Best Grants for 501(c)(3) in South Carolina

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

Ecolab Foundation

Ecolab Foundation is a philanthropic arm of Ecolab dedicated to advancing community well-being through programs that promote education, environmental stewardship, and public health. Its mission is to create positive social impact by supporting initiatives that strengthen communities and foster sustainable development.

The foundation’s primary areas of engagement include educational programs that enhance learning and workforce readiness, environmental projects that encourage conservation and sustainability, and health-related initiatives that improve hygiene and safety. It focuses on partnerships that deliver measurable benefits and long-term impact.

Ecolab Foundation operates primarily within the United States while also supporting global initiatives aligned with its corporate responsibility goals. Its geographic scope reflects a commitment to addressing local community needs and contributing to broader sustainability efforts.

The foundation collaborates with nonprofit organizations, educational institutions, and community-based groups. It prioritizes partnerships that demonstrate strong governance, clear objectives, and alignment with its mission of education, health, and environmental responsibility.

Ecolab Match Program

Ecolab established the Volunteer and Community Relations programs to encourage and reward Ecolab employee and alumni involvement in the communities where people live and work. There are three programs including the Board Leadership Volunteer Grant.

Board Leadership Volunteer Grant

Ecolab will donate up to $500 USD annually to a qualifying 501(c)3 organization (some restrictions apply) for which an eligible person serves on the Board of Directors. 

Focus Areas of Giving

• Youth and Education: programs that promote youth development, particularly for programs that ensure all students are successful
• Civic & Community Development: affordable housing, work readiness, crisis assistance and hunger relief
• Environment & Conservation: hands-on environmental learning programs, environment and conservation organizations
• Arts & Culture: arts education for children and youth as well as support for museums and the performing arts

Lilly Foundation

To extend Lilly’s charitable reach and impact, the Eli Lilly and Company Foundation (Lilly Foundation) was established in 1968 and is supported by donations from Eli Lilly and Company.

The Foundation is a tax-exempt, private foundation supporting programs that align with its philanthropic priorities.

Grantmaking Approach

The Lilly Foundation’s work is guided by a charitable vision of a world where every person has an opportunity to live their healthiest life. Through grantmaking focused on Lilly Foundation’s charitable vision, grants can serve as a catalyst for closing gaps and empowering individuals and communities to thrive.

All proposals should demonstrate clear alignment with at least one focus area and include charitable outcomes that are measurable and consistent with the Foundation’s long-term charitable goals.

Global Health, K-12 STEM Education and Economic Mobility Grant

Focus Areas

Global Health

Lilly Foundation, through its charitable grants, aims to support permissible charitable efforts to improve access to quality healthcare for resource-limited communities in low- and lower-middleincome countries (L/LMICs) and in the United States. Strengthening access to care is essential for enhancing community well-being and supporting economic stability in resource-limited settings.

The Global Health focus area aims to close gaps in quality healthcare by supporting charitable solutions that improve access, bring care closer to where people live, and address the high burden of non-communicable diseases (NCDs) in resource-limited settings. To the extent permissible, the Foundation prioritizes charitable efforts related to cardiometabolic health in resource-limited settings.

K-12 STEM Education

The K-12 STEM Education focus area aims to close the gaps for students from low-income communities by supporting programs that foster new pathways and pipelines to STEM education through focused K-12 efforts, concentrating on the critical middle school years. The Foundation’s K-12 STEM Education grants are focused on initiatives that benefit Marion County, Indiana.

Economic Mobility

The Economic Mobility focus area supports charitable and educational programs that strengthen workforce readiness, postsecondary and skills-based educational pathways, and housing stability to promote long-term prosperity. This support is focused on Marion County, Indiana, with the goal of improving economic opportunity for low-income communities and advancing community well-being.

Greenville Women Giving (GWG) is a philanthropic organization in Greenville County, SC, focused on funding impactful community projects. Grants are awarded annually based on member voting and emphasize areas such as Arts, Education, Environment, Health, and Human Services. Organizations must be tax-exempt and serve Greenville County. GWG prioritizes high-impact initiatives that foster collaboration and measurable outcomes, with a commitment to addressing community needs without discrimination. The application deadline is at the end of November each year.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

South Carolina Housing Trust Fund (HTF)

The South Carolina Housing Trust Fund (SC HTF) is a valuable resource for developing and maintaining safe, quality affordable housing for low to very low-income households within the state. Funding and assistance for eligible home repairs and supportive housing projects are provided through three core programs—The Home Repair Program, Critical Home Repair Program, and Supportive Housing Program. SC Housing administers the HTF program in partnership with other government organizations, non-profit sponsors and affordable housing developers. The HTF program also coordinates its efforts with other federal, state, and local housing assistance programs to achieve maximum benefit for participants.

The Critical Home Repair Program provide financial assistance to help low to very low-income homeowners with essential interior and exterior home repairs to correct life, health and safety issues so that they can live safely in their homes. These programs help to repair or replace major housing systems, including roofs, water heaters and HVAC equipment. It also covers home modifications, such as ramps, to provide accessibility for persons who are disabled. A home inspection is conducted to help identify any additional repairs that may be needed to provide the homeowner with safe and decent living conditions. The Sponsor then coordinates completion of the work with qualified contractors. The homeowner benefits by staying safely in a home that they can continue to enjoy for years to come. Local communities also benefit by maintaining the supply of affordable homes in their area.

The Doree Taylor Charitable Foundation supports charitable organizations focused on basic provisions for underserved populations, humane care of animals, health care services, public media, and environmental initiatives. The foundation prioritizes organizations in Boothbay Harbor, Southport, and Brunswick, and encourages requests for general operating support, program support, and capital projects, while maintaining a focus on the impact of their services.

The SC AmeriCorps Formula Grant, funded by the United Way Association of South Carolina, provides financial support ranging from $140,000 to $400,000 for organizations to enhance their service capacity through AmeriCorps Members. These members receive living allowances, education awards, and health benefits while focusing on areas such as education, economic opportunity, and disaster services. Organizations must match 24% of project costs if they are new to grant funding.

The Japan – U.S. Global Partnership Grant Program aims to foster collaborative projects addressing global issues through partnerships between Japanese and American organizations. It focuses on policy-oriented research and dialogue among diverse professionals, including academia and grassroots practitioners. Key thematic areas include resilience, inclusivity, and advancements in science and technology. Projects outside these themes may also be eligible if aligned with grant goals, covering topics like climate change, public health, and digital transformation.

The Sachs Family Foundation Grant aims to enhance the quality of life for economically and educationally disadvantaged individuals and families. The Foundation supports self-sustaining charitable organizations focusing on economic and educational opportunities, particularly in low-income communities in the U.S. and developing countries. Grants are available for various initiatives, including education, housing, and job training, with a keen interest in programs that demonstrate clear potential for sustainability.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

Alzheimer’s Resource Coordination Center (ARCC)

Overview

The Alzheimer’s Resource Coordination Center (ARCC), located within the South Carolina Department on Aging, was established by state legislation in 1994. The Center’s goal is to serve as a statewide focal point for coordination, service development, information, and education to assist persons with ADRD and their families. The ARCC is guided by a Governor-appointed advisory council composed of representatives from state agencies, organizations, and caregivers who have a special interest in Alzheimer’s disease and related dementias (ADRD). The advisory council aids the ARCC in meeting its goals of:  

• Initiating the development of systems which coordinate the delivery of programs and services
• Facilitating the coordination and integration of research, program development, planning, and quality assurance
• Identifying potential users of services and gaps in the service delivery system and expanding methods and resources to enhance statewide services
• Serving as a resource for education, research, and training and providing information and referral services
• Providing technical assistance for the development of support groups and other local initiatives to serve individuals, families, and caregivers
• Recommending public policy concerning Alzheimer's disease and related disorders to state policymakers
• Facilitating the coordination and integration of educational initiatives for healthcare providers on the importance and value of early detection and timely diagnosis of cognitive impairment, validated cognitive assessment tools, and increasing understanding and awareness of early warning signs of Alzheimer’s disease and other types of dementia and how to reduce the risk of cognitive decline.

The ARCC is staffed by the Dementia Coordinator whose role is to monitor the state’s service delivery system and work closely with the ARCC Advisory Council to develop a coordinated state-wide delivery system that caters to the needs of persons with ADRD, their families, caregivers, and communities. Additionally, the Dementia Coordinator is responsible for submitting an annual report to the Chairman of the Medical Affairs Committee of the Senate and the Chairman of the Medical, Military, Public, and Municipal Affairs Committee of the House of Representatives on the activities of the ARCC.

ARCC Grants

Each year, the ARCC receives $150,000 to award dementia-specific grants to community organizations to support respite, education, and innovative programs for individuals living with Alzheimer’s and related dementias, their families, caregivers, and communities. Grants are awarded on a 2-year cycle through a competitive selection process. 

Since its establishment in 1995, the ARCC Grants Program has awarded over 388 grants to community organizations that provide services to individuals, families, and communities affected by dementia. These services include dementia-specific respite, adult day programs, and educational programs that support the medical community, colleges and universities, first responders, and the general public. The ARCC grants have enabled more than 7,717 individuals living with ADRD to access respite care services and provided education services to over 78,117 participants. Moreover, since 2021, ARCC grants have supported the implementation of 17 innovative programs. These programs include virtual training for family caregivers, in-home activities that promote sustainability and independence in daily living for those with dementia, and technology that helps locate and safely return those with dementia who may have wandered from home.

During the FY25 grant period (July 1, 2024 to June 30, 2025), a total of 10 ARCC grants were awarded, providing services across 14 counties. 

The External Collaborative Research (ECR) program by Boehringer Ingelheim invites academic and community scientists to propose collaborative studies aimed at protocol development and result publication. This program offers potential drug and financial support, excluding direct salary for the Principal Investigator. Budgets must represent fair market value and will be negotiated further. Research interests span therapeutic areas including Cardio-Renal-Metabolic, Mental Health, Dermatology, and Oncology, encouraging innovative solutions to unmet medical needs.

The NRCS' Feral Swine Eradication and Control Pilot Program for FY 2026 aims to combat the environmental and agricultural threats posed by invasive feral swine. With over $3.4 billion in annual damage attributed to these species, the program seeks to mitigate their impact on ecosystems and human health. Funded by the USDA, this initiative targets states with high feral swine populations, emphasizing collaborative efforts with State Technical Committees to implement effective control measures.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The South Carolina Forest Renewal Cost-Share Program provides essential financial assistance to eligible landowners for tree planting and forestry management practices. This initiative, supported by the South Carolina Forestry Commission and local forest industries, aims to enhance timber supplies and promote environmental benefits such as clean air and wildlife habitats. With funding covering up to 90% of costs, the program encourages sustainable forestry practices while stimulating the local economy. Participation requires adherence to specific management plans and completion within set timelines.

What does this program do?

It provides loans and grants to Microenterprise Development Organizations (MDOs) to:

• To help microenterprises startup and growth through a Rural Microloan Revolving Fund.
• Provide training and technical assistance to microloan borrowers and micro entrepreneurs.

The Carolina Bird Club offers ongoing grants for research, monitoring, and education focused on the conservation of birds in the Carolinas. These grants support projects that promote bird observation, education, and habitat protection. Applicants must be affiliated with an educational or non-profit institution and provide detailed proposals, including a budget and a letter of support. The club encourages projects addressing local conservation needs and aims to foster a deeper appreciation for avian species and their habitats.

SITKA Ecosystem Grants support projects that enhance ecosystems and promote conservation efforts. These grants encourage both grassroots initiatives and larger organizational projects, aiming to improve habitat restoration, biodiversity, and the hunting experience. With funding ranging from $3,000 to $20,000, applicants must be 18 years or older and have relevant experience. The review process is ongoing, and projects should emphasize collaboration and measurable impacts on environmental goals, benefiting both society and ecosystems.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

South Arts, Inc. offers Professional Development Grants for Arts Organizations to enhance the skills and knowledge of Southern arts entities. These grants aim to support operational stability and growth, focusing on organizations with budgets of $500,000 or less. Eligible applicants include a range of arts organizations within South Arts' nine-state service area. The program emphasizes first-time opportunities and requires a dollar-for-dollar cash match, ensuring a commitment to professional development in the arts.

The Postdoctoral Grant Program at the University of Wisconsin School of Medicine and Public Health aims to support the growth and professional development of postdoctoral trainees, fellows, and associates. With funding up to $20,000 for one year, recipients can engage in independent research projects, attend workshops, or cover open-access publication fees. This initiative enhances research capacity and promotes health equity in Wisconsin, addressing critical health challenges while fostering career advancement in the medical field.

The National Sea Grant Law Center is inviting proposals for the Coastal Resilience Program to research laws and policies addressing coastal resilience challenges such as sea level rise and flooding. With a funding cap of $150,000 over two years, this initiative aims to assess the effectiveness of existing policies and promote informed decision-making in coastal management. Up to two projects will be selected for funding, supporting innovative solutions to enhance community resilience against environmental threats.

The Resilient and Connected Appalachians Grant Program, offered by The Nature Conservancy, provides up to $100,000 for projects that acquire land and easements throughout the Appalachian region. This program emphasizes equitable conservation, aiming to support historically marginalized communities and enhance access to nature while addressing climate change impacts. Projects must demonstrate community engagement and align with the program's goals to protect vital habitats and foster resilience in the face of environmental challenges.

South Arts, Inc. is offering Accessibility Grants of up to $2,500 to nonprofit organizations in the Southeast to enhance accessibility in arts programs for individuals with disabilities. The grants aim to foster inclusivity by supporting projects that engage disabled artists and audiences. Organizations must be located within the South Arts Service region and focus on the arts. Priority will be given to new applicants and those serving BIPOC and LGBTQIA+ communities, with a commitment to rural areas.