Best Myrtle Beach Grants for Nonprofits in South Carolina

LRPenn.com is home to the novels, plays, and screenplays of LR Penn. His books specializes in Thrillers, Dramatic Comedies, and Film Noir. Thanks to the generous support of our sponsors, grants may be available to nonprofit theater companies in the United States with 501(c)(3) status that are staging productions of plays written by LR Penn.  

The DOE Quantum Genesis Q Competition aims to accelerate the development of fault-tolerant quantum computing capabilities essential for scientific research. This initiative invites proposals from domestic entities to create viable plans for the Quantum Genesis program, aligning with national scientific goals. The competition serves as a foundational effort to scale quantum technologies and enhance scientific workflows, fostering innovation and collaboration as the nation progresses into a new era of computational power.

The Technology Development Program by the US Department of Health & Human Services focuses on advancing technology research from proof-of-concept to prototype development. This initiative prioritizes innovation to enhance biomedical research, emphasizing technological improvements without the inclusion of biological hypothesis testing. Eligible projects should aim at significant technological advancements to maximize impact in the field.

The R21 Clinical Trial Not Allowed funding opportunity invites innovative research to develop and enhance research models and biological materials vital for studying human health and diseases. It emphasizes the need for new approach methodologies (NAMs) to improve the identification of confounding factors in biomedical research. Projects should have broad applicability across multiple NIH Institutes, focusing on various body systems and disease categories, ensuring relevance to a wide range of health issues.

The FY2026/2027 Community Compass Technical Assistance and Capacity Building Program provides competitive grants to organizations capable of delivering technical assistance (TA) to communities served by HUD. With up to $86 million available, recipients are expected to develop educational tools, collaborate with HUD, and show a strong record of performance. This initiative aims to enhance community systems, support high-priority projects, and ensure effective training delivery, fostering impactful outcomes across the nation.

The National Institute of Mental Health (NIMH) is launching a funding opportunity to establish a research network focused on rapid-acting psychotropic interventional drugs (RAPIDs), including ketamine and psilocybin. This initiative seeks to generate real-world evidence on the effectiveness and safety of these treatments for serious mental illnesses. By addressing critical questions around their implementation in clinical practice, the NIMH aims to facilitate the safe integration of RAPIDs into healthcare, ultimately improving mental health outcomes.

The National Endowment for the Humanities invites K-12 teachers and higher education faculty to apply for the Landmarks of American History and Culture and Summer Institutes program. This initiative aims to enhance humanities education through professional development opportunities, fostering a deeper understanding of historical and cultural landmarks. Participants will engage in enriching experiences designed to improve teaching practices and student learning outcomes in the humanities.

Relentless Challenge Grants

The Relentless Challenge is a statewide competitive grant program and is South Carolina’s call to action for innovative problem-solving and entrepreneurial impact. Aligned with the Launch to Legacy brand, S.C. Commerce’s vision to support businesses at every stage and position the state as the new home for American innovation, the 2026 Relentless Challenge supports two complementary tracks: traditional small business and innovation.

While distinct in focus, both tracks share a common thread: empowering South Carolina’s businesses to launch, grow and innovate for long-term success. Traditional small businesses form the backbone of local economies and play a vital role in sustained economic growth. Innovation-driven companies, whether new or well-established, contribute to future advancement through R&D and product innovation. Together, they create a balanced ecosystem where stability and disruption coexist, enabling businesses to thrive and fueling statewide prosperity.

Track One: Traditional Small Business

Every business has the potential to innovate. This track funds creative, actionable solutions to the challenges facing South Carolina’s traditional small businesses. The goal is to spark the development of new ventures, strengthen existing ones, and improve access to capital through targeted funding and financial education resources — ultimately helping traditional small businesses grow, flourish, and contribute to the state’s economic vitality.

Track Two: Innovation

Designed to advance South Carolina’s innovation economy, this track supports projects that foster a resilient ecosystem for innovation. Emphasis is specifically placed on catalyzing high-growth entrepreneurship, expanding access to risk capital, and deepening collaboration between higher education institutions and companies of all sizes — laying the foundation for next-generation industries and long-term economic impact.

The National Institute of Allergy and Infectious Diseases (NIAID) is advancing Type 1 diabetes research by exploring the innate immune system's role in disease onset. This initiative aims to identify genetic and environmental factors contributing to Type 1 diabetes through multidisciplinary teams. By employing innovative methodologies, the program seeks to determine how immune responses affect pancreatic tissues, potentially leading to early detection and prevention strategies for at-risk individuals.

The Collaborative Centers in Children’s Environmental Health Research and Translation program aims to establish a national network of research centers focused on improving children's health through innovative research and public health strategies. By fostering collaboration within the children’s environmental health community, these centers will lead the way in translating scientific findings into actionable practices, ensuring a healthier future for children while addressing emerging environmental threats.

The Immune Drivers of Autoimmune Disease (IDAD) network, supported by NIAID, aims to uncover early triggers and mechanisms of autoimmunity to prevent disease. Key initiatives include developing predictive tools and biomarkers, fostering preclinical cohorts, and utilizing AI and big data. The network will leverage shared infrastructure for collaborative research, managed by the IDAD Network Coordinating Center, which ensures coordination and resource sharing among awardees. This initiative is crucial for advancing understanding and prevention of autoimmune diseases.

The NLM Grants for Scholarly Works in Biomedicine and Health (G13) program invites applications to support the creation of book-length manuscripts and scholarly works that are vital for U.S. health professionals and scientists. This initiative aims to foster critical reviews and analytical syntheses that enhance understanding of biomedical and public health challenges, ultimately contributing valuable resources for education, research, and clinical practice.

The LAST MILE program, initiated by the NIAID, aims to enhance the implementation and effectiveness of HIV prevention and treatment strategies through real-world effectiveness trials. By fostering collaborations and focusing on diverse populations, this initiative seeks to translate clinical findings into practical applications. The program supports research across various disciplines, aligning with the NIH's mission to improve HIV/AIDS outcomes and address associated comorbidities. This multifaceted approach promises to bridge the gap between clinical trials and community-based interventions.

The National Institute on Aging (NIA) is announcing a funding opportunity to support the Exceptional Longevity Data Management and Coordinating Center (EL DMCC). This initiative aims to enhance the management of large, diverse datasets and facilitate collaborative research across NIA projects. Core functions include data integration, AI/ML infrastructure development, and maintaining the ELITE Portal for secure data access. This NOFO encourages innovative approaches to longevity research, though applications are not currently being solicited.

The National Institute of Allergy and Infectious Diseases (NIAID) aims to enhance the development of diagnostic tests for infectious diseases through strategic partnerships between academia and industry. By fostering collaborations, NIAID seeks to overcome barriers to commercialization, ensuring promising diagnostics reach the market effectively. This initiative aligns with NIH's mission to advance innovative technologies that improve treatment and prevention strategies for infectious diseases, ultimately contributing to public health advancements.

About

Originally conceived by Dr Bruce Mesara in 1990 as a means to carry on his philanthropic efforts beyond his lifetime, the Mesara Family Foundation was re-envisioned by his two children Amy and Douglas in 2014, and received their 501(c)(3) status from the IRS in 2015. Amy and Douglas sought out the assistance of their cousins to build upon the charitable principals on their parents, aunts and uncles.

The foundation is headquartered in Kalamazoo Michigan.

Mission

The mission of the Mesara Family Foundation is to honor the philanthropic principles of the Mesara and Pauch families by supporting carefully selected organizations that share similar values. Our focus is to provide support toward education, conservation and other causes of special family interest where our funding will make a genuine difference.

About SCRA

The South Carolina Research Authority (SCRA) was chartered in 1983 by the State of South Carolina as a public, non-profit organization. The mission of SCRA is to fuel South Carolina’s Innovation Economy by accelerating technology-enabled growth in research, academia, entrepreneurship, and industry. SCRA supports its stakeholders in key technology sectors, which include but are not limited to, Advanced Materials/Manufacturing; Life Sciences; Clean Tech, Sustainability, and Resilience, and Information Technology. SCRA grant funding is made possible, in part, by Industry Partnership Fund (IPF) contributions. Contributors receive a dollar-for-dollar South Carolina income tax credit, making it a no-cost way to create a direct, positive economic effect and job creation

Mission

Fuel South Carolina’s innovation economy by accelerating technology-enabled growth of academia, entrepreneurship, and industry.

Vision

SCRA will be a leading catalyst in making South Carolina the top choice for technology-focused industry, entrepreneurs, investors, and academics.

Federal Matching Grant (formerly SBIR/STTR Phase I)

Managed by the Academic Innovations Team, the objective of the Federal Matching Grant is further federal funds received by small businesses in South Carolina to advance translational research in support of one or more critical milestones towards commercialization. Other Federal matches will be considered on a case-by-case basis. Key milestones include developing the technology past the minimum viable product (MVP) and demonstrating product-market fit, in the DEVELOP stage of startup development. In the ACCELERATE stage of startup development, key milestones include enabling product execution through testing and demonstrations.

2027-2028 Community Mental Health Services Block Grant

The BHDD federal fiscal year 2027-2028 Community Mental Health Services Block Grant Application was available for review and public comment from August 24-31, 2026.

Please note that this application serves as the Agency’s Community Mental Health Services Block Grant State Plan, required by Public Law 102-321, for providing comprehensive community mental health services to adults with a serious mental illness (SMI) and to children with a serious emotional disturbance (SED). The Block Grant is a noncompetitive formula grant that is provided to BHDD Office of Mental Health by the Substance Abuse and Mental Health Services Administration (SAMHSA).

Community Mental Health Services Block Grant (MHBG)

Each year, BHDD receives a two-year grant from SAMHSA. This grant is called the Community Mental Health Services Block Grant (MHBG). It is a noncompetitive grant based on a formula; funding is provided by SAMHSA to 59 recipients. The funding must be used to provide “comprehensive, community-based mental health services” to two types of people: adults with serious mental illnesses (SMI) and children with serious emotional disturbances (SED). Additionally, the funding can be used to help people who are having mental health crises, even if they have not been diagnosed with SMI or SED. Learn more about the block grant here.

There are many different services and programs that can be funded by the block grant – as long as the services fall into the category of “comprehensive, community-based mental health services” for the two types of people listed above, or the services are for people in crisis. This includes services like individual counseling, family counseling, group counseling, psychiatric services, medication management, transitional services, care coordination and crisis interventions.

BHDD provides block grant funding to each of its 16 community mental health centers (CMHCs) and several central administration programs. These CMHCs and programs provide a wide variety of services to patients and people in crisis.

BHDD also allocates block grant funding to nonprofit organizations through a competitive solicitation process. The next available solicitation will fund nonprofits from July 2026 – June 2029. Nonprofit organizations that are interested in applying for block grant funding should check this webpage in the summer of 2025 for more information about the next solicitation.

A Mental Health Planning Council is a required activity for this grant. The purpose of the Planning Council is to ensure collaboration among various state agencies and provide opportunities for people with lived experiences with mental illness to give feedback and input to BHDD. Specific state agencies are required to participate on the council. A minimum of 51% of the Planning Council members must be people with lived experiences with mental illness or family members of people with mental illnesses. 

The BJA FY 2026 John R. Justice Formula Grant Program offers loan repayment assistance to local and state prosecutors and public defenders who commit to three years of service. Administered by state agencies, this program aims to alleviate the financial burden on legal professionals dedicated to public service. Applications are due by November 10, 2026, providing a crucial opportunity for eligible beneficiaries to secure support for their educational loans.

The National Oceanic and Atmospheric Administration (NOAA) is inviting proposals for projects that enhance coastal flood protection through public-private partnerships, innovative insurance products, and improved sediment management. This initiative aims to utilize natural infrastructure to bolster flood preparedness and resilience. Funding of up to $2,000,000 is available for selected projects, supporting research teams that collaborate with regional stakeholders. Proposals must be submitted via Grants.gov, ensuring accessibility to critical resources and information.

The BJA FY 2026 Tribal Justice Training and Technical Assistance Program aims to enhance Tribal justice systems through specialized technical support. This funding opportunity addresses critical issues such as violent crime and substance-use related crime, including opioids. By assisting federally recognized Indian Tribes, the program promotes the development of sustainable legal and corrections infrastructure while fostering collaboration with federal, state, and local partners. Applications are due by October 28, 2026, at 8:59 p.m. ET.

The OJJDP FY 2026 Second Chance Act Youth Reentry Program aims to provide critical support for moderate- to high-risk youth transitioning back into their communities after confinement. This funding opportunity encourages collaboration among state agencies, local governments, Tribes, and community organizations to deliver comprehensive reentry services and assist youth in overcoming challenges related to recidivism. Applications are due by November 9, 2026, at 8:59 p.m. ET.

The OJJDP FY 2026 Internet Crimes Against Children (ICAC) Task Force Program Support aims to fortify a national network of 61 multiagency task forces dedicated to combating child sexual exploitation facilitated by technology. This funding opportunity enhances training, prevention, and outreach efforts while fostering collaboration among law enforcement entities. Applications are due in JustGrants by November 9, 2026, at 8:59 p.m. ET, ensuring timely support for critical initiatives to protect children.

The CDC is offering funding to enhance collaboration among tuberculosis control programs and various partners in the U.S. This initiative aims to strengthen relationships with national TB control entities, federal agencies, academia, and community organizations. The goal is to promote health and quality of life by preventing, controlling, and eventually eliminating tuberculosis in the United States, building on previous funding opportunities.

The Advanced Rehabilitation Research Training (ARRT) Program aims to enhance the research capabilities of individuals with advanced degrees, focusing on disability and rehabilitation research related to employment outcomes. Funded by the US HHS Administration for Community Living, this grant offers a 36-month project period, supporting multidisciplinary training for researchers, including those with disabilities, to contribute to high-quality research in the field.

The Advanced Rehabilitation Research Training (ARRT) Program, funded by the US HHS: Administration for Community Living, aims to enhance the capabilities of individuals with advanced degrees in conducting high-quality research focused on health and function outcomes for people with disabilities. The program offers advanced training opportunities over a 36-month period, specifically targeting rehabilitation researchers, including those with disabilities, to foster multidisciplinary approaches in disability and rehabilitation research.

The FY 2027 Department of War Multidisciplinary Research Program (MURI) funds U.S. academic teams engaged in innovative basic research addressing future defense challenges. Established in 1985, MURI emphasizes collaboration across multiple scientific disciplines to tackle complex, DoW-relevant issues. By fostering partnerships among faculty, postdoctoral researchers, and students, the program aims to advance the U.S. defense industrial base and nurture a skilled scientific workforce, contributing to significant breakthroughs in military technology and economic growth.