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Best Karnes County Grants for Nonprofits in Texas

Looking for grants for 501(c)(3) nonprofit organizations working in Karnes County? Find the perfect grant for your nonprofit on Instrumentl.

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$2.96B

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$5K

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$2.96B total
$5K median

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Greenawalt Foundation Skilled Trades Program Grant

Greenawalt Foundation
Private
United States
Unspecified amount

Greenawalt Foundation

Building Stronger Communities

At The Greenawalt Foundation, we believe that opportunity is the foundation of prosperity. By supporting organizations that educate, train, and empower people in the trades, we’re helping to build a stronger, more sustainable future for all.

Skilled Trades Grant Opportunities

The Greenawalt Foundation advances opportunities in the skilled trades through funding for accredited pre-apprenticeship and apprenticeship programs, workforce training initiatives, and youth career exploration experiences. These programs promote technical readiness and connect STEM education to modern trades careers, building a stronger, more sustainable workforce. Foundation support focuses on expanding access and creating equitable pathways to prosperity for individuals pursuing skilled trades careers. Through these efforts, the Foundation helps develop the next generation of skilled professionals who will shape the future of our communities.

Eligible Grant Categories

  • Skilled Trades Training Support
  • Pre-Apprenticeship or Apprenticeship Programs
  • Youth Career Exploration Camps
Vocational & Trade Education Apprenticeship & Internship Programs Youth Development & Leadership +1 more

Seeding Research, Networking, and Capacity Building at Minority-Serving Institutions (2026-09-14)

Robert Wood Johnson Foundation
Private
U.S. Territories, United States
Up to US $350,000

Seeding Research, Networking, and Capacity Building at Minority-Serving Institutions

Introduction & Purpose

RWJF is committed to ensuring everyone has a fair and just opportunity to be as healthy as possible. To achieve this goal, we support research that examines the historical and systemic factors that cause health inequities. Some of those determinants are poverty, discrimination, and limited access to quality education, housing, safe environments, and healthcare. As attacks on data and academic freedom and ongoing funding cuts to federal health equity research and programs continue, philanthropy’s work to achieve fair and equitable health, including a more equitable research funding ecosystem, is more important than ever. While philanthropic support for Minority-Serving Institutions (MSIs) has increased in recent years, there is more to be done to rectify historical disparities in funding. 

This call for proposals (CFP) provides support to health equity research centers at MSIs to strengthen research infrastructure and capacity-building. Capacity-building will help develop staff, skills, culture, resources, and systems that enable research to happen effectively. Specific work that RWJF may fund under this CFP includes specific skill or methodology training; faculty release time; support for research assistants, advisors, and project staffing; mentoring, professional development and collaboration, and more.

Through this CFP, RWJF will expand its efforts to transform deeply rooted beliefs about which data and research methods are valued, whose perspectives are prioritized, and which populations deserve resources. By supporting the infrastructure and capacity-building needs of MSIs, this opportunity strengthens their ability to generate critical evidence and to cultivate transformative, actionable solutions toward health equity. 

RWJF believes in health equity research that is grounded in systems thinking; supports and disseminates evidence identifying and implementing structural solutions to racial and health inequities. This CFP seeks mission-aligned institutions to participate in cohort-style peer learning to advance their ability to engage in health equity research and apply for competitive funding opportunities in the future.

Although no single philanthropy can fill the gap left by federal funding cuts, this CFP demonstrates strong support for research, historically underrepresented researchers, and research centers that are positioned to pave the way toward a future where health is not a privilege, but a right.

Health Care Access & Delivery Health Disparities & Social Determinants of Health Minority Services +1 more

F26AS00030 Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program

US Department of the Interior: Fish and Wildlife Service (FWS)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $14,162,000
The Cooperative Endangered Species Conservation Fund: Recovery Land Acquisition Grant Program, initiated in FY 2001, aims to foster collaboration between State and Federal entities in conserving listed species. This program provides funding for acquiring critical land parcels to support U.S. Fish and Wildlife Service-approved recovery plans. By securing habitats at risk from development, the initiative directly addresses the primary threat to endangered species, ensuring effective and immediate conservation actions.
Wildlife Management Land / Habitat Conservation Wildlife Health

Somatic Mosaicism across Human Tissues (SMaHT) Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of biological processes driven by somatic mutations in human tissues through innovative technology development. Since its inception in 2023, the program has produced multi-omic datasets from human tissues representing all germ layers. The NIH is now advancing to Stage 2, focusing on collaborative efforts to refine and implement validated technologies for somatic mutation detection and functional interpretation, promoting rigorous and cost-effective methodologies.
Biology Genetics & Genomics Computer Science & Engineering +1 more

Cancer Prevention and Control Programs for State, Territorial, and Tribal Organizations (363855)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +7 more
Unspecified amount
The Cancer Prevention and Control Programs aim to eliminate cancer through collaborative efforts among state, territorial, and tribal organizations. Funded by the CDC, this program supports initiatives such as breast and cervical cancer screening, cancer control planning, and cancer surveillance. By fostering partnerships and community involvement, the program seeks to improve health outcomes and achieve the mission of 'All People Free of Cancer.' This comprehensive approach ensures that resources are effectively coordinated to address the cancer burden in communities.
Cancer / Oncology Epidemiology & Public Health Health Care Access & Delivery +2 more

Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $100,000 - US $500,000
This funding opportunity from the US Dept. of Health & Human Services: National Institutes of Health (NIH) aims to advance mechanistic research on metal exposure and its effects on human health. Studies should focus on biological processes altered by metals, including their absorption, transport, and immune interactions. Innovative methodologies and human biospecimens are encouraged to explore how metals might impact immune homeostasis and cross biological barriers, providing insights into health risks associated with metal exposure.
Biology Environmental Contamination & Pollution Neurological Diseases & Disorders +1 more

Limited Competition: Tribal Undergraduate and Graduate Research Training and Leadership Experiences (TURTLE) Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The TURTLE Program aims to empower Tribal Entities by fostering a skilled workforce in biomedical research. It supports undergraduate and graduate students in health research, ensuring they complete their degrees and transition into impactful careers. With phased awards, the program emphasizes effective training and mentoring, inviting eligible organizations to apply. Applications will undergo NIH's peer-review process, ensuring only the most meritorious proposals are funded, ultimately enhancing Tribal health research capabilities.
Education - Higher Education Workforce Preparation & Job Readiness Native American Services +1 more

Limited Competition: Tribal Institutional Review Board Establishment and Enhancement (TIRBEE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The TIRBEE funding opportunity supports federally-recognized Tribes and Tribal Entities in establishing or enhancing Institutional Review Boards. This initiative aims to strengthen the capacity for biomedical research involving human participants within these communities by improving review and oversight capabilities. Eligible organizations are invited to apply, with applications subject to NIH's standard peer-review process to ensure only the most meritorious proposals are considered.
Epidemiology & Public Health Native American Services Health Disparities & Social Determinants of Health +1 more

Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (R24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance our understanding of somatic mutations and their impact on human biology and disease. This initiative will establish a Tissue Procurement Center (TPC) to collect and provide clinically relevant tissue samples from a diverse set of healthy donors. The TPC will support ongoing research by ensuring high-quality, well-characterized specimens are available for functional analyses, advancing the field of somatic mosaicism.
Biology Genetics & Genomics

Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required) (363926)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Neurological Disorders and Stroke (NINDS) aims to enhance research on Amyotrophic Lateral Sclerosis (ALS) through intermediate patient population expanded access protocols. These protocols will provide investigational drugs to ALS patients while collecting vital data to inform future treatments and care strategies. This initiative seeks to better understand the disease's biomarkers, patient experiences, and the overall impact of investigational therapies, fostering advancements in ALS research and care.
Neurological Diseases & Disorders Stroke Amyotrophic Lateral Sclerosis (ALS)

Research Scholar Grants (RSG) Summer Cycle

American Cancer Society
Association/Society
American Samoa, Guam +4 more
Up to US $215,000

American Cancer Society

The mission of the American Cancer Society is to improve the lives of people with cancer and their families through advocacy, research, and patient support, to ensure everyone has an opportunity to prevent, detect, treat, and survive cancer.

ACS Research Priority Areas

The American Cancer Society (ACS) has identified these 6 areas to categorize and track the research we fund to help advance our mission. Applicants (except Institutional Research Grants and Professor grants) are asked to select at least 1 of these research areas that aligns with their proposal:

  • Etiology (causes of cancer)
  • Obesity/Healthy Eating and Active Living (HEAL)
  • Screening and Diagnosis
  • Treatment
  • Survivorship
  • Health Equity Across the Cancer Continuum

Research Scholar Grants

Research Scholar Grants (RSG) provide support for independent, self-directed researchers.

Applicants' institutions must provide space and other resources customary for independent investigators.

Grant proposals are investigator-initiated and may pursue questions across the cancer research continuum, as long as they fit within an American Cancer Society (ACS) priority research area.

These grants typically contribute to the cost of salaries, consumable supplies, and other miscellaneous items required in the research. 

Research Scholar Grants are funded up to $215,000 per year (direct costs), plus 10% allowable indirect costs, with a project period up to four years.

Cancer / Oncology

Broad Street Children's Foundation Grant

Broad Street Childrens Foundation
Private
United States
Unspecified amount

Who We Are

Broad Street Children's Foundation is committed to providing financial support to privately funded children's homes caring for the orphaned, abandoned and broken children right here in the United States.

Grant Seekers

Broad Street Children's Foundation supports self-sustaining children's homes across the United States that actively foster the development of strong, well-rounded children in their care.

Since the start of the Foundation, over $1,000,000.00 in grants have been donated to children's homes across the country. Additionally, through the Bill and Jackie Hazelgrove Scholarship Program, we have been able to assist a number of young people to continue their education and work towards a college or vocational degree.

Today, the Broad Street Children's Foundation is continuing the dream of it's original founders through the second generation. Equally as dedicated to changing the lives of children in need across America and striving to break the cycle of abuse and neglect for other children and their families.

Child Welfare Services Vocational & Trade Education Child Abuse & Neglect +2 more

Easement Restoration and Stewardship

USDA: Natural Resources Conservation Service (NRCS)
Federal Government
American Samoa, Guam +4 more
US $250,000 - US $5,000,000
The Easement Restoration and Stewardship program, funded by the USDA NRCS, focuses on restoring and managing Wetland and Floodplain Easements. It includes developing restoration plans, conducting assessments, and implementing stewardship activities to enhance ecological health. Awardees will collaborate with NRCS personnel to ensure effective restoration design and maintenance strategies, fostering sustainable landscapes. This initiative addresses critical habitat conditions and promotes long-term environmental benefits for protected lands.
Habitat & Ecosystem Restoration Freshwater Conservation Land / Habitat Conservation +1 more

OJP FY 2026 Special Attorneys Program Round 9

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The OJP FY 2026 Special Attorneys Program provides funding for state, local, Tribal, and territorial prosecuting agencies to hire qualified prosecutors and support staff. These professionals will work under the National Fraud Enforcement Division to investigate and prosecute crimes committed by criminal aliens, as well as drug and human trafficking cases. This initiative aims to enhance law enforcement capabilities, improve intergovernmental coordination, and strengthen the prosecution of fraud and other serious crimes.
Crime & Justice Community / Public Safety Legal Services +1 more

FY 2027 Notice of Funding Opportunity: Infrastructure Investment and Jobs Act (IIJA) FAA Contract Tower (FCT) Competitive Grant Program

Airport Improvement Program Discretionary Grants
Federal Government
American Samoa, Guam +4 more
US $25,000 - US $55,000,000
The FY 2027 Notice of Funding Opportunity for the Infrastructure Investment and Jobs Act (IIJA) FAA Contract Tower Competitive Grant Program offers up to $100 million for airport traffic control tower projects. This initiative aims to support airports in modernizing and repairing aging infrastructure, ensuring safety and efficiency in air traffic management. Eligible projects may involve construction, rehabilitation, or installation of essential air traffic control equipment, enhancing the operational capabilities of the nation's airports.
Aerospace Engineering Community / Public Safety Emerging Technology Development +1 more

DOJ FY 2026 Assisting Neighborhoods and Governments with Enforcement of Laws (ANGEL) Grant Program

Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Up to US $500,000
The DOJ FY 2026 ANGEL Grant Program aims to enhance public safety by funding state, local, and tribal government initiatives to combat violent crime committed by criminal illegal aliens. This program supports hiring law enforcement personnel, retaining critical staff, and acquiring advanced technology. The objective is to prevent harm to American citizens and support Homeland Security Task Force operations. Applications must be submitted by October 27, 2026, to qualify for funding.
Crime & Justice Community / Public Safety Violence Prevention

Deployed Warfighter Protection FY27

US DOD: Office of the Secretary of Defense
Federal Government
American Samoa, Guam +4 more
US $20,000 - US $1,100,000
The Deployed Warfighter Protection FY27 program aims to safeguard military personnel from disease-carrying arthropods, including ticks and mosquitoes. It seeks innovative research to develop new insecticides, improve existing formulations, and enhance personal protection technologies. The initiative also focuses on effective pesticide application equipment, addressing both current and emerging arthropod threats. This program is crucial for maintaining the health and safety of deployed military forces.
Infectious & Parasitic Diseases Occupational Health & Safety Preventative Healthcare +1 more

The Role of the Innate Immune System in the Pathogenesis of Type 1 Diabetes

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.
Genetics & Genomics Diabetes Immune System Diseases

Collaborative Centers in Children’s Environmental Health Research and Translation (P2C Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $750,000
The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.
Epidemiology & Public Health Environmental Health Children’s Health & Pediatrics

Immune Drivers of Autoimmune Disease

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Immune Drivers of Autoimmune Disease (IDAD) network, supported by NIAID, aims to uncover early triggers and mechanisms of autoimmunity to prevent disease. Key initiatives include developing predictive tools and biomarkers, fostering preclinical cohorts, and utilizing AI and big data. The network will leverage shared infrastructure for collaborative research, managed by the IDAD Network Coordinating Center, which ensures coordination and resource sharing among awardees. This initiative is crucial for advancing understanding and prevention of autoimmune diseases.
Immune System Diseases Preventative Healthcare Emerging Technology Development

NLM Grants for Scholarly Works in Biomedicine and Health (G13 Clinical Trial Not Allowed) (363939)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $10,000 - US $80,000
The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.
Health & Medicine Epidemiology & Public Health

LeverAging StraTegies to Maximize ImpLementation and Effectiveness for HIV (LAST MILE)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.
Epidemiology & Public Health Infectious & Parasitic Diseases Health Care Access & Delivery +1 more

Continuation of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.
Biology Genetics & Genomics Emerging Technology Development

Partnerships for Advancing Development of Diagnostics for Infectious Diseases

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Allergy and Infectious Diseases (NIAID) aims to enhance the development of diagnostic tests for infectious diseases through strategic partnerships between academia and industry. By fostering collaborations, NIAID seeks to overcome barriers to commercialization, ensuring promising diagnostics reach the market effectively. This initiative aligns with NIH's mission to advance innovative technologies that improve treatment and prevention strategies for infectious diseases, ultimately contributing to public health advancements.
Infectious & Parasitic Diseases Emerging Technology Development Allergies & Allergic Diseases

Mesara Family Foundation Grant

Mesara Family Foundation
Private
United States
Unspecified amount

About

Originally conceived by Dr Bruce Mesara in 1990 as a means to carry on his philanthropic efforts beyond his lifetime, the Mesara Family Foundation was re-envisioned by his two children Amy and Douglas in 2014, and received their 501(c)(3) status from the IRS in 2015. Amy and Douglas sought out the assistance of their cousins to build upon the charitable principals on their parents, aunts and uncles.

The foundation is headquartered in Kalamazoo Michigan.

Mission

The mission of the Mesara Family Foundation is to honor the philanthropic principles of the Mesara and Pauch families by supporting carefully selected organizations that share similar values. Our focus is to provide support toward education, conservation and other causes of special family interest where our funding will make a genuine difference.

Education Environmental Conservation

Texas Historic Courthouse Preservation Program

Texas Historical Commission (THC)
State/Local Government
Texas
Up to US $10,000,000

Texas Historical Commission

The Texas Historical Commission (THC) is the state agency for historic preservation. We save the real places that tell the real stories of Texas. The Texas State Legislature established the agency in 1953 as the Texas State Historical Survey Committee with the task to identify important historic sites across the state. The Texas Legislature changed the agency's name to the Texas Historical Commission in 1973. Along with the name change came more protective powers, an expanded leadership role, and broader educational responsibilities.

The mission of the Texas Historical Commission (THC) is to protect and preserve the state’s historic and prehistoric resources for the active use and economic benefit of Texans and visitors while bridging the past with the future.

Texas Historic Courthouse Preservation Program

The Texas Historic Courthouse Preservation Program (THCPP) offers funding to counties through its nationally renowned, award-winning grant program. The THCPP may award up to $10 million to eligible counties through a biannual, competitive application process. To participate in the THCPP and be eligible to receive grant funding, a project must meet the following criteria:

  • A building that serves or has served as a county courthouse
  • A building that is over 50 years old or is certified as worthy of preservation
  • A building that has a current master plan approved by the THC. 

Courthouses with an approved Texas Historic Courthouse Preservation Program (THCPP) master plan may apply for emergency funding at any time, and construction grant recipients may apply for supplemental funding to address changes to their project.    

Historic Preservation Public Infrastructure

BJA FY 2026 John R. Justice (JRJ) Formula Grant Program

US Department of Justice: Bureau of Justice Assistance
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BJA FY 2026 John R. Justice Formula Grant Program offers loan repayment assistance to local and state prosecutors and public defenders who commit to three years of service. Administered by state agencies, this program aims to alleviate the financial burden on legal professionals dedicated to public service. Applications are due by November 10, 2026, providing a crucial opportunity for eligible beneficiaries to secure support for their educational loans.
Crime & Justice Legal Services

Karnes County Grants for Nonprofits Highlights

Looking for Karnes County grants for nonprofits?


Read more about each grant below or start your 14-day free trial to see all Karnes County grants recommended for your specific programs.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in Texas

Average Grant Size

What's the typical amount funded for Texas?

Grants are most commonly $117,103.

$117,103

Total Number of Grants

What's the total number of grants in Karnes County Grants for Nonprofits year over year?

In 2024, funders in Texas awarded a total of 139,517 grants.

2022 127,051

2023 128,136

2024 139,517

Top Grant Focus Areas

Among all the Karnes County Grants for Nonprofits given out in Texas, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Karnes County Grants for Nonprofits changing over time?

Funding has increased by 16.47%.

2022 $14,132,140,818

2023 $13,953,149,524
-1.27%

2024 $16,251,158,979
16.47%

Texas Counties That Receive the Most Funding

How does grant funding vary by county?

Dallas County, Harris County, and Travis County receive the most funding.

County Total Grant Funding in 2024
Dallas County $4,277,925,187
Harris County $3,634,451,995
Travis County $3,100,057,007
Tarrant County $1,873,714,967
Bexar County $1,567,607,630

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