OJP Bureau of Justice Assistance, facilitates crucial investigative and forensic activities to increase successful prosecutions and provide resolution for victims and their families. Full applications are due by November 5, 2026.

The Rural Communities Opioid Response Program - Evaluation aims to assess the effectiveness of behavioral health strategies in rural settings. By developing evaluation tools and resources, this initiative seeks to empower local communities in their health initiatives, ensuring that future programs are informed by comprehensive evaluations. Funded by the Health Resources and Services Administration, the program highlights the importance of tailored approaches to address opioid-related challenges in rural areas.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For concepts with preliminary feasibility evidence that are ready to advance from prototype toward an integrated workflow—optimizing performance, broadening assay or pathogen coverage, and generating more robust cost-reduction and performance data.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.

About The American Chestnut Foundation:

Our mission is to return the iconic American chestnut to its native range.

Our vision is a robust eastern forest returned to its splendor.

Small Grants Program

Are you looking for funding to support your American chestnut research? External small grants offer recipients a variety of benefits such as professional development and an expanded network. Grant activities contribute to the continuous renewal and development of faculty and staff, to the education and motivation of students, and achievement of our mutual interest — restoration of the American chestnut. This is a small grants program. TACF does not ordinarily fund projects in excess of $10,000.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

The Wilder Estate: The Long Christmas Dinner Festival Grant

In 1931, Thornton Wilder wrote The Long Christmas Dinner, a moving, funny, and ingeniously theatrical one-act play created specifically for student theater groups. In just 40 minutes, a single holiday meal becomes a 90-year journey through four generations of a family, exploring time, tradition, family, and the stories we tell about our lives.

In 2026, the Wilder Estate is launching The Long Christmas Dinner Festival, a national holiday celebration bringing schools, cultural organizations, and audiences together around this remarkable play.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

Music Theatre International: Heart of Rock and Roll "The Power of Love" Grant

Heart of Rock and Roll features a book by Jonathan Abrams and music and lyrics by Huey Lewis and his pop-rock band, Huey Lewis and the News, with new orchestrations of their music by Brian Usifer.

Selected schools will host intergenerational community events or outreach programs of their own design — because just as Huey Lewis’s music has always brought people together, school theatre has the power to do the same.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

Disney on Broadway: School of Excellence Grant

In collaboration with the Educational Theatre Foundation and Music Theatre International, Disney Theatrical Group will award complimentary licenses of select Disney musicals to middle and high schools throughout the United States to be performed each school year.

This nationwide program celebrates schools that display both outstanding artistic achievement and student-led engagement in theatrical disciplines such as stagecraft, theatrical design, choreography, direction, or performance. Together, these schools will honor the timeless magic of Disney musicals on stage and represent the future of theatrical storytelling for the next generation.

Building a global community of creative problem solvers, effective collaborators, and empathetic individuals through theatre

Our Mission and Goals

The Educational Theatre Foundation (ETF) is the philanthropic arm of the Educational Theatre Association (EdTA).

ETF advances the field of educational theatre by broadening representation and increasing access for all. ETF’s programs aim to support students, educators and the field at large by realizing three strategic goals:

• Subsidizing new, emerging, and underserved student theatre programs;
• Creating paths for theatre educators to develop new skills; and
• Commissioning research to showcase the value of a theatre education.

Grants for Educators & Theatre Programs

A core piece of the Educational Theatre Foundation’s work is supporting theatre educators and theatre programs directly. We do this through a series of production and educator grants available to both members of EdTA as well as non-members.

For EdTA Members

Production Grants are offered in collaboration with the rights holders for specific plays and musicals or for initiative-based productions that build community.

Production Grants

Show-specific financial assistance for educational theatre programs

Austen's Pride: A New Musical of Pride and Prejudice Grant

The Authors of Austen’s Pride: A New Musical of Pride & Prejudice are thrilled to announce a collaboration with ETF to grant five (5) high schools free performance rights and materials to produce this beautiful new musical during the 2026-27 school year. Access a free digital perusal of the script.