Best Grants for Science Research in South Dakota

South Dakota nonprofits working on economic advancement, affordable housing, or community arts and culture can access funding through US Bancorp Foundation to support programs that address racial and economic inequities. 501(c)(3) organizations in designated U.S. Bank communities, especially those led by people of color or advancing diversity, equity, and inclusion, may be competitive applicants.

Grants from Costco Foundation help South Dakota 501(c)(3) nonprofits fund community programs for children, education, and health and human services. Organizations conducting science-related education or health initiatives that benefit children or families may be eligible. Funding decisions consider documented community need, measurable outcomes, collaboration, and a broad base of financial support.

Focused on innovative human services, the Creag Foundation invites South Dakota 501(c)(3) nonprofits to seek support for new approaches to social problems. Organizations with at least one year of tax-exempt status, including those advancing science-related human or environmental services, may be eligible to submit a letter of inquiry by invitation.

501(c)(3) nonprofits conducting youth-focused programs, including science and research initiatives, can apply for the DanPaul Foundation’s grants, with awards up to US $15,000. Organizations in South Dakota may be eligible if their work advances the health, education, development, or welfare of children and youth worldwide, including scientific endeavors improving quality of life.

Early-stage, impact-first nonprofits and mission-driven for-profits working on scalable social or environmental solutions in South Dakota can access funding through Draper Richards Kaplan Foundation, with awards up to US $300,000 over three years. Organizations conducting applied science or research-based interventions that directly benefit underserved communities may be competitive applicants.

Nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment, including those serving South Dakota, can seek Global Impact Cash Grants to tackle critical social challenges. Cisco Systems Foundation prioritizes innovative, early-stage, tech-enabled solutions for underserved communities worldwide, with awards up to US $100,000 and applications accepted year-round via an initial LOI.

South Dakota educational institutions, government programs, 501(c)(3) nonprofits, and volunteer fire companies can access funding through State Farm Companies Foundation to support safety, education, and community development initiatives. Projects may include disaster preparedness, auto and home safety, K–12 or higher education, STEM programs, job training, financial literacy, affordable housing, and neighborhood revitalization that could complement science-related work.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

South Dakota nonprofits providing direct social services that address chronic poverty and strengthen families can access funding through William Randolph Hearst Foundation for program, capital, or general support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million and strong, scalable outcomes may be eligible for grants of more than US $100,000.

Organizations such as nonprofits, social enterprises, schools, and government entities in South Dakota working on education or children’s health can apply for Michael & Susan Dell Foundation grants; awards are More than US $50,000 for project support or scaling. Eligible projects must serve urban low-income children or youth in the U.S., India, or South Africa and align with the foundation’s values.

Nonprofit organizations with 501(c)(3) or 170(c)(2) status in South Dakota counties served by NorthWestern Energy can seek funding for education, health and human services, civic projects, culture and the arts, and resource conservation. With a mission to build stronger communities, NorthWestern Energy provides monetary support for programs, equipment, and facility improvements.

Focused on science and education, this corporate philanthropy program invites accredited charities to propose innovative projects that promote sustainable development and can leverage Roche’s scientific expertise and logistics capabilities. Eligible organizations in South Dakota may be able to access support for youth science education, health-related research outreach, or community-focused STEM initiatives through local Roche affiliates.

Nonprofit and humanitarian organizations conducting health, education, or disaster relief programs for marginalized communities worldwide, including South Dakota, can apply for support from the Semnani Family Foundation. Grants may benefit projects in areas like health care access, disease prevention, child and women’s health, literacy, and broader human and social services that intersect with scientific or health-related research.

With a mission to support charitable, scientific, medical, and educational work, Sidney Stern Memorial Trust provides South Dakota science organizations and other 501(c)(3) nonprofits with funding for U.S.-based programs. Eligible tax-exempt organizations conducting chemistry, biology, physics, or related research in the U.S. may be strong candidates.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

Southern 501(c)(3) organizations conducting education or health-related science work can access funding through Robinson Foundation if they serve communities below the Mason-Dixon line. Grants support single-year projects in areas like medical assistance, education, environmental conservation, and disaster relief, which may benefit South Dakota partners working collaboratively in these fields.

Nonprofit 501(c)(3) organizations conducting community-focused or environmental science work in South Dakota may be eligible for funding that supports research and related programs. Focused on community services, environmental conservation, and peacebuilding, the Dudley T Dougherty Foundation invites proposals that advance understanding, stewardship, and well-being in a changing world.

Nonprofit 501(c)(3) organizations supporting basic needs, at-risk youth education, workforce readiness, or safety from domestic violence near TJX locations, including South Dakota, can seek program funding. The TJX Foundation invites eligible groups to complete an online eligibility questionnaire, then a Letter of Inquiry, with full applications accepted by invitation only.

Nonprofit 501(c)(3) organizations, public schools, and libraries conducting environmental or human services work in South Dakota can seek unrestricted program or operating support from the Lawrence Foundation, with typical awards of US $5,000 - US $10,000. With a mission to support environmental and human services causes, the foundation welcomes applications that may include science-related environmental research or conservation projects.

Max and Victoria Dreyfus Foundation provides South Dakota nonprofit organizations with grants of US $1,000 - US $20,000 for museums, cultural and performing arts, education, health facilities, environmental and wildlife protection, and community services. U.S.-based 501(c)(3) groups conducting science-related education or community programs may be eligible if a relatively small award would have significant impact.

Individuals and institutions affiliated with NNLM Region 4 member libraries, including those in South Dakota, can apply for National Library of Medicine professional development awards of US $2,500 to build skills in health information access, data science, and related areas. Funding supports workshops, conferences, courses, speakers, and other training that enhance health information services for underrepresented communities.

Nonprofit 501(c)(3) organizations working on basic needs, community development, cultural enrichment, or volunteer-driven programs in the U.S., including South Dakota, may be eligible for Ameriprise Financial Community Grants. Focused on hunger, housing, adult self-sufficiency, and community vitality, these grants prioritize measurable outcomes, financial stability, and strong engagement from Ameriprise employee and advisor volunteers.

The Nordstrom Community Grant focuses on supporting youth and families by providing over $1 million in grants annually. It aims to assist grassroots organizations that address essential community needs such as food, shelter, and clothing, as well as creating opportunities for economic mobility through mentorship and workforce development. Eligible organizations must be 501(c)(3) nonprofits located in areas where Nordstrom operates. Applications are encouraged for those meeting these criteria.

The Dr. Scholl Foundation offers grants annually to IRS 501(c)(3) organizations, primarily focusing on U.S. applicants. The foundation supports projects in education, social services, healthcare, civic and cultural initiatives, and environmental efforts. While the grant cycle runs from October 1 to March 1, it encourages innovative solutions to global challenges. Only one application per organization is accepted each year, and funding is limited to one year. Unqualified organizations, including political entities, are ineligible.

South Dakota nonprofits supporting youth education, basic needs, housing, or environmental programs can access funding through Chick Fil A Foundation’s True Inspiration Awards. Eligible 501(c)(3) organizations may receive US $30,000 - US $350,000 for initiatives such as academic enrichment, food security, family services, community development, or environmental stewardship, including garden and outdoor learning projects.

U.S. nonprofit organizations leading strong, replicable community partnerships, including those in South Dakota and potentially involving science research collaborations, can apply for Mutual of America Foundation’s national Community Partnership Award. Funding recognizes exemplary cross-sector partnerships that measurably improve communities, model effective collaboration, and inspire innovative approaches to significant social issues.

Non-sectarian human and social service nonprofits helping disadvantaged people become self-reliant can apply for US $5,000 - US $250,000 in project or program support, including work in South Dakota. With a mission to expand opportunity, Gupta Family Foundation provides smaller 501(c)(3)s and qualifying foreign entities with grants for poverty alleviation, disability services, and humanitarian relief that may intersect with science-related initiatives.