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Best Lee County Grants for Nonprofits in South Carolina

Looking for grants for 501(c)(3) nonprofit organizations working in Lee County, South Carolina? Find the perfect grant for your nonprofit on Instrumentl.

9,000+

Available grants

$2.61B

Total funding

$5K

Median grant

9,000+ grants
$2.61B total
$5K median

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9,250 Results based on applied filters

St. Baldrick’s Foundation Fellowship Award

St Baldricks Foundation Inc
Private
United States
Up to US $195,000
The St. Baldrick’s Foundation Fellowship Award supports pediatric oncology training through a two-year fellowship, with a potential third year based on need and achievements. This initiative, powered by community fundraising events, aims to advance research for childhood cancer cures. The award provides a salary capped at $97,500 per year, covering salary and benefits for fellows. This fellowship not only fosters professional growth but also contributes significantly to the fight against childhood cancers.
Pediatric Cancers

Numotion Foundation Grants

Numotion Foundation
Private
United States
US $500 - US $10,000
The Numotion Foundation Grants aim to enhance the lives of individuals with mobility disabilities by supporting IRS-designated 501(c)(3) nonprofit organizations. By fostering partnerships with various charities, including national and local organizations, the foundation raises awareness and funds for necessary research and support services. Contributions are made for each new wheelchair sold, ensuring a coordinated approach to charitable giving while prioritizing programs that specifically assist those with mobility-related challenges.
Disability Care & Services Children With Disabilities Physical Disabilities

Tipgoomoogus Memorial Trust Grant

1992 Tipgoomoogus Memorial Trust
Private
United States
US $5,000 - US $10,000
The Tipgoomoogus Memorial Trust Grant supports organizations dedicated to the care and comfort of small household pets, including dogs, cats, and birds. Founded by Thomas and Ellen Fallon, the trust primarily funds New Jersey-based charities that qualify as 501(c)(3) organizations. Applications are accepted year-round, with a submission deadline of April 30 for annual review. The foundation prefers to assist animal shelters and dog pounds, while excluding funding for salaries or animals raised for commercial or research purposes.
Animal Welfare - Domestic Animals & Pets

Harry Kramer Memorial Fund Grant

Harry Kramer Memorial Fund
Private
Israel, United States
US $10,000 - US $25,000
The Harry Kramer Memorial Fund Grant supports U.S. charitable organizations that assist individuals and institutions in Israel, focusing on welfare, healthcare for the sick and aged, and education in South Florida. Founded by Harry A. Kramer, a successful entrepreneur and veteran, the fund reflects his deep commitment to charitable causes. Organizations must qualify under Section 501(c)(3) and meet specific eligibility criteria to apply for funding, ensuring that aid reaches those in need.
Jewish Culture Senior Services Religion & Spirituality +4 more

Downing-Nix Trust Grant

Frances Downing Nix 1013002741
Private
United States
US $6,000 - US $12,000
The Downing-Nix Trust Grant provides funding for organizations engaged in research on muscular dystrophy, maintaining treatment wards in Atlanta hospitals, offering veterinary medicine scholarships, and supporting shelters for small animals. Organizations must qualify as 501(c)(3) charities. Applications are accepted year-round, but submissions by April 15 are required for annual meeting reviews. Priority may be given to hospitals and veterinary schools within Atlanta, GA.
Muscular Dystrophy Health Facilities & Clinics Veterinary Science & Services +2 more

Howe Foundation Grant

Howe Foundation 45871100
Private
United States
Approximately US $5,000
The Howe Foundation, established by Thomas E. Howe in Clark County, Nevada, supports U.S. charitable organizations focused on education, medical advancements, and game hunters associations. Grants are administered by Wells Fargo Bank, with applications reviewed annually in September. Eligible organizations must be 501(c)(3) exempt under the Internal Revenue Code, ensuring support for meaningful community initiatives.
Education Health & Medicine Wildlife Management +1 more

Hunger to Health Collaboratory (H2HC) 2026 Prizes for Innovation

Newmans Own Foundation
Corporate
United States
Up to US $100,000
The Hunger to Health Collaboratory (H2HC) 2025 Prizes for Innovation aim to enhance health equity for youth through innovative funding in three categories: Food and Nutrition Policy, Nutrition Education & School Food, and Indigenous Food Justice. Supported by Newman’s Own Foundation, these prizes include $100K grants for policy work and $25K grants for education and justice initiatives. Winners will participate in the H2HC Fall Summit in Boston, fostering collaborative solutions to food challenges.
Food Access & Hunger Youth Services Indigenous Sovereignty & Rights +2 more

George William Groh Trust Grant

Groh George W Tr FBO Med Research
Private
United States
US $11,500
The George William Groh Trust Grant supports medical research initiatives by providing funding to organizations that qualify as exempt under Section 501(c)(3) of the Internal Revenue Code. Applications are accepted year-round, with a deadline of May 1 for consideration at the annual grant meeting. The foundation aims to enhance medical research efforts and contribute to advancements in healthcare.
Health & Medicine

Elizabeth Hurlock Beckman Award Trust Grant

The Elizabeth@Hurlock Beckman Award Trust
Private
United States
More than US $25,000
The Elizabeth Hurlock Beckman Award Trust Grant honors educators who inspire students to create impactful organizations or movements. Established in 2008, the trust has awarded over $3.5 million to 148 professors across the U.S. The grant primarily supports those teaching in psychology, medicine, or law, emphasizing the importance of community contribution. Eligibility is limited to U.S. citizens or permanent residents who have inspired their former students to make a difference.
Law Health & Medicine Psychology +1 more

Kids’ Chance of South Carolina Scholarship

Kids’ Chance of South Carolina, Inc.
Association/Society
South Carolina
Unspecified amount
The Kids’ Chance of South Carolina Scholarship provides financial assistance to children of South Carolina workers who have been killed or seriously injured in work-related incidents. Ranging from $500 to $3,000, these scholarships aim to alleviate the financial hardships faced by these families, empowering students aged 16-25 to pursue post-secondary education. Eligible applicants must demonstrate financial need and be accepted or enrolled in an educational institution, ensuring support for their educational aspirations.
Disability Care & Services Academic Scholarship Programs Educational Access & Equity +2 more

Kids' Chance of South Carolina Renewal Scholarship

Kids’ Chance of South Carolina, Inc.
Association/Society
South Carolina
Unspecified amount
Kids' Chance of South Carolina offers educational scholarships to children whose parents have been seriously injured or killed in work-related accidents. This initiative aims to alleviate the financial burdens these children face, enabling them to pursue their educational goals. Eligible applicants must be between 16-25 years old, have completed the FAFSA, and be accepted into an accredited educational program. This scholarship is vital for supporting the educational aspirations of those affected by workplace tragedies.
Education - Higher Education Disability Care & Services Academic Scholarship Programs +2 more

Undergraduate Development Program Student Travel Award

Society of Toxicology
Association/Society
United States
Unspecified amount
The Undergraduate Development Program Student Travel Award offers undergraduate science majors a unique opportunity to attend the Society of Toxicology Annual Meeting from March 21–23, 2026. The program aims to inspire students pursuing research careers in toxicology and related biomedical sciences. Participants will engage with professionals, attend sessions, and explore various educational and career paths. SOT emphasizes inclusiveness, encouraging diverse perspectives to enhance innovation in the field.
Biomedical informatics Environmental Chemistry & Toxicology Education - Higher Education

Undergraduate Development Program Advisor Travel Award

Society of Toxicology
Association/Society
United States
Unspecified amount
The Undergraduate Development Program Advisor Travel Award, hosted by the Society of Toxicology, enables faculty advisors to attend the Undergraduate Development Program from March 21-23, 2026. This initiative aims to familiarize advisors with toxicology and encourage them to guide students toward careers in biomedical sciences. Recipients of the award will participate in educational sessions, networking opportunities, and receive support for travel-related expenses, fostering diversity and innovation within the field.
Environmental Chemistry & Toxicology Biomedical informatics

UPMC Microvascular Reconstructive Fellowship

Upmc
Private
United States
Unspecified amount
The UPMC Microvascular Reconstructive Fellowship offers a one-year clinical program designed for qualified surgeons, focusing on mentorship in microsurgical techniques and comprehensive patient care. Participants will gain hands-on experience in reconstructive surgeries, including extremity trauma and facial reanimation, while also engaging in multidisciplinary cancer treatment. The fellowship emphasizes both clinical and didactic learning, with opportunities for research in renowned laboratories, ensuring fellows acquire a deep understanding of the field.
Medical Education & Professional Training Reconstructive Surgery

Joan M Wismer Foundation Grant

Joan M Wismer Foundation
Private
United States
US $2,500 - US $25,000
The Joan M. Wismer Foundation, established in 2001, honors the legacy of Joan Marilynn Wismer, who was dedicated to charitable work and community service. The foundation focuses on improving lives through education, youth development, safety, humanitarian services, and medical research. It primarily supports IRS-recognized 501(c)(3) organizations, schools, and churches, while emphasizing the importance of sustainable funding and effective financial management in its grant-making process.
Education Youth Services Art & Culture +4 more

Art Bridges Cohort Program

Art Bridges
Private
United States
Unspecified amount
The Art Bridges Cohort Program aims to enhance access to American art by fostering multi-year partnerships among museums across the U.S. This initiative creates sustainable art-sharing ecosystems that promote collaboration and community engagement. The program supports museums through funding for various phases, including research, small art shares, and large art shares, ensuring resources for travel, exhibition design, and educational opportunities. Eligibility includes a strong commitment to community engagement and existing art collections.
Art & Culture Community Culture & Heritage

AWI Implementing Refinement Grant

Animal Welfare Institute
Private
Canada, United States
Up to US $8,000
The AWI Implementing Refinement Grant, offered by the Animal Welfare Institute, aims to enhance the welfare of animals in experimentation. Grants up to $8,000 support equipment purchases or staff training for implementing proven refinements. Eligible applicants must be from the U.S. or Canada, and projects should be completed within a year. The grant focuses on improving animal lives beyond basic needs, ensuring no funds are misused for indirect costs or basic care.
Animal Welfare - General

James B and Lois R Archer Charitable Foundation Large Grant

James B And Lois R Archer Charitable Foundation
Private
United States
More than US $10,000
The James B and Lois R Archer Charitable Foundation offers Large Grants for requests exceeding $10,000. Focused on fostering positive change, the foundation supports initiatives in Arts and Culture, Civic Engagement, Education, Health, and Human Services. Eligibility includes 501(c)(3) organizations, while restrictions apply to consecutive grant cycles and non-qualifying purposes such as endowments and fundraising events. Organizations are encouraged to apply for various projects to enhance community well-being.
Art & Culture Civic Engagement & Education Human & Social Services +2 more

James B and Lois R Archer Charitable Foundation Smaller Grant

James B And Lois R Archer Charitable Foundation
Private
United States
Up to US $10,000
The James B and Lois R Archer Charitable Foundation offers Smaller Grants of $10,000 or less to support initiatives in Arts and Culture, Civic Engagement, Education, Health, and Human Services. Organizations must have 501(c)(3) status and comply with eligibility criteria, including a one-year waiting period for reapplications. The foundation aims to have a significant impact on communities, especially in West Texas, while avoiding funding for specific exclusions such as endowments and fundraising events.
Art & Culture Civic Engagement & Education Human & Social Services +2 more

AMVETS Veteran, Active Duty & Guard/Reserve Scholarship

Amvets National Service Foundation
Private
United States
Up to US $12,000
The AMVETS Veteran, Active Duty & Guard/Reserve Scholarship provides financial assistance up to $12,000 for qualified U.S. Veterans and active military members pursuing undergraduate degrees. This scholarship is designed to bridge the financial gap after all other federal and state aid has been utilized. Eligibility includes being an honorably discharged veteran or active service member, enrolled in an accredited institution, and demonstrating financial need. AMVETS is dedicated to serving those who have served our country.
Military & Veterans Services Academic Scholarship Programs

AMVETS Spouse Scholarship

Amvets National Service Foundation
Private
United States
Unspecified amount
The AMVETS Spouse Scholarship offers financial support to the spouses of honorably discharged veterans and active military personnel, including National Guard and Reserves. This scholarship aims to bridge financial gaps after other federal and state resources have been exhausted. Eligible applicants must be U.S. citizens enrolled in accredited undergraduate programs, demonstrate financial need, and not be in default on federal student loans. AMVETS stands committed to empowering military families through education.
Military & Veterans Services Academic Scholarship Programs

AMVETS Children and Grandchildren Scholarship

Amvets National Service Foundation
Private
United States
US $4,000
The AMVETS Children/Grandchildren Scholarship supports the educational aspirations of children and grandchildren of honorably discharged U.S. veterans and active military. This scholarship aims to bridge financial gaps after all federal and state assistance has been utilized. Eligible applicants must be U.S. citizens, high school seniors, and demonstrate financial need while enrolled in accredited four-year universities. Incomplete applications will be disqualified, ensuring that the award goes to deserving candidates committed to their education.
Military & Veterans Services Academic Scholarship Programs

The Anna Fuller Fund Grant

The Anna Fuller Fund
Association/Society
Countries
US $75,000 - US $150,000
The Anna Fuller Fund Grant provides year-round support for organizations dedicated to alleviating suffering caused by cancer. Established in memory of Egbert C. Fuller’s wife, the fund prioritizes applications that focus on cancer research and education initiatives. Eligible applicants must be 501(c)(3) organizations or equivalent charities outside the U.S. Grant funds cannot be used for direct treatment, ensuring that resources are allocated to research and public education.
Cancer / Oncology Preventative Healthcare

Arbor Rising Grant

Arbor Brothers Inc
Private
Alabama, Arizona +43 more
US $125,000 - US $175,000
Arbor Rising Grant, established in 2010, is a NYC-based nonprofit providing unrestricted multi-year funding and capacity-building support to nonprofits focused on alleviating poverty. The grant process occurs every three years, with the next round in 2025 being invitation-only. Eligible organizations must demonstrate high potential and effective leadership, typically operating on a modest budget. Arbor Rising prioritizes applicants from the NYC metro area while expanding to cover the lower 48 US states.
Poverty Alleviation & Services Nonprofit Growth & Development Workforce Preparation & Job Readiness +1 more

State Abstinence Until Marriage—Emerging Programs RFP

South Carolina Department of Education
State/Local Government
South Carolina
Up to US $100,000
The State Abstinence Until Marriage—Emerging Programs funding aims to support innovative programs that promote Sexual Risk Avoidance Education (SRAE). Designed for organizations not yet validated by evidence-based data, it encourages new outreach methods and activities in priority areas. Key criteria include a focus on local service area organizations and the use of consistent curriculum for no more than three years, ensuring unique approaches to abstinence education.
Reproductive Education

The Fox Family Foundation Grant

Robert A Fox Family Charitable Foundation
Private
United States
Unspecified amount
The Fox Family Foundation Grant focuses on empowering individuals with disabilities through workforce development, education, and advocacy. By promoting accessibility and inclusion, the foundation creates opportunities for differently-abled individuals to thrive in their careers. With a commitment to innovative programs and partnerships, it seeks to bridge the gap in funding for disability initiatives, ensuring equitable access to meaningful careers and education for all.
Disability Care & Services Educational Access & Equity

Frederic C. Collin Trust Grant

COLLIN FREDERIC C TUW
Private
United States
US $2,000 - US $3,800
The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.
Tennis Equestrian Sports

Lee County Grants for Nonprofits Highlights

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Read more about each grant below or start your 14-day free trial to see all Lee County grants recommended for your specific programs in South Carolina.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Grant Funding Trends in South Carolina

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $74,506.

$74,506

Total Number of Grants

What's the total number of grants in Lee County Grants for Nonprofits year over year?

In 2024, funders in South Carolina awarded a total of 24,410 grants.

2022 21,855

2023 21,722

2024 24,410

Top Grant Focus Areas

Among all the Lee County Grants for Nonprofits given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Lee County Grants for Nonprofits changing over time?

Funding has increased by 22.06%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $1,813,067,383
22.06%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Charleston County receive the most funding.

County Total Grant Funding in 2024
Greenville County $580,646,902
Richland County $413,417,941
Charleston County $355,724,083
Spartanburg County $325,246,878
Pickens County $159,596,081