Best Grants for 501(c)(3) in South Carolina

The David, Helen and Marian Woodward Fund, established by Marian Woodward Ottley in 1974, aims to support non-profit organizations in Georgia and neighboring states. The fund prioritizes capital projects and educational programs that enhance graduation rates, particularly those with religious affiliations. Grants are awarded exclusively to 501(c)(3) organizations, while governmental agencies can also apply. The foundation's mission underscores a commitment to improving the world for future generations.

The Norfolk Southern In-Kind Donation Grant supports organizations seeking physical donations of materials that align with their focus areas, including safety, sustainability, workforce development, and thriving communities. This grant is available year-round, with no application deadline. Recipients must be located within Norfolk Southern territory and are encouraged to apply for resources that will enhance their community projects and initiatives, fostering growth and resilience.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Karen Colina Wilson Foundation Grant supports programs for children, youth, and women, enhancing their health and well-being through education, art, literature, and music. Established in 2006, the foundation aims to make a positive difference in their lives, particularly in Southern and Western Wayne County, Michigan. Grants typically range from $500 to $10,000, often as matching funds, fostering broader fundraising efforts by local nonprofit organizations.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Kids’ Chance of South Carolina Scholarship provides financial assistance to children of South Carolina workers who have been killed or seriously injured in work-related incidents. Ranging from $500 to $3,000, these scholarships aim to alleviate the financial hardships faced by these families, empowering students aged 16-25 to pursue post-secondary education. Eligible applicants must demonstrate financial need and be accepted or enrolled in an educational institution, ensuring support for their educational aspirations.

The Wallace F. Pate Scholarship, established by the Hampton Wildlife Fund in 2004, awards $2,500 annually to a South Carolina resident pursuing higher education in natural resource disciplines. This scholarship honors Wallace F. Pate, a pioneer in offshore big game fishing. Eligible applicants must be seniors in South Carolina high schools, planning to major in fields such as wildlife biology or environmental science. The scholarship aims to support future conservation leaders and promote educational growth in South Carolina.

The Therapeutic Giving program by Johnson & Johnson focuses on funding initiatives that enhance patient access to treatment and advance health equity, particularly in immunology. Eligible nonprofit organizations can apply for support aimed at improving health outcomes through innovative programs. The initiative prioritizes measurable impacts over fundraising activities, emphasizing the importance of addressing healthcare disparities and promoting disease awareness efforts for diseases like rheumatoid arthritis and psoriasis.

Grants

Through our grantmaking, we support nonprofits that serve South Carolina at local, regional and state levels to address root causes of poverty while honoring the dignity of every South Carolinian.

Starting in 2026, our grants focus primarily on systems change in the areas of

• economic mobility,
• housing security and
• health care (with health care systems change grants by invitation only).

By focusing our efforts and going deeper on these three issues, we aim to have an even greater impact on the nonprofits and communities we serve.

Systems Change Grants

Systems Change Grants fund organizations and coalitions that are working to change the policies, power structures and mindsets that cause and reinforce poverty in South Carolina. These grants specifically fund systems change that supports economic mobility and housing security.

Through these grants, we aim to generate a larger impact through more intentional funding, highly focused work and alignment across our Foundation’s activities.

What Systems Change Grants Support

• Organizations that are actively working on systems change that impacts people experiencing poverty and addresses economic mobility or housing security. To see how the Foundation defines these terms, visit our Strategic Plan webpage.
• Organizations that are seeking to change systems at the local, regional or state level. Systems Change Grants provide up to $75,000 annually for local or regional work.
  • State-level grants have a $100,000 maximum each year. 
• Organizations addressing systems change in at least one of the following ways:
  • Participating in advocacy and lobbying
    • Focus on changing policies, practices, processes, rules or laws
    • Impacting resource flows (i.e., reallocated and/or new funding streams)
    • Holding systems accountable to their intended purpose through the above as well as through litigation
  • Addressing unequal power
    • Focus on changing the distribution and dynamics of privilege, relationships and tradition
    • Organizing and building connections and coalitions that center community voices and perspectives
    • Civic engagement
  • Affirming the dignity of people experiencing poverty
    • Focus on changing the narrative around poverty
    • Focus on changing attitudes, mindsets, values, belief systems, norms, mental models and paradigms
  • Implementing big impact, scalable, or innovative solutions
    • Focus on changing results, especially for groups experiencing inequitable outcomes as a result of historic and current marginalization

All grants are for one year, with the possibility of renewal up to three years based on meeting reporting requirements and the availability of funding.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

The Vulcan Materials Company Foundation Grant focuses on enhancing community quality of life through education, environmental stewardship, and employee involvement. Established in 1988, the Foundation supports public charities and government units, prioritizing proposals that improve public education and promote sustainable practices. Special consideration is given to initiatives that engage Vulcan employees and integrate multiple focus areas, ensuring a positive impact in the local communities where Vulcan operates.

2026-27 Career Cluster Partnership Program

Description

The South Carolina General Assembly has provided funds to the South Carolina Department of Education (SCDE) through a legislative proviso (H. 5126 General Appropriations Bill, Proviso 1A.27) for one year to award grants on a competitive basis to private-sector statewide trade associations that provide nationally certified programs in career and technical education representing the automotive, construction, engineering, healthcare, mechanical contracting/construction, and hospitality and tourism career clusters. The purpose of this program is to support instructor/student training and student testing in industry clusters to increase the state’s skilled workforce. The SCDE administers the program through its Office of Career Readiness (OCR).

The Wabtec Direct Grant Program focuses on creating sustainable impacts in local communities by funding 501(c)(3) non-profit organizations. Emphasizing education and environmental stewardship, the program supports initiatives that improve literacy, academic outcomes, and workforce readiness. Grants range from $1,000 to $10,000, prioritizing organizations that engage local Wabtec employees in volunteerism. The program promotes equitable access and non-discrimination while ensuring measurable results in funded projects.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CRRP 

Through the competitive Collaborative Regional Research Programme (CRRP), we promote regional research that has potential to improve our understanding of global change and its implications while contributing to a sound scientific basis for policymaking in areas affected by global change. Under this pillar, APN supports collaborative research that contributes to the evolving science-policy arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction and the UN Decade of Ocean Science as well as ongoing and new global change and sustainability research programmes.

Activities of interest under the CRRP Programme

APN promotes regional collaborative research that improves understanding of the physical, biological and human dimensions of change in the Earth system and advances actionable science that informs decision-making. APN accepts proposals that engage at least 3 member/approved countries in the region, and prioritise collaboratively designed, actionable research with non-academic stakeholders. Proposals must address one or more of the following activities:

• Collaborative research on global change and sustainability that particularly addresses GAPS, ANALYSIS, SYNTHESIS and ASSESSMENT work.
• Collaborative research that develops PATHWAYS and MECHANISMS to achieve sustainable development, and develop adaptation strategies.
• Collaborative PLACE-BASED INTEGRATIVE RESEARCH, particularly from developing countries.
• Collaborative research that is CO-DESIGNED to contribute to the Paris Agreeemnt, Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, Post-2020 Global Biodiversity Framework, UN Decade of Ocean Science (2021-2030), and the accumulation of scientific knowledge at IPCC, IPBES, etc.

The Pinetop Assistance League (PAL) Grant provides crucial financial support to elderly blues musicians, ensuring their well-being during emergencies. This grant, part of the Pinetop Perkins Foundation's mission, offers assistance for medical expenses, home care, and essential living costs. Eligible applicants must be professional artists aged 50 or older with a household income below $35,000. By addressing these needs, PAL plays a vital role in preserving the legacy and care of blues musicians.

The National Institutes of Health (NIH) is inviting applications for the Screening, Brief Intervention, and Referral to Treatment or Prevention (SBIRT/P) program. This funding opportunity aims to explore innovative methods for addressing alcohol, tobacco, and other drug use among adults facing health disparities. The initiative seeks research proposals that will implement and evaluate SBIRT/P strategies in collaboration with healthcare and community partners. This approach is crucial for enhancing public health and ensuring effective interventions.

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

The NHLBI Career Transition Award (K22) program supports postdoctoral fellows in transitioning their research to extramural institutions. The program includes a mentored intramural phase (up to two years) followed by an extramural phase (three years), totaling five years of support. Applications have multiple deadlines, including October 12, 2024, and February 12, 2025, among others. Successful transition depends on the awardee's progress during the mentored phase, evaluated by NHLBI.

The Josh Turner Scholarship Fund for the Arts, established by the Community Foundation of Middle Tennessee, empowers high school seniors from rural areas across ten southern states to pursue careers in music and the arts. This fund honors Josh Turner's journey in the music industry and aims to support students focusing on diverse opportunities within the music business, including performance, writing, and production, as well as various art disciplines.

South Carolina State Firefighters’ Association

The South Carolina State Firefighters’ Association was founded in 1905 by a group of determined fire service leaders committed to strengthening the fire service through education, training, benefit provision, and legislative representation. Today, our mission stands: to serve the membership as the leader in fire service advocacy, benefits, education, and safety, while acting as the steward of the Firemen’s Insurance and Inspection Fund.

To fulfill this mission, the Association is supported by a family of programs and organizations that extend our reach and impact. These include the South Carolina Firefighters Foundation, the South Carolina Burned Children’s Fund (operating under the Foundation), the South Carolina Firefighters Insurance Services, and the South Carolina Firefighters Assistance Team.

Lieutenant Taylor A. Graham Memorial Scholarship

Lieutenant Graham served in the fire service for more than 30 years, dedicating his career to protecting citizens across Greenville and Spartanburg Counties. He proudly served 22 years with the City of Greer Fire Department as a Lieutenant and was also a member of the Greenville County Emergency Response Team (ERT). Beyond his years of service, Lieutenant Graham was deeply passionate about mentoring and teaching future firefighters. As an instructor at the fire academy, he took great pride in helping develop the next generation of fire service professionals and was honored to share his knowledge and experience with others entering the profession.

The Graham family has established an annual scholarship in remembrance of Lieutenant Taylor A Graham’s dedication and passion for the citizens of Greenville and Spartanburg Counties, and South Carolina’s fire service.

Applicants must complete the application, offer a letter of support from the applicant’s Fire Chief, and provide a general reference letter of support from a person of the applicant’s choosing. 

The Professional Development and Artistic Planning Grants, offered by South Arts, support the professional growth of presenters, programmers, and curators in the Southern U.S. These grants facilitate travel to conferences, workshops, and other opportunities to enhance organizational capacity and program design. Emphasizing diversity and inclusion, South Arts encourages applications from organizations led by BIPOC, LGBTQIA+, and disabled individuals. Funding covers travel, training, and related expenses, promoting equitable access to professional development.

The Duke Endowment's Child and Family Well-Being Grant provides implementation support to public and private agencies in North and South Carolina. This funding aims to adopt and sustain evidence-based programs that prevent and treat child maltreatment. Eligible organizations must have two years of audited financial statements and work with accredited groups. The grant prioritizes innovative solutions and advocacy to improve child welfare systems, ensuring effective support for children and families at risk.

The Big Bets Fellowship: Economic Opportunity in the United States is a transformative 4-month program designed to empower emerging leaders to tackle economic challenges head-on. With a focus on innovative solutions for job creation, affordable housing, and equitable access to resources, the fellowship equips participants with essential skills and a supportive network. The initiative aims to drive systemic change and promote sustainable economic prosperity, addressing inequalities while fostering resilient communities across the nation.

The Summer Reading Camp Community Partnership Grant aims to support students struggling with reading proficiency by providing quality instructional services and engaging learning experiences. With approximately $700,000 available, the grant encourages partnerships with community organizations to enhance student achievement. Applicants are urged to ensure regular attendance and parental involvement. The South Carolina Department of Education will award 10-15 grants based on the quality of applications received, with final budgets subject to negotiation based on needs.

The South Carolina Commodity Supplemental Food Program (CSFP) aims to enhance the health of individuals aged 60 and above by providing nutritious USDA food packages. Administered by the South Carolina Department of Agriculture, the program helps eligible participants with limited income access essential nutrients. Local agencies distribute food and offer nutrition education while connecting them to additional support services like SNAP and Medicaid. This initiative addresses dietary deficiencies in the senior population of South Carolina.

The Tribal Wildlife Grants (TWG) program, offered by the US Department of the Interior's Fish and Wildlife Service, provides vital technical and financial assistance to federally recognized Tribes. This funding supports various conservation activities, including habitat protection, species monitoring, and wildlife management, helping to preserve both culturally significant species and ecosystems. TWG grants empower Tribes to implement their conservation priorities effectively and sustainably.

Arbor Rising Grant, established in 2010, is a NYC-based nonprofit providing unrestricted multi-year funding and capacity-building support to nonprofits focused on alleviating poverty. The grant process occurs every three years, with the next round in 2025 being invitation-only. Eligible organizations must demonstrate high potential and effective leadership, typically operating on a modest budget. Arbor Rising prioritizes applicants from the NYC metro area while expanding to cover the lower 48 US states.